Zika virus may be useful in treating brain tumours

Conclusion This is an interesting piece of research that shows how knowledge in one field of medicine can sometimes be applied to another field with surprising results. But it's important to be realistic about the stage of research. This is very much a "proof of concept" study, and tests on cells, tissues and mice don't necessarily translate into a safe and effective treatment for humans. The study has several limitations, but the fact the treatment so far hasn't been tested on humans is the most important. For one thing, Zika virus doesn't naturally infect mice, so researchers had to use a specially engineered virus that's different from the virus that infects humans. Also, the glioma tumours in mice were taken from mouse models, so they weren't the same as human glioma tumours. The researchers say there are "technical challenges" to overcome before they can test human-derived glioma cells in mice. They say it may be possible to make the Zika virus safe enough to use in glioma treatment, possibly by injecting it into tumour sites at the same time as surgery to remove tumours. But clinical trials of such a therapy are still some way off. Links To The Headlines Zika virus used to treat aggressive brain cancer. BBC News, September 5 2017 Zika can kill brain tumors like John McCain's, study shows - paving the way to a groundbreaking new use for the mosquito-borne virus. Mail Online, September 5 2017 Links To Science Zhu Z, Gorman MJ, McKenzie LD, et al. Zi...
Source: NHS News Feed - Category: Consumer Health News Tags: Cancer Source Type: news

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In this study, we compared the long-term side effects of proton radiation to equivalent doses of X-rays in the initiation and progression of premalignant lesions in a lung cancer susceptible mouse model (K-rasLA1). We show proton irradiation causes more complex DNA damage that is not completely repaired resulting in increased oxidative stress in the lungs both acutely and persistently. We further observed K-rasLA1 mice irradiated with protons had an increased number and size of initiated and premalignant lesions and adenomas that were often infiltrated with inflammatory cells. Proton irradiated mice had a lower median surv...
Source: Life Sciences in Space Research - Category: Biology Source Type: research
In this study, we have shown that NOL8, a binding protein of beta-catenin, enhanced the interaction between beta-catenin and TCF4, and activated beta-catenin/TCF signaling. NOL8 is up-regulated in the prostate cancer, and promoted the growth, migration and colony formation of cancer cells. Knocking down the expression of NOL8 inhibited the growth, migration and colony formation of prostate cancer cells. The molecular mechanism study demonstrated that NOL8 promoted the migration and colony formation of cancer cells by activating beta-catenin/TCF signaling. Taken together, this study demonstrated the oncogenic roles of NOL8 ...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
Publication date: Available online 18 August 2018Source: Chemico-Biological InteractionsAuthor(s): Seon-A. Jang, Dae Won Park, Eun Hwa Shon, Sung Ryul Lee, Se Chan KangAbstractVascular inflammation has been suggested to play a key role in the initiation and progression of atherosclerosis. Hyperoside (HPS) is a plant-derived quercetin 3-d-galactoside reported to have anti-inflammatory, anti-oxidant, anti-cancer, anti-hyperglycemic, anti-coagulant, and cardioprotective activities. However, the effects of HPS on vascular inflammation have not been studied. Therefore, in this study, we investigated the suppressive effect of HP...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
Publication date: September 2018Source: Chinese Chemical Letters, Volume 29, Issue 9Author(s): Chao Yang, Jing Xu, Dandan Yang, Xiaoxiao Wang, Bin Liu, Nongyue He, Zhifei WangAbstractHow to fabricate zeolitic imidazole framework-8 (ZIF-8) based therapeutic nanoplatform will be of significance in biomedicine considering its good biocompatibility. Herein, we report a one-step encapsulation of indocyanine green (ICG) in ZIF-8 nanoparticles (NPs). The as-prepared ICG@ZIF-8 NPs possess an absorption band in the near infrared region and have the good photothermal conversion efficiency. The in vivo and in vitro studies show that,...
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
Publication date: September 2018Source: Chinese Chemical Letters, Volume 29, Issue 9Author(s): Huibo Li, Changmai Chen, Qin An, Guoyan Huo, Mingtao RunAbstractDrug efficiency delivery and release to target site play an important role in the treatment of cancer. To achieve these goals, developing drug delivery systems is the key step. The common materials used for drug delivery like liposomes, micelles, dendrimers cannot control the delivery and releasing by spatial and temporal. In this paper, we design a photoresponsive drug delivery system to reduce the side effects of traditional chemotherapy on normal cells and improve...
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
In conclusion, the association between allopurinol and teratogenicity appears to be weak and limited to two reports with uncertain causality. However, the available data are insufficient to make a certain judgement, and as allopurinol treatment evolves, report and prospective follow-up of all exposed infants (i.e. deviant and normal cases) should be encouraged.
Source: Reproductive Toxicology - Category: Toxicology Source Type: research
Publication date: Available online 18 August 2018Source: EpidemicsAuthor(s): Aldrin M., Jansen P.A., Stryhn H.AbstractThe parasitic salmon louse constrains growth in the Norwegian salmon farming industry through density dependent host-parasite interaction. Hence, there is a need for insight into how increases in salmon production, varying spatial organisation of the production and pest control strategies affect salmon louse population dynamics. Here we present a new salmon louse model for exploring effects of varying salmon farming conditions on spatio-temporal abundances of the parasite. The salmon louse model is partly s...
Source: Epidemics - Category: Epidemiology Source Type: research
Authors: Zhang S, Cai J, Xie W, Luo H, Yang F Abstract MicroRNA (miR)-202 has been reported to be involved in the regulation of human cancer progression including bladder cancer, non-small cell lung cancer, pancreatic cancer and esophageal squamous cell carcinoma. However, the function of miR-202 in prostate cancer remains largely unknown. The present study demonstrated that miR-202 was downregulated in human prostate cancer tissues and cell lines. And overexpression of miR-202 significantly inhibited the proliferation, migration and invasion of prostate cancer cells, but induced cell apoptosis. Moreover, miR-202 s...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Authors: Hao B, Chen X, Cao Y Abstract Yes-associated protein 1 (YAP1) is overexpressed in a number of human cancer types as an oncogene and takes part in processes of tumor cell proliferation, apoptosis and metastasis. The Notch pathway also has an important role in tumorigenesis and progression. However, the possible association between YAP1 and Notch signaling in glioma has remained to be determined. The present study verified the high expression of YAP1, Jagged 1 (JAG1), NOTCH1 and HES1 in the U251 glioma cell line via reverse-transcription quantitative polymerase chain reaction and western blot analysis. The e...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Effect of TGF-β1 on blood CD4+CD25high regulatory T cell proliferation and Foxp3 expression during non-small cell lung cancer blood metastasis. Exp Ther Med. 2018 Aug;16(2):1403-1410 Authors: Hu Y, Qi W, Sun L, Zhou H, Zhou B, Yang Z Abstract Metastatic circulating tumor cells in non-small cell lung cancer (NSCLC) metastasis have been reported to be associated with an immune response. The present study aimed to provide a theoretical basis for the immunomodulatory processes during NSCLC blood metastasis. NSCLC blood and normal peripheral blood mononuclear cells (PBMCs) were collected. The quantity ...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
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