Organs-at-risk dose and normal tissue complication probability with dynamic trajectory radiotherapy (DTRT) for head and neck cancer
Radiother Oncol. 2024 Mar 19:110237. doi: 10.1016/j.radonc.2024.110237. Online ahead of print.ABSTRACTWe compared dynamic trajectory radiotherapy (DTRT) to state-of-the-art volumetric modulated arc therapy (VMAT) for 46 head and neck cancer cases. DTRT had lower dose to salivary glands and swallowing structure, resulting in lower predicted xerostomia and dysphagia compared to VMAT. DTRT is deliverable on C-arm linacs with high dosimetric accuracy.PMID:38513960 | DOI:10.1016/j.radonc.2024.110237 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 21, 2024 Category: Radiology Authors: Jenny Bertholet Paul-Henry Mackeprang Hannes A Loebner Silvan Mueller Gian Guyer Daniel Frei Werner Volken Olgun Elicin Daniel M Aebersold Michael K Fix Peter Manser Source Type: research
Organs-at-risk dose and normal tissue complication probability with dynamic trajectory radiotherapy (DTRT) for head and neck cancer
Radiother Oncol. 2024 Mar 20;195:110237. doi: 10.1016/j.radonc.2024.110237. Online ahead of print.ABSTRACTWe compared dynamic trajectory radiotherapy (DTRT) to state-of-the-art volumetric modulated arc therapy (VMAT) for 46 head and neck cancer cases. DTRT had lower dose to salivary glands and swallowing structure, resulting in lower predicted xerostomia and dysphagia compared to VMAT. DTRT is deliverable on C-arm linacs with high dosimetric accuracy.PMID:38513960 | DOI:10.1016/j.radonc.2024.110237 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 21, 2024 Category: Radiology Authors: Jenny Bertholet Paul-Henry Mackeprang Hannes A Loebner Silvan Mueller Gian Guyer Daniel Frei Werner Volken Olgun Elicin Daniel M Aebersold Michael K Fix Peter Manser Source Type: research
Financial toxicity associated with dry mouth
Dry mouth is a common condition affecting approximately 22% of the population.1 Estimates vary greatly depending on the specific condition tested (xerostomia vs. salivary hypofunction) and the population examined. In particular, dry mouth has been reported to affect up to 93.5% of patients with Sjogren's disease (SD)2, 65% of people who have received radiation therapy (RT) for head and neck cancer3, 39% of the elderly4, and 28% of medicated individuals5. Sequela of chronic dry mouth include increased dental caries, fungal infections, traumatic ulcerations, and diminished quality of life. (Source: Oral Surgery, Oral Medicin...
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - March 19, 2024 Category: ENT & OMF Authors: Alessandro Villa, Vidya Sankar Source Type: research
Organs-at-risk dose and normal tissue complication probability with dynamic trajectory radiotherapy (DTRT) for head and neck cancer
We compared dynamic trajectory radiotherapy (DTRT) to state-of-the-art volumetric modulated arc therapy (VMAT) for 46 head and neck cancer cases. DTRT had lower dose to salivary glands and swallowing structure, resulting in lower predicted xerostomia and dysphagia compared to VMAT. DTRT is deliverable on C-arm linacs with high dosimetric accuracy. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - March 19, 2024 Category: Radiology Authors: Jenny Bertholet, Paul-Henry Mackeprang, Hannes A. Loebner, Silvan Mueller, Gian Guyer, Daniel Frei, Werner Volken, Olgun Elicin, Daniel M. Aebersold, Michael K. Fix, Peter Manser Tags: Technical Note Source Type: research
Update on Sj ögren's syndrome : Diagnostics, treatment, and challenges
Z Rheumatol. 2024 Mar 18. doi: 10.1007/s00393-024-01493-z. Online ahead of print.ABSTRACTSjögren's syndrome (SjS) is the most common connective tissue disease with a prevalence of 1:200. Predominantly affecting women, SjS is associated with destruction of the exocrine glands, leading to xerophthalmia and xerostomia. In over 50% of patients, there are also extraglandular manifestations, leading to multiple organ manifestations including polyneuropathies and interstitial lung disease as well as symptoms such as fatigue and arthralgia. Diagnostic procedures include biomarkers, in particular anti-SS-A/Ro antibodies, histology...
Source: Zeitschrift fur Rheumatologie - March 18, 2024 Category: Rheumatology Authors: Nadine Zehrfeld Torsten Witte Diana Ernst Source Type: research
Reducing Salivary Toxicity with Adaptive Radiotherapy (ReSTART): A Randomized Controlled Trial comparing conventional IMRT to adaptive IMRT in head and neck Squamous Cell Carcinomas
The utility of Adaptive Radiotherapy (ART) in Head and Neck Squamous Cell Carcinoma (HNSCC) remains to be ascertained. While multiple retrospective and single-arm prospective studies have demonstrated its efficacy in decreasing parotid doses and reducing xerostomia, there is a lack of adequate randomized evidence. (Source: Clinical Oncology)
Source: Clinical Oncology - March 18, 2024 Category: Radiology Authors: Sarbani Ghosh-Laskar, Shwetabh Sinha, Anuj Kumar, Asesh Samanta, Samarpita Mohanty, Srikant Kale, Faizalam Khan, Shirley Lewis Salins, Vedang Murthy Tags: Original Article Source Type: research
Proton beam radiotherapy head and neck cancer study design and endpoints
We thank Friborg et al for sharing Denmark ’s important contributions to the evidence base for proton beam therapy in head and neck cancer patients [1]. In the Danish model, head and neck squamous cell cancer (SCC) in all sub-sites excluding early T1-2N0M0 larynx were included. Patients are double planned with comparisons made between prot on-photon dosimetry and a 5% superiority in the normal tissue complication probability (NTCP) model estimated risk for xerostomia and dysphagia is used to guide randomisation into DAHANCA35. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - March 15, 2024 Category: Radiology Authors: Cheng S. Boon, Shanmugasundaram Ramkumar, Ian S. Boon Tags: Letter to the Editor Source Type: research
Association of Radiation Dose to Pharynx with Long-term Quality of Life in Patients with Head and Neck Cancer
Radiation therapy (RT) is often the primary curative treatment modality for head and neck cancer (HNC). Patients receiving definitive RT for HNC are at high risk for long-term toxicity, including dry mouth, swallowing difficulties, and speech difficulties. Previous studies have suggested structure sparing during RT planning may reduce treatment toxicity as a way to mitigate these long-term effects. The purpose of this study was to evaluate the association of RT dose to the pharynx, larynx, and esophagus with long-term patient-reported quality of life (QOL) in the domains of xerostomia, dysphagia, and dysarthria. (Source: I...
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: M.A. Azam, A. Jhuma, H. Joseph, A.J. Iovoli, A.K. Singh Tags: 199 Source Type: research
