POPs and Gut Microbiota: Dietary Exposure Alters Ratio of Bacterial Species

Carol Potera, based in Montana, also writes for Microbe, Genetic Engineering News, and the American Journal of Nursing. About This Article open Citation: Potera C. 2015. POPs and gut microbiota: dietary exposure alters ratio of bacterial species. Environ Health Perspect 123:A187; http://dx.doi.org/10.1289/ehp.123-A187 News Topics: Dioxins and Furans, Microbiology, Microbiome, Obesity, Persistent Organic Pollutants (POPs) Published: 1 July 2015 PDF Version (403 KB) Related EHP Article Persistent Organic Pollutants Modify Gut Microbiota–Host Metabolic Homeostasis in Mice Through Aryl Hydrocarbon Receptor Activation Limin Zhang, Robert G. Nichols, Jared Correll, Iain A. Murray, Naoki Tanaka, Philip B. Smith, Troy D. Hubbard, Aswathy Sebastian, Istvan Albert, Emmanuel Hatzakis, Frank J. Gonzalez, Gary H. Perdew, and Andrew D. Patterson Persistent organic pollutants (POPs) have been implicated in myriad human health problems, including cancer, neurologic, immunologic, and reproductive defects, among many other adverse health effects.1 New lines of research suggest that chronic dietary exposure to POPs may also contribute to obesity and type 2 diabetes.2 In this issue of EHP, researchers examine how one POP in particular—2,3,7,8 tetrachlorodibenzofuran (TCDF)—affects the composition of the mouse gut microbiome.3 They report that TCDF exposure alters the gut microbiome in ways that may prove to contribute to obesity and other metabolic diseases. TCDF b...
Source: EHP Research - Category: Environmental Health Authors: Tags: Featured News Science Selection Dioxins and Furans July 2015 Microbiology Microbiome Obesity Persistent Organic Pollutants (POPs) Source Type: research

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In this study, we identified 37 genus-level core bacteria from feces of 101 healthy mice with different ages, sexes, and mouse strains in three previous studies. They collectively represented nearly half of the total sequences, and predominantly included carbohydrate- and amino acids-metabolizing bacteria and immunomodulatory bacteria. Among them, Anaerostipes indwelt the gut of all healthy mice. Co-abundance analysis showed that these core genera were clustered into five groups (Group C1–C5), which were ecologically related. For example, the abundances of Group C2 including probiotics Bifidobacterium and Lactobacill...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Conclusions In conclusion, articles in this Research Topic made a very significant contribution to our understanding of the role played by environmental factors, dysbiotic conditions, and infections in triggering diseases. Since this is a rapidly expanding area of research, many other factors contributing to the onset of these diseases are not covered here. We are confident, however, that further studies will expand the list as well as bring a better understanding of mechanisms involved in the onset of autoimmune and autoinflammatory diseases. Author Contributions All authors listed have made a substantial, direct and i...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
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Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
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