GSE234789 Perturbation of the circadian clock contributes to radiotherapy-induced salivary gland hypofunction
Contributors : Zhicao Yue ; Shiting Song ; Kaibin YangSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusSalivary gland hypofunction is a common adverse effect during and after radiotherapy of head and neck cancers, resulting in the dry mouth syndrome called xerostomia. Previous studies suggested that the functionality of the salivary gland is under the regulation of the circadian clock, however, the extent and scope of this regulation remains unexplored. Here, we profiled the diurnal fluctuation of gene expression in ...
Source: GEO: Gene Expression Omnibus - January 1, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research
Examination of age-related changes in the submandibular glands of male mice
AbstractSalivary gland hypofunction adversely affects the oral environment and daily life by causing dry mouth (xerostomia). Senescence-related atrophy of salivary gland tissues is one cause of xerostomia, and it is particularly common among the elderly. However, the underlying mechanism is poorly understood, and no treatment has been established. Therefore, we examined age-related changes in senescence-associated secretory phenotype (SASP) factors, which regulate stemness and cellular senescence, in mouse submandibular glands. We analyzed the submandibular glands of 6-week-old (young group,n = 6) and 82-week-old mice ...
Source: Odontology - January 1, 2024 Category: Dentistry Source Type: research
Longitudinal evaluation of major salivary gland functioning in Sj ögren's disease patients in a prospective standard-of-care cohort
CONCLUSIONS: Overall, major salivary gland functioning assessed with SGUS, sialometry and PROMs did not change significantly up to 5 years of follow-up in a standard-of-care cohort of SjD patients from daily clinical practice.PMID:38149509 | DOI:10.55563/clinexprheumatol/cjxd4i (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 27, 2023 Category: Rheumatology Authors: Niels R F Sluijpers Konstantina Delli Liseth De Wolff Alja J Stel Fred K L Spijkervet Frans G M Kroese Hendrika Bootsma Suzanne Arends Arjan Vissink Source Type: research
Human Minor Salivary Glands: A Readily Available Source of Salivary Stem/Progenitor Cells for Regenerative Applications
Methods Mol Biol. 2024;2749:25-38. doi: 10.1007/978-1-0716-3609-1_3.ABSTRACTResident stem/progenitor cells within the secretory salivary glands offer a potential therapeutic resource for use in the regeneration of salivary glands needed to restore saliva production in patients with chronic xerostomia, or dry mouth. Methods were developed previously to isolate human stem/progenitor cells (hS/PCs) from major salivary glands (parotid/submandibular). Abundant minor salivary glands located in readily accessible locations in the oral cavity and lip could provide an additional valuable therapeutic resource. An advantage of this c...
Source: Mol Biol Cell - December 22, 2023 Category: Molecular Biology Authors: Caitlynn M L Barrows Danielle Wu Simon Young Mary C Farach-Carson Source Type: research
Human Minor Salivary Glands: A Readily Available Source of Salivary Stem/Progenitor Cells for Regenerative Applications
Methods Mol Biol. 2024;2749:25-38. doi: 10.1007/978-1-0716-3609-1_3.ABSTRACTResident stem/progenitor cells within the secretory salivary glands offer a potential therapeutic resource for use in the regeneration of salivary glands needed to restore saliva production in patients with chronic xerostomia, or dry mouth. Methods were developed previously to isolate human stem/progenitor cells (hS/PCs) from major salivary glands (parotid/submandibular). Abundant minor salivary glands located in readily accessible locations in the oral cavity and lip could provide an additional valuable therapeutic resource. An advantage of this c...
Source: Mol Biol Cell - December 22, 2023 Category: Molecular Biology Authors: Caitlynn M L Barrows Danielle Wu Simon Young Mary C Farach-Carson Source Type: research
Effect of mandibular advancement appliance use on oral and periodontal health in patients with OSA: a systematic review
ConclusionMAA use is associated with a number of clinical consequences on oral health, but there is no evidence to conclude whether or not MAA affects periodontal health in patients with OSA. This aspect appears to be under-evaluated and should be further investigated in relation to the type of MAA, the duration of treatment, and prior history of periodontitis. (Source: Sleep and Breathing)
Source: Sleep and Breathing - December 21, 2023 Category: Respiratory Medicine Source Type: research
Effect of mandibular advancement appliance use on oral and periodontal health in patients with OSA: a systematic review
CONCLUSION: MAA use is associated with a number of clinical consequences on oral health, but there is no evidence to conclude whether or not MAA affects periodontal health in patients with OSA. This aspect appears to be under-evaluated and should be further investigated in relation to the type of MAA, the duration of treatment, and prior history of periodontitis.PMID:38123720 | DOI:10.1007/s11325-023-02971-5 (Source: Sleep and Breathing)
Source: Sleep and Breathing - December 20, 2023 Category: Sleep Medicine Authors: Nathalie Mansour Yara Saade Francis Mora Philippe Bouchard Stephane Kerner Maria Clotilde Carra Source Type: research
Effect of mandibular advancement appliance use on oral and periodontal health in patients with OSA: a systematic review
CONCLUSION: MAA use is associated with a number of clinical consequences on oral health, but there is no evidence to conclude whether or not MAA affects periodontal health in patients with OSA. This aspect appears to be under-evaluated and should be further investigated in relation to the type of MAA, the duration of treatment, and prior history of periodontitis.PMID:38123720 | DOI:10.1007/s11325-023-02971-5 (Source: Sleep and Breathing)
Source: Sleep and Breathing - December 20, 2023 Category: Sleep Medicine Authors: Nathalie Mansour Yara Saade Francis Mora Philippe Bouchard Stephane Kerner Maria Clotilde Carra Source Type: research
Patients with oral lichen planus display lower levels of salivary acidic glycoproteins than individuals without oral mucosal disease
ConclusionsPatients with OLP showed a high prevalence of xerostomia and lower levels of salivary acidic type glycoproteins compared to the individuals without oral mucosa disease.Clinical relevanceIt is relevant to investigate the role of acidic glycoproteins in the pathogenesis of OLP. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - December 20, 2023 Category: Dentistry Source Type: research
The Photobiomodulation effect of 980 nm Diode Laser on Patients with Xerostomia
ConclusionIn this study, the volume and weight of the unstimulated saliva in most patients with xerostomia increased with using PBM. (Source: Lasers in Medical Science)
Source: Lasers in Medical Science - December 20, 2023 Category: Laser Surgery Source Type: research
Characterization of dysgeusia and xerostomia in patients with multiple myeloma treated with the T-cell redirecting GPRC5D bispecific antibody talquetamab
ConclusionStudying taste changes in patients treated with talquetamab following up on the described leads provides a new and unique opportunity to further unravel the pathophysiology of taste changes after cancer treatment. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - December 14, 2023 Category: Cancer & Oncology Source Type: research
Characterisation of crevicular fluid microbiota in primary Sj ögren's syndrome
CONCLUSIONS: The crevicular fluid microbiota of pSS patients and controls differed significantly, even in SSP patients depending on their serology, parotid gland enlargement, and periodontal disease status.PMID:38079342 | DOI:10.55563/clinexprheumatol/k3vx8u (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 11, 2023 Category: Rheumatology Authors: Gabriela Ang élica Martínez-Nava Alberto L ópez-Reyes Carlos Hern ández-Hernández Vanessa Ruiz-Gonz ález Amaya Llorente-Ch ávez Vanessa Saavedra-Gonz ález Luis Llorente Gabriela Hern ández-Molina Source Type: research
