Stem Cell Vaccine Carries Potential as Mesothelioma Treatment

Researchers at the Stanford University School of Medicine believe a patient-specific stem cell vaccine could become part of mesothelioma treatment — and possibly prevention — in the future. The belief stems from their recent study that demonstrated a consistent immunologic response with genetically-altered stem cells in laboratory mice carrying particular cancer cells. “This could potentially play a role for a large group of — if not all — cancers,” Dr. Joseph Wu, director of the Stanford Cardiovascular Institute, told “We envision it potentially being used as a vaccine or adjuvant treatment for mesothelioma.” The study involved induced pluripotent stem cells (IPS), which are cells taken from the blood or skin and genetically reprogramed. This allows the cells to attack or prevent cancerous tumors when mixed with a generic immune-stimulating agent. Vaccine Shows Anti-Tumor Response The study tested mice infected separately with breast cancer, melanoma and mesothelioma cells. The anti-tumor response rate was similar in all three types of cancer. “This is significant for future cancer therapies, that we now have a surrogate cell that can provide the immune system with a large amount of cancer-related antigens,” Wu said. “Based on preliminary studies, the effectiveness of our vaccine is not limited to one cancer.” IPS cells typically are used in regenerative medicine, often to repair damage fro...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news

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Publication date: Available online 17 August 2018Source: Journal of Visceral SurgeryAuthor(s): T. Sarcher, B. Dupont, A. Alves, B. MenahemSummaryMultidisciplinary management of infra-peritoneal rectal cancer has pushed back the frontiers of sphincter preservation, without impairment of carcinological outcome. However, functional intestinal sequelae, grouping together several symptoms known under the name of anterior resection syndrome (ARS), have emerged and become an increasingly frequent concern for both patients and physicians. The pathophysiology is complex: ARS is a combination in various degrees of stool frequency, i...
Source: Journal of Visceral Surgery - Category: Surgery Source Type: research
ConclusionExploring perspectives in LARS patients resulted in the identification of potential improvements in current care pathways. Recommendations on ways to improve information provision, screening of LARS and methods to intervene in the gap of supportive care after discharge are presented. We recommend to implement these measures as QoL of patients undergoing colorectal cancer surgery may be improved.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
In this study, we compared perioperative and oncologic outcomes of patients treated with either open or robot-assisted radical cystectomy and intracorporeal neobladder at a tertiary care center.MethodsThe institutional prospective bladder cancer database was queried for “cystectomy with curative intent” and “neobladder”. All patients underwent robot-assisted radical cystectomy and intracorporeal neobladder or open radical cystectomy and orthotopic neobladder for high-grade non-muscle invasive bladder cancer or muscle invasive bladder cancer with a follow-up length ≥2 years were included. A 1:1 pr...
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
ConclusionBoth types of organ-sparing surgeries assessed in this study achieved good outcomes, in terms of the aesthetics, sexual functions, urinary functions, and HRQOL in patients, without compromising the therapeutic effects of these surgeries. However, the observed decreases in orgasmic function will need to be addressed further.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Publication date: September 2018Source: European Journal of Surgical Oncology, Volume 44, Issue 9Author(s): Ricard Ramos, Ernest Nadal, Inma Peiró, Cristina Masuet-Aumatell, Ivan Macia, Francisco Rivas, Gabriela Rosado, Pau Rodriguez, Anna Ureña, Susana Padrones, Samantha Aso, Carlos Deniz, Arturo Navarro, Ignacio EscobarAbstractBackgroundAs nutritional status plays an important role in outcomes after surgery, this study evaluated the association between preoperative nutritional status (NS) and postoperative outcomes after major resection for lung cancer.MethodsWe identified 219 patients with a diagnosis of c...
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
ConclusionsThe EORTC-STBSG response score is applicable for determining the histopathological response to neoadjuvant ESTS treatment. However, this response does not seem to predict LRFS nor OS in locally advanced ESTS.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Cardiac tumors have generally been considered to be rare. They are often found incidentally as they tend to remain clinically silent, but they can sometimes present with symptoms secondary to obstruction, embolization, or invasion of the myocardium. Most cardiac tumors are secondary tumors from metastases, with primary cardiac tumors constituting approximately 15% of all cardiac tumors1. Although melanoma and pleural mesothelioma often have cardiac involvement, the most common cancers to be identified in cardiac metastases are lung cancer (36-39%), breast cancer (10-12%), and hematologic cancers (10-21%)2.
Source: The American Journal of Medicine - Category: General Medicine Authors: Tags: Clinical Communication to the Editor Source Type: research
Autologous iPSC-Based Vaccines Elicit Anti-tumor Responses In Vivo. Cell Stem Cell. 2018 Feb 08;: Authors: Kooreman NG, Kim Y, de Almeida PE, Termglinchan V, Diecke S, Shao NY, Wei TT, Yi H, Dey D, Nelakanti R, Brouwer TP, Paik DT, Sagiv-Barfi I, Han A, Quax PHA, Hamming JF, Levy R, Davis MM, Wu JC Abstract Cancer cells and embryonic tissues share a number of cellular and molecular properties, suggesting that induced pluripotent stem cells (iPSCs) may be harnessed to elicit anti-tumor responses in cancer vaccines. RNA sequencing revealed that human and murine iPSCs express tumor-associated antige...
Source: Cell Stem Cell - Category: Stem Cells Authors: Tags: Cell Stem Cell Source Type: research
Conclusion: PTX3 could be a promising biomarker to differentiate PPE from other causes of pleural effusions. In PPE, an increased level of pleural fluid PTX3 level without a significant increase in serum PTX3 level may reflect a more intense local inflammation than those occur in MPE or TPE.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Others Source Type: research
Conclusions • Physicians should have no hesitation prescribing natural progesterone. The evidence is clear that progesterone does not cause breast cancer. Indeed, progesterone is protective and preventative of breast cancer. PMID: 29055286 [PubMed - as supplied by publisher]
Source: Alternative Therapies in Health and Medicine - Category: Complementary Medicine Authors: Tags: Altern Ther Health Med Source Type: research
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