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Treatment planning comparison for head and neck cancer between photon, proton, and combined proton-photon therapy - from a fixed beam line to an arc
CONCLUSION: CPPT for HNC needs adaptive treatments. Increasing proton beam flexibility in CPPT, either by using a gantry or an upright-positioned patient, improves treatment plan quality. However, the photon component is substantially reduced, therefore, the balance between improved plan quality and costs must be further determined.PMID:37913953 | DOI:10.1016/j.radonc.2023.109973 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 1, 2023 Category: Radiology Authors: Florian Amstutz Reinhardt Krcek Barbara Bachtiary Damien C Weber Antony J Lomax Jan Unkelbach Ye Zhang Source Type: research

Unusual Gingival Presentation Following Treatment With Pembrolizumab: A Case Report
Immune checkpoint PD-1 inhibitors such as pembrolizumab plus gemcitabine, vinorelbine, and liposomal doxorubicin (pembro-GVD) has demonstrated efficacy in second-line therapy for relapsed/refractory classical Hodgkin lymphoma (cHL). Although generally well tolerated, pembrolizumab could lead to immune-related adverse events (irAEs) such as rash, fatigue, hyperthyroidism, pneumonitis, hepatitis, and colitis. Oral irAEs are not uncommon among immune checkpoint inhibitors which include xerostomia, dysgeusia, lichenoid reactions and mucositis. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - November 1, 2023 Category: ENT & OMF Authors: ANNU SINGH, JENNA MARCINCZYK, JOSEPH HURYN, CHERRY ESTILO Source Type: research

Supraglottic Jet Oxygenation and Ventilation to Minimize Hypoxia in Patients Receiving Flexible Bronchoscopy Under Deep Sedation: A 3-Arm Randomized Controlled Trial
CONCLUSIONS: SJOV via WNJ effectively reduces the incidence of hypoxia during FB under deep sedation.PMID:37874765 | DOI:10.1213/ANE.0000000000006678 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - October 24, 2023 Category: Anesthesiology Authors: Juan Wei Xiaowei Zhang Keting Min Huanping Zhou Xuan Shi Huimin Deng Wei Mo Huafeng Wei Yang Gu Xin Lv Source Type: research

Considerations for study design in the DAHANCA 35 trial of protons versus photons for head and neck cancer
We present our considerations on the trial design and a test of the selection procedure conducted before initiating the randomised study.PMID:37871751 | DOI:10.1016/j.radonc.2023.109958 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 23, 2023 Category: Radiology Authors: J Friborg K Jensen J G Eriksen E Sams øe C Maare M Farhadi P Sibolt M Nielsen M Andersen A I S Holm P Skyt B Smulders J Johansen J Overgaard C Grau C R Hansen Source Type: research