NIDCR Grand Rounds: Women in Science - Targeted therapy for fibrous dysplasia/McCune-Albright syndrome: Lessons learned and new approaches
Fibrous dysplasia/McCune-Albright syndrome (FD/MAS) is a mosaic disease resulting in fractures, pain, and disability. G α s mutations disrupt differentiation of skeletal stem cells, leading to marrow fibrosis and increased bone-resorbing osteoclasts. The resulting bone develops one or many expansile, deforming lesions. There are no effective treatments for FD/MAS, and clinical studies have been challenging due to knowledge gaps in pathogenesis, natural history, and clinically relevant endpoints for clinical trials. Anti-resorptive therapy with bisphosphonates has been advocated due to prominent osteoclastogenesis in FD ti...
Source: Videocast - All Events - September 18, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
