A Rare Reason for Severe Hypocalcemia Following Kidney Transplant: Denosumab Treatment
Exp Clin Transplant. 2024 Jan;22(Suppl 1):342-344. doi: 10.6002/ect.MESOT2023.P10.ABSTRACTDeviations of calcium, phosphate, parathyroid hormone, and vitamin D levels are the basis for the diagnosis of calcium-phosphate metabolism disorders. The plasma concentration of the biologically active form known as free calcium is regulated in a harmonious manner by its exchange in the bones and reabsorption by the kidneys. These steps take place under the control of parathyroid hormone and calcitriol. In the process of chronic kidney disease, the kidney cannot synthesize adequate calcitriol, and the resulting hypocalcemia and hyper...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 22, 2024 Category: Transplant Surgery Authors: Muride Aktas Hayriye Nur Oray Unlu Murat Karatas Gokalp Okut Berna Eren Adam Uslu Erhan Tatar Source Type: research
A Rare Reason for Severe Hypocalcemia Following Kidney Transplant: Denosumab Treatment
Exp Clin Transplant. 2024 Jan;22(Suppl 1):342-344. doi: 10.6002/ect.MESOT2023.P10.ABSTRACTDeviations of calcium, phosphate, parathyroid hormone, and vitamin D levels are the basis for the diagnosis of calcium-phosphate metabolism disorders. The plasma concentration of the biologically active form known as free calcium is regulated in a harmonious manner by its exchange in the bones and reabsorption by the kidneys. These steps take place under the control of parathyroid hormone and calcitriol. In the process of chronic kidney disease, the kidney cannot synthesize adequate calcitriol, and the resulting hypocalcemia and hyper...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 22, 2024 Category: Transplant Surgery Authors: Muride Aktas Hayriye Nur Oray Unlu Murat Karatas Gokalp Okut Berna Eren Adam Uslu Erhan Tatar Source Type: research
Effect of Osteoporosis Treatments on Osteoarthritis Progression in Postmenopausal Women: A Review of the Literature
AbstractPurpose of ReviewThe purpose of this literature review was to determine if medications used to treat osteoporosis are also effective for treating osteoarthritis (OA).Recent FindingsA total of 40 relevant articles were identified. Studies were categorized into those (1) discussing estrogen and selective estrogen receptor modulators (SERMs), (2) bisphosphonates, (3) parathyroid hormone (PTH) analogs, and (4) denosumab, and (5) prior review articles. A large amount of evidence suggests that estrogen and SERMs are effective at reducing OA symptoms and disease progression. Evidence suggests that bisphosphonates, the mos...
Source: Current Rheumatology Reports - February 19, 2024 Category: Rheumatology Source Type: research
Efficacy and risk of osteonecrosis of the jaw for pamidronate, zoledronic acid, and denosumab in comparison to alendronate in multiple myeloma patients
CONCLUSION: This study shows that fracture reduction risk is comparable for all four treatments in multiple myeloma patients, but ONJ risk is lowest for alendronate and pamidronate. Overall, these data support the continued use of pamidronate and alendronate in multiple myeloma patients.PMID:38343457 | PMC:PMC10857533 | DOI:10.1080/08998280.2023.2298667 (Source: Baylor University Medical Center Proceedings)
Source: Baylor University Medical Center Proceedings - February 12, 2024 Category: Universities & Medical Training Authors: Micah Browne Brittany Miles James Mackey Source Type: research
Zinc improves Denosumab and eldecalcitol efficacy for bone mineral density in patients with hypozincemia
ConclusionHypozincemia may reduce the efficacy of DMAb and eldecalcitol in increasing BMD and fracture prevention. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - February 7, 2024 Category: Orthopaedics Source Type: research
Using Denosumab as a Nonsurgical Management of Aneurysmal Bone Cysts in the Pelvis
CONCLUSIONS: Denosumab may provide a reliable option in the nonsurgical treatment of ABCs of pelvic origin with expected lower morbidity than the surgical solution and tolerable complications. Further studies on the safety profile and long-term effects of denosumab especially in skeletally immature patients are required.PMID:38304208 | PMC:PMC10825244 | DOI:10.4055/cios22228 (Source: Clinics in Orthopedic Surgery)
Source: Clinics in Orthopedic Surgery - February 2, 2024 Category: Orthopaedics Authors: Ayman Mohammad El Masry Sherif Ishak Azmy Mohamed Abdel Rahman Mustafa Mohammad Abdelmoemen Abuelhadid Source Type: research
