Hyaluronic acid from bleufin tuna by-product: Structural analysis and pharmacological activities
Int J Biol Macromol. 2024 Feb 28:130424. doi: 10.1016/j.ijbiomac.2024.130424. Online ahead of print.ABSTRACTThe fishing and aquaculture industries generate a huge amount of waste during processing and preservation operations, especially those of tuna. Recovering these by-products is a major economic and environmental challenge for manufacturers seeking to produce new active biomolecules of interest. A new hyaluronic acid was extracted from bluefin tuna's vitreous humour to assess its antioxidant and pharmacological activities. The characterization by infrared spectroscopy (FT-IR), nuclear magnetic resonance ((1D1H) and 2D ...
Source: International Journal of Biological Macromolecules - March 1, 2024 Category: Biochemistry Authors: Sawsen Elhiss Assia Hamdi Latifa Chahed Catherine Boisson-Vidal Hatem Majdoub Nadia Bouchemal Jamila Laschet Jamil Kraiem Didier Le Cerf Raoui Mounir Maaroufi Fr édéric Chaubet Mohamed Ben Mansour Source Type: research

Design of low-cost natural casein biopolymer based adsorbent for efficient adsorption of multiple anionic dyes and diclofenac sodium from aqueous solutions
Chemosphere. 2024 Feb 27:141571. doi: 10.1016/j.chemosphere.2024.141571. Online ahead of print.ABSTRACTThe treatment of various organic pollutants from industrial wastewater using bio-based materials has gained significant attention owing to their excellent properties such as low-cost, eco-friendly, non-toxic, and biodegradability. In this perspective, casein (Cn), a protein-based biopolymer, was extracted from the cow milk as a low-cost adsorbent, and the adsorption performances were determined for the pristine Cn. The adsorbent was employed for the removal of two different classes of targeted pollutant anionic dyes such ...
Source: Chemosphere - February 29, 2024 Category: Chemistry Authors: Vinayak Hegde U T Uthappa PadmajaV Mane Seong Min Ji Maduru Suneetha Ben Wang Tariq Altalhi T M Subrahmanya Mahaveer D Kurkuri Source Type: research

Design of low-cost natural casein biopolymer based adsorbent for efficient adsorption of multiple anionic dyes and diclofenac sodium from aqueous solutions
Chemosphere. 2024 Feb 27:141571. doi: 10.1016/j.chemosphere.2024.141571. Online ahead of print.ABSTRACTThe treatment of various organic pollutants from industrial wastewater using bio-based materials has gained significant attention owing to their excellent properties such as low-cost, eco-friendly, non-toxic, and biodegradability. In this perspective, casein (Cn), a protein-based biopolymer, was extracted from the cow milk as a low-cost adsorbent, and the adsorption performances were determined for the pristine Cn. The adsorbent was employed for the removal of two different classes of targeted pollutant anionic dyes such ...
Source: Chemosphere - February 29, 2024 Category: Chemistry Authors: Vinayak Hegde U T Uthappa PadmajaV Mane Seong Min Ji Maduru Suneetha Ben Wang Tariq Altalhi T M Subrahmanya Mahaveer D Kurkuri Source Type: research

Screening of 16 major drug glucuronides for time-dependent inhibition of nine drug-metabolizing CYP enzymes - detailed studies on CYP3A inhibitors
In conclusion, we identified several glucuronide metabolites with CYP inhibitory properties. Based on detailed experiments, the inactivation of CYP3A by carvedilol may cause clinically significant drug-drug interactions.PMID:38423227 | DOI:10.1016/j.ejps.2024.106735 (Source: European Journal of Pharmaceutical Sciences)
Source: European Journal of Pharmaceutical Sciences - February 29, 2024 Category: Drugs & Pharmacology Authors: Helin ä Kahma Marie-No ëlle Paludetto Mikko Neuvonen Mika Kurkela Anne M Filppula Mikko Niemi Janne T Backman Source Type: research

Design of low-cost natural casein biopolymer based adsorbent for efficient adsorption of multiple anionic dyes and diclofenac sodium from aqueous solutions
Chemosphere. 2024 Feb 27:141571. doi: 10.1016/j.chemosphere.2024.141571. Online ahead of print.ABSTRACTThe treatment of various organic pollutants from industrial wastewater using bio-based materials has gained significant attention owing to their excellent properties such as low-cost, eco-friendly, non-toxic, and biodegradability. In this perspective, casein (Cn), a protein-based biopolymer, was extracted from the cow milk as a low-cost adsorbent, and the adsorption performances were determined for the pristine Cn. The adsorbent was employed for the removal of two different classes of targeted pollutant anionic dyes such ...
Source: Chemosphere - February 29, 2024 Category: Chemistry Authors: Vinayak Hegde U T Uthappa PadmajaV Mane Seong Min Ji Maduru Suneetha Ben Wang Tariq Altalhi T M Subrahmanya Mahaveer D Kurkuri Source Type: research

Design of low-cost natural casein biopolymer based adsorbent for efficient adsorption of multiple anionic dyes and diclofenac sodium from aqueous solutions
Chemosphere. 2024 Feb 27:141571. doi: 10.1016/j.chemosphere.2024.141571. Online ahead of print.ABSTRACTThe treatment of various organic pollutants from industrial wastewater using bio-based materials has gained significant attention owing to their excellent properties such as low-cost, eco-friendly, non-toxic, and biodegradability. In this perspective, casein (Cn), a protein-based biopolymer, was extracted from the cow milk as a low-cost adsorbent, and the adsorption performances were determined for the pristine Cn. The adsorbent was employed for the removal of two different classes of targeted pollutant anionic dyes such ...
Source: Chemosphere - February 29, 2024 Category: Chemistry Authors: Vinayak Hegde U T Uthappa PadmajaV Mane Seong Min Ji Maduru Suneetha Ben Wang Tariq Altalhi T M Subrahmanya Mahaveer D Kurkuri Source Type: research

Screening of 16 major drug glucuronides for time-dependent inhibition of nine drug-metabolizing CYP enzymes - detailed studies on CYP3A inhibitors
In conclusion, we identified several glucuronide metabolites with CYP inhibitory properties. Based on detailed experiments, the inactivation of CYP3A by carvedilol may cause clinically significant drug-drug interactions.PMID:38423227 | DOI:10.1016/j.ejps.2024.106735 (Source: European Journal of Pharmaceutical Sciences)
Source: European Journal of Pharmaceutical Sciences - February 29, 2024 Category: Drugs & Pharmacology Authors: Helin ä Kahma Marie-No ëlle Paludetto Mikko Neuvonen Mika Kurkela Anne M Filppula Mikko Niemi Janne T Backman Source Type: research

Screening of 16 major drug glucuronides for time-dependent inhibition of nine drug-metabolizing CYP enzymes - detailed studies on CYP3A inhibitors
In conclusion, we identified several glucuronide metabolites with CYP inhibitory properties. Based on detailed experiments, the inactivation of CYP3A by carvedilol may cause clinically significant drug-drug interactions.PMID:38423227 | DOI:10.1016/j.ejps.2024.106735 (Source: European Journal of Pharmaceutical Sciences)
Source: European Journal of Pharmaceutical Sciences - February 29, 2024 Category: Drugs & Pharmacology Authors: Helin ä Kahma Marie-No ëlle Paludetto Mikko Neuvonen Mika Kurkela Anne M Filppula Mikko Niemi Janne T Backman Source Type: research

The Protective Effects of Vitamin B Complex on Diclofenac Sodium-Induced Nephrotoxicity: The Role of NOX4/RhoA/ROCK
In conclusion, vitamin B complex administration could be a renoprotective approach during treatment with DIC via, at least in part, suppressing the NOX4/RhoA/ROCK pathway. (Source: Inflammation)
Source: Inflammation - February 28, 2024 Category: Allergy & Immunology Source Type: research

Topical Diclofenac for Prevention of Capecitabine-Associated Hand-Foot Syndrome: A Double-Blind Randomized Controlled Trial
CONCLUSION: Topical diclofenac prevented HFS in patients receiving capecitabine. This trial supports the use of topical diclofenac to prevent capecitabine-associated HFS.PMID:38412399 | DOI:10.1200/JCO.23.01730 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - February 27, 2024 Category: Cancer & Oncology Authors: Akhil Santhosh Atul Sharma Sameer Bakhshi Akash Kumar Vinod Sharma Prabhat Singh Malik Raja Pramanik Ajay Gogia Chandra Prakash Prasad Tushar Sehgal Sneha Gund Arundhathi Dev Winson Y Cheung R M Pandey Saran Kumar Ishaan Gupta Atul Batra D-TORCH Trial Inv Source Type: research

Topical Diclofenac for Prevention of Capecitabine-Associated Hand-Foot Syndrome: A Double-Blind Randomized Controlled Trial
CONCLUSION: Topical diclofenac prevented HFS in patients receiving capecitabine. This trial supports the use of topical diclofenac to prevent capecitabine-associated HFS.PMID:38412399 | DOI:10.1200/JCO.23.01730 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - February 27, 2024 Category: Cancer & Oncology Authors: Akhil Santhosh Atul Sharma Sameer Bakhshi Akash Kumar Vinod Sharma Prabhat Singh Malik Raja Pramanik Ajay Gogia Chandra Prakash Prasad Tushar Sehgal Sneha Gund Arundhathi Dev Winson Y Cheung R M Pandey Saran Kumar Ishaan Gupta Atul Batra D-TORCH Trial Inv Source Type: research

The mechanism and reaction kinetics of visible light active bismuth oxide deposited on titanium vanadium oxide for aqueous diclofenac photocatalysis
Environ Sci Pollut Res Int. 2024 Feb 28. doi: 10.1007/s11356-024-32477-w. Online ahead of print.ABSTRACTNon-uniform, non-spherical bismuth oxide deposited on titanium vanadium oxide (3%-BVT1) was successfully synthesized via co-precipitation method and assessed for visible light degradation of aqueous diclofenac. The synthesized photocatalysts were characterized using X-ray diffraction, diffuse reflectance spectroscopy, X-ray photoelectron spectroscopy, scanning electron microscopy, and high-resolution transmission electron microscopy. Up to 80.7% diclofenac degradation was observed with a significant increment in reaction...
Source: Environmental Science and Pollution Research International - February 27, 2024 Category: Environmental Health Authors: Mehmooda Bibi Jamshaid Rashid Asima Siddiqa Ming Xu Source Type: research

Topical Diclofenac for Prevention of Capecitabine-Associated Hand-Foot Syndrome: A Double-Blind Randomized Controlled Trial
CONCLUSION: Topical diclofenac prevented HFS in patients receiving capecitabine. This trial supports the use of topical diclofenac to prevent capecitabine-associated HFS.PMID:38412399 | DOI:10.1200/JCO.23.01730 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - February 27, 2024 Category: Cancer & Oncology Authors: Akhil Santhosh Atul Sharma Sameer Bakhshi Akash Kumar Vinod Sharma Prabhat Singh Malik Raja Pramanik Ajay Gogia Chandra Prakash Prasad Tushar Sehgal Sneha Gund Arundhathi Dev Winson Y Cheung R M Pandey Saran Kumar Ishaan Gupta Atul Batra D-TORCH Trial Inv Source Type: research

Topical Diclofenac for Prevention of Capecitabine-Associated Hand-Foot Syndrome: A Double-Blind Randomized Controlled Trial
CONCLUSION: Topical diclofenac prevented HFS in patients receiving capecitabine. This trial supports the use of topical diclofenac to prevent capecitabine-associated HFS.PMID:38412399 | DOI:10.1200/JCO.23.01730 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - February 27, 2024 Category: Cancer & Oncology Authors: Akhil Santhosh Atul Sharma Sameer Bakhshi Akash Kumar Vinod Sharma Prabhat Singh Malik Raja Pramanik Ajay Gogia Chandra Prakash Prasad Tushar Sehgal Sneha Gund Arundhathi Dev Winson Y Cheung R M Pandey Saran Kumar Ishaan Gupta Atul Batra D-TORCH Trial Inv Source Type: research