An Illustrated Guide To The Zika Outbreak

In October 2015, Brazilian health authorities notified the World Health Organization that an alarming number of Brazilian babies had been born with microcephaly, a rare, debilitating birth defect with lifelong consequences. Researchers quickly linked the spike in birth defects to the outbreak of a little-known tropical disease called Zika virus, which is transmitted by mosquito. Since its discovery in Uganda in 1947, Zika virus has popped up in different African and Asian countries, but no widespread outbreaks had occurred until 2013, when the virus infected an estimated 11 percent of the population of French Polynesia and spread to neighboring Pacific islands. Then, in 2014, Brazil hosted a series of international sporting events -- the FIFA World Cup and the Va'a World Elite &Club Sprint Championships canoe race. Researchers suspect that this is when people from the Pacific islands who were infected with Zika virus first introduced it to South America.  Since then, the virus has spread across South and Central America, as well as the Caribbean -- reaching as far as the U.S. territory of Puerto Rico. So far, two people have tested positive for the virus in Spain, and approximately a dozen people in the U.S. have tested positive for it since 2015. The virus has also been linked to a microcephalic baby born in Hawaii. However, it's important to note that the U.S. and European cases of the virus were acquired by travelers who had recently visited areas a...
Source: Science - The Huffington Post - Category: Science Source Type: news

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We report about hirudotherapy in a patient with chronic complex regional pain syndrome (CRPS) in the right hand. CRPS is a multifactorial disease associated with disabling pain as well as sensory and motor deficits. The optimal therapeutic management is based on personalized multimodal treatment approaches; however, hirudotherapy has not been described in the available literature. To date, we have completed five medicinal leech treatments. Altogether, hirudotherapy led to rapid and substantial relief of symptoms, especially with respect to pain intensity ratings and skin temperature asymmetries. In Addition, the patient&rs...
Source: Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
Conclusion: The decision-to-delivery interval was ≤ 15 min in most women, suggesting that optimised organisation ensures short decision-to-delivery interval independently of the anaesthetic technique performed. As general anaesthesia was associated with worse neonatal outcomes, our results support the early insertion of an epidural catheter whenever there is any potential concern that an emergency caesarean section may be required.
Source: Anaesthesia, Critical Care and Pain Medicine - Category: Anesthesiology Source Type: research
Publication date: Available online 24 May 2019Source: Accident Analysis &PreventionAuthor(s): Guibing Li, Fang Wang, Dietmar Otte, Ciaran SimmsAbstractHead injury is one of the most common injury types in vehicle-to-pedestrian collisions, which leads to death and long-term disabilities. However, detailed analysis of pedestrian head injuries in real world collisions is scarce. Thus the current study used two samples of 120 cases and 184 cases extracted from 1060 pedestrian collision cases captured during 2000–2015 from the GIDAS (German In-Depth-Accident Study) database to investigate the detailed characteristics ...
Source: Accident Analysis and Prevention - Category: Accident Prevention Source Type: research
Conclusion MTDWe conducted a two-cohort, open-label study of the timing of toci on CTL019-associated CRS. Pts were 1-24 yo with CD19-expressing relapsed or refractory B-cell acute lymphoblastic leukemia (r/r B-ALL). CTL019 was manufactured at the UPenn Cell and Vaccine Production Facility. Enrolled pts were assigned to high (≥ 40%) or low (38.5 C measured twice in 24 hours (“early toci”) and subsequently treated per standard CRS algorithm. Primary endpoint: frequency of gr4 CRS (Penn scale) in ≤5/15 pts. Secondary endpoints: D28 tumor response, remission duration, additional toxicities.RES78 pts were scre...
Source: Cytotherapy - Category: Cytology Source Type: research
ConclusionUsing pharmacological compounds that selectively inhibit pro-survival proteins to induce apoptosis in MSCs, we show that mouse and human bone marrow (BM) MSCs engage different molecules for survival. In addition, we are genetically manipulating the apoptotic pathways in mouse and human BM MSCs to gain a greater understanding of how these cells exert their therapeutic effects in vivo, an outstanding question in MSC therapy.
Source: Cytotherapy - Category: Cytology Source Type: research
ConclusionHere we show that in twelve clinical cases, the cartilage was observed successfully regenerating and covering the defect region in knees after the intra-articular injection with adipose-derived mesenchymal stem cells (MSCs), and the treatment highly improves the symptoms of osteoarthritis. Basically, the adipose-derived MSCs from the patients are cultured and expanded to a specific amount with the optimized stem cell culture medium, the HELENE MEDIUM. After that, the cultured MSCs are directly injected into the injured knee joints of patients. The cartilage has gradually regenerated and been monitored by MRI phot...
Source: Cytotherapy - Category: Cytology Source Type: research
ConclusionNeoSERA is produced in Japan, considered to be a negligible bovine spongiform encephalopathy (BSE) risk country. We obtain adult donor bovine blood from animal less than 36 months old according to the regulation of EMA for BSE (EMA/410/01 rev.3). Using apheresis medical devices with closed disposable kits, sterile platelet-rich plasma (PRP) is collected from healthy donor bovine receiving a regular veterinary check. After stimulation and removal of coagulated fibrin by centrifugation, NeoSERA is collected in a completely closed system. To meet the scope of directives that apply to produce medicinal products from ...
Source: Cytotherapy - Category: Cytology Source Type: research
Publication date: Available online 23 May 2019Source: Neurochemistry InternationalAuthor(s): Sanjay Kumar, Ajeet Kumar Singh, Manjula VinayakAbstractReactive oxygen species (ROS) have a key role in different etiologies of pain. At sub-cellular level, mitochondria and plasma membranes have been identified as endogenous sources of ROS required for pain generation. NADPH oxidase (NOX) is the main contributor of membrane associated ROS generation. Out of 7 isozymes, NOX1, NOX2 and NOX4 are reported to be associated with nociceptive sensitization. Therefore, it has been hypothesized that specific inhibition of the NOX isozymes ...
Source: Neurochemistry International - Category: Neuroscience Source Type: research
This study confirms the critical role of PLA2s in arthritis and unveils the distinct contribution of cPLA2α and sPLA2-IIA to the eicosanoid profile in arthritis.
Source: Prostaglandins and Other Lipid Mediators - Category: Lipidology Source Type: research
Authors: Bravo-Pérez C, Vicente V, Corral J Abstract Introduction. Antithrombin is a serpin that inhibits multiple procoagulant serine proteases and acts as an endogenous anticoagulant. Thus, congenital antithrombin deficiency constitutes a major thrombophilic state, the most severe so far. Areas covered. In the present work, we globally review the biology, genetics, diagnosis, and management of congenital antithrombin deficiency, and also discuss puzzling questions and future perspectives regarding this severe inherited thrombophilia. Expert opinion. Although this disorder exerts high clinical heterogeneity...
Source: Expert Review of Hematology - Category: Hematology Tags: Expert Rev Hematol Source Type: research
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