Effect of Pelvic External Beam Radiation Therapy on Bone Mineral Density: A Secondary Analysis of a Phase III Randomized Controlled Trial
CONCLUSION: We did not find sufficient evidence to suggest any detrimental impact of pelvic XRT on the treatment effect from denosumab on percent BMD change with only about 5% incidence of clinical fractures.PMID:37924987 | DOI:10.1016/j.ijrobp.2023.10.046 (Source: Ann Oncol)
Source: Ann Oncol - November 4, 2023 Category: Cancer & Oncology Authors: Soumyajit Roy Shawn Malone Yilun Sun Nicholas G Zaorsky Daniel E Spratt Scott C Morgan Robert T Dess Christopher J D Wallis Amar U Kishan Deborah E Citrin Fred Saad Source Type: research
Effect of Pelvic External Beam Radiation Therapy on Bone Mineral Density: A Secondary Analysis of a Phase III Randomized Controlled Trial
CONCLUSION: We did not find sufficient evidence to suggest any detrimental impact of pelvic XRT on the treatment effect from denosumab on percent BMD change with only about 5% incidence of clinical fractures.PMID:37924987 | DOI:10.1016/j.ijrobp.2023.10.046 (Source: Health Physics)
Source: Health Physics - November 4, 2023 Category: Physics Authors: Soumyajit Roy Shawn Malone Yilun Sun Nicholas G Zaorsky Daniel E Spratt Scott C Morgan Robert T Dess Christopher J D Wallis Amar U Kishan Deborah E Citrin Fred Saad Source Type: research
Denosumab and Mortality in a real ‐world setting – A Comparative Study
This study examined the association between Dmab and all-cause mortality compared to no treatment in subjects with a fracture and BPs in subjects without a fracture. The study population was from The Sax Institute's 45 and Up Study (n= 267,357), a prospective population-based cohort with questionnaire data linked to hospital admissions1, medication records2 and stored securely3.The new-user cohort design with propensity-score (PS) matching was implemented.In the Fracture cohort, Dmab and oral BP users were matched 1:2 to no treatment (Dmab: 617 women, 154 men, and oral BPs: 615 women, 266 men).In the No-fracture cohort,...
Source: Journal of Bone and Mineral Research - November 2, 2023 Category: Orthopaedics Authors: Dunia Alarkawi,
Thach Tran,
Weiwen Chen,
Lyn M March,
Fiona M Blyth,
Robert D Blank,
Dana Bliuc,
Jacqueline R Center Tags: Research Article Source Type: research
Micropetrosis: Osteocyte Lacunar Mineralization in Aging and Disease
AbstractPurpose of ReviewAs the importance of osteocytes for bone mineral homeostasis is increasingly recognized, there is growing interest in osteocyte cell death as a relevant indicator in various physiological and pathological conditions. Micropetrosis is an established term used to describe osteocyte lacunae that are filled with minerals following osteocyte death. While the early reports of micropetrosis were purely descriptive, there is now an increasing body of literature showing quantitative data on micropetrosis in various conditions such as aging, osteoporosis, immobilization, and diabetes, and in osteoporosis tre...
Source: Current Osteoporosis Reports - November 2, 2023 Category: Orthopaedics Source Type: research
Indication and adverse event profiles of denosumab and zoledronic acid: based on U.S. FDA adverse event reporting system (FAERS)
Conclusion: Our analysis of FAERS database provided postmarketing surveillance data and revealed different strengths of reported AE signals between Dmab and ZA in some of their common AEs. It’s also worth noting that both drugs have potential off-label applications, which could introduce new AEs. This highlights the necessity for safety monitoring when using Dmab and ZA off-label. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - November 1, 2023 Category: Drugs & Pharmacology Source Type: research
Influence of antiresorptive/antiangiogenic therapy on changes in periodontal and oral tissue structures: a histomorphometrical analysis in rats
ConclusionsThe present evaluation was not able to find any morphological effects of different antiresorptive and antiangiogenic medications on periodontal and oral tissue structures. The presence of inflammatory cell infiltrates was more frequently observed in the animals administered with antiresorptive and antiangiogenic medications as well as combinations thereof.Clinical relevanceAdministration of antiresorptive and antiangiogenic medications may be capable of inducing inflammatory reactions in periodontal tissues. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - November 1, 2023 Category: Dentistry Source Type: research
Denosumab
(Source: Reactions Weekly)
Source: Reactions Weekly - November 1, 2023 Category: Drugs & Pharmacology Source Type: research
Five-Year Outcomes of Continuous Zoledronic Acid vs. Denosumab Treatment in Older Men with High Fracture Risk: Effects on Bone Density Improvement and Risk Factor Analysis of Improvement of Bone Density and Incidence of New Fracture
This study investigated the treatment efficacy of these agents in older male patients with low a bone mass and history of fragility fracture. 175 male patients receiving continuous zoledronic acid treatment and 366 male patients receiving continuous denosumab treatment at our medical center between 2015 and 2020 were included and we analyzed the efficacy of treatment from the improvement in bone mineral density (BMD) and the new-onset low-energy fracture rate after 5 years of continuous medication from their data. BMD significantly improved after 5 years of medication, and higher than 90% patients were satisfied with their...
Source: The Journal of Clinical Pharmacology - October 28, 2023 Category: Drugs & Pharmacology Authors: Tong-Che Wu Yun-Jui Tsou Wen-Tien Wu Ru-Ping Lee Jen-Hung Wang Kuang-Ting Yeh Source Type: research
Five-Year Outcomes of Continuous Zoledronic Acid vs. Denosumab Treatment in Older Men with High Fracture Risk: Effects on Bone Density Improvement and Risk Factor Analysis of Improvement of Bone Density and Incidence of New Fracture
This study investigated the treatment efficacy of these agents in older male patients with low a bone mass and history of fragility fracture. 175 male patients receiving continuous zoledronic acid treatment and 366 male patients receiving continuous denosumab treatment at our medical center between 2015 and 2020 were included and we analyzed the efficacy of treatment from the improvement in bone mineral density (BMD) and the new-onset low-energy fracture rate after 5 years of continuous medication from their data. BMD significantly improved after 5 years of medication, and higher than 90% patients were satisfied with their...
Source: The Journal of Clinical Pharmacology - October 28, 2023 Category: Drugs & Pharmacology Authors: Tong-Che Wu Yun-Jui Tsou Wen-Tien Wu Ru-Ping Lee Jen-Hung Wang Kuang-Ting Yeh Source Type: research
Five-Year Outcomes of Continuous Zoledronic Acid vs. Denosumab Treatment in Older Men with High Fracture Risk: Effects on Bone Density Improvement and Risk Factor Analysis of Improvement of Bone Density and Incidence of New Fracture
This study investigated the treatment efficacy of these agents in older male patients with low a bone mass and history of fragility fracture. 175 male patients receiving continuous zoledronic acid treatment and 366 male patients receiving continuous denosumab treatment at our medical center between 2015 and 2020 were included and we analyzed the efficacy of treatment from the improvement in bone mineral density (BMD) and the new-onset low-energy fracture rate after 5 years of continuous medication from their data. BMD significantly improved after 5 years of medication, and higher than 90% patients were satisfied with their...
Source: The Journal of Clinical Pharmacology - October 28, 2023 Category: Drugs & Pharmacology Authors: Tong-Che Wu Yun-Jui Tsou Wen-Tien Wu Ru-Ping Lee Jen-Hung Wang Kuang-Ting Yeh Source Type: research
Five-Year Outcomes of Continuous Zoledronic Acid vs. Denosumab Treatment in Older Men with High Fracture Risk: Effects on Bone Density Improvement and Risk Factor Analysis of Improvement of Bone Density and Incidence of New Fracture
This study investigated the treatment efficacy of these agents in older male patients with low a bone mass and history of fragility fracture. 175 male patients receiving continuous zoledronic acid treatment and 366 male patients receiving continuous denosumab treatment at our medical center between 2015 and 2020 were included and we analyzed the efficacy of treatment from the improvement in bone mineral density (BMD) and the new-onset low-energy fracture rate after 5 years of continuous medication from their data. BMD significantly improved after 5 years of medication, and higher than 90% patients were satisfied with their...
Source: The Journal of Clinical Pharmacology - October 28, 2023 Category: Drugs & Pharmacology Authors: Tong-Che Wu Yun-Jui Tsou Wen-Tien Wu Ru-Ping Lee Jen-Hung Wang Kuang-Ting Yeh Source Type: research
Conversion in a Resectable Tumor after Denosumab Neoadjuvant in a Large Dorsal Giant Cells Tumor: A Case Report and a Literature Review
We present the case of a young patient with a large spinal tumor who, after neoadjuvant Denosumab, underwent complete en bloc surgery with clean margins and a great pathological response.PMID:37887575 | DOI:10.3390/curroncol30100675 (Source: Current Oncology)
Source: Current Oncology - October 27, 2023 Category: Cancer & Oncology Authors: Mar ía Sereno Silvia Roa Franco Laura de la Reina Jos é Luis Campo-Cañaveral de la Cruz Marta Mu ñoz de Legaría Enrique Casado Sa énz Source Type: research
Conversion in a Resectable Tumor after Denosumab Neoadjuvant in a Large Dorsal Giant Cells Tumor: A Case Report and a Literature Review
We present the case of a young patient with a large spinal tumor who, after neoadjuvant Denosumab, underwent complete en bloc surgery with clean margins and a great pathological response.PMID:37887575 | PMC:PMC10605573 | DOI:10.3390/curroncol30100675 (Source: Current Oncology)
Source: Current Oncology - October 27, 2023 Category: Cancer & Oncology Authors: Mar ía Sereno Silvia Roa Franco Laura de la Reina Jos é Luis Campo-Cañaveral de la Cruz Marta Mu ñoz de Legaría Enrique Casado Sa énz Source Type: research
