SPECT/CT-guided elective nodal irradiation for head and neck cancer is oncologically safe and less toxic: A potentially practice-changing approach.
Abstract BACKGROUND AND PURPOSE: Bilateral elective nodal irradiation (ENI) remains the standard treatment for head and neck squamous cell carcinoma (HNSCC). Unilateral ENI could reduce treatment toxicity and improve health-related quality-of-life (HRQOL). This prospective proof-of-principle trial (NCT02572661) investigated the feasibility, safety and clinical benefits of SPECT/CT-guided ENI of the node-negative contralateral neck. MATERIALS AND METHODS: Patients with lateralized T1-3N0-2bM0 HNSCC of the oropharynx, oral cavity, larynx and hypopharynx underwent SPECT/CT after peritumoral 99mTc-nanocolloid inj...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 30, 2020 Category: Radiology Authors: de Veij Mestdagh PD, Walraven I, Vogel WV, Schreuder WH, van Werkhoven E, Carbaat C, Donswijk ML, van den Brekel MWM, Al-Mamgani A Tags: Radiother Oncol Source Type: research

Early onset primary Sj ögren syndrome, clinical and laboratory characteristics
In this study, we aimed to investigate the clinical and laboratory characteristics of early onset pSS patients.MethodThe data of 352 pSS patients were analyzed retrospectively. The patients were divided into two groups as those with the onset age of 35 or younger (early-onset) and those with the onset age of older than 35. The clinical, laboratory, and serological characteristics of the two groups were compared.p 
Source: Clinical Rheumatology - March 27, 2020 Category: Rheumatology Source Type: research

A phase II study of adaptive two-step intensity-modulated radiation therapy (IMRT) with chemotherapy for loco-regionally advanced nasopharyngeal cancer (JCOG1015)
ConclusionsAdaptive two-step IMRT for NPC demonstrated an excellent 3-year OS with acceptable toxicities. This method may be one treatment option for locally advanced NPC. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 27, 2020 Category: Cancer & Oncology Source Type: research

Lactoferrin and oral pathologies: a therapeutic treatment.
Abstract The oral cavity is a non-uniform, extraordinary environment characterized by mucosal, epithelial, abiotic surfaces and secretions as saliva. Aerobic and anaerobic commensal and pathogenic microorganisms colonize the tongue, teeth, jowl, gingiva and periodontium. Commensals exert an important role in host defenses, while pathogenic microorganisms can nullify this protective function causing oral and systemic diseases. Every day, 750-1,000 ml of saliva, containing several host defense constituents including lactoferrin (Lf), are secreted and swallowed. Lf is a multifunctional iron-chelating cationic glycopr...
Source: Biochemistry and Cell Biology - March 26, 2020 Category: Biochemistry Authors: Rosa L, Lepanto MS, Cutone A, Ianiro G, Pernarella S, Sangermano R, Musci G, Ottolenghi L, Valenti P Tags: Biochem Cell Biol Source Type: research

Oral and Oropharyngeal Sensory Function in Adults With Chronic Obstructive Pulmonary Disease.
This study aimed to describe and compare oral and oropharyngeal sensory function measured using noninstrumental clinical methods in adults with COPD and healthy controls. Method Participants included 27 adults (18 men, nine women) with a diagnosis of COPD and a mean age of 66.56 years (SD = 8.68). The control group comprised 11 healthy adults (five men, six women) with a mean age of 60.09 years (SD = 11.57). Spirometry measures confirmed reduced functional expiratory volumes (% predicted) in the COPD patients compared to the control participants. All participants completed a case history interview and underwent clinical ev...
Source: American Journal of Speech-Language Pathology - March 23, 2020 Category: Speech-Language Pathology Authors: da Rosa FB, Pasqualoto AS, Steele CM, Mancopes R Tags: Am J Speech Lang Pathol Source Type: research

Mitigating Radiation Induced Xerostomia with Nigella Sativa Oil
Xerostomia, dry mouth, is one of the most common complications during and after radiotherapy for head and neck cancers due to terminal damage to the salivary glands. Xerostomia often contributes to both minor and serious health problems, which severely decrease quality of life for patients. Current methods of management and preventative measures of xerostomia have shown little success and effectiveness. Like all tissues, salivary glands are maintained by a small group of cells, stem/progenitor cells, with the capacity to repopulate and differentiate into the needed cell types upon tissue injury. (Source: International Jour...
Source: International Journal of Radiation Oncology * Biology * Physics - March 12, 2020 Category: Radiology Authors: Y.M. Alhiyari, K. Kwan, B. Cameron, M. St John Tags: Toxicity, Quality of Life, Survivorship, Costs of Care Source Type: research

Mid-treatment assessment of dose to parotid gland stem cell region and change in parotid gland volume predicts for long-term patient-reported xerostomia
To determine whether the radiation (RT) dose to the parotid gland stem cell (SC) region or pre- and mid-treatment CT scans as well as change in parotid gland volume is associated with long-term patient-reported xerostomia after definitive head and neck cancer (HNC) RT. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 12, 2020 Category: Radiology Authors: R. Kabarriti, P. Brodin, S. Ahmed, W.A. Tome, C. Guha, S. Kalnicki, M.K. Garg Tags: Toxicity, Quality of Life, Survivorship, Costs of Care Source Type: research

Ameliorating radiation-induced hyposalivation and xerostomia with Adipose-derived Mesenchymal Stem/stromal cells (MESRIX-II)
Salivary gland hypofunction and xerostomia remain major obstacles after radiation of head and neck cancers. There is large unmet need for new treatment strategies as only insufficient symptomatic therapies exits. The randomized controlled MESRIX-trial indicates that autologous adipose-derived mesenchymal stem/stromal cells (ASCs) can safely restore function of the irradiated submandibular glands in former oropharynx cancer patients. Allogeneic ASCs from healthy donors as a ready-to-use therapies have been proved safe for several diseases and may be a new intervention for radiation-induced xerostomia. (Source: International...
Source: International Journal of Radiation Oncology * Biology * Physics - March 12, 2020 Category: Radiology Authors: C.D. Lynggaard, C. Gr ønhøj, C.V. Buchwald Tags: Toxicity, Quality of Life, Survivorship, Costs of Care Source Type: research

The impact of primary Sjogren's syndrome on female sexual function.
CONCLUSIONS: The genital disorders secondary to SS can strongly alter the quality of female life both physically and psychologically as they alter sexuality. However, the observation of certain behavioral norms and the use of appropriate local substances can alleviate the symptoms and effectively contribute to reducing the discomfort. PMID: 32153164 [PubMed - in process] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - March 12, 2020 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Generalizability assessment of head and neck cancer NTCP models based on the TRIPOD criteria.
Abstract This review aimed to provide an overview of the level of maturity of normal tissue complication probability (NTCP) models for head and neck cancer (HNC) patients. A systematic literature review was performed to retrieve NTCP models for HNC toxicities. Patient population characteristics, NTCP model and the predictors, treatment technique and endpoint definition were extracted per article. Models were then scored based on the TRIPOD (transparent reporting of a multivariable prediction model for individual prognosis or diagnosis) consensus guidelines to evaluate their generalizability. 335 articles on photon...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 7, 2020 Category: Radiology Authors: Sharabiani M, Clementel E, Andratschke N, Hurkmans C Tags: Radiother Oncol Source Type: research

Sicca Symptoms in Parkinson's Disease: Association with Other Nonmotor Symptoms and Health-Related Quality of Life.
Conclusion: Sicca symptoms are common in PD and negatively influence QoL. The observed association between sicca symptoms and other nonmotor symptoms provides further preliminary evidence for the growing recognition of different nonmotor clusters in PD. PMID: 32104559 [PubMed] (Source: Parkinsons Disease)
Source: Parkinsons Disease - February 28, 2020 Category: Neurology Tags: Parkinsons Dis Source Type: research

Xerostomia and Clinical Outcomes in Definitive Intensity Modulated Radiotherapy (IMRT) Versus Three-dimensional Conformal Radiotherapy (3D-CRT) for Head and Neck Squamous Cell Carcinoma: A Meta-analysis
Conclusion: This meta-analysis explored the value of IMRT compared to 3D-CRT and confirmed the superiority of IMRT over 3D-CRT in terms of grade ≥2 xerostomia rates, but not on clinical outcomes. Its positive impact on tumor control and survival remains to be proven. (Source: In Vivo)
Source: In Vivo - February 28, 2020 Category: Research Authors: DE FELICE, F., PRANNO, N., PAPI, P., BRUGNOLETTI, O., TOMBOLINI, V., POLIMENI, A. Tags: Experimental Studies Source Type: research

Thirst in patients on chronic hemodialysis: What do we know so far?
AbstractThirst has been defined as “the sensation that leads animal’s and human’s actions toward the goal of finding and drinking water” or as “any drive that can motivate water intake, regardless of cause”. Thirst, together with xerostomia, is the main cause of poor adherence to fluid restriction and of excessive intake of fluids in patients on chronic hemodialysis, and consequently of high interdialytic weight gain. Interdialytic weight gain (IDWG) should be lower than 4.0–4.5% of dry weight. Unfortunately, many patients have an IDWG greater than this value and some have IDWG of ...
Source: International Urology and Nephrology - February 25, 2020 Category: Urology & Nephrology Source Type: research

Mixed-beam approach in locally advanced nasopharyngeal carcinoma: IMRT followed by proton therapy boost versus IMRT-only. Evaluation of toxicity and efficacy.
Conclusions: Sequential MB approach for LANPC patients provides a significantly lower acute toxicity profile compared to full course of IMRT. There were no differences in early-late morbidities and disease-related outcomes (censored at two-years) but a longer follow-up is required to achieve conclusive results. PMID: 32090645 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - February 23, 2020 Category: Cancer & Oncology Authors: Alterio D, D'Ippolito E, Vischioni B, Fossati P, Gandini S, Bonora M, Ronchi S, Vitolo V, Mastella E, Magro G, Franco P, Ricardi U, Krengli M, Ivaldi G, Ferrari A, Fanetti G, Comi S, Tagliabue M, Verri E, Ricotti R, Ciardo D, Jereczek-Fossa BA, Valvo F, O Tags: Acta Oncol Source Type: research

Quantitative evaluation of salivary gland scintigraphy in Sj ögren’s syndrome: comparison of diagnostic efficacy and relationship with pathological features of the salivary glands
ConclusionConventional scintigraphic parameters could be used as simple, reliable, and sensitive indicators for the early diagnosis of SS and determination of disease severity. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - February 20, 2020 Category: Nuclear Medicine Source Type: research

Xerostomia: prevention with Pycnogenol ® supplementation: a pilot study.
Xerostomia: prevention with Pycnogenol® supplementation: a pilot study. Minerva Stomatol. 2019 Dec;68(6):303-307 Authors: Belcaro G, Cesarone MR, Cornelli U, Scipione C, Scipione V, Dugall M, Hu S, Feragalli B, Hosoi M, Maione C, Cotellese R, Cesinaro Di Rocco P Abstract BACKGROUND: The aim of this pilot study was the evaluation of primary, idiopathic mucosal dryness (xerostomia or dry mouth) in subjects without cancer. METHODS: A group of non-diabetic subjects and a group of diabetics were managed with standard management (SM) or with SM+Pycnogenol® (150 mg/day) for 2 weeks. RESULTS: I...
Source: Minerva Stomatologica - February 15, 2020 Category: Dentistry Tags: Minerva Stomatol Source Type: research

Temporomandibular Disorders and Oral Features in Systemic Lupus Erythematosus Patients: An Observational Study of Symptoms and Signs.
Authors: Crincoli V, Piancino MG, Iannone F, Errede M, Di Comite M Abstract Aims: Systemic Lupus Erythematosus (SLE) is a connective tissue disease characterized by a wide range of pleomorphic pictures, including mucocutaneous, renal, musculoskeletal and neurological symptoms. It involves oral tissues, with hyposalivation, tooth decay, gingivitis, angular cheilitis, ulcers and glossitis. Temporomandibular disorders represent a heterogeneous group of inflammatory or degenerative diseases of the stomatognatic system, with algic and/or dysfunctional clinical features involving temporomandibular joint (TMJ) and related...
Source: International Journal of Medical Sciences - February 12, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Comparing the Frequency of Some Oral Lesions in Prediabetic and Healthy Individuals: Is There Any Difference?
This study aimed to compare some oral complications between prediabetic andhealthy control groups.Methods:The   present two‑group cross‑sectional study was carried outon 302 prediabetic and non ‑diabetic (healthy) 20‑ to 60‑year‑old subjects. In this study, dataon age, gender, educational level, medications use, smoking, and some other variables wereextracted through history taking. In addition, orodental examination was carried out by an oralmedicine specialist to diagnose oral lesions including candidiasis, lichen planus, periodontitis,gingivitis, xerostomia, delayed wound healing, geographic tongue, fissur...
Source: International Journal of Preventive Medicine - February 9, 2020 Category: International Medicine & Public Health Source Type: research

The 68 Ga/ 177 Lu-theragnostic concept in PSMA-targeting of metastatic castration –resistant prostate cancer: impact of post-therapeutic whole-body scintigraphy in the follow-up
AbstractIntroductionA new therapeutic option for metastatic castration –resistant prostate cancer (mCRPC) of heavily pre-treated patients lies in177Lu-PSMA-617 radioligand therapy.MethodsOn the basis of PSMA-targeted68Ga-PSMA-11 PET/CT, 32 consecutive mCRPC patients were selected for177Lu-PSMA-617 therapy (6 GBq/cycle, 2 to 6 cycles, 6 –10 weeks apart) and followed until death. Post-therapy whole-body (WB) dosimetry and68Ga-PSMA-11 PET/CT data were compared and related to progression free and overall survival.Results177Lu-PSMA-617 dosimetry after the first cycle indicated high tumor doses for skeletal (4.01 &pl...
Source: European Journal of Nuclear Medicine and Molecular Imaging - February 6, 2020 Category: Nuclear Medicine Source Type: research

Diffusion-weighted imaging as a  follow-up modality for evaluation of major salivary gland function in nasopharyngeal carcinoma patients: a preliminary study
ConclusionAs part of routine follow-up MRI in NPC patients, DWI might be a  promising modality for follow-up assessing the dynamic changes of major salivary gland function and might be more powerful in the late post-RT period. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - February 5, 2020 Category: Cancer & Oncology Source Type: research

Involvement of TRPV4 ionotropic channel in tongue mechanical hypersensitivity in dry-tongue rats.
Authors: Chen JY, Kubo A, Shinoda M, Okada-Ogawa A, Imamura Y, Iwata K Abstract Although xerostomia can cause persistent oral pain, the mechanisms underlying such pain are not well understood. To evaluate whether a phosphorylated p38 (pp38)-TRPV4 mechanism in trigeminal ganglion (TG) neurons has a role in mechanical hyperalgesia of dry tongue, a rat model of dry tongue was used to study the nocifensive reflex and pp38 and TRPV4 expression in TG neurons. The head-withdrawal reflex threshold for mechanical stimulation of the tongue was significantly lower in dry-tongue rats than in sham rats. The numbers of TRPV4- an...
Source: Journal of oral science - January 31, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research

Prognostic nomogram of xerostomia for patients with nasopharyngeal carcinoma after intensity-modulated radiotherapy.
This study was conducted to establish an effective predictive nomogram for xerostomia by assessing stage I-IVb (AJCC 7th edition) NPC patients between September 2015 and March 2016. Xerostomia was evaluated via the RTOG/EORTC system. The primary endpoint was grade 2-3 xerostomia 1 year after treatment. The predictive factors for xerostomia were analysed using logistic regression analysis. A nomogram was constructed based on combining the predictors and clinical variables. In total, 102 patients with grade 0-1 xerostomia and 93 patients with grade 2-3 xerostomia were included. The independent predictive factors for xerostom...
Source: Aging - January 31, 2020 Category: Biomedical Science Authors: Pan XB, Liu Y, Li L, Qu S, Chen L, Liang SX, Chen KH, Liang ZG, Zhu XD Tags: Aging (Albany NY) Source Type: research

The prevalence of patient-reported dysphagia and oral complications in cancer patients
ConclusionsThis is the first time comprehensive data on dysphagia and oral complications across all cancer patients have been collected. We have identified that dysphagic symptoms and oral complications —which have implications for quality of life and function—are common in all cancer patients, not just those with head and neck cancer. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - January 29, 2020 Category: Cancer & Oncology Source Type: research

Two- Versus Four-Times Weekly Acupuncture-Like Transcutaneous Electrical Nerve Stimulation for Treatment of Radiation-Induced Xerostomia: A Pilot Study
The Journal of Alternative and Complementary Medicine, Ahead of Print. (Source: The Journal of Alternative and Complementary Medicine)
Source: The Journal of Alternative and Complementary Medicine - January 27, 2020 Category: Complementary Medicine Authors: Austin J. Iovoli Alexander Ostrowski Charlotte I. Rivers Gregory M. Hermann Adrienne Groman Austin Miller Anurag K. Singh Source Type: research

Protocolised odontological assessment of patients with primary Sjögren’s syndrome
ConclusionsThe presence of xerostomia in this cohort of pSS patients was high and hyposialia was present in 61% of the patients. Oral lesions appeared in more than half of the subjects. Oral health had a negative impact on the quality of life of patients with pSS, being higher in those with pathological objective oral signs and in those with peripheral nervous system involvement.ResumenObjetivoEl objetivo de este estudio es describir los hallazgos de una evaluación odontológica protocolizada en pacientes con síndrome de Sjögren primario (SSp) atendidos en las consultas de reumatología de la...
Source: Reumatologia Clinica - January 26, 2020 Category: Rheumatology Source Type: research

Reduced radiation-induced toxicity by using proton therapy for the treatment of oropharyngeal cancer.
Abstract Patients with squamous cell carcinoma of the oropharynx are generally treated with (chemo) radiation. Patients with oropharyngeal cancer (OPC) have better survival than patients with squamous cell carcinoma of other head and neck subsites, especially when related to human papillomavirus (HPV). However, radiotherapy results in a substantial percentage of survivors suffering from significant treatment-related side-effects. Late radiation-induced side-effects are mostly irreversible and may even be progressive, and particularly xerostomia and dysphagia affect health-related quality of life (HRQoL). As the ri...
Source: The British Journal of Radiology - January 23, 2020 Category: Radiology Authors: Meijer TWH, Scandurra D, Langendijk JA Tags: Br J Radiol Source Type: research

A biological active artificial saliva formulation containing flower mucilage from Ceylon Spinach (Basella alba Linn.)
Publication date: Available online 16 January 2020Source: Saudi Journal of Biological SciencesAuthor(s): Aranya Manosroi, Kassara Pattamapun, Charinya Chankhampan, Bang-on Kietthanakorn, Worapong Kitdamrongtham, Jie Zhang, Jiradej ManosroiAbstractCeylon Spinach (Basella albe) is an edible perennial vine found in tropical Asia and Africa, known as vegetables containing mucilage. Its mucilage from flowers was extracted by microwaving and precipitated with 95% ethanol. Five artificial saliva formulations composing of mucilage from Ceylon Spinach, calcium chloride (CaCl2), potassium chloride (KCl) and sodium fluoride (NF) were...
Source: Saudi Journal of Biological Sciences - January 17, 2020 Category: Biology Source Type: research

Suppression of high-mobility group box 1 ameliorates xerostomia in a sjogren syndrome-triggered mouse model.
This study aimed at clarifying the role of HMGB1 in sjogren syndrome (SS)-triggered xerostomia. The non-obese diabetic (NOD)/Ltj mice were used to establish a SS-triggered xerostomia model. The results showed that saliva production was decreased and anti-sjogren syndrome B (anti-SSB) level was increased in SS. PCR, western blot and immunohischemistry experiments indicated that the HMGB1 and aquaporin 5 (AQP5) levels were enhanced and diminished in SS than those in Control, respectively. While the mice were treated with anti-HMGB1, xerostomia was reversed due to the elevated saliva production and reduced anti-SSB level. In ...
Source: Canadian Journal of Physiology and Pharmacology - January 14, 2020 Category: Drugs & Pharmacology Authors: Wang D, Zhou M, Wang Y, Sun S Tags: Can J Physiol Pharmacol Source Type: research

Diffuse palatal swelling
A 66-year-old white female presented to the Oral Medicine clinic at the Tufts University School of Dental Medicine (Boston, MA) with a 6-year history of bilateral submandibular and parotid gland swelling. She described asymptomatic swelling in the submandibular region, with intermittent increases and decreases in size, accompanied by subjective xerostomia and xerophthalmia. The patient had an empirical diagnosis of sicca syndrome and had been evaluated by the Departments of Otolaryngology and Rheumatology without resolution of her symptoms. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - January 13, 2020 Category: ENT & OMF Authors: Alaa F. Bukhari, Britta E. Magnuson, Bhavik Desai, Monika Pilichowska, Mark A. Lerman Source Type: research

Anti-inflammatory potential of an essential oil-containing mouthwash in elderly subjects enrolled in supportive periodontal therapy: a 6-week randomised controlled clinical trial
ConclusionThe irrigation with a sage-containing mouthwash did not result in a superior beneficial effect on inflammatory parameters and plaque indices compared with the placebo. The expected contribution of the plant extracts to their potential impact on oral health may need further investigation.Clinical relevanceThe proposed mouthwash might be suitable for patients with inflammatory signs of the gingiva who prefer natural remedies. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - January 8, 2020 Category: Dentistry Source Type: research

Young head and neck cancer patients are at increased risk of developing oral mucositis and trismus
AbstractObjectivesTo evaluate cancer treatment –related toxicities in young head and neck cancer (HNC) patients.Material and methodsA total of 44 patients were included in the present retrospective cohort study, which was designed to access oral toxicities of cancer treatment in young (  58 years of age, Group II,n = 22) HNC patients with similar tumor stage and treatment protocols. Oral mucositis (OM), xerostomia, dysphagia, dysgeusia, trismus, and radiodermatitis were assessed during days 7th, 21st, and 35th of head and neck radiotherapy (HNRT) according to previously validated scales (Wor...
Source: Supportive Care in Cancer - January 7, 2020 Category: Cancer & Oncology Source Type: research

Characteristics of patients with primary Sj ögren’s syndrome associated interstitial lung disease and relevant features of disease progression
AbstractObjectiveTo investigate characteristics of patients with primary Sj ögren’s syndrome (pSS)-associated interstitial lung disease (ILD) and relevant features of ILD progression.MethodPatients with pSS were retrospectively reviewed, and pSS-ILD and pSS non-ILD were identified. Clinical data, laboratory parameters, pulmonary high-resolution CT (HRCT), and pulmonary function tests (PFTs) were collected. pSS-ILD patients were further categorized into subgroups according to HRCT patterns or PFTs.ResultsEighty-five pSS-ILD patients and 85 pSS non-ILD patients were included. The average age at disease onset and m...
Source: Clinical Rheumatology - January 5, 2020 Category: Rheumatology Source Type: research

Stress or injury induces cellular plasticity in salivary gland acinar cells
AbstractSalivary gland function is severely disrupted by radiation therapy used to treat patients diagnosed with head and neck cancer and by Sj ögren’s syndrome. The resulting condition, which results in xerostomia or dry mouth, is due to irreversible loss of the secretory acinar cells within the major salivary glands. There are presently no treatments for the resolution of xerostomia. Cell-based approaches could be employed to repopulat e acinar cells in the salivary gland but investigations into potential therapeutic strategies are limited by the challenges of maintaining and expanding acinar cells in vitro. W...
Source: Cell and Tissue Research - January 4, 2020 Category: Cytology Source Type: research

Stress or injury induces cellular plasticity in salivary gland acinar cells.
Abstract Salivary gland function is severely disrupted by radiation therapy used to treat patients diagnosed with head and neck cancer and by Sjögren's syndrome. The resulting condition, which results in xerostomia or dry mouth, is due to irreversible loss of the secretory acinar cells within the major salivary glands. There are presently no treatments for the resolution of xerostomia. Cell-based approaches could be employed to repopulate acinar cells in the salivary gland but investigations into potential therapeutic strategies are limited by the challenges of maintaining and expanding acinar cells in vitro....
Source: Cell Research - January 4, 2020 Category: Cytology Authors: Shubin AD, Sharipol A, Felong TJ, Weng PL, Schutrum BE, Joe DS, Aure MH, Benoit DSW, Ovitt CE Tags: Cell Tissue Res Source Type: research

Predictors of Overall and Disease-Free Survival in Metastatic Castration-Resistant Prostate Cancer Patients Receiving 225Ac-PSMA-617 Radioligand Therapy
Metastatic prostate carcinoma overexpresses prostate-specific membrane antigen (PSMA), making this antigen a suitable target for radioligand therapy of the disease. Here we report on our experience with a series of 73 castration-resistant prostate carcinoma patients treated with 225Ac-PSMA-617, identifying variables predictive for overall survival (OS) and progression-free survival (PFS) after 225Ac-PSMA-617 treatment. Methods: 225Ac-PSMA-617 was administered to patients who had metastatic castration-resistant prostate carcinoma and who had exhausted available therapy options for their disease. Full blood count, glomerular...
Source: Journal of Nuclear Medicine - January 2, 2020 Category: Nuclear Medicine Authors: Sathekge, M., Bruchertseifer, F., Vorster, M., Lawal, I. O., Knoesen, O., Mahapane, J., Davis, C., Reyneke, F., Maes, A., Kratochwil, C., Lengana, T., Giesel, F. L., Van de Wiele, C., Morgenstern, A. Tags: Clinical Source Type: research

Fluctuations of antimitochondrial antibodies and anti-gp210 antibody in a patient with primary biliary cholangitis and Sjögren syndrome with subsequent autoimmune hemolytic anemia: A case report
This study investigated a 60-year-old woman admitted to our hospital with complaints of xerostomia for 5 years, pruritus for 3 years, and abnormal liver function for 3 months. Diagnoses: The patient was suffering from typical clinical PBC and SS, and developed decompensated liver cirrhosis after 32 months of ursodeoxycholic acid (UDCA) therapy. In May 2018, she was readmitted to the hospital with a high fever of 39 °C, coughing, and sever fatigue without remission after 3 days of cephalosporin antibiotic therapy. During the clinical course of PBC, her antimitochondrial antibodies (AMA) titers fluctuated from 1:100...
Source: Medicine - January 1, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Predictors of iron-deficiency anemia in primary care older adults: a real-world European multi-country longitudinal study.
CONCLUSIONS: Specific signs and symptoms, chronic conditions, a greater comorbidity burden, and specific pharmacological treatments registered in primary care databases represent relevant predictors and correlates of incident IDA in older people in Europe. General practitioners might employ this information to obtain early diagnosis of IDA in community-dwelling older adults. PMID: 31893385 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - January 1, 2020 Category: Geriatrics Authors: Vetrano DL, Zucchelli A, Marconi E, Levi M, Pegoraro V, Cataldo N, Heiman F, Cricelli C, Lapi F Tags: Aging Clin Exp Res Source Type: research

Effects of Phyllanthus emblicaspray interventions on xerostomia after general anesthesia for gynecologic tracheal intubation: A randomised controlled trial
ConclusionsThe use of p. emblica spray appeared to be superior to warm water spray for treating postoperative xerostomia. (Source: European Journal of Integrative Medicine)
Source: European Journal of Integrative Medicine - December 31, 2019 Category: Complementary Medicine Source Type: research

Relationship Between Xerostomia and Hyposalivation in Senior Chilean People
ABSTRACT: Background: Hyposalivation is an objective decrease in salivary flow and it can produce xerostomia; which is a subjective sensation of dry mouth, common condition in senior population. Objectives: To identify the association between xerostomia and hyposalivation and its risk factors in people aged 60 years and older, and to investigate the association with medications, habits and other oral complications. Methods: 211 participants were included. Xerostomia data was collected using a validated Spanish-Xerostomia Inventory (XI-sp). Unstimulated whole-salivary flow rates were measured to detect hyposalivation. Resul...
Source: Revista clinica de periodoncia, implantologia y rehabilitacion oral - December 31, 2019 Category: Dentistry Source Type: research

Effects of Phyllanthus emblica spray interventions on xerostomia after general anesthesia for gynecologic tracheal intubation: A randomised controlled trial
ConclusionsThe use ofp. emblica spray appeared to be superior to warm water spray for treating postoperative xerostomia. (Source: European Journal of Integrative Medicine)
Source: European Journal of Integrative Medicine - December 25, 2019 Category: Complementary Medicine Source Type: research

Salivary gland function in nasopharyngeal carcinoma before and late after intensity-modulated radiotherapy evaluated by dynamic diffusion-weighted MR imaging with gustatory stimulation
Xerostomia caused by radiation-induced salivary glands injury has a considerable impact on patients ’ quality of life. Nowadays, the existed different methods of evaluating xerostomia in clinical practice there... (Source: BMC Oral Health)
Source: BMC Oral Health - December 21, 2019 Category: Dentistry Authors: Dai Shi, Jian-Jun Qian, Guo-Hua Fan, Jun-Kang Shen, Ye Tian and Liang Xu Tags: Research article Source Type: research

Disruption of tight junction structure contributes to secretory dysfunction in IgG4-related sialadenitis
AbstractIgG4-related sialadenitis (IgG4-RS) is a chronic fibro-inflammatory disease characterized by swelling of salivary glands and varying degrees of xerostomia. Tight junctions (TJs) play an essential role in maintaining secretory function by regulating the paracellular flow of ions and water. However, whether TJs are altered and contribute to the hyposecretion in IgG4-RS is not fully understood. Here, a total of 399 differentially expressed proteins were identified in IgG4-RS submandibular glands (SMGs) and enriched in the regulation of actin cytoskeleton and the salivary secretion. Real-time PCR results showed that th...
Source: Journal of Molecular Histology - December 21, 2019 Category: Laboratory Medicine Source Type: research

Intensity Modulated Radiotherapy (IMRT) With Carbon Ion Boost in the Multimodal Treatment of Salivary Duct Carcinoma
Conclusions: Multimodal therapy approaches with surgery followed by IMRT and CIRT boost for SDC leads to good local and locoregional disease control. However, the frequent occurrence of distant metastases limits the prognosis and requires optimization of adjuvant systemic therapies. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - December 20, 2019 Category: Cancer & Oncology Source Type: research

A patient with primary Sjogren ’s syndrome, cystic lung disease, and MALT lymphoma treated successfully with rituximab: a case-based review
AbstractPrimary Sjogren ’s syndrome (pSS) can have a myriad of presentations, ranging from mild xerostomia to more diffuse systemic involvement. It is well established that pSS is associated with a variety of pulmonary pathologies, and it is also known that pSS patients are at higher risk for lymphoma development. Here, we present an unusual case of a woman with primary Sjogren’s syndrome who had both diffuse cystic lung disease as well as extranodal MALT lymphoma, successfully treated for both conditions with the CD-20 monoclonal antibody rituximab. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - December 20, 2019 Category: Rheumatology Source Type: research

Whole saliva and residual mucosal saliva in patients with burning mouth syndrome: a case-control study
Publication date: January 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 129, Issue 1Author(s): Sumeia Gamal Werfalli, Mark Drangsholt, Michael Martin, Linda LerescheObjectivesBurning mouth syndrome (BMS) is a chronic pain condition. Xerostomia is a common complaint among patients with BMS. However, previous studies have reported inconsistent findings regarding salivary flow rate reduction among these patients. The aim of this study was to examine unstimulated whole saliva (UWS) and stimulated whole saliva (SWS) flow rates, degree of mucosal hydration, and xerostomia in female patients w...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - December 15, 2019 Category: ENT & OMF Source Type: research

Radiation-induced dental caries in a patient with head and neck radiotherapy: a case report
Radiation-induced dental caries are aggressive and rapid lesions that destroy the dental crown usually located at the cervical region and are the main reason for pulp exposure in most cases. They are caused by xerostomia associated with poor hygiene. We contribute a case of a man with a history of oral radiotherapy to cure a laryngeal tumor 2 years ago. On intraoral exam, we have observed extensive cervical caries in 8 upper teeth with a total prosthesis on the mandible associated with poor salivary secretion. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - December 15, 2019 Category: ENT & OMF Authors: SARAH NERY FIGORELLE DE CARVALHO MILAGRES, LET ÍCIA FELICIANO DUQUE, ROBERTA MANSUR CAETANO, MAÍRA TAVARES DE FARIA Source Type: research

Burning mouth syndrome: laser therapy as a biomodulator treatment
Burning mouth syndrome (BMS) is an idiopathic and chronic condition affecting women in the postmenopausal period. Case: A 64-year-old female patient came to the stomatology clinic complaining of xerostomia and burning lips. She has controlled hypertension using an antihypertensive, and she has had osteoporosis for 2 years. At the physical examination, there was no noticeable change. Therefore, the patient was diagnosed with BMS. Low-intensity laser therapy was the chosen treatment in addition to orientation for constant hydration. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - December 15, 2019 Category: ENT & OMF Authors: BRUNNA RODRIGUES GRISI, SANDRA APARECIDA MARINHO, JOABE DOS SANTOS PEREIRA, GUSTAVO GOMES AGRIPINO, ERNANI CANUTO FIGUEIR ÊDO, GUSTAVO PINA GODOY, SÉRGIO HENRIQUE GONÇALVES DE CARVALHO Source Type: research

Chronic graft-vs-host disease: a case report
This study presents a case report of a 42-year-old black woman who showed up in a clinic of pathology and stomatology because of oral manifestations of chronic graft-vs-host disease (cGVHD) after allogeneic bone marrow transplant. The disease manifestations showed as multiple white plaques and striations on the lips, labial mucosa, ventral surface of the tongue, oropharynx, palate, and buccal mucosa as well as areas of atrophic mucosa, burning mouth, and xerostomia. Based on the clinical findings and the patient's history, the diagnosis was cGVHD, and an incisional biopsy of the minor salivary glands of the inferior lip wa...
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - December 15, 2019 Category: ENT & OMF Authors: MATEUS JOS É DE CARVALHO PEREIRA, FELIPE PAIVA FONSECA, RICARDO ALVES DE MESQUITA, TARCÍLIA APARECIDA DA SILVA, VAGNER RODRIGUES SANTOS Source Type: research

Low-level laser therapy for xerostomia control in a patient with scleroderma: clinical case report
The aim of this study was to report the effect of low-level laser therapy for xerostomia control in a patient with scleroderma. A 7-year-old female patient with medical history of scleroderma was attended with dry and rigid appearance of facial skin and xerostomia. Baseline stimulated salivary flow was assessed before and after treatment. Low-level laser therapy was performed by xerostomia with 6 intraoral points at sublingual glands, 10 points at parotid glands, and 8 points at submandibular glands with 808 nm, 100 mW, and 0.8 J for 8 seconds at each point. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiol...
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - December 15, 2019 Category: ENT & OMF Authors: ANAL Ú BARROS DE OLIVEIRA, JULIANA CRISTINA SARDELLA, ANDREIA BUFALINO, LARISSA NATIELE MIOTTO, TÚLIO MORANDIN FERRISSE, FERNANDA LOURENÇÃO BRIGHENTI Source Type: research

Evaluation of clinical risk factors for oral complications of head and neck radiotherapy
The aim of this study was to evaluate the clinical risk factors (RF) for acute (mucositis and candidiasis) and chronic (radiation caries and xerostomia) complications of the treatment in patients undergoing intensity modulated radiotherapy (IMRT) for head and neck cancer. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - December 15, 2019 Category: ENT & OMF Authors: VANESSA TONETTO MARQUES, ARIANE DE SOUZA OLIVEIRA, LARA MARIA ALENCAR RAMOS INNOCENTINI, TATIANE CRISTINA FERRARI, ANA LAURA POLIZEL RANIERI, HILTON MARCOS ALVES RICZ, LEANDRO DORIGAN DE MACEDO Source Type: research