Denosumab combined with precision radiotherapy for recurrent giant cell tumor of the thoracic spine: a case report and literature review
Giant cell tumors of the spine have a high recurrence rate owing to their special anatomical site; hence, further treatment after recurrence is very challenging. Achieving effective tumor control and improving the long-term quality of life of the patients are the main treatment purposes to consider for recurrent giant cell tumors of the spine. A patient showing giant cell tumor recurrence of the thoracic spine after curettage received denosumab combined with precision radiotherapy, through which the tumor gained good control and the patient could regain normal functioning. A review of the relevant literature suggested that...
Source: Frontiers in Neurology - January 4, 2024 Category: Neurology Source Type: research
Prevalence of denosumab-induced hypocalcemia: a retrospective observational study of patients routinely monitored with ionized calcium post-injection
ConclusionsDenosumab-induced hypocalcemia is a prevalent adverse event, which occurs independently of the number of injections. However, severe hypocalcemia is a rare occurrence, and severe renal failure and nutritional status appear to be important predictive factors. Magnesium and phosphate might add value in the pre-injection risk assessment; however, this observation needs to be confirmed in larger cohorts. (Source: Osteoporosis International)
Source: Osteoporosis International - January 1, 2024 Category: Orthopaedics Source Type: research
GSE206540 99-MiDeTe
Contributors : David Carro V ázquez ; Zora Messner ; Matthias Hackl ; Roland Kocijan ; Andreas B DiendorferSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensWe studied microRNA expression levels from serum of postmenopausal women with osteoporosis by investigating the anti-osteoporotic treatment denosumab for a period of 2 years in a longitudinal study. Serum RNA was extracted and subject to small RNA sequencing on an Illumina HiSeqV4 SR50 using 50bp, single end reads. After mapping against GRCh38.p12 provided by Ensembl and miRBase v22.1 differential expression analysis was un...
Source: GEO: Gene Expression Omnibus - December 31, 2023 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research
Giant negative T waves in an elder with generalized pain and weakness
A 72-year-old man with a history of hypertension and chronic kidney disease presented to our emergency department complaining of numbness in his arms and legs, diarrhea, generalized pain, and weakness for 10 days, which gradually worsened and made moving difficult. His medications included trichloromethiazide, azosemide, doxazosin, nifedipine, carvedilol, and cilostazol. Additionally, prednisone had been used to treat cholesterol embolisms in the toes. Approximately 1 month prior, osteoporosis due to chronic kidney disease and steroid use was suspected, and denosumab therapy and calcium replacement ware initiated. (Source:...
Source: The American Journal of Medicine - December 30, 2023 Category: General Medicine Authors: Yoshikazu Hirose, Nobuhiro Sato, Yasuo Hirose Tags: ECG image of the month Source Type: research
Giant Negative T Waves in an Elderly Patient with Generalized Pain and Weakness
A 72-year-old male with a history of hypertension and chronic kidney disease presented to our emergency department complaining of numbness in his arms and legs, diarrhea, generalized pain, and weakness for 10 days, which gradually worsened and made moving difficult. His medications included trichloromethiazide, azosemide, doxazosin, nifedipine, carvedilol, and cilostazol. Additionally, prednisone had been used to treat cholesterol embolisms in the toes. Approximately 1 month prior, osteoporosis due to chronic kidney disease and steroid use was suspected, and denosumab therapy and calcium replacement were initiated. (Source...
Source: The American Journal of Medicine - December 30, 2023 Category: General Medicine Authors: Yoshikazu Hirose, Nobuhiro Sato, Yasuo Hirose Tags: ECG image of the month Source Type: research
Recurrent Giant Cell Tumor of Sphenoid Bone: A Rare Finding
AbstractGiant Cell Tumors of the skull are rare and mostly occur in the middle cranial fossa. Radiological investigations serve as adjunct modalities; however, histopathological confirmation is mandatory. Ten to forty% of GCTs may be recurrent. Complete surgical resection is the treatment of choice, however, partial resection with adjuvant radiotherapy can serve as a secondary alternative. Recurrent cases require post-op radiotherapy. Here, we describe a case of recurrent giant cell tumor of sphenoid bone in a young male, who underwent surgical resection twice, after which he was advised adjuvant radiotherapy and denosumab...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - December 28, 2023 Category: ENT & OMF Source Type: research
Transient osteoporosis of the hip following discontinuation of denosumab and switch to alendronate treatment
(Source: Osteoporosis International)
Source: Osteoporosis International - December 26, 2023 Category: Orthopaedics Source Type: research
Efficacy and safety of denosumab treatment for Korean patients with Stage 3b-4 chronic kidney disease and osteoporosis
CONCLUSIONS: If carefully monitored and supplemented with calcium and vitamin D, denosumab treatment for 1 year provides significant benefits in patients with Stage 3b-4 CKD and osteoporosis. However, denosumab treatment did not affect coronary artery calcifications in these patients.PMID:38145616 | DOI:10.3904/kjim.2023.292 (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - December 25, 2023 Category: Internal Medicine Authors: Jin Taek Kim You Mi Kim Kyong Yeun Jung Hoonsung Choi So Young Lee Hyo-Jeong Kim Source Type: research
Efficacy and safety of denosumab treatment for Korean patients with Stage 3b-4 chronic kidney disease and osteoporosis
CONCLUSIONS: If carefully monitored and supplemented with calcium and vitamin D, denosumab treatment for 1 year provides significant benefits in patients with Stage 3b-4 CKD and osteoporosis. However, denosumab treatment did not affect coronary artery calcifications in these patients.PMID:38145616 | DOI:10.3904/kjim.2023.292 (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - December 25, 2023 Category: Internal Medicine Authors: Jin Taek Kim You Mi Kim Kyong Yeun Jung Hoonsung Choi So Young Lee Hyo-Jeong Kim Source Type: research
Efficacy and safety of denosumab treatment for Korean patients with Stage 3b-4 chronic kidney disease and osteoporosis
CONCLUSIONS: If carefully monitored and supplemented with calcium and vitamin D, denosumab treatment for 1 year provides significant benefits in patients with Stage 3b-4 CKD and osteoporosis. However, denosumab treatment did not affect coronary artery calcifications in these patients.PMID:38145616 | DOI:10.3904/kjim.2023.292 (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - December 25, 2023 Category: Internal Medicine Authors: Jin Taek Kim You Mi Kim Kyong Yeun Jung Hoonsung Choi So Young Lee Hyo-Jeong Kim Source Type: research
Methotrexate ‑related other iatrogenic immunodeficiency‑associated lymphoproliferative disorder in the CNS and medication‑related osteonecrosis of the jaw occurring simultaneously: A case report
Exp Ther Med. 2023 Nov 28;27(1):41. doi: 10.3892/etm.2023.12329. eCollection 2024 Jan.ABSTRACTMethotrexate-related other iatrogenic immunodeficiency-associated lymphoproliferative disorder (MTX-OIIA-LPD) is prone to extranodal involvement but rarely involves the central nervous system (CNS). The present study reports a case of MTX-OIIA-LPD of the CNS discovered during medication-related osteonecrosis of the jaw (MRONJ) treatment in a 76-year-old woman with rheumatoid arthritis (RA). The chief complaint of the patient was bone exposure and pain in the right mandibular molar. The patient had been receiving MTX for RA and ale...
Source: Experimental and Therapeutic Medicine - December 21, 2023 Category: General Medicine Authors: Tomoki Kato Chisaki Mizumoto Fuminori Inoue Takuma Watanabe Shigeki Yamanaka Shizuko Fukuhara Kazumasa Nakao Source Type: research
