The causal relationship between sarcopenia-related traits and ischemic stroke: Insights from univariable and multivariable Mendelian randomization analyses
CONCLUSION: Our study revealed a causal protective effect of higher ALM on IS, independent of physical activity and adiposity-related indices. Moreover, we found that higher ALM could reduce susceptibility to IS partially by lowering the risk of vascular risk factors, including CHD, hypertension, T2DM, and hyperlipidemia. In brief, we elucidated another modifiable factor for IS and implied that maintaining sufficient muscle mass may reduce the risk of such disease.PMID:38757378 | DOI:10.1111/cns.14759 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 17, 2024 Category: Neuroscience Authors: Jiahao Song Da Zhou Jingrun Li Mengqi Wang Lina Jia Duo Lan Haiqing Song Xunming Ji Ran Meng Source Type: research
Astrocytic HILPDA promotes lipid droplets generation to drive cognitive dysfunction in mice with sepsis-associated encephalopathy
CONCLUSION: The accumulation of astrocytic lipid droplets plays a crucial role in the pathological process of SAE. HILPDA is an attractive therapeutic target for lipid metabolism regulation and cognitive improvement in septic patients.PMID:38757390 | DOI:10.1111/cns.14758 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 17, 2024 Category: Neuroscience Authors: Ling Li Du Lixia Guifen Gan Jin Li Lin Yang You Wu Zongping Fang Xijing Zhang Source Type: research
Transcutaneous vagus nerve stimulation modulates depression-like phenotype induced by high-fat diet via P2X7R/NLRP3/IL-1 β in the prefrontal cortex
CONCLUSION: The P2X7R/NLRP3/IL-1β signaling pathway may play an important role in the antidepressant-like behavior of taVNS, which provides a promising mechanism for taVNS clinical treatment of diabetes combined with depression.PMID:38752512 | PMC:PMC11097256 | DOI:10.1111/cns.14755 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 16, 2024 Category: Neuroscience Authors: Shaoyuan Li Yuzhengheng Zhang Yu Wang Zixuan Zhang Chen Xin Yifei Wang Peijing Rong Source Type: research
An update on noninvasive neuromodulation in the treatment of patients with prolonged disorders of consciousness
CONCLUSIONS: Noninvasive neuromodulation is a valuable and promising technique to treat pDoC. Further studies are needed to determine a unified stimulus protocol to achieve optimal effects as well as safety.PMID:38747078 | PMC:PMC11094579 | DOI:10.1111/cns.14757 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 15, 2024 Category: Neuroscience Authors: Xiaoping Wan Ye Zhang Yanhua Li Weiqun Song Source Type: research
An update on noninvasive neuromodulation in the treatment of patients with prolonged disorders of consciousness
CONCLUSIONS: Noninvasive neuromodulation is a valuable and promising technique to treat pDoC. Further studies are needed to determine a unified stimulus protocol to achieve optimal effects as well as safety.PMID:38747078 | PMC:PMC11094579 | DOI:10.1111/cns.14757 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 15, 2024 Category: Neuroscience Authors: Xiaoping Wan Ye Zhang Yanhua Li Weiqun Song Source Type: research
Meta-analysis and transcriptomic analysis reveal that NKRF and ZBTB17 regulate the NF- κB signaling pathway, contributing to the shared molecular mechanisms of Alzheimer's disease and atherosclerosis
CONCLUSIONS: This research uncovers a novel shared molecular pathway between AD and AS, underscoring the significant roles of NKRF and ZBTB17 in the pathogenesis of these disorders.PMID:38738952 | PMC:PMC11090078 | DOI:10.1111/cns.14683 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 13, 2024 Category: Neuroscience Authors: Di Zhang Keyan Chen Li Shen Shan Source Type: research
The biological behavior and clinical outcome of pituitary adenoma are affected by the microenvironment
CONCLUSION: Overall, we summarize the similarities and differences between the TME of pituitary adenomas and refractory pituitary adenomas as well as the changes in the biological behavior of pituitary adenomas that may be caused by the microenvironment. These changes greatly affect the outcome of patients.PMID:38738958 | PMC:PMC11090080 | DOI:10.1111/cns.14729 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 13, 2024 Category: Neuroscience Authors: Yuhe Li Xiufang Ren Wei Gao Ruikai Cai Jianqi Wu Tianqi Liu Xin Chen Daoming Jiang Chong Chen Quan Cheng Anhua Wu Wen Cheng Source Type: research
TNF- α can promote membrane invasion by activating the MAPK/MMP9 signaling pathway through autocrine in bone-invasive pituitary adenoma
CONCLUSION: Bone-invasive pituitary adenoma secretes higher levels of TNF-α, which then acts on itself in an autocrine manner, activating the MAPK pathway and promoting the expression of MMP9, thereby accelerating the membrane invasion process. SPD304 significantly inhibits the effect of TNF-α and may be applied in the clinical treatment of bone-invasive pituitary adenoma.PMID:38739004 | PMC:PMC11090077 | DOI:10.1111/cns.14749 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 13, 2024 Category: Neuroscience Authors: Xinzhi Wu Lei Gong Bin Li Jiwei Bai Chuzhong Li Yazhuo Zhang Haibo Zhu Source Type: research
A predictive nomogram for short-term outcomes of myasthenia gravis patients treated with low-dose rituximab
CONCLUSIONS: The nomogram achieved an optimal prediction of short-term outcomes in patients treated with low-dose rituximab.PMID:38739094 | PMC:PMC11090079 | DOI:10.1111/cns.14761 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 13, 2024 Category: Neuroscience Authors: Yufan Zhou Rongjing Guo Xingyu Xia Sisi Jing Jun Lu Zhe Ruan Sushan Luo Xiao Huan Chongbo Zhao Ting Chang Jianying Xi Source Type: research
CD22 blockade aggravates EAE and its role in microglia polarization
CONCLUSION: Collectively, our study indicates that CD22 may be protective against EAE and may play a critical role in the maintenance of immune homeostasis in EAE mice.PMID:38739106 | PMC:PMC11090149 | DOI:10.1111/cns.14736 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 13, 2024 Category: Neuroscience Authors: Weiwei Xiang Kan Wang Lu Han Ze Wang Zhiyang Zhou Shuwei Bai Jing Peng Chong Xie Yangtai Guan Source Type: research
Unveiling convergent and divergent intrinsic brain network alternations in depressed adolescents engaged in non-suicidal self-injurious behaviors with and without suicide attempts
CONCLUSION: Convergent alterations suggest a shared neurobiological mechanism along the self-destructiveness continuum. Divergent alterations may indicate biomarkers differentiating risk for SA, informing neurobiologically guided interventions.PMID:38739217 | PMC:PMC11090151 | DOI:10.1111/cns.14684 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 13, 2024 Category: Neuroscience Authors: Linling Li Zhen Liang Guohua Li Hong Xu Xing Yang Xia Liu Xin Zhang Jianhong Wang Zhiguo Zhang Yongjie Zhou Source Type: research
Meta-analysis and transcriptomic analysis reveal that NKRF and ZBTB17 regulate the NF- κB signaling pathway, contributing to the shared molecular mechanisms of Alzheimer's disease and atherosclerosis
CONCLUSIONS: This research uncovers a novel shared molecular pathway between AD and AS, underscoring the significant roles of NKRF and ZBTB17 in the pathogenesis of these disorders.PMID:38738952 | PMC:PMC11090078 | DOI:10.1111/cns.14683 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 13, 2024 Category: Neuroscience Authors: Di Zhang Keyan Chen Li Shen Shan Source Type: research
The biological behavior and clinical outcome of pituitary adenoma are affected by the microenvironment
CONCLUSION: Overall, we summarize the similarities and differences between the TME of pituitary adenomas and refractory pituitary adenomas as well as the changes in the biological behavior of pituitary adenomas that may be caused by the microenvironment. These changes greatly affect the outcome of patients.PMID:38738958 | PMC:PMC11090080 | DOI:10.1111/cns.14729 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 13, 2024 Category: Neuroscience Authors: Yuhe Li Xiufang Ren Wei Gao Ruikai Cai Jianqi Wu Tianqi Liu Xin Chen Daoming Jiang Chong Chen Quan Cheng Anhua Wu Wen Cheng Source Type: research
TNF- α can promote membrane invasion by activating the MAPK/MMP9 signaling pathway through autocrine in bone-invasive pituitary adenoma
CONCLUSION: Bone-invasive pituitary adenoma secretes higher levels of TNF-α, which then acts on itself in an autocrine manner, activating the MAPK pathway and promoting the expression of MMP9, thereby accelerating the membrane invasion process. SPD304 significantly inhibits the effect of TNF-α and may be applied in the clinical treatment of bone-invasive pituitary adenoma.PMID:38739004 | PMC:PMC11090077 | DOI:10.1111/cns.14749 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 13, 2024 Category: Neuroscience Authors: Xinzhi Wu Lei Gong Bin Li Jiwei Bai Chuzhong Li Yazhuo Zhang Haibo Zhu Source Type: research
A predictive nomogram for short-term outcomes of myasthenia gravis patients treated with low-dose rituximab
CONCLUSIONS: The nomogram achieved an optimal prediction of short-term outcomes in patients treated with low-dose rituximab.PMID:38739094 | PMC:PMC11090079 | DOI:10.1111/cns.14761 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 13, 2024 Category: Neuroscience Authors: Yufan Zhou Rongjing Guo Xingyu Xia Sisi Jing Jun Lu Zhe Ruan Sushan Luo Xiao Huan Chongbo Zhao Ting Chang Jianying Xi Source Type: research
