High bone tumor burden to identify advanced non-small cell lung cancer patients with survival benefit upon bone targeted agents and immune checkpoint inhibitors
Bone is a frequent metastatic site in advanced non-small cell lung cancer (aNSCLC), with up to 40 % of patients harboring bone metastases (BM) at diagnosis [1–3]. Bone targeted agents (BTA) – such as zoledronic acid and denosumab – demonstrated to prevent and/or delay the occurrence of skeletal related events (SRE) in patients with BM, with a manageable toxicity profile and a significan t benefit also in terms of quality of life [4–7]. (Source: Lung Cancer)
Source: Lung Cancer - October 27, 2023 Category: Cancer & Oncology Authors: Sara Manglaviti, Marta Bini, Giulia Apollonio, Ernesto Zecca, Giulia Galli, Sabina Sangaletti, Alice Labianca, Elisa Sottotetti, Marta Brambilla, Mario Occhipinti, Claudia Proto, Arsela Prelaj, Diego Signorelli, Alessandro De Toma, Giuseppe Viscardi, Tere Source Type: research
The clinical feature and optimal treatment strategy of bone metastasis in EGFR mutated NSCLC patients
Conclusion: BoM was identified as an inferior prognostic factor for NSCLC patients with EGFR mutation, which may be due to extra thoracic metastasis. However, adding an anti-angiogenesis drug and denosumab to patients with BoM and sequential osimertinib treatment can provide survival benefits. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Cheng, W.-C., Chen, W.-C., Chen, C.-L., Liao, W.-C., Tu, C.-Y., Hsia, T.-C., Chen, H.-J., Chen, C.-H. Tags: Lung cancer Source Type: research
Identification of Key Osteoporosis Genes Through Comparative Analysis of Men's and Women's Osteoblast Transcriptomes
AbstractOsteoporosis disproportionately affects older women, yet gender differences in human osteoblasts remain unexplored. Identifying mechanisms and biomarkers of osteoporosis will enable the development of preventative and therapeutic approaches. Transcriptome data of 187 osteoblast samples from men and women were compared. Differentially expressed genes (DEGs) were identified, and weighted gene co-expression network analysis (WGCNA) was used to discover co-expressed modules. Enrichment analysis was performed to annotate DEGs. Preservation analysis determined whether modules and pathways were similar between genders. Bl...
Source: Calcified Tissue International - October 25, 2023 Category: Orthopaedics Source Type: research
Three-dimensional clinical assessment for MRONJ risk in oncologic patients following tooth extractions
CONCLUSIONS: Periosteal reaction and sequestrum formation are suspected to be pre-clinical MRONJ lesions. Furthermore, ARD induced bony changes and radiographic variations between ARD types were seen.PMID:37874081 | DOI:10.1259/dmfr.20230238 (Source: Dentomaxillofacial Radiology)
Source: Dentomaxillofacial Radiology - October 24, 2023 Category: Radiology Authors: Catalina Moreno Rabie Rocharles Cavalcante Fontenele Nicolly Oliveira Santos Fernanda Nogueira Reis Tim Van den Wyngaert Reinhilde Jacobs Source Type: research
