Inhibitory effect of diacerein on diclofenac-induced acute nephrotoxicity in rats via modulating SIRT1/HIF-1 α/NF-κB and SIRT1/p53 regulatory axes
In conclusion, for the first time, DCN counteracts acute kidney injury induced by DCF in rats by its anti-oxidative, anti-inflammatory, antinecrotic, and anti-apoptotic effects in a dose-dependent manner, which are mainly via targeting SIRT1/HIF-1α/NF-κB and SIRT1/p53 regulatory axes.PMID:38471363 | DOI:10.1016/j.intimp.2024.111776 (Source: International Immunopharmacology)
Source: International Immunopharmacology - March 12, 2024 Category: Allergy & Immunology Authors: Abduallah Nasser Mansoure Mahmoud Elshal Manar G Helal Source Type: research
Inhibitory effect of diacerein on diclofenac-induced acute nephrotoxicity in rats via modulating SIRT1/HIF-1 α/NF-κB and SIRT1/p53 regulatory axes
In conclusion, for the first time, DCN counteracts acute kidney injury induced by DCF in rats by its anti-oxidative, anti-inflammatory, antinecrotic, and anti-apoptotic effects in a dose-dependent manner, which are mainly via targeting SIRT1/HIF-1α/NF-κB and SIRT1/p53 regulatory axes.PMID:38471363 | DOI:10.1016/j.intimp.2024.111776 (Source: International Immunopharmacology)
Source: International Immunopharmacology - March 12, 2024 Category: Allergy & Immunology Authors: Abduallah Nasser Mansoure Mahmoud Elshal Manar G Helal Source Type: research
Cancers, Vol. 16, Pages 1133: Topical Immunotherapy for Actinic Keratosis and Field Cancerization
nda Gilaberte
This comprehensive review delves into various immunotherapeutic approaches for the management of actinic keratoses (AKs), precancerous skin lesions associated with UV exposure. Although there are treatments whose main mechanism of action is immune modulation, such as imiquimod or diclofenac, other treatments, apart from their main effect on dysplastic cells, exert some immunological action, which in the end contributes to their efficacy. While treatments like 5-fluorouracil, imiquimod, photodynamic therapy, and nicotinamide are promising in the management of AKs, especially in immunocompetent individuals,...
Source: Cancers - March 12, 2024 Category: Cancer & Oncology Authors: Laura Bernal Masferrer Tamara Gracia Caza ña Isabel Bernad Alonso Marcial Álvarez-Salafranca Manuel Almenara Blasco Mar ía Gallego Rentero Ángeles Juarranz de la Fuente Yolanda Gilaberte Tags: Review Source Type: research
Synthesis of sustainable mesoporous sulfur-doped biobased carbon with superior performance sodium diclofenac removal: Kinetic, equilibrium, thermodynamic and mechanism
Environ Res. 2024 Mar 8:118595. doi: 10.1016/j.envres.2024.118595. Online ahead of print.ABSTRACTOver the last years, the strategy of employing inevitable organic waste and residue streams to produce valuable and greener materials for a wide range of applications has been proven an efficient and suitable approach. In this research, sulphur-doped porous biochar was produced through a single-step pyrolysis of birch waste tree in the presence of zinc chloride as chemical activator. The sulfur doping process led to a remarkable impact on the biochar structure. Moreover, it was shown that sulfur doping also had an important imp...
Source: Environmental Research - March 10, 2024 Category: Environmental Health Authors: Glaydson S Dos Reis Alejandro Grimm Denise Alves Fungaro Tao Hu Irineu A S de Brum Eder C Lima Mu Naushad Guilherme L Dotto Ulla Lassi Source Type: research
Removal of diclofenac sodium from aqueous solution using different ionic liquids functionalized tragacanth gum hydrogel prepared by radiation technique
In this study, different alkyl substituted ionic liquids (1-alkyl -3-vinyl- imidazolium bromide [CnVIm]Br, n = 4, 6, 8, 10, 12) functionalized tragacanth gum (TG-CnBr) are prepared by radiation induced grafting and crosslinking polymerization. The adsorption behaviors of ionic liquids functionalized tragacanth gum for diclofenac sodium from aqueous solutions are examined. The adsorption capacity of TG-CnBr for diclofenac sodium increases with the increasing of alkyl chain length of the imidazolium cation and the hydrophobicity of the hydrogels. The maximum adsorption capacity by TG-C12Br for diclofenac sodium at 30, 40 and...
Source: International Journal of Biological Macromolecules - March 10, 2024 Category: Biochemistry Authors: Jifu Du Ke Xu Xin Yang Zhen Dong Long Zhao Source Type: research
Synthesis of sustainable mesoporous sulfur-doped biobased carbon with superior performance sodium diclofenac removal: Kinetic, equilibrium, thermodynamic and mechanism
Environ Res. 2024 Mar 8:118595. doi: 10.1016/j.envres.2024.118595. Online ahead of print.ABSTRACTOver the last years, the strategy of employing inevitable organic waste and residue streams to produce valuable and greener materials for a wide range of applications has been proven an efficient and suitable approach. In this research, sulphur-doped porous biochar was produced through a single-step pyrolysis of birch waste tree in the presence of zinc chloride as chemical activator. The sulfur doping process led to a remarkable impact on the biochar structure. Moreover, it was shown that sulfur doping also had an important imp...
Source: Environmental Research - March 10, 2024 Category: Environmental Health Authors: Glaydson S Dos Reis Alejandro Grimm Denise Alves Fungaro Tao Hu Irineu A S de Brum Eder C Lima Mu Naushad Guilherme L Dotto Ulla Lassi Source Type: research
Removal of diclofenac sodium from aqueous solution using different ionic liquids functionalized tragacanth gum hydrogel prepared by radiation technique
In this study, different alkyl substituted ionic liquids (1-alkyl -3-vinyl- imidazolium bromide [CnVIm]Br, n = 4, 6, 8, 10, 12) functionalized tragacanth gum (TG-CnBr) are prepared by radiation induced grafting and crosslinking polymerization. The adsorption behaviors of ionic liquids functionalized tragacanth gum for diclofenac sodium from aqueous solutions are examined. The adsorption capacity of TG-CnBr for diclofenac sodium increases with the increasing of alkyl chain length of the imidazolium cation and the hydrophobicity of the hydrogels. The maximum adsorption capacity by TG-C12Br for diclofenac sodium at 30, 40 and...
Source: International Journal of Biological Macromolecules - March 10, 2024 Category: Biochemistry Authors: Jifu Du Ke Xu Xin Yang Zhen Dong Long Zhao Source Type: research
Drug-induced liver injury (DILI) ascribed to non-steroidal anti-inflammatory drugs (NSAIDs) in the USA-Update with genetic correlations
CONCLUSIONS: Despite prevalent use, NSAID-DILI is infrequent in the United States. Diclofenac is the most commonly implicated, and adherence to warnings of risk and close observation are recommended. The increased frequency of HLA-B*35:03 and DRB1*04:03, driven by diclofenac, suggests the importance of immune-mediated responses.PMID:38451034 | DOI:10.1111/liv.15892 (Source: Cancer Control)
Source: Cancer Control - March 7, 2024 Category: Cancer & Oncology Authors: Herbert L Bonkovsky Marwan Ghabril Paola Nicoletti Andrew Dellinger Robert J Fontana Huiman Barnhart Jiezhun Gu Ann K Daly Guruprasad P Aithal Elizabeth J Phillips David E Kleiner US DILIN Investigators Source Type: research
β-keto amyrin isolated from Cryptostegia grandiflora R. br. inhibits inflammation caused by Daboia russellii viper venom: Direct binding of β-keto amyrin to phospholipase A < sub > 2 < /sub >
Toxicon. 2024 Mar 4:107679. doi: 10.1016/j.toxicon.2024.107679. Online ahead of print.ABSTRACTThe search for mechanism-based anti-inflammatory therapies is of fundamental importance to avoid undesired off-target effects. Phospholipase A2 (PLA2) activity is a potential molecular target for anti-inflammatory drugs because it fuels arachidonic acid needed to synthesize inflammation mediators, such as prostaglandins. Herein, we aim to investigate the molecular mechanism by which β-keto amyrin isolated from a methanolic extract of Cryptostegia grandiflora R. Br. Leaves can inhibit inflammation caused by Daboia russellii viper ...
Source: Toxicon - March 6, 2024 Category: Toxicology Authors: K H Santhosh V Krishna K Kemparaju H Manjunatha R Shashi Kumar Mukherjee Arnab S E Gomez Mejiba D C Ramirez B S Ravindranath Source Type: research
β-keto amyrin isolated from Cryptostegia grandiflora R. br. inhibits inflammation caused by Daboia russellii viper venom: Direct binding of β-keto amyrin to phospholipase A < sub > 2 < /sub >
Toxicon. 2024 Mar 4:107679. doi: 10.1016/j.toxicon.2024.107679. Online ahead of print.ABSTRACTThe search for mechanism-based anti-inflammatory therapies is of fundamental importance to avoid undesired off-target effects. Phospholipase A2 (PLA2) activity is a potential molecular target for anti-inflammatory drugs because it fuels arachidonic acid needed to synthesize inflammation mediators, such as prostaglandins. Herein, we aim to investigate the molecular mechanism by which β-keto amyrin isolated from a methanolic extract of Cryptostegia grandiflora R. Br. Leaves can inhibit inflammation caused by Daboia russellii viper ...
Source: Toxicon - March 6, 2024 Category: Toxicology Authors: K H Santhosh V Krishna K Kemparaju H Manjunatha R Shashi Kumar Mukherjee Arnab S E Gomez Mejiba D C Ramirez B S Ravindranath Source Type: research
Adsorption Capacity of Carbon-Silica Composites towards Diclofenac in Poly(acrylic acid) Containing Systems: A Crucial Study on Common Wastewater Contaminants
Chemphyschem. 2024 Mar 2:e202300813. doi: 10.1002/cphc.202300813. Online ahead of print.ABSTRACTDiclofenac is one of the most popular over-the-counter non-steroidal anti-inflammatory drug and poly(acrylic acid) is a frequently used as thickener, filler or stabilizer. For these reasons, they are common organic contaminants in raw wastewater. The purpose of the presented studies was to compare the adsorption capacity of three carbon-silica composites - metal-free C/SiO2, iron-enriched C/Fe/SiO2 and manganese-enriched C/Mn/SiO2 towards diclofenac. The studies were carried out in single, and mixed systems in the presence of po...
Source: Chemphyschem - March 2, 2024 Category: Chemistry Authors: Magdalena Medykowska Ma łgorzata Wiśniewska Katarzyna Szewczuk-Karpisz Mariia Galaburda Source Type: research
A novel and sustainable composite of L@PSAC for superior removal of pharmaceuticals from different water matrices: Production, characterization, and application
This study endeavors to develop cost-effective environmentally friendly technology for removing harmful residual pharmaceuticals from water and wastewater by utilizing the effective adsorption of pistachio shell (PS) biochar and the degradation potency of laccase immobilized on the biochar (L@PSAC). The carbonatization and activation of the shells were optimized regarding temperature, time, and NH4NO3/PS ratio. This step yielded an optimum PS biochar (PSAC) with the highest porosity and surface area treated at 700 °C for 3 h using an NH4NO3/PS ratio of 3% wt. The immobilization of laccase onto PSAC (L@PSAC) was at its bes...
Source: Environmental Research - March 2, 2024 Category: Environmental Health Authors: Osamah J Al-Sareji Shatha Y Al Samarrai Ruqayah Ali Grmasha M ónika Meiczinger Raed A Al-Juboori Mikl ós Jakab Viola Somogyi Norbert Miskolczi Khalid S Hashim Source Type: research
Adsorption Capacity of Carbon-Silica Composites towards Diclofenac in Poly(acrylic acid) Containing Systems: A Crucial Study on Common Wastewater Contaminants
Chemphyschem. 2024 Mar 2:e202300813. doi: 10.1002/cphc.202300813. Online ahead of print.ABSTRACTDiclofenac is one of the most popular over-the-counter non-steroidal anti-inflammatory drug and poly(acrylic acid) is a frequently used as thickener, filler or stabilizer. For these reasons, they are common organic contaminants in raw wastewater. The purpose of the presented studies was to compare the adsorption capacity of three carbon-silica composites - metal-free C/SiO2, iron-enriched C/Fe/SiO2 and manganese-enriched C/Mn/SiO2 towards diclofenac. The studies were carried out in single, and mixed systems in the presence of po...
Source: Chemphyschem - March 2, 2024 Category: Chemistry Authors: Magdalena Medykowska Ma łgorzata Wiśniewska Katarzyna Szewczuk-Karpisz Mariia Galaburda Source Type: research
Adsorption Capacity of Carbon-Silica Composites towards Diclofenac in Poly(acrylic acid) Containing Systems: A Crucial Study on Common Wastewater Contaminants
Chemphyschem. 2024 Mar 2:e202300813. doi: 10.1002/cphc.202300813. Online ahead of print.ABSTRACTDiclofenac is one of the most popular over-the-counter non-steroidal anti-inflammatory drug and poly(acrylic acid) is a frequently used as thickener, filler or stabilizer. For these reasons, they are common organic contaminants in raw wastewater. The purpose of the presented studies was to compare the adsorption capacity of three carbon-silica composites - metal-free C/SiO2, iron-enriched C/Fe/SiO2 and manganese-enriched C/Mn/SiO2 towards diclofenac. The studies were carried out in single, and mixed systems in the presence of po...
Source: Chemphyschem - March 2, 2024 Category: Chemistry Authors: Magdalena Medykowska Ma łgorzata Wiśniewska Katarzyna Szewczuk-Karpisz Mariia Galaburda Source Type: research
Adsorption Capacity of Carbon-Silica Composites towards Diclofenac in Poly(acrylic acid) Containing Systems: A Crucial Study on Common Wastewater Contaminants
Chemphyschem. 2024 Mar 2:e202300813. doi: 10.1002/cphc.202300813. Online ahead of print.ABSTRACTDiclofenac is one of the most popular over-the-counter non-steroidal anti-inflammatory drug and poly(acrylic acid) is a frequently used as thickener, filler or stabilizer. For these reasons, they are common organic contaminants in raw wastewater. The purpose of the presented studies was to compare the adsorption capacity of three carbon-silica composites - metal-free C/SiO2, iron-enriched C/Fe/SiO2 and manganese-enriched C/Mn/SiO2 towards diclofenac. The studies were carried out in single, and mixed systems in the presence of po...
Source: Chemphyschem - March 2, 2024 Category: Chemistry Authors: Magdalena Medykowska Ma łgorzata Wiśniewska Katarzyna Szewczuk-Karpisz Mariia Galaburda Source Type: research
