Compound Interest: Assessing the Effects of Chemical Mixtures

This study … gives the field a new perspective on how to approach the question of adequately and accurately describing how the different chemicals in a mixture can exert biological effects,” says Gabriel Knudsen, a toxicologist at the National Cancer Institute, who was not involved in the study. Knudsen says he hopes that applying this new “mixtures” approach can help inform agencies tasked with setting and enforcing chemical regulations. “More mixtures studies like this one could help shape more well-informed and useful regulations for chemicals that are encountered by people every day,” he says. Lindsey Konkel is a New Jersey-based journalist who reports on science, health, and the environment. References 1. Pollock T, Mantella L, Reali V, deCatanzaro D. 2017. Influence of tetrabromobisphenol A, with or without concurrent triclosan, upon Bisphenol A and estradiol concentrations in mice. Environ Health Perspect 125(8):087014, PMID: 28886593, 10.1289/EHP1329. 2. U.S. Food and Drug Administration (FDA). 2017. 5 Things to Know about Triclosan. https://www.fda.gov/forconsumers/consumerupdates/ucm205999.htm [accessed 6 November 2017]. 3. FDA. 2016. Safety and effectiveness of consumer antiseptics; topic antimicrobial drug products for over-the-counter human use. Fed Reg 81(172):61106–61130. https://www.federalregister.gov/documents/2016/09/06/2016-21337/safety-and-effectiveness-of-consumer-antiseptics-topical-antimicrobial...
Source: EHP Research - Category: Environmental Health Authors: Tags: Science Selection Source Type: research

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This article evaluates access to the Papanicolaou test in the Family Health Strategy (FHS) in municipalities in a health region. Cervical cancer control depends on a well-organized Family Health Strategy, so assessment of access to the Papanicolaou test reflects the quality of care at this level. This is a qualitative study with data produced in 10 focus groups, totaling 70 participants in four municipalities. We analyzed the organizational, symbolic, and technical dimensions of access to the Pap test, with cervical cancer control as the marker. The results indicate that living in rural areas was a barrier to access to the...
Source: Cadernos de Saude Publica - Category: International Medicine & Public Health Authors: Tags: Cad Saude Publica Source Type: research
Abstract Objective To evaluate the level of information possessed by pregnant adolescents regarding the human papillomavirus (HPV). Methods Descriptive study developed in the adolescent prenatal outpatient clinic of a tertiary hospital fromthe state of S ão Paulo, Brazil. Data were collected between June and December 2017 following approval from the ethics and research committee (CAAE: 1.887.892/2017). Pregnant adolescents, ≤ 18 years old, who attended the abovementioned outpatient section, composed the sample. Those diagnosed with a psychiatric disorder and those with hearing or cognitive disabilities were exclu...
Source: Revista Brasileira de Ginecologia e Obstetricia - Category: OBGYN Source Type: research
The objective of the current study was to explore the genetic architecture in one of the most important muscle quality attributes, filet firmness in relation to protein content, and identify QTL associated with these traits in a rainbow trout population developed by the USDA/NCCCWA selective breeding program. Materials and Methods Ethics Statement Institutional Animal Care and Use Committee of the United States Department of Agriculture, National Center for Cool and Cold Water Aquaculture (Leetown, WV, United States) specifically reviewed and approved all husbandry practices used in this study (IACUC approval #056). Fi...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Li Liu, Jiajing Lin and Hongying He* Department of Obstetrics and Gynecology, Liuzhou Worker’s Hospital, Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, China Background and Objective: Endometrial cancer (EC) is a common gynecological malignancy worldwide. Despite advances in the development of strategies for treating EC, prognosis of the disease remains unsatisfactory, especially for advanced EC. The aim of this study was to identify novel genes that can be used as potential biomarkers for identifying the prognosis of EC and to construct a novel risk stratification using these genes. Me...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
ConclusionsSLN mapping technique using NIR fluorescence imaging with ICG appears to be accurate method in most of the patients with cervical or endometrial carcinoma, regardless of demographic characteristics, tumor-related features and surgical approach. Surgeons ’ expertise in that field allows obtaining excellent detection rates.
Source: Archives of Gynecology and Obstetrics - Category: OBGYN Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
ConclusionAdequate and timely treatment of malignancy in the DRC faces a multitude of challenges. Access to surgical services for diagnosis and management as well as chemotherapeutic agents is prohibitively limited. Increased collaboration with local clinicians and remote specialist consultants is needed to deliver subspecialty care in resource-poor settings.
Source: World Journal of Surgery - Category: Surgery Source Type: research
Conclusions: Our results provide suggestive evidence of the potential for environmental exposure to phthalates and/or BPA to disrupt circulating vitamin D levels in pregnancy. https://doi.org/10.1289/EHP1178 Received: 03 October 2016 Revised: 10 May 2017 Accepted: 12 May 2017 Published: 31 August 2017 Address correspondence to J.D. Meeker, Dept. of Environmental Health Sciences, University of Michigan School of Public Health, 1835 SPH I, 1415 Washington Heights, Ann Arbor, Michigan 48109-2029 USA. Telephone: (734) 764-7184. Email: meekerj@umich.edu Supplemental Material is available online (https://doi.org/10.1289/EH...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
Conclusions: Mitochondrial inhibition in vitro occurred at a CPC concentration that may be relevant to human exposures. The antiestrogenic activity of CPC, BAK, rotenone, and triclosan may be related to their mitochondrial inhibitory activity. Our findings support the need for additional research on the mitochondrial inhibitory and antiestrogenic effects of QUATS, including CPC and BAK. https://doi.org/10.1289/EHP1404 Received: 22 November 2016 Revised: 04 May 2017 Accepted: 09 May 2017 Published: 22 August 2017 Address correspondence to G. Cortopassi, 1089 Veterinary Medicine Drive, Davis, CA 95616 USA. Phone: (530)...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
Conclusion: These data indicate that TBBPA, triclosan, and BPA interact in vivo, consistent with evidence that TBBPA and triclosan inhibit enzymes that are critical for BPA and E2 metabolism. https://doi.org/10.1289/EHP1329 Received: 04 November 2016 Revised: 11 April 2017 Accepted: 13 April 2017 Published: 21 August 2017 Address correspondence to D. deCatanzaro, Dept. of Psychology, Neuroscience &Behaviour, McMaster University, 1280 Main St. West, Hamilton ON L8S 4K1, Canada. Telephone: (905) 525-9140, ext. 23014. Email: decatanz@mcmaster.ca Supplemental Material is available online (https://doi.org/10.1289/EHP1...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
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