Evaluation and management of dry mouth and its complications in rheumatology practice
Expert Rev Clin Immunol. 2023 Oct 12. doi: 10.1080/1744666X.2023.2268283. Online ahead of print.ABSTRACTINTRODUCTION: The symptom of dry mouth has multiple potential etiologies and can be a diagnostic clue to the presence of common systemic diseases encountered in rheumatology practice. The presence of decreased saliva flow (i.e. salivary hypofunction) defines a subset of dry mouth patients in whom there may be reversible drug effects, an iatrogenic insult such as head and neck irradiation, or a disease that directly involves the salivary glands (e.g. Sjögren's disease). The assessment of salivary hypofunction includes si...
Source: Expert Review of Clinical Immunology - October 12, 2023 Category: Allergy & Immunology Authors: Zohreh Khavandgar Blake M Warner Alan N Baer Source Type: research
Xerostomia, sticky saliva and dysphonia
(Source: European Archives of Oto-Rhino-Laryngology)
Source: European Archives of Oto-Rhino-Laryngology - October 11, 2023 Category: ENT & OMF Source Type: research
Dose planning study of proton versus photon radiotherapy for head and neck squamous cell carcinoma of unknown primary in the primary and recurrent setting
CONCLUSION: Omitting contralateral nCTV irradiation and mCTV irradiation will significantly reduce toxicity. The accumulated high dose volumes can be minimised using protons for re-irradiation. However, the use of protons for primary treatment provides limited benefit in most patients.PMID:37815913 | DOI:10.1080/0284186X.2023.2263156 (Source: Acta Oncologica)
Source: Acta Oncologica - October 10, 2023 Category: Cancer & Oncology Authors: Anne Ivalu Sander Holm Ulrik Vindelev Elstr øm Signe Bergliot Nielsen Kenneth Jensen Source Type: research
Xerostomia, sticky saliva and dysphonia
(Source: European Archives of Oto-Rhino-Laryngology)
Source: European Archives of Oto-Rhino-Laryngology - October 9, 2023 Category: ENT & OMF Source Type: research
Effectiveness of thyme honey in the management of xerostomia in geriatric patients with end-stage renal disease: a randomized controlled clinical trial with a biochemical assessment
ConclusionsThe results of the current study have revealed the efficacy of Thyme honey oral rinse in the management of xerostomia in geriatric patients with ESRD.Trial registration The ClinicalTrials.gov Identifier for this study is NCT05247008. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - October 7, 2023 Category: Research Source Type: research
Use of Explainable AI Algorithm Revealing Longitudinal Changes in Practice Patterns and Toxicity Models
CONCLUSION: As OAR doses were systematically reduced, statistical and AI models evidence highlighted contralateral SMG dose as important to both dysphagia and xerostomia for clinical practice change. The "real-world" database + eAI + visualization dashboards provided a method for continuous learning as clinical practice changes.PMID:37785877 | DOI:10.1016/j.ijrobp.2023.06.2020 (Source: Ann Oncol)
Source: Ann Oncol - October 3, 2023 Category: Cancer & Oncology Authors: S Su C Mayo B S Rosen E Covington Z Zhang A K Bryant S G Allen K A Morales Rivera D M Edwards J Takayesu D J Herr S R Miller S N Regan M P Dykstra G Y Sun A L Elaimy M L Mierzwa Source Type: research
Results of a Multi-institutional Randomized Phase 3 Trial of Parotid-Sparing Whole Brain Radiotherapy
CONCLUSION: Parotid-sparing without coverage of the C1 vertebra appears safe and may meaningfully reduce acute xerostomia in patients with limited life expectancy who are candidates for conventional WBRT, although the study was underpowered to detect a significant difference at 1 month.PMID:37784566 | DOI:10.1016/j.ijrobp.2023.06.387 (Source: Ann Oncol)
Source: Ann Oncol - October 3, 2023 Category: Cancer & Oncology Authors: K Wang C Shen H D Pacholke A Deal K A Pearlstein A A Weiner V Xu F Danquah D R Wahl W C Jackson R T Dess A F Dragovic L B Marks B S Chera M M Kim Source Type: research
Assessment of Acute Side Effects Among 3D-Concurrent Radiotherapy With Cisplatin-Treated Head and Neck Cancer Patients
CONCLUSION: It was concluded that 3D-CRT was associated with dermatitis and xerostomia during and immediately after follow-up, even though the treatment response was good. However, clinical signs and symptoms improved, indicating that radiation therapy is a relatively safe treatment modality among cancer patients. Moreover, 40 mg/m2 cisplatin once weekly for seven weeks resulted in better loco-regional control and survival among advanced-stage head and neck cancer patients as a part of treatment. Although, higher doses of cisplatin (100 mg/m2 ) every three weeks have more harmful acute side effects and delay treatment for ...
Source: Cancer Control - September 29, 2023 Category: Cancer & Oncology Authors: Hina Mehmood Talha Laique Ayesha Ahmad Rizwan Ahmad Source Type: research
Atrophy and Inflammatory Changes in Salivary Glands Induced by Oxidative Stress after Exposure to Drugs and Other Chemical Substances: A Systematic Review
Conclusions: Substances such as hesperidin, selenium, 10-dehydrogingerdione, and glycyrrhizic acid are antioxidants with proven restorative effects on salivary glands for the damage induced by oxidative stress after exposure to drugs and other chemical substances; however, demonstrating their similar effects in human salivary glands is challenging.PMID:37763811 | DOI:10.3390/medicina59091692 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - September 28, 2023 Category: Universities & Medical Training Authors: Loredana Beatrice Ungureanu Irina Gr ădinaru Cristina Mihaela Ghiciuc Cornelia Am ălinei Gabriela Lumini ța Gelețu Cristina Gabriela Petrovici Raluca Ștefania Stănescu Source Type: research
A New Model of Salivary Pacemaker-A Proof of Concept and First Clinical Use
Conclusions: The MD increased saliva secretion of the patient, and we are confident it will be a good solution for future management of salivary gland hypofunction.PMID:37763766 | DOI:10.3390/medicina59091647 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - September 28, 2023 Category: Universities & Medical Training Authors: Cristian Funieru Dan Ștefan Tudose Bogdan Dobric ă Mihai S ăndulescu Ion Alexandru Popovici Emil Ioan Slu șanschi Sorin Mihai Croitoru Daniela Vr înceanu Bogdan B ănică Mihnea Ioan Nicolescu Source Type: research
Atrophy and Inflammatory Changes in Salivary Glands Induced by Oxidative Stress after Exposure to Drugs and Other Chemical Substances: A Systematic Review
Conclusions: Substances such as hesperidin, selenium, 10-dehydrogingerdione, and glycyrrhizic acid are antioxidants with proven restorative effects on salivary glands for the damage induced by oxidative stress after exposure to drugs and other chemical substances; however, demonstrating their similar effects in human salivary glands is challenging.PMID:37763811 | PMC:PMC10535338 | DOI:10.3390/medicina59091692 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - September 28, 2023 Category: Universities & Medical Training Authors: Loredana Beatrice Ungureanu Irina Gr ădinaru Cristina Mihaela Ghiciuc Cornelia Am ălinei Gabriela Lumini ța Gelețu Cristina Gabriela Petrovici Raluca Ștefania Stănescu Source Type: research
