Fasting potentiates diclofenac-induced liver injury via inductions of oxidative/endoplasmic reticulum stresses and apoptosis, and inhibition of autophagy by depleting hepatic glutathione in mice
Food Chem Toxicol. 2024 Mar 29:114624. doi: 10.1016/j.fct.2024.114624. Online ahead of print.ABSTRACTDiclofenac, a widely used non-steroidal anti-inflammatory drug, can cause liver damage via its metabolic activation by hepatic CYP450s and UGT2B7. Fasting can affect drug-induced liver injury by modulating the hepatic metabolism, but its influence on diclofenac hepatotoxicity is unknown. Thus, we investigated diclofenac-induced liver damage after fasting in mice, and the cellular events were examined. Male ICR mice fasted for 16 h showed the elevation of CYP3A11, but the decreases of UGT2B7, glutathione (GSH), and GSH S-tra...
Source: Food and Chemical Toxicology - March 31, 2024 Category: Food Science Authors: Doyoung Kwon Hyeji Seo Sou Hyun Kim Ki Wung Chung Jaewon Lee Young-Suk Jung Source Type: research
Application of non-lethal bioSPME-LC-MS/MS for the detection of human pharmaceuticals in soft corals: A survey at the North Nilandhe atoll (Maldives)
Chemosphere. 2024 Mar 28:141781. doi: 10.1016/j.chemosphere.2024.141781. Online ahead of print.ABSTRACTAt present the information regarding the occurrence of human pharmaceuticals (PhaCs) in coral reefs and their potential impacts on the associated fauna is limited. To optimize the collection of data in these delicate environments, we employed a solid-phase microextraction (bioSPME) and liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) procedure that enabled in vivo determinations in soft corals. Specifically, we researched the antibiotics Ofloxacin Sulfamethoxazole and Clarithromycin, the anti-inflammat...
Source: Chemosphere - March 30, 2024 Category: Chemistry Authors: Alessandro Becchi Marco Mantovani Marina Lasagni Elena Collina Simone Montano Paolo Galli Francesco Saliu Source Type: research
Application of non-lethal bioSPME-LC-MS/MS for the detection of human pharmaceuticals in soft corals: A survey at the North Nilandhe atoll (Maldives)
Chemosphere. 2024 Mar 28:141781. doi: 10.1016/j.chemosphere.2024.141781. Online ahead of print.ABSTRACTAt present the information regarding the occurrence of human pharmaceuticals (PhaCs) in coral reefs and their potential impacts on the associated fauna is limited. To optimize the collection of data in these delicate environments, we employed a solid-phase microextraction (bioSPME) and liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) procedure that enabled in vivo determinations in soft corals. Specifically, we researched the antibiotics Ofloxacin Sulfamethoxazole and Clarithromycin, the anti-inflammat...
Source: Chemosphere - March 30, 2024 Category: Chemistry Authors: Alessandro Becchi Marco Mantovani Marina Lasagni Elena Collina Simone Montano Paolo Galli Francesco Saliu Source Type: research
Application of non-lethal bioSPME-LC-MS/MS for the detection of human pharmaceuticals in soft corals: A survey at the North Nilandhe atoll (Maldives)
Chemosphere. 2024 Mar 28:141781. doi: 10.1016/j.chemosphere.2024.141781. Online ahead of print.ABSTRACTAt present the information regarding the occurrence of human pharmaceuticals (PhaCs) in coral reefs and their potential impacts on the associated fauna is limited. To optimize the collection of data in these delicate environments, we employed a solid-phase microextraction (bioSPME) and liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) procedure that enabled in vivo determinations in soft corals. Specifically, we researched the antibiotics Ofloxacin Sulfamethoxazole and Clarithromycin, the anti-inflammat...
Source: Chemosphere - March 30, 2024 Category: Chemistry Authors: Alessandro Becchi Marco Mantovani Marina Lasagni Elena Collina Simone Montano Paolo Galli Francesco Saliu Source Type: research
Application of non-lethal bioSPME-LC-MS/MS for the detection of human pharmaceuticals in soft corals: A survey at the North Nilandhe atoll (Maldives)
Chemosphere. 2024 Mar 28:141781. doi: 10.1016/j.chemosphere.2024.141781. Online ahead of print.ABSTRACTAt present the information regarding the occurrence of human pharmaceuticals (PhaCs) in coral reefs and their potential impacts on the associated fauna is limited. To optimize the collection of data in these delicate environments, we employed a solid-phase microextraction (bioSPME) and liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) procedure that enabled in vivo determinations in soft corals. Specifically, we researched the antibiotics Ofloxacin Sulfamethoxazole and Clarithromycin, the anti-inflammat...
Source: Chemosphere - March 30, 2024 Category: Chemistry Authors: Alessandro Becchi Marco Mantovani Marina Lasagni Elena Collina Simone Montano Paolo Galli Francesco Saliu Source Type: research
The comparative efficacy of buprenorphine to diclofenac for pain control in acute pancreatitis
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 29, 2024 Category: Gastroenterology Authors: Hsueh-Chien Chiang Tags: Letter to the Editor Source Type: research
Effects of root-derived organic acids on sorption of pharmaceutically active compounds in sandy topsoil
Chemosphere. 2024 Mar 24:141759. doi: 10.1016/j.chemosphere.2024.141759. Online ahead of print.ABSTRACTThe presence and fate of pharmaceutically active compounds (PhACs) in agricultural fields are rarely investigated. The present study highlights that root-derived low-molecular-weight organic acids (LWMOAs) affect the mobility of PhACs in cultivated humic Arenosol. Sorption experiments are conducted using three PhACs characterised by different physicochemical properties: carbamazepine (CBZ), 17α-ethinylestradiol (EE2), and diclofenac-sodium (DFC). The results suggest that the adsorption of EE2 is more intense than the oth...
Source: Chemosphere - March 26, 2024 Category: Chemistry Authors: Lili Szabo Anna Vancsik Laszlo Bauer Gergely Jakab Csilla Kiraly Istvan Hatvani Attila Csaba Kondor Zoltan Szalai Source Type: research
Effects of root-derived organic acids on sorption of pharmaceutically active compounds in sandy topsoil
Chemosphere. 2024 Mar 24:141759. doi: 10.1016/j.chemosphere.2024.141759. Online ahead of print.ABSTRACTThe presence and fate of pharmaceutically active compounds (PhACs) in agricultural fields are rarely investigated. The present study highlights that root-derived low-molecular-weight organic acids (LWMOAs) affect the mobility of PhACs in cultivated humic Arenosol. Sorption experiments are conducted using three PhACs characterised by different physicochemical properties: carbamazepine (CBZ), 17α-ethinylestradiol (EE2), and diclofenac-sodium (DFC). The results suggest that the adsorption of EE2 is more intense than the oth...
Source: Chemosphere - March 26, 2024 Category: Chemistry Authors: Lili Szabo Anna Vancsik Laszlo Bauer Gergely Jakab Csilla Kiraly Istvan Hatvani Attila Csaba Kondor Zoltan Szalai Source Type: research
Effects of root-derived organic acids on sorption of pharmaceutically active compounds in sandy topsoil
Chemosphere. 2024 Mar 24:141759. doi: 10.1016/j.chemosphere.2024.141759. Online ahead of print.ABSTRACTThe presence and fate of pharmaceutically active compounds (PhACs) in agricultural fields are rarely investigated. The present study highlights that root-derived low-molecular-weight organic acids (LWMOAs) affect the mobility of PhACs in cultivated humic Arenosol. Sorption experiments are conducted using three PhACs characterised by different physicochemical properties: carbamazepine (CBZ), 17α-ethinylestradiol (EE2), and diclofenac-sodium (DFC). The results suggest that the adsorption of EE2 is more intense than the oth...
Source: Chemosphere - March 26, 2024 Category: Chemistry Authors: Lili Szabo Anna Vancsik Laszlo Bauer Gergely Jakab Csilla Kiraly Istvan Hatvani Attila Csaba Kondor Zoltan Szalai Source Type: research
Effects of root-derived organic acids on sorption of pharmaceutically active compounds in sandy topsoil
Chemosphere. 2024 Mar 24:141759. doi: 10.1016/j.chemosphere.2024.141759. Online ahead of print.ABSTRACTThe presence and fate of pharmaceutically active compounds (PhACs) in agricultural fields are rarely investigated. The present study highlights that root-derived low-molecular-weight organic acids (LWMOAs) affect the mobility of PhACs in cultivated humic Arenosol. Sorption experiments are conducted using three PhACs characterised by different physicochemical properties: carbamazepine (CBZ), 17α-ethinylestradiol (EE2), and diclofenac-sodium (DFC). The results suggest that the adsorption of EE2 is more intense than the oth...
Source: Chemosphere - March 26, 2024 Category: Chemistry Authors: Lili Szabo Anna Vancsik Laszlo Bauer Gergely Jakab Csilla Kiraly Istvan Hatvani Attila Csaba Kondor Zoltan Szalai Source Type: research
Is Diclofenac Transbuccal Mucoadhesive Patch Superior to Oral Diclofenac for Management of Postoperative Sequelae after Third Molar Surgery?
Pain, swelling and trismus are the most common sequalae following surgical removal of mandibular third molars. They pose significant challenges for clinicians, prompting the exploration of efficacious management approaches. (Source: Journal of Oral and Maxillofacial Surgery)
Source: Journal of Oral and Maxillofacial Surgery - March 26, 2024 Category: ENT & OMF Authors: Zenish Bhatti, Shital Patel, Swasti Shah, Naiya Shah, Rajan Savani, Shyam Chauhan Source Type: research
Is Diclofenac Transbuccal Mucoadhesive Patch Superior to Oral Diclofenac for the Management of Postoperative Sequelae After Third Molar Surgery?
Pain, swelling, and trismus are the most common sequalae following the surgical removal of mandibular third molars. They pose significant challenges for clinicians, prompting the exploration of efficacious management approaches. (Source: Journal of Oral and Maxillofacial Surgery)
Source: Journal of Oral and Maxillofacial Surgery - March 26, 2024 Category: ENT & OMF Authors: Zenish Bhatti, Shital Patel, Swasti Shah, Naiya Shah, Rajan Savani, Shyam Chauhan Tags: Dentoalveolar Surgery Source Type: research
Green synthesis of carbon nanotubes functionalized with iron nanoparticles and coffee husk biomass for efficient removal of losartan and diclofenac: Adsorption kinetics and ANN modeling studies
This study focused on the production of green functionalized carbon nanotubes (CNTs) and using them in the adsorption of the pharmaceuticals Losartan (LOS) and Diclofenac (DIC). The efficiency of the methodology was verified by characterization techniques. Elemental composition analysis indicated a significant increase in the iron content after the green functionalization, proving the effectiveness of the method. Thermogravimetric analysis showed similar thermal degradation profiles for pristine CNTs and functionalized CNTs, indicating better post-functionalization thermal stability. BET analysis revealed mesoporous charac...
Source: Environmental Research - March 23, 2024 Category: Environmental Health Authors: Heloisa P S Costa Emanuele D V Duarte Fl ávio V da Silva Meuris G C da Silva Melissa G A Vieira Source Type: research
Green synthesis of carbon nanotubes functionalized with iron nanoparticles and coffee husk biomass for efficient removal of losartan and diclofenac: Adsorption kinetics and ANN modeling studies
This study focused on the production of green functionalized carbon nanotubes (CNTs) and using them in the adsorption of the pharmaceuticals Losartan (LOS) and Diclofenac (DIC). The efficiency of the methodology was verified by characterization techniques. Elemental composition analysis indicated a significant increase in the iron content after the green functionalization, proving the effectiveness of the method. Thermogravimetric analysis showed similar thermal degradation profiles for pristine CNTs and functionalized CNTs, indicating better post-functionalization thermal stability. BET analysis revealed mesoporous charac...
Source: Environmental Research - March 23, 2024 Category: Environmental Health Authors: Heloisa P S Costa Emanuele D V Duarte Fl ávio V da Silva Meuris G C da Silva Melissa G A Vieira Source Type: research
Optimal duration of medical expulsive therapy for lower ureteral stones: a critical evaluation
AbstractTo evaluate the optimal duration of Medical Expulsive Therapy (MET) application for distal ureteric stones on a time period based manner. 89 patients with 5 –10 mm distal ureter stones received tamsulosin (0.4 mg) for MET and diclofenac sodium (75 mg) for analgesia. Patients were evaluated once a week for 4 weeks. Radiologic stone passage was evaluated by kidney ureter bladder (KUB) and ultasonography where non-contrast computed tomography (NCCT) w as also performed if needed. While 23 cases (28.4%) were SF after first week, 23 were SF (28.4%) after 2 weeks, 9 cases (11.1%) after 3 and lastly 7 cases (8.6%) be...
Source: Urolithiasis - March 23, 2024 Category: Urology & Nephrology Source Type: research
