Analgesic efficacy of combination therapy versus monotherapy on postoperative pain control in percutaneous nephrolithotomy: a meta-analysis of randomized controlled trials
(Source: Urolithiasis)
Source: Urolithiasis - October 22, 2019 Category: Urology & Nephrology Source Type: research

Dual-frequency setting for urinary stone fragmentation during shock wave lithotripsy: an in vitro study
AbstractExtracorporeal shock wave lithotripsy (SWL) is less invasive compared to the other invasive modalities of stone treatment that are gaining popularity. Hence, methods to improve the efficacy of SWL are desirable. We studied the effectiveness of dual frequency on the efficacy of stone fragmentation, but minimizing treatment time. A phantom 10  mm spherical BegoStone was fragmented in vitro in a kidney model using an electromagnetic lithotripter (Storz MODULITH®SLX-F2). A total of 78 stones were fragmented each with 3000 shocks at 60  Hz or 120 Hz or a dual frequency (DF) of 60–120 Hz. Fo...
Source: Urolithiasis - October 17, 2019 Category: Urology & Nephrology Source Type: research

Use 3D printing technology to enhance stone free rate in single tract percutaneous nephrolithotomy for the treatment of staghorn stones
This study assesses the feasibility and effectiveness of using a three-dimensional (3D) printing model for preoperative planning in the treatment of full staghorn stones, specifically in the selection of the most optimal calyx for puncture. Twelve patients were enrolled in this trial. A preoperative CT taken in prone position was performed on each of the patients. 3D models were reconstructed using digital imaging and 3D printers. Three identical models were printed for each patient. Three puncture sites from the upper-, middle-, and lower-pole calyces of the kidney models were selected for simulation of percutaneous nephr...
Source: Urolithiasis - October 15, 2019 Category: Urology & Nephrology Source Type: research

Correction to: Recent advances in the identification and management of inherited hyperoxalurias
The original version of this article unfortunately contained a mistake. On page 84, the dose for oral potassium citrate is incorrectly written as “0.1 mg/kg/day divided BID-QID for children, 30–60 mg per day divided BID-QID for adults”. (Source: Urolithiasis)
Source: Urolithiasis - October 13, 2019 Category: Urology & Nephrology Source Type: research

Does the presence or degree of hydronephrosis affect the stone disintegration efficacy of extracorporeal shock wave lithotripsy? A systematic review and meta-analysis
AbstractThe aim of this study was to determine whether the presence or degree of hydronephrosis (HN) affects the stone disintegration efficacy of shock wave lithotripsy (SWL). A comprehensive literature search using PubMed, Embase, Cochrane Library, and Web of Science was conducted to retrieve relevant studies. Risk ratios (RRs) and mean differences (MDs) with corresponding 95% confidence intervals (CIs) were calculated for comparisons of outcomes of interest. In total, seven comparative studies with 2033 patients were included. Overall results indicated no significant difference in stone-free rate (SFR) and retreatment ra...
Source: Urolithiasis - October 12, 2019 Category: Urology & Nephrology Source Type: research

Could surgical experience of adult endourologist overcome the learning curve of retrograde intrarenal surgery in children?
AbstractWith the increasing of the prevalence of pediatric urolithiasis (1 –5%), retrograde intrarenal surgery (RIRS) is emerging as preferred option for the management of stones in pediatric patients. Although the principles of RIRS developed in adults can be applied in children, also expert adult endourologists feel uncomfortable to approach young patients due to long learning curve that usually is expected to be required in this particular setting. The aim of the study was to compare peri- and postoperative outcomes of RIRS in pediatric and adult patients performed by a single surgeon expert in adult endourology (...
Source: Urolithiasis - September 19, 2019 Category: Urology & Nephrology Source Type: research

Evaluation of day-care versus inpatient mini-percutaneous nephrolithotomy: a propensity score-matching study
AbstractDay-care percutaneous nephrolithotomy (day-PCNL) is being performed more routinely, however, safety remains a concern. The purpose of this study was to compare the complication rate, readmission rate and medical cost saving between day-PCNL and inpatient-PCNL. A protocol for day-PCNL was applied. A retrospective review of 86 patients planned day-PCNL by one surgeon were conducted. Using propensity matching, 86 inpatients (minimum 2-day  post-operative stay) treated with the same procedure were matched. For each cohort, 14-day occurrence of complications and unplanned readmissions were recorded and compared. Mo...
Source: Urolithiasis - September 14, 2019 Category: Urology & Nephrology Source Type: research

Association of vitamin D receptor gene polymorphisms and risk of urolithiasis: results of a genetic epidemiology study and comprehensive meta-analysis
In conclusion, this meta-analysis suggests thatVDR FokI polymorphism is significantly associated with urolithiasis risk, especially in Asians, whereasApaI,BsmI andTaqI polymorphisms are not associated. (Source: Urolithiasis)
Source: Urolithiasis - September 12, 2019 Category: Urology & Nephrology Source Type: research

Comparative efficacy of 22 drug interventions as medical expulsive therapy for ureteral stones: a systematic review and network meta-analysis
AbstractTo perform a systematic review and meta-analysis for the evaluation of 22 drug interventions in the management of ureteral stones, MEDLINE, Web of Science, EMBASE, and Cochrane central databases were searched to identify RCTs focusing on the evaluation of the efficacy of multiple drug interventions in medical expulsive therapy (MET) for ureteral stones, with no restrictions on year or language. Study quality assessment and data extraction were performed by independent reviewers. Major outcome measures were the stone expulsion rate, stone expulsion time, and pain episodes during treatment. A total of 78 RCTs with 14...
Source: Urolithiasis - September 11, 2019 Category: Urology & Nephrology Source Type: research

Idiopathic calcium nephrolithiasis with pure calcium oxalate composition: clinical correlates of the calcium oxalate dihydrate/monohydrate (COD/COM) stone ratio
The objective of this observational study was to verify the association of clinical and laboratory parameters of kidney stone disease with COD/COM ratio in a group of 465 (322  M, age 46 ± 14) patients suffering from idiopathic calcium nephrolithiasis with pure calcium oxalate stones (≥ 97%). Each participant underwent a complete clinical examination, serum chemistry, 24-h urine collection for the determination of the profile of lithogenic risk, and had stones a nalyzed by FT-IR. Most (62%) of the stones had a COD/COM ratio ≤ 0.25, and the urine chemistry of the correspo...
Source: Urolithiasis - September 10, 2019 Category: Urology & Nephrology Source Type: research

miRNA-34a inhibits cell adhesion by targeting CD44 in human renal epithelial cells: implications for renal stone disease
This study has explored the anti-adhesion function of the microRNA, miR-34a, by targeting CD44, a cell surface receptor, in human renal epithelial (HK-2) cells. The expression of CD44 was monitored by qPCR and western blot. A luciferase assay validated the target of miR-34a in CD44 3′ UTR. Immunofluorescence staining under confocal microscopy was used to detect the cell–crystal adhesion effects in vitro. Pizzolato staining was performed to examine the adhesion role of miR-34a in vivo. In HK-2 cells, miR-34a was down- regulated and CD44 was up-regulated when exposed to calcium oxalate monohydrate crystals. Moreo...
Source: Urolithiasis - September 10, 2019 Category: Urology & Nephrology Source Type: research

Materialise ’s interactive medical image control system (MIMICS) is feasible for volumetric measurement of urinary calculus
In this study, we aimed to investigate the feasibility of using Materialise ’s interactive medical image control system (MIMICS) to measure urinary calculi volume. We used a cylinder measuring to measure the same polymer clay volume in different groups. Polymer clay was made into an oval shape, an antler type, and a multiple irregular shapes by hand. They are divided into three groups, that is, A, B, and C, each of which has seven polymer clays. The computer tomography (CT) 3D images of each sample were obtained by 256iCT scanning. The CT 3D image was imported into MIMICS to measure the theoretical volume and average...
Source: Urolithiasis - September 10, 2019 Category: Urology & Nephrology Source Type: research

Ureteral wall volume at ureteral stone site is a critical predictor for shock wave lithotripsy outcomes: comparison with ureteral wall thickness and area
AbstractOur objectives were to compare measurements of ureteral wall area, ureteral wall volume and ureteral wall thickness for their use in prediction of shock wave lithotripsy outcomes. We retrospectively identified 218 patients that underwent shock wave lithotripsy for ureteral calculi with pretreatment non-contrast computed tomography. We measured ureteral wall thickness, ureteral wall area and ureteral wall volume by high functional viewer. Ureteral wall thickness was defined as the maximum thickness of ureteral wall, and ureteral wall area as the area of ureteral wall around the stone in the maximal stone diameter on...
Source: Urolithiasis - August 23, 2019 Category: Urology & Nephrology Source Type: research

A case of allograft ureteral stone successfully treated with antegrade ureteroscopic lithotripsy: use of a 3D-printed model to determine the ideal approach
We present the case of a 46-year-old man who underwent successful antegrade ureteroscopy for lithiasis in his allograft ureter. At a scheduled follow-up 15  years after transplantation, computed tomography (CT) detected a 12-mm renal stone in the renal pelvis of the transplanted kidney. During his follow-up, gross hematuria was seen; the stone moved to the ureter, causing hydronephrosis. Ultrasound and non-contrast CT revealed hydronephrosis and a 15- mm stone in the transplanted ureter. Considering the stone size, location, and the difficulty of the access to the anastomosed ureteral orifice, percutaneous ureteroscop...
Source: Urolithiasis - August 9, 2019 Category: Urology & Nephrology Source Type: research

Formula for predicting the impaction of ureteral stones
AbstractThe purpose of the study was to investigate variables that may predict ureteral stone impaction and create a new model to predict more accurately stone impaction based on preoperative NCCT findings. Data of 238 patients who underwent URS were analyzed. Stone size, stone location, Hounsfield unit (HU) value of the stone, ureteral wall thickness (UWT) and grade of hydronephrosis were recorded. HU values of the ureter which are measured proximal and distal to the stone were recorded. Subsequently, we determined the factors that could predict the stone impaction in univariate and multivariate logistic regression analys...
Source: Urolithiasis - August 5, 2019 Category: Urology & Nephrology Source Type: research

Trends in urinary calculi composition from 2005 to 2015: a single tertiary center study
AbstractThe goal of this study was to investigate recent changes in stone composition and patient demographics to identify factors influencing stone formation for the purpose of reducing the incidence of urolithiasis and preventing stone recurrence. This retrospective analysis includes patients who underwent percutaneous nephrolithotripsy or ureteroscopy at our institution from 2005 to 2015. Northwestern Medicine Enterprise Data Warehouse was used to retrieve demographic information and stone composition analyses. The composition of mixed stones containing uric acid (UA) and calcium oxalate monohydrate (COM) was analyzed f...
Source: Urolithiasis - August 1, 2019 Category: Urology & Nephrology Source Type: research

Role of pelvicalyceal anatomy in the outcomes of retrograde intrarenal surgery (RIRS) for lower pole stones: outcomes with a systematic review of literature
AbstractControversies exist on the influence of lower pole anatomy (infundibular pelvic angle, IPA; infundibular length, IL; and infundibular width, IW) for success and outcomes related to the treatment of stones in the lower pole. We wanted to look at the role of lower pole anatomy to study clinical outcomes in patients treated for isolated lower pole stones (LPS) using retrograde intra renal surgery (RIRS), and also perform a review to look at the published literature on the influence of pelvicalyceal anatomy on success with RIRS. Data were prospectively collected (June 2013 –June 2016) for all patients who underwe...
Source: Urolithiasis - August 1, 2019 Category: Urology & Nephrology Source Type: research

Kidney volume loss following percutaneous nephrolithotomy utilizing 3D planimetry
This study aims to evaluate post-operative changes in renal volume after PCNL. We retrospectively analyzed baseline and post-PCNL CT images from 25 eligible patients from a single tertiary care center. All CT imaging was reviewed using 3D planimetry software (3D Splicer®, Version 4.0). Segmentation was utilized to obtain total kidney volume (TKV), total kidney surface area, total stone surface area, and total stone volume. Wilcoxon signed-rank test was used for pair analysis, and univariate and multivariable analyses were performed to examine the relationships between clinical and planimetry data and renal volume loss....
Source: Urolithiasis - July 25, 2019 Category: Urology & Nephrology Source Type: research

Does preoperative urine culture still play a role in predicting post-PCNL SIRS? A retrospective cohort study
AbstractThere is controversy regarding the predicting value of preoperative urine culture for post-percutaneous nephrolithotripsy (PCNL) infection. The purpose of our study was to re-evaluate the importance of preoperative urine culture for developing post-PCNL systemic inflammatory response syndrome (SIRS) in China. A total of 303 patients undergone PCNL from March 2012 to January 2018 were recruited. Urine tests, urine cultures and the perioperative data were prospectively recorded and analyzed. 95 patients (31.4%) were identified with positive preoperative urine cultures. Female patients had significantly higher rate of...
Source: Urolithiasis - July 19, 2019 Category: Urology & Nephrology Source Type: research

Intracutaneous sterile water injection for pain relief during extracorporeal shock wave lithotripsy: comparison with diclofenac sodium
AbstractVarious analgesic applications can be used during extracorporeal shock wave lithotripsy (SWL) for pain relief and maximal success rate. Intracutaneous sterile water injection (ISWI) has been shown to be effective in several types of pain, but a gap exists about its use during SWL. In this paper, we aimed to evaluate the effect of ISWI during SWL and compare that with diclofenac sodium injection used commonly to provide ideal patient contentment. Patients with kidney stone were randomized to have either ISWI therapy or intramuscular non-steroid anti-inflammatory drug (diclofenac sodium) injection. Using a syringe, 2...
Source: Urolithiasis - July 5, 2019 Category: Urology & Nephrology Source Type: research

The impact of urinary stone disease and their treatment on patients ’ quality of life: a qualitative study
The objective is to understand the impact of urinary stone disease and treatment s on patients’ HRQoL, from patients’ and their relatives’ perspective using qualitative and quantitative methodologies. Semi-structured interviews and a focus group were used to understand the HRQoL issues of patients with urinary stones disease, covering the American Urology Association index stone categories. Thematic analysis was performed (using qualitative data analysis software). Familial impact was assessed using the family-related outcome measure (FROM-16©). 62 patients with stone disease and interventions (mean ...
Source: Urolithiasis - June 25, 2019 Category: Urology & Nephrology Source Type: research

The microbiome of calcium-based urinary stones
AbstractHistorically, the role of bacteria in urinary stone disease (USD) has been limited to urease-producing bacteria associated with struvite stone formation. However, growing evidence has revealed bacteria associated with stones of non-struvite composition. These bacteria may be derived from either urine or from the stones themselves. Using 16S rRNA gene sequencing and an enhanced culture technique (EQUC), we identified the urine and stone microbiota of USD patients and then determined if bacteria were statistically enriched in the stones relative to the urine. From 52 patients, bladder urine and urinary stones were co...
Source: Urolithiasis - June 25, 2019 Category: Urology & Nephrology Source Type: research

Better sleep quality could reinforce the relationship between sleep posture and kidney stone laterality in obstructive sleep apnea patients
AbstractUrolithiasis is a common urologic problem among adults worldwide. It is interesting that urinary stones tend to recur on the same side and the pathophysiology of unilateral stone formation is not clearly understood. Researchers found that sleep posture could alter renal perfusion, and subsequent vascular injury may lead to urolithiasis formation. The aim of this study is to retrospectively evaluate the correlations between the specific sleep postures recorded in polysomnography (PSG) and the stone laterality in unilateral urinary stone formers with obstructive sleep apnea (OSA). We retrospectively reviewed patients...
Source: Urolithiasis - June 17, 2019 Category: Urology & Nephrology Source Type: research

Induction of enteric oxalate secretion by Oxalobacter formigenes in mice does not require the presence of either apical oxalate transport proteins Slc26A3 or Slc26A6
AbstractOxalobacter sp. promotion of enteric oxalate excretion, correlating with reductions in urinary oxalate excretion, was previously reported in rats and mice, but the mechanistic basis for this affect has not been described. The main objective of the present study was to determine whether the apical oxalate transport proteins, PAT1 (slc26a6) and DRA (slc26a3), are involved in mediating theOxalobacter-induced net secretory flux across colonized mouse cecum and distal colon. We measured unidirectional and net fluxes of oxalate across tissues removed from colonized PAT1 and DRA knockout (KO) mice and also across two doub...
Source: Urolithiasis - June 14, 2019 Category: Urology & Nephrology Source Type: research

P38 MAPK signaling pathway mediates COM crystal-induced crystal adhesion change in rat renal tubular epithelial cells
This study demonstrated that the p38 MAPK signaling pathway mediated the COM crystal-induced crystal adhesion change in NRK-52E cells and required the involvement of NLRP3 inflammasome. (Source: Urolithiasis)
Source: Urolithiasis - June 10, 2019 Category: Urology & Nephrology Source Type: research

An easy risk stratification to recommend the optimal patients with 2 –3 cm kidney stones to receive retrograde intrarenal surgery or mini-percutaneous nephrolithotomy
AbstractTo create an easy risk stratification to recommend the optimal subset of patients with 2 –3 cm kidney stones to receive retrograde intrarenal surgery (RIRS) or mini-percutaneous nephrolithotomy (MPCNL). A retrospective patient cohort was reviewed and compared (RIRS,n = 147 and MPCNL,n = 129). Overall, RIRS group obtained a lower SFR (66% vs. 93.3%,p 
Source: Urolithiasis - May 17, 2019 Category: Urology & Nephrology Source Type: research

Assessment of conservative dietary management as a method for normalization of 24-h urine pH in stone formers
AbstractLow urine pH is a metabolic risk factor for stone formation. While medical therapy is typically prescribed (as urinary alkalinization), patients typically prefer dietary modifications. We aimed to assess capacity to alter urine pH with dietary management alone. We analyzed a retrospective cohort of stone formers seen between 2000 and 2015 with multiple 24-h urine collections (24hUC). Patients  ≥ 18 years old with low urine pH (
Source: Urolithiasis - May 6, 2019 Category: Urology & Nephrology Source Type: research

Effect of mechanical percussion combined with patient position change on the elimination of upper urinary stones/fragments: a systematic review and meta-analysis
The objective of this study is to explore the efficacy and safety of mechanical percussion combined with changed patient position (MPPP) on elimination of residual stones/fragments in the upper urinary tract. The study was a systematic review and meta-analysis. A systematic literature review using Pubmed, Embase, Medline, and Cochrane Library was conducted to obtain randomized-controlled trials (RCTs) evaluating the efficacy and safety of MPPP treatment of patients with residual stones/fragments in the upper urinary tract. The retrieval of data ended in October 2018. Statistical analysis was carried out using summarized un...
Source: Urolithiasis - May 6, 2019 Category: Urology & Nephrology Source Type: research

Retrograde nephrostomy access for percutaneous nephrolithotomy: a simple and safe technique
This study aimed at illustrating our experience with the retrograde nephrostomy access technique for percutaneous nephrolithotomy (PCNL).This retrospective study was conducted between June 1997 and September 2018 for 648 patients who underwent PCNL with retrograde nephrostomy access. Included in the study were the patient demographic, operative time, site of the access, fluoroscopic exposure time, stone clearance rate, additional procedures and complications. A total of 648 patients aged between 25 and 70  years had renal stones and were included in this study. Retrograde nephrostomy access was achieved through the ...
Source: Urolithiasis - April 29, 2019 Category: Urology & Nephrology Source Type: research

Anthropometric variables, physical activity and dietary intakes of patients with uric acid nephrolithiasis
AbstractTo evaluate anthropometric variables, energy expenditure by physical activity and nutrient intake of uric acid stone formers (UA-RSFs) compared to non-forming subjects (C). The study included 33 consecutive male patients with a diagnosis of “pure” stones of anhydrous uric acid at infrared spectroscopy and 49 male control subjects with no history of urinary stones. A personal interview was conducted including questionnaires for physical activity and dietary intakes. Anthropometric parametric and blood pressure were measured. Mean ag e, weight, height, waist circumference, body mass index, systolic and di...
Source: Urolithiasis - April 29, 2019 Category: Urology & Nephrology Source Type: research

Association of spontaneous expulsion with C-reactive protein and other clinico-demographic factors in patients with lower ureteric stone
AbstractThe purpose of our study is to analyze the definitive relation of C-reactive protein (CRP) and other factors with the spontaneous stone passage in patients with distal ureteric calculus of 5 –10 mm and to calculate the risk of failure of expectant management in patients. 185 patients of ureteric colic, who were subjected to medical expulsive therapy (MET), were included prospectively from August 2016 to May 2018 and followed up for 4 weeks. Patients were divided into two groups. Gro up A included successful spontaneous passage patients and group B included failure in the same. The parameters analyze...
Source: Urolithiasis - April 25, 2019 Category: Urology & Nephrology Source Type: research

Disparities in care among patients presenting to the emergency department for urinary stone disease
AbstractTo determine whether patients with ureteral stones received different standard of care in the emergency department (ED) according to various sociodemographic factors. We conducted a retrospective study of patients presenting to EDs in a large tertiary-care hospital in the Bronx, New York with a diagnosis of ureteral stones. Electronic chart review was used to assess each patient ’s ED course and to gather socio-demographic information. The primary outcomes of interest were administration of pain medication, prescription of alpha-1 antagonists to facilitate stone passage, and whether or not patients received C...
Source: Urolithiasis - April 25, 2019 Category: Urology & Nephrology Source Type: research

Selective protein enrichment in calcium oxalate stone matrix: a window to pathogenesis?
AbstractUrine proteins are thought to control calcium oxalate stone formation, but over 1000 proteins have been reported in stone matrix obscuring their relative importance. Proteins critical to stone formation should be present at increased relative abundance in stone matrix compared to urine, so quantitative protein distribution data were obtained for stone matrix compared to prior urine proteome data. Matrix proteins were isolated from eight stones (>  90% calcium oxalate content) by crystal dissolution and further purified by ultradiafiltration (>  10 kDa membrane). Proteomic analyses were perf...
Source: Urolithiasis - April 16, 2019 Category: Urology & Nephrology Source Type: research

Adolescents with urinary stones have elevated urine levels of inflammatory mediators
This study indicates that urine levels of cytokines involved in chronic inflammation and fibrosis are elevated in urina ry stone formers as early as adolescence. Because stone formers are at risk for chronic kidney disease, macrophage inflammatory protein 1β and interleukin 13 represent investigative targets. (Source: Urolithiasis)
Source: Urolithiasis - April 16, 2019 Category: Urology & Nephrology Source Type: research

Effect of increasing doses of cystine-binding thiol drugs on cystine capacity in patients with cystinuria
In this study, we gave increasing doses of tiopronin ord-penicillamine, depending on the patients ’ own prescriptions, to ten patients with cystinuria and measured cystine excretion and cystine capacity. The doses were 0, 1, 2, 3 g per day, given in two divided doses, and administered in a random order. Going from 0 to 1 g/day led to an increase in cystine capacity from − 39.1 to 130.4  mg/L (P 
Source: Urolithiasis - April 13, 2019 Category: Urology & Nephrology Source Type: research

1 H NMR-based metabolomic study of metabolic profiling for the urine of kidney stone patients
AbstractKidney stone is a chronic metabolic disease that caused by many factors, especially by the metabolic disturbances of urine compositions, but the metabolic profiling of the urine from kidney stone patients remains poorly explored. In the present study,1H NMR spectroscopy and multivariate pattern recognition analytical techniques were combined to explore the metabolic profiling of the urine from kidney stone patients. A total of 216 urine samples obtained from kidney stone patients (n = 110) and healthy controls (n = 106) were investigated. The results indicated that principal component an...
Source: Urolithiasis - April 4, 2019 Category: Urology & Nephrology Source Type: research

Hydroxycitrate: a potential new therapy for calcium urolithiasis
AbstractAlkali supplements are used to treat calcium kidney stones owing to their ability to increase urine citrate excretion which lowers stone risk by inhibiting crystallization and complexing calcium. However, alkali increases urine pH, which may reduce effectiveness for patients with calcium phosphate stones and alkaline urine. Hydroxycitrate is a structural analog of citrate, widely available as an over-the-counter supplement for weight reduction. In vitro studies show hydroxycitrate has the capacity to complex calcium equivalent to that of citrate and that it is an effective inhibitor of calcium oxalate monohydrate c...
Source: Urolithiasis - March 26, 2019 Category: Urology & Nephrology Source Type: research

Sex differences in the temperature dependence of kidney stone presentations: a population-based aggregated case-crossover study
AbstractPrevious studies assumed a uniform relationship between heat and kidney stone presentations. Determining whether sex and other characteristics modify the temperature dependence of kidney stone presentations has implications for explaining differences in nephrolithiasis prevalence and improving projections of the effect of climate change on nephrolithiasis. We performed an aggregated case-crossover study among 132,597 children and adults who presented with nephrolithiasis to 68 emergency departments throughout South Carolina from 1997 to 2015. We used quasi-Poisson regression with distributed lag non-linear models t...
Source: Urolithiasis - March 21, 2019 Category: Urology & Nephrology Source Type: research

In vitro bactericidal effect of Ho:YAG laser and pneumatic lithotripsy on ureteral stones colonized with Escherichia coli and Enterococcus faecalis
AbstractThe endoscopic treatment of urolithiasis has a high success rate and the complications decreased after the development of lithotripsy techniques. The aim of this study is to investigate the in vitro bactericidal effect of laser and pneumatic lithotripsy on urinary stones colonized withEscherichia coli andEnterococcus faecalis. A total of 40 natural calcium oxalate stones, which were obtained from the patients ’ urinary systems with rigid ureteroscopy were used in the study. Surfaces of the stones were colonized withE. coli andE. faecalis strains. The fragmentation of the stones was performed using holmium:ytt...
Source: Urolithiasis - March 20, 2019 Category: Urology & Nephrology Source Type: research

Cancer as a risk factor for urinary tract calculi: a retrospective cohort study using ‘The Health Improvement Network’
This study aims to identify if cancer is a risk factor for the development of UTC.MethodsA population-based retrospective cohort study was conducted for the period 1st January 1990 to 1st May 2016. 124,901 exposed patients identified using clinical codes with newly diagnosed cancer were matched to 476,203 unexposed controls by age, gender, BMI, and general practice. The main outcome measure was the risk of developing UTC described by hazard ratios.ResultsThere were 512 incident UTC events in the cancer group compared to 1787 in the unexposed controls. This translated to an adjusted hazard ratio of 1.26 (95% CI 1.14 –1.39;p 
Source: Urolithiasis - March 16, 2019 Category: Urology & Nephrology Source Type: research

It is efficient to monitor the status of implanted ureteral stent using a mobile social networking service application
AbstractForgotten ureteral stents (FUS) is a great threat to both patients and doctors. Applications on smartphones can significantly reduce the incidence of FUS. But existing applications do not have instant notification and consultation functions. To implement those function, we developed a ureteral stent tracking system embedded in a social networking service application, WeChat. “Ureteral Stent Tracking System” was developed on WeChat, a social media application using by 1.4 million active users. The study consecutively enrolled patients who underwent ureteral stent installation from April 2018 to July...
Source: Urolithiasis - March 14, 2019 Category: Urology & Nephrology Source Type: research

Comparison of outcomes in totally tubeless percutaneous nephrolithotomy according to nephrostomy tract sealing with fibrin versus gelatin matrix: a propensity score matching study
AbstractTo investigate and compare surgical outcomes in totally tubeless percutaneous nephrolithotomy (ttPCNL) patients according to the type of sealant during nephrostomy tract closure, the records of 158 patients who underwent ttPCNL were retrospectively reviewed. Fibrin sealant [Tisseel®;n = 107, fibrin-only sealant (FS)] or gelatin matrix hemostatic sealant [FloSeal®;n = 51, gelatin matrix sealant (GS)] was applied during tract closure according to surgeon’s preference. On the first postoperative day, computed tomography (CT) was scanned for all patients. Unsatisfactory radiolo...
Source: Urolithiasis - March 14, 2019 Category: Urology & Nephrology Source Type: research

The usefulness of the maximum Hounsfield units (HU) in predicting the shockwave lithotripsy outcome for ureteral stones and the proposal of novel indicators using the maximum HU
In conclusion, maximum HU and mean HU have equivalent predictive accuracy, and maximum HU is easier to measure and less biased than mean HU. (Source: Urolithiasis)
Source: Urolithiasis - March 11, 2019 Category: Urology & Nephrology Source Type: research

A preliminary survey of practice patterns across several European kidney stone centers and a call for action in developing shared practice
AbstractCurrently an evidence-based approach to nephrolithiasis is hampered by a lack of randomized controlled trials. Thus, there is a need for common platforms for data sharing and recruitment of patients to interventional studies. A first step in achieving this objective would be to share practice methods and protocols for subsequent standardization in what is still a heterogeneous clinical field. Here, we present the results of a pilot survey performed across 24 European clinical kidney stone centers. The survey was distributed by a voluntary online questionnaire circulated between June 2017 and January 2018. About 46%...
Source: Urolithiasis - March 8, 2019 Category: Urology & Nephrology Source Type: research

Editorial comment
(Source: Urolithiasis)
Source: Urolithiasis - March 8, 2019 Category: Urology & Nephrology Source Type: research

Hypertension and renal impairment in patients with cystinuria: findings from a specialist cystinuria centre
We present the prevalence of hypertension and renal impairment in patients with cystinuria from our specialist single centre. We analysed our prospective database of adult patients with cystinuri a who attend our cystinuria service. This included details of the medical and operative management of their disease. Descriptive statistics were used to analyse and present the data. 120 patients were included with a median age of 40 (19–76) years, 66 were male (55%) and 54 were female (45%). 54/1 20 patients (45%) were taking medications to prevent stone formation. 78% (94/120) patients reported having undergone one or more...
Source: Urolithiasis - February 25, 2019 Category: Urology & Nephrology Source Type: research

Evaluating pathogenicity of SLC34A3 -Ser192Leu, a frequent European missense variant in disorders of renal phosphate wasting
AbstractLoss-of-function mutations ofSLC34A3 represent an established cause of a distinct renal phosphate wasting disorder termed hereditary hypophosphatemic rickets with hypercalciuria (HHRH).SLC34A3 encodes the renal phosphate transporter NaPi2c expressed at the apical brush border of proximal renal tubules. Substitution of p.Ser192Leu is one of the most frequent genetic changes among HHRH patients in Europe, but has never been systematically evaluated, clinically or on a cellular level. Identification of a 32-year-old female with a homozgyous c.575C>T, p.Ser192Leu substitution enabled a more comprehensive assessment ...
Source: Urolithiasis - February 23, 2019 Category: Urology & Nephrology Source Type: research

Protective effect of salvianolic acid B against oxidative injury associated with cystine stone formation
AbstractThe aim of this study was to investigate the role of oxidative stress in cystine crystal formation and whether salvianolic acid B, a natural antioxidant, could prevent cystine-mediated oxidative injury in vivo and in vitro. The levels of oxidative stress and antioxidase activity in cystine stone patients were assessed. Then, the oxidative stress exerted by cystine on human kidney-2 (HK-2) cell viability and biochemical parameters including antioxidase activity and antioxidant protein expression were evaluated, and the protective action of salvianolic acid B was also examined. Finally, salvianolic acid B was tested ...
Source: Urolithiasis - February 18, 2019 Category: Urology & Nephrology Source Type: research

Potential thermodynamic and kinetic roles of phytate as an inhibitor of kidney stone formation: theoretical modelling and crystallization experiments
AbstractKidney stone formation is governed by thermodynamic (supersaturation) and kinetic (crystal nucleation, growth, aggregation) mechanisms. We adopted a dual theoretical and experimental approach to investigate the potential role of urinary phytate in this regard. Thermodynamic constants for eight protonated phytate species and seven calcium –phytate complexes were determined by potentiometry and incorporated into the speciation program JESS. Urine was collected from 16 heathy males and their urine compositions were used as input for JESS. Phytate concentration was varied during modelling. No statistically signif...
Source: Urolithiasis - February 14, 2019 Category: Urology & Nephrology Source Type: research

The significance of intraoperative renal pelvic urine and stone cultures for patients at a high risk of post-ureteroscopy systemic inflammatory response syndrome
We examined the renal pelvic urine culture (RPUC) and stone culture (SC) during ureteroscopy and evaluated their associations with postoperative systemic inflammatory response syndrome (SIRS). We prospectively collected data of 224 patients who underwent ureteroscopic laser lithotripsy from March 2015 to December 2017. We examined the bladder urine culture pre-operatively. If the patients had positive culture results, we treated them with antibiotics for 5 –7 days before surgery based on the sensitivity profile. We collected RPUC and SC samples during surgery. After ureteroscopy, patients were closely monitored ...
Source: Urolithiasis - February 13, 2019 Category: Urology & Nephrology Source Type: research