Radiation-associated changes in saliva composition of head and neck cancer patients: A systematic review
Radiother Oncol. 2024 Apr 20:110279. doi: 10.1016/j.radonc.2024.110279. Online ahead of print.ABSTRACTXerostomia is a common radiation-associated toxicity in patients with head and neck cancer. Although several studies examined the decrease in saliva production due to radiotherapy (RT) and investigated the factors associated with this side effect, little is known about the change in radiation-associated saliva composition. This systematic review is the first to summarize existing data and give an overview of the change in pH/buffer capacity, electrolytes, proteins, enzymes, and mucins due to radiation to the salivary gland...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 22, 2024 Category: Radiology Authors: Michal Staruch Marlene M Speth Peter Neyer Oliver Riesterer Daniel M Aebersold Sonja Stieb Source Type: research
Efficacy of natural enzymes mouthwash: a randomised controlled trial
ConclusionUse of natural enzymes mouthwash improved signs and symptoms of xerostomia.Clinical relevanceNatural enzymes mouthwash is potentially effective to treat xerostomia, well-tolerated and safe to be used by xerostomia patients.Clinical trial registration numberThis study was retrospectively registered in ClinicalTrials.gov ID NCT05640362 on 7 December 2022. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - April 19, 2024 Category: Dentistry Source Type: research
Putting the Brakes on Xerostomia in Oropharyngeal Cancer: Can Brachytherapy Be the Key?
There is no question as to the efficacy of brachytherapy in the management of de novo and recurrent head and neck cancers. It has been shown to contribute to both excellent oncologic outcomes in the upfront setting and durable local control and symptom relief in the recurrent setting.1-3 (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 15, 2024 Category: Radiology Authors: Shauna McVorran, Arash Naghavi, Philip Schaner Tags: Editorial Source Type: research
Radiation-induced xerostomia is related to stem cell dose-dependent reduction of saliva production
This study aimed to test whether the relationship between patient-reported xerostomia and Dmean,SCR is explained by a dose-dependent reduction of saliva production. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 15, 2024 Category: Radiology Authors: Maria I. van Rijn – Dekker, Sacha la Bastide – van Gemert, Monique A. Stokman, Arjan Vissink, Robert P. Coppes, Johannes A. Langendijk, Peter van Luijk, Roel J.H.M. Steenbakkers Tags: Clinical Investigation Source Type: research
Oral health status, related behaviours and perceived stress in xerostomia, Sicca and Sj ögren’s syndromes patients - a cross-sectional study
Mouth dryness increases the risk of some oral health-related conditions. Furthermore, it is unclear if patients with dry mouth engage in appropriate oral health-related behaviours. The study examined oral heal... (Source: BMC Oral Health)
Source: BMC Oral Health - April 15, 2024 Category: Dentistry Authors: Indre Stankeviciene, Lina Stangvaltaite-Mouhat, Jolanta Aleksejuniene, Diana Mieliauskaite, Ieva Talijuniene, Irena Butrimiene, Ruta Bendinskaite and Alina Puriene Tags: Research Source Type: research
Postradiation trismus in head and neck cancer survivors: a qualitative study of effects on life, rehabilitation, used coping strategies and support from the healthcare system
ConclusionThe results highlight areas of unmet need among HNC survivors that healthcare providers can target by establishing multi-professional teams dedicated to individualizing post-cancer rehabilitation care. (Source: European Archives of Oto-Rhino-Laryngology)
Source: European Archives of Oto-Rhino-Laryngology - April 8, 2024 Category: ENT & OMF Source Type: research
Does lower dose pilocarpine have a role in radiation-induced xerostomia in the modern radiotherapy era? A single-center experience based on patient-reported outcome measures
ConclusionPilocarpine may be considered at doses lower for late-term dry mouth. With modern radiotherapy techniques effectively preserving the parotid gland, short-term use may be recommended in these patients. Future studies may enhance the development of a more robust patient selection criteria model. (Source: European Archives of Oto-Rhino-Laryngology)
Source: European Archives of Oto-Rhino-Laryngology - April 4, 2024 Category: ENT & OMF Source Type: research
High dose total marrow irradiation (TMI) does not increase long-term toxicity of myeloablative fludarabine/busulfan (FluBu4) conditioning regimen in allogeneic hematopoietic stem cell transplantation (HSCT)
CONCLUSION: Our results suggest that a conditioning regimen with TMI 9Gy and FluBu4 does not increase long-term adverse events after allogeneic HSCT.PMID:38566462 | DOI:10.1111/ejh.14195 (Source: Cancer Control)
Source: Cancer Control - April 3, 2024 Category: Cancer & Oncology Authors: Lucas Maahs Pritesh Patel Matthew Koshy Karen Sweiss Zhengjia Chen Ziqiao Xu Bulent Aydogan Damiano Rondelli Source Type: research
Primary and adjuvant intensity-modulated radiotherapy in oropharyngeal carcinoma patients from a single institution
CONCLUSION: Intensity-modulated radiotherapy for OPC is an important part of the treatment algorithm alone and in particular after surgery while the additional benefits of chemotherapy might be age dependent. Despite advanced tumor stages, nearly half of our patients were alive in the long term. The majority of patients had relatively mild chronic adverse events.PMID:38554349 | DOI:10.4103/jcrt.jcrt_2178_22 (Source: Cancer Control)
Source: Cancer Control - March 30, 2024 Category: Cancer & Oncology Authors: Henrik Hauswald Eugen Petrow Falk Roeder Juergen Debus Felix Zwicker Peter E Huber Source Type: research
Fixed prosthodontic rehabilitation of a patient after bariatric surgery using a facially driven fully digital workflow: A clinical report with a 3-year follow-up
Patients who have received bariatric surgery have specific and complex dental needs. After surgery, nutrient deficiencies, osteoporosis, gastroesophageal reflux, and changes to the oral cavity may be seen, and erosion, caries, wear, xerostomia, hypersensitivity, and changes to the salivary buffering capacity may occur. In addition, patients are advised to ingest smaller, more frequent, meals throughout the day, and the oral condition may decline rapidly after surgery. Without oversight, this accelerated decline may even necessitate complete mouth rehabilitation postoperatively. (Source: Journal of Prosthetic Dentistry)
Source: Journal of Prosthetic Dentistry - March 30, 2024 Category: Dentistry Authors: Naif Sinada, Christina I. Wang Tags: Clinical report Source Type: research
COVID-19 and oral lesions: 2020-2024 outpatient case series and literature review
We present 15 patients that came for their first specialist examination to the Oral Medicine Outpatient Clinic, Dental Clinic, Split, Croatia between November 2020 and January 2024. Their medical and dental history was taken following CARE guidelines. The prevalence of oral lesions associated with SARS-CoV-2 was 1.42% during the 4-year follow-up period. The most common oral lesions were nonspecific erosions, stomatitis, salivary flow disorders (xerostomia, oligosialia), salivary gland diseases (sialadenitis, chronic sialadenitis), candidiasis, pigmentation, aphthae, burning mouth syndrome, and geographic and fissured tongu...
Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica - March 27, 2024 Category: Dermatology Authors: Ana Glavina Jozo Badrov Marino Lukenda Karmela D žaja Dolores Bio čina-Lukenda Liborija Lugovi ć-Mihić Source Type: research
