A comparative study of endoscopic combined intrarenal surgery (ECIRS) in the galdakao-modified supine valdivia (GMSV) position and minimally invasive percutaneous nephrolithotomy for complex nephrolithiasis: a retrospective single-center study
AbstractThe aim of this research is to compare the efficiency and safety between endoscopic combined intrarenal surgery (ECIRS) in the Galdakao-modified Supine Valdivia (GMSV) position and minimally invasive percutaneous nephrolithotomy (Mini-PCNL) in a single session for the treatment of complex nephrolithiasis. 140 consecutive patients who were diagnosed with multiple pyelocaliceal stones or staghorn renal calculi were enrolled and reviewed retrospectively. Demographic, clinical information and surgical outcomes were collected and analyzed. Demographic variables and stone characteristics did not show statistically differ...
Source: Urolithiasis - August 10, 2020 Category: Urology & Nephrology Source Type: research

Decreased hemoglobin as a quantifiable indicator of renal arterial embolization in post-percutaneous nephrolithotomy hemorrhage
AbstractTo determine quantifiable indicators for post-percutaneous nephrolithotomy (PCNL) renal arterial embolization. A total of 2043 patients who underwent PCNL from September 2012 to March 2018 were reviewed retrospectively. Post-operative hemorrhage patients were extracted and divided into two groups according to treatment methods (conservative methods or super-selective renal arterial embolization [SRAE]). Demographic characteristics and hemorrhage outcomes were compared between the two groups by univariable analysis. Multivariable logistic regression was used to reveal the association between hemorrhage outcome facto...
Source: Urolithiasis - August 8, 2020 Category: Urology & Nephrology Source Type: research

Oral chemolysis is an effective, non-invasive therapy for urinary stones suspected of uric acid content
AbstractDespite the possible benefit from avoiding stone surgery with all its possible complications, oral chemolysis is rarely performed in patients with urinary stones suspected of uric acid content. Among the reasons for its limited use is the sparse and low-quality data on its efficacy and the lack of reliable factors predicting its outcome. We thus performed a retrospective single-center cohort study of 216 patients (median patient age 63  years) with 272 renal (48%) and/or ureteral (52%) stones treated with oral chemolysis from 01/2010 to 12/2019. Patients with low urine pH (
Source: Urolithiasis - August 7, 2020 Category: Urology & Nephrology Source Type: research

SIRS following percutaneous nephrolithotomy is unpreventable by intensive therapeutic antibiotics in patients with positive urine culture: too soon to conclude
(Source: Urolithiasis)
Source: Urolithiasis - August 5, 2020 Category: Urology & Nephrology Source Type: research

Preoperative risk factors for complications of percutaneous nephrolithotomy
This study was conducted to evaluate preoperative risk factors for development of complications of percutaneous nephrolithotomy (PCNL). All consecutive patients aged  ≥ 16 years who underwent PCNL during 2015 were retrospectively reviewed. Non-contrast CT (NCCT) was performed for all patients to evaluate stone complexity. The technique of PCNL was the same for all patients. Intra-operative and postoperative complications were recorded and classified based on modified Clavien system. The differences in preoperative data (patients, renal and stone characteristics including Guy’s and STONE scores) ...
Source: Urolithiasis - August 1, 2020 Category: Urology & Nephrology Source Type: research

Calcium oxalate crystal deposition in the kidney: identification, causes and consequences
AbstractCalcium oxalate (CaOx) crystal deposition within the tubules is often a perplexing finding on renal biopsy of both native and transplanted kidneys. Understanding the underlying causes may help diagnosis and future management. The most frequent cause of CaOx crystal deposition within the kidney is hyperoxaluria. When this is seen in native kidney biopsy, primary hyperoxaluria must be considered and investigated further with biochemical and genetic tests. Secondary hyperoxaluria, for example due to enteric hyperoxaluria following bariatric surgery, ingested ethylene glycol or vitamin C overdose may also cause CaOx de...
Source: Urolithiasis - July 27, 2020 Category: Urology & Nephrology Source Type: research

Characteristics of the genotype and phenotype in Chinese primary hyperoxaluria type 1 populations
Conclusions: heterogeneity between genotype and phenotype was observed and described in Chinese PH1 patients. c.815_816insGA and c.33_34insC which were recognized asAGXT mutation hotspot regions in China implied a poor prognosis. And c.1049G>A was not determined as the race-specific mutation of Pakistani. (Source: Urolithiasis)
Source: Urolithiasis - June 18, 2020 Category: Urology & Nephrology Source Type: research

A single center ’s experience in pediatric cystine stone disease management: what changed over time?
AbstractThe authors aimed to evaluate the factors affecting clinical outcomes of cystine stone disease in children and to understand the change in disease management over time. Between January 1991 and September 2017, the demographic and clinical data of pediatric patients with documented cystine stone disease were retrospectively analyzed. Patients with at least 12-month follow-up were included. Disease management and clinical outcomes were compared between the first and second 35 patients managed during the study ’s time frame. A total of 70 patients were included. The female to male ratio was 30/40. The mean age a...
Source: Urolithiasis - June 17, 2020 Category: Urology & Nephrology Source Type: research

Simple dietary advice targeting five urinary parameters reduces urinary supersaturation in idiopathic calcium oxalate stone formers
AbstractAmong 208 kidney stone patients referred within 2  years, 75 patients (66 men, nine women) with truly idiopathic calcium oxalate stones (ICSF) were recruited. Dietary advice (DA) aimed at (1) urine dilution, (2) reduced crystallization promotion (lowering oxalate), and (3) increased crystallization inhibition (increasing citrate). We recommended h igher intakes of fluid and calcium with meals/snacks (reducing intestinal oxalate absorption) as well as increased alkali and reduced meat protein (acid) for increasing urinary citrate. The intended effects of DA were elevations in urine volume, calcium (U-Ca) and ci...
Source: Urolithiasis - June 10, 2020 Category: Urology & Nephrology Source Type: research

Plasma oxalate: comparison of methodologies
AbstractMeasurement of oxalate in the blood is essential for monitoring primary hyperoxaluria patients with progressive renal impairment and on dialysis prior to transplantation. As no external quality assurance scheme is available for this analyte, we conducted a sample exchange scheme between six laboratories specifically involved with the investigation of primary hyperoxaluria to compare results. The methodologies compared were gas chromatography/mass spectrometry (GCMS), ion chromatography with mass spectrometry (ICMS), and enzymatic methods using oxalate oxidase and spectrophotometry. Although individual laboratories ...
Source: Urolithiasis - May 29, 2020 Category: Urology & Nephrology Source Type: research

How urinary stone emergencies changed in the time of COVID-19?
(Source: Urolithiasis)
Source: Urolithiasis - May 28, 2020 Category: Urology & Nephrology Source Type: research

Editorial comment
(Source: Urolithiasis)
Source: Urolithiasis - May 26, 2020 Category: Urology & Nephrology Source Type: research

Derivation of a clinical predicting rule for obstructive urolithiasis and alternative diagnosis requiring urgent intervention: the CLAD score
AbstractMost patients with renal colic are discharged from the emergency department (ED) after evaluation and pain alleviation. These patients may not require urgent imaging by computed tomography. We derived a clinical prediction score in patients with renal colic to identify those at very low risk for complications and alternative diagnoses requiring urgent intervention. This retrospective chart review was carried out in 2 ED at an urban university hospital from January to December 2015. All patients with a diagnosis of renal colic were included. The primary outcome was an intervention required for renal colic or alterna...
Source: Urolithiasis - May 20, 2020 Category: Urology & Nephrology Source Type: research

How does the COVID-19 pandemic affect the preoperative evaluation and anesthesia applied for urinary stones? EULIS eCORE –IAU multicenter collaborative cohort study
In this study it is aimed to identify the up-to-date practice patterns related to preoperative evaluation and anesthesia for stone disease interventions during COVID-19 pandemic. The data of 473 patients from 11 centers in 5 different countries underwent interventions for urinary stones during the Covid-19 pandemic was collected and analyzed retrospectively. Information on the type of the stone related conditions, management strategies, anesthesiologic evaluation, anesthesia methods, and any alterations related to COVID-19 pandemic was collected. During the preoperative anesthesia evaluation thorax CT was performed in 268 ...
Source: Urolithiasis - May 20, 2020 Category: Urology & Nephrology Source Type: research

The surgeon ’s role on chemical investigations of the composition of urinary stones
AbstractThe chemical analysis of an urolith is often interpreted as “stone’s composition”. However, it must be taken into consideration, that in most cases, only a fragment of the stone has been sent to the laboratory. In some recurrent patients, stone compositions either vary considerably between episodes or the analytical result obtained from the stone fragm ent does not fit with the data of e.g. current 24 h-urinalysis or urinary pH-records. The question arises, whether this outcome may be the result of an improper stone sampling scheme. On a simple layered 2D-stone model composed of two mine...
Source: Urolithiasis - May 20, 2020 Category: Urology & Nephrology Source Type: research

Are conventional stone analysis techniques reliable for the identification of 2,8-dihydroxyadenine kidney stones? A case series
The objective of this study was to examine the accuracy of stone analysis for identification of DHA. Medical records of patients referred to the APRT Deficiency Research Program of the Rare Kidney Stone Consortium in 2010 –2018 with a diagnosis of APRT deficiency based on kidney stone analysis were reviewed. The diagnosis was verified by measurement of APRT enzyme activity or genetic testing. Attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectra of pure crystalline DHA and a kidney stone obtaine d from one of the confirmed APRT deficiency cases were generated. The ATR-FTIR spectrum of the kidney s...
Source: Urolithiasis - May 12, 2020 Category: Urology & Nephrology Source Type: research

Gender-related differences in the performance of sequential organ failure assessment (SOFA) to predict septic shock after percutaneous nephrolithotomy
AbstractThe study aims to identify whether gender differences exist in the sequential organ failure assessment (SOFA) score to the extent of affecting its predictive accuracy for septic shock after percutaneous nephrolithotomy (PCNL). A retrospective study of 612 patients undergoing PCNL was performed. The SOFA scores of male and female groups were compared to identify any gender differences. The ROC curve was used to find differences between the original and adjusted SOFA scores. Postoperative septic shock developed in 21 (3.43%) cases. A marginally significant discrepancy in median SOFA scores between genders was discove...
Source: Urolithiasis - May 5, 2020 Category: Urology & Nephrology Source Type: research

Quality of life in patients with kidney stones: translation and validation of the Spanish Wisconsin Stone Quality of Life Questionnaire
AbstractThe Spanish version of the Wisconsin Stone Quality of Life (WISQOL) questionnaire was developed and validated. A double-back translation of the WISQOL was conducted and syntactic amendments were made, resulting in the Spanish version of the WISQOL (S-WISQOL) which then went through a readability analysis. Stone formers from two hospitals in Mexico (Merida and Monterrey) filled in the S-WISQOL and the Short Form 36 (SF36). Convergent validity was assessed by the correlation of both questionnaires. Internal consistency was evaluated by Cronbach ’sα, and external validity by comparing between centers. The ...
Source: Urolithiasis - May 5, 2020 Category: Urology & Nephrology Source Type: research

Correction to: Nutrients, vitamins, probiotics and herbal products: an update of their role in urolithogenesis
The original version of this article unfortunately contained a mistake. (Source: Urolithiasis)
Source: Urolithiasis - April 28, 2020 Category: Urology & Nephrology Source Type: research

Fractioned urine collections to assess urine supersaturation in urolithiasis; a pathway worth exploring
(Source: Urolithiasis)
Source: Urolithiasis - April 13, 2020 Category: Urology & Nephrology Source Type: research

Does the renal parenchymal thickness affect the efficacy of the retrograde intrarenal surgery? A prospective cohort study
This study is a single-centered prospective surgical cohort study. A total of 383 patients were analyzed. Regularly followed 304 patients with unilateral kidney stone at single pole or renal pelvis and who underwent single-session RIRS were included in the final analysis, and the patients ’ preoperative and postoperative 1st and 3rd months’ data were evaluated. RPT was measured on the non-contrast computed tomography (CT) images. ROC analysis was performed to estimate the cutoff value of RPT for SFR. Univariate and multivariate logistic regression analyses were used to model the relationship between RPT and SFR...
Source: Urolithiasis - April 13, 2020 Category: Urology & Nephrology Source Type: research

Factors affecting success in the treatment of proximal ureteral stones larger than 1  cm with extracorporeal shockwave lithotripsy in adult patients
AbstractThe aim of the study was to analyze the factors predicting success for the treatment of proximal ureteral stones larger than 1  cm with extracorporeal shockwave lithotripsy (SWL) in adult patients. Between January 2014 and December 2018, 480 adult patients in total underwent SWL and data were retrospectively evaluated. Patients with multiple ureteral stones, solitary kidney, congenital abnormality, skeletal system abnormal ity, history of previous urinary system surgery and SWL, renal insufficiency, patients who could not tolerate SWL and pediatric patients were excluded from the study. The remaining 415 patie...
Source: Urolithiasis - April 11, 2020 Category: Urology & Nephrology Source Type: research

Effective and quick discharge of residual fragments after minimal invasive stone procedures with “EPVL” modality: a new and promising approach
(Source: Urolithiasis)
Source: Urolithiasis - April 2, 2020 Category: Urology & Nephrology Source Type: research

Bone mineral density in adolescent urinary stone formers: is sex important?
AbstractUrinary stone disease (USD) is affecting a greater number of children and low bone mineral density (BMD) and increased skeletal fractures have been demonstrated in stone patients; however, the mechanism(s) driving bone disease remain unclear. This pilot study was undertaken to assess an adolescent kidney stone cohort ’s BMD and evaluate for an inverse correlation between BMD and urine concentration of lithogenic minerals and/or inflammatory levels. Prospective case–control study was carried out at a large pediatric center. 15 participants with USD (12–18 years of age, 8 female) were matched b...
Source: Urolithiasis - March 31, 2020 Category: Urology & Nephrology Source Type: research

Nutrients, vitamins, probiotics and herbal products: an update of their role in urolithogenesis
AbstractNutrients, vitamins, probiotics, and herbal products may be risk factors, or alternately, protect against the formation of urinary stones. The purpose of this review was to update knowledge of the role of nutraceuticals in renal stone formation. A systematic search of the relevant literature published in PubMed in the last ten years was conducted and a narrative review of the data from the included studies was done. Search screened 513 studies that were reduced to 34 after evaluation by title and abstract; other 38 studies were retrieved by references of the selected studies. Beverages high fluid intake confirmed p...
Source: Urolithiasis - March 2, 2020 Category: Urology & Nephrology Source Type: research

The relationship between calcium oxalate lithiasis and chronic proinflammatory intestinal dysbiosis pattern: a prospective study
The objective is to establish whether a pattern of intestinal dysbiosis exists in calcium oxalate (CaOx) lithiasis and, if so, to identify its characteristics and explore whether there are differences in the pattern between CaOx dihydrate (COD) and monohydrate (COM) lithiasis. With this aim 24 patients diagnosed with CaOx lithiasis by means of optical microscopy and spectrometry were prospectively recruited. Faecal analysis was carried out by means of RT-PCR 16S rRNA assay and agar plate culture according to the methodology proposed by theInstitute of Microecology(Herborn, Germany). The total number of bacteria was deplete...
Source: Urolithiasis - February 27, 2020 Category: Urology & Nephrology Source Type: research

Stone recurrence among childhood kidney stone formers: results of a nationwide study in Iceland
ConclusionsIn our population-based sample of childhood kidney stone formers, the stone recurrence rate is similar to that reported for adults. The observed rise in stone recurrence with time may be related to closer patient follow-up in recent years or increased stone risk in general. (Source: Urolithiasis)
Source: Urolithiasis - February 27, 2020 Category: Urology & Nephrology Source Type: research

Differentiation of distal ureteral stones and pelvic phleboliths using a convolutional neural network
In conclusion, the CNN differentiated ureteral stones from phleboliths with higher accuracy than the mean of seven radiologists’ assessments using local features. However, more than local feature s are needed to reach optimal discrimination. (Source: Urolithiasis)
Source: Urolithiasis - February 27, 2020 Category: Urology & Nephrology Source Type: research

Three-dimensional mean stone density on non-contrast computed tomography can predict ureteroscopic lithotripsy outcome in ureteral stone cases
This study aims to investigate whether 3D-MSD can predict ureteroscopic lithotripsy outcome. We retrospectively identified 218 patients who underwent ureteroscopic lithotripsy for kidney stones (n = 135) and ureteral stones (n = 83) between February 2011 and April 2017 with pretreatment non-contrast computed tomography (NCCT) at our hospital. Stone volume and 3D-MSD were automatically measured using high functional viewer. Logistic regression analysis was performed to identify factors contributing to treatment failur e. Treatment failure was determined as residual fragments ≥ 4&...
Source: Urolithiasis - January 28, 2020 Category: Urology & Nephrology Source Type: research

Urinary supersaturation on fractioned urine collections: which urine sample can explain better the variability observed on 24-h urine? A proof-of-concept study
In conclusion, urinary SS varies throughout the day, being higher for CaOx and CaP at night, and in the early morning for UA. For CaOx and UA, the overnight and 12–4 pm urine samples, respectively, contribute most to the variability ob served in the SS of 24-h urine. (Source: Urolithiasis)
Source: Urolithiasis - January 24, 2020 Category: Urology & Nephrology Source Type: research

When is the best time to perform external physical vibration lithecbole (EPVL) after retrograde intrarenal surgery (RIRS): a multi-center study based on randomized controlled trials
AbstractTo determine the best time to perform EPVL treatment by evaluating the efficacy and safety of active stone extraction in treating residual fragments at different time points after RIRS. All participants had renal or upper ureteral stones preoperatively and still had residual stones after receiving RIRS. They were prospectively randomized into four groups: patients in group A received EPVL 3  days after RIRS; patients in group B received EPVL 7 days after RIRS; patients in group C received EPVL 14 days after RIRS; patients in group D did not receive EPVL after RIRS. Follow-up examinations were perform...
Source: Urolithiasis - December 16, 2019 Category: Urology & Nephrology Source Type: research

Assessment of health-related quality of life in patients with cystinuria on tiopronin therapy
The objective of this study was to assess the HRQOL of patients with or without tiopronin treatment. For this cross-sectional survey, patients on tiopronin treatment were recruited through the “Thiola® Total Care Hub, ” a specialty pharmacy used to dispense tiopronin, and compared with patients not taking tiopronin (non-tiopronin group) who were identified from the Cystinuria Contact Registry at New York University School of Medicine. Consented patients responded to a survey that included questions about their experiences with kidney stones, the Wisconsin stone quality of life (WISQOL) (disease-specific) qu...
Source: Urolithiasis - December 13, 2019 Category: Urology & Nephrology Source Type: research

Safety and efficacy of a single middle calyx access (MCA) in mini-PCNL
AbstractTo compare outcomes of a single middle calyx access (MCA) with a single upper or lower calyceal access in mini-PCNL. From May 2015 through August 2018, patients ’ files who underwent a single renal access mini-PCNL were retrospectively reviewed. All patients underwent fluoroscopic-guided access (16–20 F) in the prone position. They were categorized into group 1 (MCA) and group 2 (either upper or lower calyceal access). Compared preoperative items includ ed stone location, size, number and complexity (according to Guy’s score). The compared outcome parameters were complication and stone-free rates....
Source: Urolithiasis - December 10, 2019 Category: Urology & Nephrology Source Type: research

Predicting the risk of kidney stone formation in the nephron by ‘reverse engineering’
AbstractAlthough most kidney stones are found in the calyx, they are usually initiated upstream in the nephron by precipitation there of certain incipient mineral phases. The risk of kidney stone formation can thus be indicated by changes in the degree of saturation of these minerals in the nephron fluid. To this end, relevant concentration profiles in the fluid along the nephron have been calculated by starting with specified urine compositions and imposing constraints from the corresponding, much less variable, blood compositions. A model for supersaturation within ten sections of both long and short nephrons has accordi...
Source: Urolithiasis - November 26, 2019 Category: Urology & Nephrology Source Type: research

Response to letter to the editor regarding ‘Could Surgical Experience of Adult Endourologist Overcome the Learning Curve of Retrograde Intrarenal Surgery in Children?’
(Source: Urolithiasis)
Source: Urolithiasis - November 16, 2019 Category: Urology & Nephrology Source Type: research

Successful removal of an encrusted metallic ureteral stent using a disposable ureteroscope and Ho:YAG laser lithotripsy
(Source: Urolithiasis)
Source: Urolithiasis - November 7, 2019 Category: Urology & Nephrology Source Type: research

Expression of vitamin D receptor, CYP27B1 and CYP24A1 hydroxylases and 1,25-dihydroxyvitamin D 3 levels in stone formers
AbstractThe expression of vitamin D receptor (VDR) and 1,25-dihydroxyvitamin D3 [1,25(OH)D] levels exceed the values of controls in some but not all hypercalciuric stone formers (HSF). We aimed to evaluate serum 1,25(OH)D levels, the expression of VDR, CYP27B1, and CYP24A1 hydroxylases in HSF in comparison with normocalciuric stone formers (NSF) and healthy subjects (HS). Blood samples, 24-h urine collections and a 3-day dietary record were obtained from 30 participants from each of the groups. The expression of VDR, CYP27B1, and CYP24A1 was measured by flow cytometry. HSF presented significantly higher urinary volume, sod...
Source: Urolithiasis - November 6, 2019 Category: Urology & Nephrology Source Type: research

Nox1-derived oxidative stress as a common pathogenic link between obesity and hyperoxaluria-related kidney injury
AbstractSpecific relationships among reactive oxygen species, activation pathways, and inflammatory mechanisms involved in kidney injury were assessed in a combined model of obesity and hyperoxaluria. Male Wistar rats were divided into four groups: Control, HFD (high fat diet), OX (0.75% ethylene glycol), and HFD  + OX (combined model) Changes in basal O2− levels were evaluated by chemiluminescence in renal interlobar arteries and renal cortex. Furthermore, the effect of different inhibitors on NADPH-stimulated O2− generation was assessed in renal cortex. Oxidative stress sources, and local inflam...
Source: Urolithiasis - November 5, 2019 Category: Urology & Nephrology Source Type: research

A neural network-based algorithm for predicting the spontaneous passage of ureteral stones
In this study, a prototype artificial neural network model (ANN) was used to estimate the stone passage rate and to determine the effectivity of predictive factors on this rate in patients with ureteral stones. The retrospective study included a total of 192 patients with ureteral stones, comprising 128 (66.7%) men and 64 (33.3%) women. Patients were divided into two groups. Group 1 (n: 125) consisted of people who spontaneously passed their stones, Group 2 (n: 67) consisted of people who could not pass stones spontaneously. The groups were compared with regard to the relationship between input data and stone passage rate ...
Source: Urolithiasis - October 30, 2019 Category: Urology & Nephrology Source Type: research

Letter to Editor
(Source: Urolithiasis)
Source: Urolithiasis - October 25, 2019 Category: Urology & Nephrology Source Type: research

Analgesic efficacy of combination therapy versus monotherapy on postoperative pain control in percutaneous nephrolithotomy: a meta-analysis of randomized controlled trials
(Source: Urolithiasis)
Source: Urolithiasis - October 22, 2019 Category: Urology & Nephrology Source Type: research

Dual-frequency setting for urinary stone fragmentation during shock wave lithotripsy: an in vitro study
AbstractExtracorporeal shock wave lithotripsy (SWL) is less invasive compared to the other invasive modalities of stone treatment that are gaining popularity. Hence, methods to improve the efficacy of SWL are desirable. We studied the effectiveness of dual frequency on the efficacy of stone fragmentation, but minimizing treatment time. A phantom 10  mm spherical BegoStone was fragmented in vitro in a kidney model using an electromagnetic lithotripter (Storz MODULITH®SLX-F2). A total of 78 stones were fragmented each with 3000 shocks at 60  Hz or 120 Hz or a dual frequency (DF) of 60–120 Hz. Fo...
Source: Urolithiasis - October 17, 2019 Category: Urology & Nephrology Source Type: research

Use 3D printing technology to enhance stone free rate in single tract percutaneous nephrolithotomy for the treatment of staghorn stones
This study assesses the feasibility and effectiveness of using a three-dimensional (3D) printing model for preoperative planning in the treatment of full staghorn stones, specifically in the selection of the most optimal calyx for puncture. Twelve patients were enrolled in this trial. A preoperative CT taken in prone position was performed on each of the patients. 3D models were reconstructed using digital imaging and 3D printers. Three identical models were printed for each patient. Three puncture sites from the upper-, middle-, and lower-pole calyces of the kidney models were selected for simulation of percutaneous nephr...
Source: Urolithiasis - October 15, 2019 Category: Urology & Nephrology Source Type: research

Correction to: Recent advances in the identification and management of inherited hyperoxalurias
The original version of this article unfortunately contained a mistake. On page 84, the dose for oral potassium citrate is incorrectly written as “0.1 mg/kg/day divided BID-QID for children, 30–60 mg per day divided BID-QID for adults”. (Source: Urolithiasis)
Source: Urolithiasis - October 13, 2019 Category: Urology & Nephrology Source Type: research

Does the presence or degree of hydronephrosis affect the stone disintegration efficacy of extracorporeal shock wave lithotripsy? A systematic review and meta-analysis
AbstractThe aim of this study was to determine whether the presence or degree of hydronephrosis (HN) affects the stone disintegration efficacy of shock wave lithotripsy (SWL). A comprehensive literature search using PubMed, Embase, Cochrane Library, and Web of Science was conducted to retrieve relevant studies. Risk ratios (RRs) and mean differences (MDs) with corresponding 95% confidence intervals (CIs) were calculated for comparisons of outcomes of interest. In total, seven comparative studies with 2033 patients were included. Overall results indicated no significant difference in stone-free rate (SFR) and retreatment ra...
Source: Urolithiasis - October 12, 2019 Category: Urology & Nephrology Source Type: research

Could surgical experience of adult endourologist overcome the learning curve of retrograde intrarenal surgery in children?
AbstractWith the increasing of the prevalence of pediatric urolithiasis (1 –5%), retrograde intrarenal surgery (RIRS) is emerging as preferred option for the management of stones in pediatric patients. Although the principles of RIRS developed in adults can be applied in children, also expert adult endourologists feel uncomfortable to approach young patients due to long learning curve that usually is expected to be required in this particular setting. The aim of the study was to compare peri- and postoperative outcomes of RIRS in pediatric and adult patients performed by a single surgeon expert in adult endourology (...
Source: Urolithiasis - September 19, 2019 Category: Urology & Nephrology Source Type: research

Evaluation of day-care versus inpatient mini-percutaneous nephrolithotomy: a propensity score-matching study
AbstractDay-care percutaneous nephrolithotomy (day-PCNL) is being performed more routinely, however, safety remains a concern. The purpose of this study was to compare the complication rate, readmission rate and medical cost saving between day-PCNL and inpatient-PCNL. A protocol for day-PCNL was applied. A retrospective review of 86 patients planned day-PCNL by one surgeon were conducted. Using propensity matching, 86 inpatients (minimum 2-day  post-operative stay) treated with the same procedure were matched. For each cohort, 14-day occurrence of complications and unplanned readmissions were recorded and compared. Mo...
Source: Urolithiasis - September 14, 2019 Category: Urology & Nephrology Source Type: research

Association of vitamin D receptor gene polymorphisms and risk of urolithiasis: results of a genetic epidemiology study and comprehensive meta-analysis
In conclusion, this meta-analysis suggests thatVDR FokI polymorphism is significantly associated with urolithiasis risk, especially in Asians, whereasApaI,BsmI andTaqI polymorphisms are not associated. (Source: Urolithiasis)
Source: Urolithiasis - September 12, 2019 Category: Urology & Nephrology Source Type: research

Comparative efficacy of 22 drug interventions as medical expulsive therapy for ureteral stones: a systematic review and network meta-analysis
AbstractTo perform a systematic review and meta-analysis for the evaluation of 22 drug interventions in the management of ureteral stones, MEDLINE, Web of Science, EMBASE, and Cochrane central databases were searched to identify RCTs focusing on the evaluation of the efficacy of multiple drug interventions in medical expulsive therapy (MET) for ureteral stones, with no restrictions on year or language. Study quality assessment and data extraction were performed by independent reviewers. Major outcome measures were the stone expulsion rate, stone expulsion time, and pain episodes during treatment. A total of 78 RCTs with 14...
Source: Urolithiasis - September 11, 2019 Category: Urology & Nephrology Source Type: research

Idiopathic calcium nephrolithiasis with pure calcium oxalate composition: clinical correlates of the calcium oxalate dihydrate/monohydrate (COD/COM) stone ratio
The objective of this observational study was to verify the association of clinical and laboratory parameters of kidney stone disease with COD/COM ratio in a group of 465 (322  M, age 46 ± 14) patients suffering from idiopathic calcium nephrolithiasis with pure calcium oxalate stones (≥ 97%). Each participant underwent a complete clinical examination, serum chemistry, 24-h urine collection for the determination of the profile of lithogenic risk, and had stones a nalyzed by FT-IR. Most (62%) of the stones had a COD/COM ratio ≤ 0.25, and the urine chemistry of the correspo...
Source: Urolithiasis - September 10, 2019 Category: Urology & Nephrology Source Type: research