Antiarthritic and Antioxidant Activities of < em > Antrocaryon micraster < /em > Seed Extract and Its Fractions
This study, therefore, reports the antiarthritic and antioxidant activities of A. micraster seed extract and its fractions. The seed extract (ASE) was produced by Soxhlet extraction and partitioned into petroleum ether (ASEP), ethyl acetate (ASEE), and aqueous (ASEA) fractions. The total polyphenolic content, DPPH antioxidant activity, and in vitro arthritic activity using the protein denaturation assay were evaluated for ASE and its fractions. The arthritic activity of the crude extract (ASE) and its most effective fraction (ASEA), in the in vitro assay, were then evaluated against CFA-induced arthritis in rats. The polyp...
Source: Biomed Res - February 5, 2024 Category: Research Authors: Emmanuel Kofi Kumatia Prince Kyei Baffour Peter Bolah Source Type: research
Evaluating the effect of ursodeoxycholic acid (UDCA) in comparison with dexamethasone and diclofenac in a rat model of rheumatoid arthritis
This study aimed to assess the effectiveness of UDCA in controlling rheumatoid arthritis (RA) in an in vivo setting. Experimental RA was induced in rats using Freund's complete adjuvant, and the effects of UDCA (50,100 mg/kg) were compared to those of dexamethasone and diclofenac by measuring changes in paw size, IL-17, pro-inflammatory cytokines, oxidative stress (GSH, MDA), and radiological changes. The administration of UDCA resulted in decreased cartilage damage, reduced paw edema, and a decrease in the release of pro-inflammatory cytokines and oxidative stress. Additionally, X-ray joint alterations were observed in th...
Source: Journal of Medicine and Life - February 5, 2024 Category: General Medicine Authors: Yamama Raad Abduljaleel Ahmed Hamed Jwaid Aseel Kamil Hussein Source Type: research
Physiological responses on the reproductive, metabolism and stress endpoints of Astyanax lacustris females (Teleostei: Characiformes) after diclofenac and ibuprofen exposure
Comp Biochem Physiol C Toxicol Pharmacol. 2024 Feb 4;278:109846. doi: 10.1016/j.cbpc.2024.109846. Online ahead of print.ABSTRACTDiclofenac (DCF) and ibuprofen (IBU) are pharmaceutical compounds frequently detected in aquatic compartments worldwide. Several hazard effects including developmental abnormalities and redox balance impairment have been elucidated in aquatic species, but multiple endocrine evaluations are scarce. Therefore, the present study aimed to assess the disruptive physiological effects and toxicity of DCF and IBU isolated and combined, using females of the native freshwater teleost Astyanax lacustris. In ...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - February 5, 2024 Category: Biochemistry Authors: Filipe G A Godoi Mariana A Dias Amanda da S Guerreiro Giovana S Branco Cassiana C Montagner Renata G Moreira Fabiana L Lo Nostro Source Type: research
Evaluating the effect of ursodeoxycholic acid (UDCA) in comparison with dexamethasone and diclofenac in a rat model of rheumatoid arthritis
This study aimed to assess the effectiveness of UDCA in controlling rheumatoid arthritis (RA) in an in vivo setting. Experimental RA was induced in rats using Freund's complete adjuvant, and the effects of UDCA (50,100 mg/kg) were compared to those of dexamethasone and diclofenac by measuring changes in paw size, IL-17, pro-inflammatory cytokines, oxidative stress (GSH, MDA), and radiological changes. The administration of UDCA resulted in decreased cartilage damage, reduced paw edema, and a decrease in the release of pro-inflammatory cytokines and oxidative stress. Additionally, X-ray joint alterations were observed in th...
Source: Journal of Medicine and Life - February 5, 2024 Category: General Medicine Authors: Yamama Raad Abduljaleel Ahmed Hamed Jwaid Aseel Kamil Hussein Source Type: research
A Single Dose of Intrathecal Morphine Without Local Anesthetic Provides Long-Lasting Postoperative Analgesia After Radical Prostatectomy and Nephrectomy
CONCLUSIONS: The results of our study confirmed that preoperative intrathecal morphine provides long-lasting analgesia and reduces the need for postoperative systemic administration of opioids. Adverse effects are minor and comparable between groups.PMID:38300193 | DOI:10.1016/j.jopan.2023.10.019 (Source: Journal of Perianesthesia Nursing)
Source: Journal of Perianesthesia Nursing - February 1, 2024 Category: Nursing Authors: Alice Kurzova Jiri Malek Petr Klezl Ladislav Hess Jiri Sliva Source Type: research
Toxic effects of combined exposure to cadmium and diclofenac on freshwater crayfish (Procambarus clarkii): Insights from antioxidant enzyme activity, histopathology, and gut microbiome
This study examined the effects of combined exposure to Cd and DCF on the tissue accumulation, physiology, biochemistry, and gut microflora of P. clarkii. The results showed that Cd and DCF accumulated in tissues in the order of hepatopancreas > gill > intestine > muscle. The hepatopancreas and intestines were subjected to severe oxidative stress, with significantly increased antioxidant enzyme activity. Pathological examination revealed lumen expansion and epithelial vacuolisation in the hepatopancreas and damage to the villous capillaries and wall in the intestine. The co-exposure to Cadmium (Cd) and Diclofenac ...
Source: Aquatic Toxicology - January 31, 2024 Category: Toxicology Authors: Hucheng Jiang Runbo Li Muzi Zhao Xinran Peng Mengling Sun Chongwan Liu Guoxing Liu Hui Xue Source Type: research
Subchronic doses of artemether-lumefantrine, ciprofloxacin and diclofenac precipitated inflammatory and immunological dysfunctions in female Wistar rats
This study evaluated the effects of co-administration of artemether-lumefantrine (AL), ciprofloxacin (CPX) and diclofenac (DFC) on inflammatory and immunological status of female Wistar rats. Ninety-six female Wistar rats were assigned into eight groups of twelve animals each. Group A was control, groups B, C, D, E, F, G and H were administered AL, CPX, DFC, AL + CPX, AL + DFC, CPX + DFC and AL + CPX + DFC respectively. Dosages of administered drugs were 178 mg/kg b/w of AL, 185 mg/kg b/w of CPX and 9 mg/kg b/w of DFC. Animals were sacrificed after 6 and 12 weeks of oral administration. Blood was obtained through cardiac p...
Source: Cytokine - January 30, 2024 Category: Molecular Biology Authors: Juliana Oluwafunmilayo Ajayi Emmanuel Bukoye Oyewo Adeniran Sanmi Adekunle Peace Temidayo Ige Peter Ayomide Akomolafe Source Type: research
Breast milk concentrations of acetaminophen and diclofenac - unexpectedly high mammary transfer of the general-purpose drug acetaminophen
Breastfeeding is considered to be the most effective way of ensuring the health and survival of newborns. However, mammary transfer of drugs administered to mothers to breastfeeding infants remains a pressing ... (Source: BMC Pregnancy and Childbirth)
Source: BMC Pregnancy and Childbirth - January 29, 2024 Category: OBGYN Authors: Ryo Tamaki, Kiwamu Noshiro, Ayako Furugen, Ayako Nishimura, Hiroshi Asano, Hidemichi Watari, Masaki Kobayashi and Takeshi Umazume Tags: Research Source Type: research
