Mosquito-Borne Viruses, Zika and Pregnancy

This study suggests that the risk of microcephaly is especially high with a Zika infection during the first trimester of pregnancy. Teams of scientists from CDC are now in Brazil, where the connection was first identified, working with local health officials to conduct the first large-scale investigation into Zika and microcephaly. That research will take time. We now know that when a woman becomes infected with rubella, also known as German measles, during her first trimester of pregnancy, her baby has up to an 80 percent chance of being born with a wide range of birth defects -- including deafness, eye defects, heart defects, and cognitive impairments -- known as congenital rubella syndrome. But it took more than a decade for that link to be definitively verified. We are likely to know still more about Zika and microcephaly in May, when two "case control" studies are expected, but the World Health Organization has said that it's likely to be closer to six months before we can say with some certainty that there is a direct connection. So what should you do until then? If you're pregnant or want to become pregnant soon, you should postpone travel to Zika outbreak areas. The CDC's most current recommendation is that pregnant women in any trimester delay trips to any area where the Zika virus is spreading. If your partner is pregnant, postpone travel to Zika outbreak areas or use protection when you return. Men who have traveled to a Zika-infected area are cautio...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news

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We present a surgical technique that diminishes tension of the repair with MCPJ flexion. Twenty-two EDC tendon stabilization procedures were performed between 2006 and 2017 using a tendon flap method. The selection criteria for this group of patients included completely dislocating extensor tendons with persistent complaints of pain and decrease in finger extension despite at least a 6-week conservative treatment attempt. All subjects underwent surgical treatment for tendon centralization using a distally based tendinous flap from the EDC sutured to the adjacent finger volar plate. A mathematical model was developed to ana...
Source: Techniques in Hand and Upper Extremity Surgery - Category: Surgery Tags: Technique Source Type: research
Radiocapitellar arthrosis represents a serious sequela of pediatric elbow injuries. Although persistent pain and disability are not uncommon in such cases, treatment remains controversial. The present study aimed to review the clinical outcomes after a new surgical treatment with partial radial head resection and corium interposition arthroplasty. To date, 3 adolescent cases underwent the surgical procedure and postoperative care. Thorough clinical and radiographic follow-up was performed. The mean age at the time of surgery was 14.4 years (range, 13 to 16 y) and mean duration of follow-up was 19 months (range, 12 t...
Source: Techniques in Hand and Upper Extremity Surgery - Category: Surgery Tags: Technique Source Type: research
We present a case report of an adult woman with AKL-positive ALCL, diagnosed by endobronchial ultrasound-guided transbronchial needle aspirate (EBUS-TBNA).A 59-year-old women with no history of breast implants, was admitted for a four-month low back pain. Initially, the patient was treated for a spondyloarthropathy, but due to persistence of the symptoms, a lumbosacral MRI was performed, showing changes in morphology and signal intensity in the vertebral body of L3, along with edema and a paravertebral collection that affected the left psoas muscle, suggesting granulomatous spondylodiscitis. Chest CT-scan showed mild left ...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
Although the papers I have written with residents and faculty are not always accepted, most reviewers begin their comments with “This is a clearly written paper.” I think this must be why several people have asked me if I have a formula for writing research papers. The answer is yes, I do, so I decided to write this brief essay to describe it. I do this because I have learned the hard way that good data can be sunk by ba d writing and have seen the pain in some colleagues’ faces when they have a good project but can only stare at a blank computer screen, not knowing how to start.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Education Source Type: research
A 58-year-old female presents with a 1-year history of hematochezia, 20-pound weight loss, and increased straining with bowel movements. She denies increased bowel frequency or change in stool caliber. Her medical history is notable for irritable bowel syndrome, but otherwise unremarkable. She has no family history of malignancy and does not take any prescribed medications or supplements. She denies abdominal pain, bone pain, or any symptoms concerning for metastatic disease. Her initial physical examination was notable for an Eastern Cooperative Oncology Group performance status of 0, and presence on digital rectal examin...
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Gray Zone Source Type: research
This study demonstrates that next-generation sequencing (NGS) is uniquely well suited for parental testing, in particular due to its ability to detect clinically relevant germline mosaicism. Parental variant testing by NGS was performed in a clinical laboratory for one year. The detection of mosaicism by NGS was compared to its detection by Sanger sequencing. Eight cases of previously unrevealed mosaicism were detected by NGS across eight different genes. Mosaic variants were differentiated from sequencing noise using custom bioinformatics analyses in combination with familial inheritance data and complementary Sanger sequ...
Source: The Journal of Molecular Diagnostics - Category: Pathology Source Type: research
Conclusions: Intraoperative liposomal bupivacaine use reduced opioid use and postoperative pain for the first 24 hours after fixation of intertrochanteric femur fractures. Significant increases in likelihood of discharge to home may present an opportunity for cost savings. Level of Evidence: Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Source: Journal of Orthopaedic Trauma - Category: Orthopaedics Tags: Original Article Source Type: research
Purpose: To compare intraocular pressure, anterior segment optical coherence tomography, and ultrasound biomicroscopy parameters over 3 months after panretinal photocoagulation (PRP) for proliferative diabetic retinopathy after 1 of 2 sittings by conventional laser (half PRP) and a single sitting of Pattern Scan Laser (PASCAL) PRP. Methods: This was a prospective, randomized, interventional study. All tests were performed at baseline, and at 1, 6, and 24 hours, and 1, 4, 8, and 12 weeks after PRP. Results: The intraocular pressure at 1 hour and 6 hours after PRP was significantly raised in both groups. Mean intraoc...
Source: RETINA - Category: Opthalmology Tags: Original Study Source Type: research
Introduction: Fibromyalgia (FM) is a chronic condition of unknown aetiology, characterized by muscular pain, sleep disorders as well as gastrointestinal symptoms. Among the non-pharmacological treatments, growing evidence suggests a link between nutrition and FM.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - Category: Nutrition Authors: Source Type: research
Traumatic brain injury (TBI) is a leading cause of disability in the United States. With decreasing mortality rates, a higher number of patients are impacted by long-term neuropsychiatric sequelae, such as cognitive deficits, depression, anxiety, and sleep-wake disorders. These sequelae are primarily driven by the disruption of key neurotransmitter homeostasis including dopamine, norepinephrine, serotonin, and acetylcholine. Neurostimulants are centrally acting medications used to assist in restoring these neurotransmitter abnormalities and are pharmacologic options to ameliorate symptoms in post-TBI patients. Examples of ...
Source: Critical Care Nursing Quarterly - Category: Nursing Tags: Original Articles Source Type: research
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