Investigations on Compaction Behavior of Kollidon < sup > ® < /sup > SR-Based Multi-component Directly Compressed Tablets for Preparation of Controlled Release Diclofenac Sodium
In conclusion, optimum quaternary tablets were obtained with optimum crushing strengths, relatively low Py, and moderate percentage porosities among all prepared quaternary tablets. The drug release of the optimum quaternary tablets demonstrated similar in vitro release profile compared to that of the marketed product with a mechanism of release that follows Korsmeyer-Peppas model.PMID:37945987 | DOI:10.1208/s12249-023-02685-7 (Source: AAPS PharmSciTech)
Source: AAPS PharmSciTech - November 9, 2023 Category: Drugs & Pharmacology Authors: Wasfy M Obeidat Ishraq K Lahlouh Shadi F Gharaibeh Source Type: research
Histopathological, physiological, and multi-omics insights into the hepatotoxicity mechanism of nanopolystyrene and/or diclofenac in Mylopharyngodon piceus
Environ Pollut. 2023 Nov 7:122894. doi: 10.1016/j.envpol.2023.122894. Online ahead of print.ABSTRACTNanopolystyrene (NP) and diclofenac (DCF) are common environmental contaminants in the aquatic ecosystem; therefore, the present study aimed to investigate the hepatotoxicity of NP and/or DCF exposure on aquatic organisms and the underlying mechanisms. Juvenile Mylopharyngodon piceus were used as a model organism to study the effects of NP and/or DCF exposure at environmentally relevant concentrations for 21 days. Subchronic exposure to NP and/or DCF resulted in liver histological damage. In the NP group, the presence of lar...
Source: Environmental Pollution - November 9, 2023 Category: Environmental Health Authors: Tiantian Chen Hewei Jiang Yaoji He Yawei Shen Jiajie Fang Zequn Huang Yubang Sheng Xiaowu Chen Source Type: research
Investigations on Compaction Behavior of Kollidon < sup > ® < /sup > SR-Based Multi-component Directly Compressed Tablets for Preparation of Controlled Release Diclofenac Sodium
In conclusion, optimum quaternary tablets were obtained with optimum crushing strengths, relatively low Py, and moderate percentage porosities among all prepared quaternary tablets. The drug release of the optimum quaternary tablets demonstrated similar in vitro release profile compared to that of the marketed product with a mechanism of release that follows Korsmeyer-Peppas model.PMID:37945987 | DOI:10.1208/s12249-023-02685-7 (Source: AAPS PharmSciTech)
Source: AAPS PharmSciTech - November 9, 2023 Category: Drugs & Pharmacology Authors: Wasfy M Obeidat Ishraq K Lahlouh Shadi F Gharaibeh Source Type: research
Histopathological, physiological, and multi-omics insights into the hepatotoxicity mechanism of nanopolystyrene and/or diclofenac in Mylopharyngodon piceus
Environ Pollut. 2023 Nov 7:122894. doi: 10.1016/j.envpol.2023.122894. Online ahead of print.ABSTRACTNanopolystyrene (NP) and diclofenac (DCF) are common environmental contaminants in the aquatic ecosystem; therefore, the present study aimed to investigate the hepatotoxicity of NP and/or DCF exposure on aquatic organisms and the underlying mechanisms. Juvenile Mylopharyngodon piceus were used as a model organism to study the effects of NP and/or DCF exposure at environmentally relevant concentrations for 21 days. Subchronic exposure to NP and/or DCF resulted in liver histological damage. In the NP group, the presence of lar...
Source: Environmental Pollution - November 9, 2023 Category: Environmental Health Authors: Tiantian Chen Hewei Jiang Yaoji He Yawei Shen Jiajie Fang Zequn Huang Yubang Sheng Xiaowu Chen Source Type: research
Investigations on Compaction Behavior of Kollidon < sup > ® < /sup > SR-Based Multi-component Directly Compressed Tablets for Preparation of Controlled Release Diclofenac Sodium
In conclusion, optimum quaternary tablets were obtained with optimum crushing strengths, relatively low Py, and moderate percentage porosities among all prepared quaternary tablets. The drug release of the optimum quaternary tablets demonstrated similar in vitro release profile compared to that of the marketed product with a mechanism of release that follows Korsmeyer-Peppas model.PMID:37945987 | DOI:10.1208/s12249-023-02685-7 (Source: AAPS PharmSciTech)
Source: AAPS PharmSciTech - November 9, 2023 Category: Drugs & Pharmacology Authors: Wasfy M Obeidat Ishraq K Lahlouh Shadi F Gharaibeh Source Type: research
