Comparison of radiological and functional outcomes of conservative treatment with teriparatide and denosumab in thoracolumbar osteoporotic vertebral fracture
ConclusionsTeriparatide and denosumab, despite of their different pharmacological mechanisms, showed similar radiological deformation and functional outcomes in the conservative treatment of TL-OVF. However, teriparatide showed a significantly higher incidence of fracture union with paravertebral bone bridge formation. (Source: Osteoporosis International)
Source: Osteoporosis International - January 23, 2024 Category: Orthopaedics Source Type: research
Relationship between Medication-Related Osteonecrosis of the Jaw and CDK4/6 Inhibitors in Breast Cancer
CONCLUSIONS: These results suggest that the incidence of MRONJ in patients with metastatic breast cancer treated with denosumab is higher, and the onset of MRONJ occurs earlier in the presence of CDK4/6 inhibitors. The differences were statistically significant in the patients who used abemaciclib. Given that the use of this combination is very common in routine clinical practice, it would be advisable to carry out larger prospective studies to clarify the risk of this association.PMID:38248101 | PMC:PMC10814865 | DOI:10.3390/curroncol31010016 (Source: Current Oncology)
Source: Current Oncology - January 22, 2024 Category: Cancer & Oncology Authors: Loreto Dom ínguez Senín David Morales Pancorbo Mar ía Yeray Rodríguez Garcés Mar ía Dolores Santos-Rubio Juan Bayo Calero Source Type: research
Cost-consequence analysis of continuous denosumab therapy for osteoporosis treatment in South Korea
This study aimed to evaluate the financial impact and fracture preventio... (Source: BMC Musculoskeletal Disorders)
Source: BMC Musculoskeletal Disorders - January 20, 2024 Category: Orthopaedics Authors: Seungju Cha, Minjeong Sohn, Hyowon Yang, Eric J. Yeh, Ki-Hyun Baek, Jeonghoon Ha and Hyemin Ku Tags: Research Source Type: research
Denosumab, teriparatide and bisphosphonates for glucocorticoid-induced osteoporosis: a Bayesian network meta-analysis
Conclusion: Teriparatide denosumab and the bisphosphonates are all effective in improving BMD for GIO patients. Based on this network meta-analysis, teriparatide and denosumab have higher efficiency in improving lumbar spine and femur neck BMD, and reducing vertebrae fracture.Systematic Review Registration:10.17605/OSF.IO/2G8YA, identifier CRD42023456305. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - January 19, 2024 Category: Drugs & Pharmacology Source Type: research
Severe Hypocalcemia With Denosumab Among Older Female Dialysis-Dependent Patients
This cohort study assesses the incidence of severe and very severe hypocalcemia in female dialysis-dependent patients aged 65 years or older receiving denosumab compared with oral bisphosphonates. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - January 19, 2024 Category: General Medicine Source Type: research
Changes in mandibular radiomorphometric indices in osteoporosis patients treated with denosumab: a retrospective case-control study
Radiomorphometric indices measured on Dental Panoramic Radiography (DPR) can reflect Bone Mineral Density (BMD). The aim of our study is to evaluate changes in DPR radiographic markers in patients undergoing a... (Source: BMC Oral Health)
Source: BMC Oral Health - January 16, 2024 Category: Dentistry Authors: Katia Rupel, Chiara Dal Broi, Giulia Ottaviani, Laura Bellassai, Theodora Magdalena Bogdan Preda, Roberto Di Lenarda and Matteo Biasotto Tags: Research Source Type: research
Differential effects of teriparatide, denosumab and zoledronate on hip structural and mechanical parameters in osteoporosis; a real-life study
ConclusionsAnalysis of the effect of OP therapies on hip geometry is useful in understanding the mechanisms of their anti-fracture effect and may provide additional information on their efficacy. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 9, 2024 Category: Endocrinology Source Type: research
Medication-related osteonecrosis of the lower jaw without osteolysis on computed tomography images
ConclusionsSurgical treatment yielded good treatment outcomes in most patients with mandibular MRONJ; however, the cure rate was lower in patients with malignancy who showed no osteolysis on CT images. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - January 9, 2024 Category: Orthopaedics Source Type: research
Differential effects of teriparatide, denosumab and zoledronate on hip structural and mechanical parameters in osteoporosis; a real-life study
ConclusionsAnalysis of the effect of OP therapies on hip geometry is useful in understanding the mechanisms of their anti-fracture effect and may provide additional information on their efficacy. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 9, 2024 Category: Endocrinology Source Type: research
Bone mineral density fall during aromatase inhibitor treatment may predict lower breast cancer recurrence
ConclusionsThe findings suggest an association may exist between lumbar spine BMD change and breast cancer recurrence for patients treated with adjuvant AI. Further research is required to determine whether BMD change can be utilised as a biomarker. (Source: Cancer Medicine)
Source: Cancer Medicine - January 8, 2024 Category: Cancer & Oncology Authors: Hilary Martin,
Andrew Redfern Tags: RESEARCH ARTICLE Source Type: research
Denosumab use reduces risk of rheumatoid arthritis in patients with osteoporosis
CONCLUSIONS: Denosumab use reduces the risk of RA in patients with osteoporosis. Receptor activator of nuclear factor kappa B ligand (RANKL) mediated osteoclast joint damage may be involved in the pathogenesis of RA during the preclinical stage.PMID:38179713 | DOI:10.55563/clinexprheumatol/3ohsj3 (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 5, 2024 Category: Rheumatology Authors: Chun-Hsiung Chen Hsien-Tzung Liao Hung-An Chen Yi-Ning Yen Chen-Hung Chen Source Type: research
Cardiometabolic Effects of Denosumab in Premenopausal Women with Breast Cancer Receiving Estradiol Suppression: RCT
CONCLUSIONS: In premenopausal women receiving estradiol suppression, denosumab decreases some measures of fat mass with no detectable effects on other measures of body composition or metabolic parameters.PMID:38181438 | DOI:10.1210/clinem/dgae003 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - January 5, 2024 Category: Cancer & Oncology Authors: Sabashini K Ramchand Rudolf Hoermann Shane White Belinda Yeo Prudence A Francis Cecilia L H Xu Jeffrey D Zajac Ego Seeman Mathis Grossmann Source Type: research
Cardiometabolic Effects of Denosumab in Premenopausal Women with Breast Cancer Receiving Estradiol Suppression: RCT
CONCLUSIONS: In premenopausal women receiving estradiol suppression, denosumab decreases some measures of fat mass with no detectable effects on other measures of body composition or metabolic parameters.PMID:38181438 | DOI:10.1210/clinem/dgae003 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - January 5, 2024 Category: Cancer & Oncology Authors: Sabashini K Ramchand Rudolf Hoermann Shane White Belinda Yeo Prudence A Francis Cecilia L H Xu Jeffrey D Zajac Ego Seeman Mathis Grossmann Source Type: research
Efficacy and safety of denosumab versus zoledronic acid in OI adults: A prospective, open-label, randomized study
CONCLUSION: Denosumab effectively increases aBMD in OI adults, with similar efficacy to zoledronic acid. Long-term and large-sample studies are needed to confirm the anti-fracture efficacy and safety of denosumab in adult OI patients.PMID:38181430 | DOI:10.1210/clinem/dgae012 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 5, 2024 Category: Endocrinology Authors: Xiaoyun Lin Jing Hu Bingna Zhou Xiaojie Wang Qian Zhang Yan Jiang Ou Wang Weibo Xia Xiaoping Xing Mei Li Source Type: research
