CMV-induced Hearing Loss
Newborn (Clarksville). 2023 Oct-Dec;2(4):249-262. doi: 10.5005/jp-journals-11002-0081. Epub 2024 Jan 5.ABSTRACTCongenital cytomegalovirus (cCMV) infection is the most common fetal viral infection and contributes to about 25% of childhood hearing loss by the age of 4 years. It is the leading nongenetic cause of sensorineural hearing loss (SNHL). Infants born to seroimmune mothers are not completely protected from SNHL, although the severity of their hearing loss may be milder than that seen in those whose mothers had a primary infection. Both direct cytopathic effects and localized inflammatory responses contribute to the p...
Source: Herpes - February 13, 2024 Category: Infectious Diseases Authors: Srijan Singh Akhil Maheshwari Suresh Boppana Source Type: research
Counseling in fetal medicine: Congenital cytomegalovirus infection
Eur J Obstet Gynecol Reprod Biol. 2024 Feb 1;295:8-17. doi: 10.1016/j.ejogrb.2024.01.037. Online ahead of print.ABSTRACTAlthough the clinical work-up of CMV in pregnancy has gradually become more accurate, counseling for CMV is still challenging. Despite the potential feasibility of universal prenatal serological screening, its introduction in prenatal diagnosis continues to raise concerns related to its real cost-effectiveness. Contextually, anticipating the confirmation of fetal infection earlier in pregnancy is one of the most pressing issues to reduce the parental psychological burden. Amniocentesis is still the gold s...
Source: Reproductive Biology - February 4, 2024 Category: Reproduction Medicine Authors: Elena D'Alberti Giuseppe Rizzo Asma Khalil Ilenia Mappa Maria Elena Pietrolucci Giulia Capannolo Sara Alameddine Sara Sorrenti Fabrizio Zullo Antonella Giancotti Daniele Di Mascio Francesco D'Antonio Source Type: research
Valacyclovir neurotoxicity and kinetics in a patient with impaired kidney function
Volume 61, Issue 12, December 2023, Page 1062-1063 . (Source: Clinical Toxicology)
Source: Clinical Toxicology - January 25, 2024 Category: Toxicology Authors: Bradley RyanJagarlamudi BhashitaaAngela L. ChiewBetty S. ChanClinical Toxicology, Prince of Wales Hospital and Community Health Services Ringgold Standard Institution Source Type: research
Fatal severe persistent pulmonary hypertension with lung microvasculature parietal hyperplasia in a neonate with congenital cytomegalovirus infection treated in-utero with valacyclovir: A case report
We found that congenital cytomegalovirus (cCMV) can cause severe persistent pulmonary hypertension (PPH) subsequent to lung microvasculature parietal hyperplasia. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - January 10, 2024 Category: OBGYN Authors: Federica Fernicola, Anna Carli, Francesca Arienti, Maria Viola Vasarri, Laura Lanteri, Gaia Scandella, Valeria Poletti De Chaurand, Marianna Zicoia, Lucia Iozzi, Sonia Gorla, Maria Luisa Ventura, Anna Locatelli, Mariateresa Sinelli, Sara Ornaghi Source Type: research
Valacyclovir neurotoxicity and kinetics in a patient with impaired kidney function
. (Source: Clinical Toxicology)
Source: Clinical Toxicology - January 8, 2024 Category: Toxicology Authors: Bradley RyanJagarlamudi BhashitaaAngela L. ChiewBetty S. ChanClinical Toxicology, Prince of Wales Hospital and Community Health Services Ringgold Standard Institution Source Type: research
876 Universal Screening and Valacyclovir for Maternal Primary CMV in the First Trimester: A Cost-Effectiveness Analysis
This study examined the cost-effectiveness of universal screening for first trimester primary CMV and subsequent valacyclovir treatment for congenital CMV prevention in the United States. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - January 1, 2024 Category: OBGYN Authors: Sarah K. Dzubay, Amelia H. Gagliuso, Megha Arora, Uma Doshi, Aaron B. Caughey Source Type: research
Imiquimod in Association With Valacyclovir for Refractory Verrucous Perianal Herpes in an AIDS Patient
Actas Dermosifiliogr. 2023 Dec 2:S0001-7310(23)00947-X. doi: 10.1016/j.ad.2023.11.006. Online ahead of print.NO ABSTRACTPMID:38048950 | DOI:10.1016/j.ad.2023.11.006 (Source: Actas Dermo-Sifiliograficas)
Source: Actas Dermo-Sifiliograficas - December 4, 2023 Category: Dermatology Authors: S Antunes-Duarte A Marcos-Pinto L Soares-de-Almeida J Borges-Costa Source Type: research
Imiquimod in Association With Valacyclovir for Refractory Verrucous Perianal Herpes in an AIDS Patient
Actas Dermosifiliogr. 2023 Dec 2:S0001-7310(23)00947-X. doi: 10.1016/j.ad.2023.11.006. Online ahead of print.NO ABSTRACTPMID:38048950 | DOI:10.1016/j.ad.2023.11.006 (Source: Herpes)
Source: Herpes - December 4, 2023 Category: Infectious Diseases Authors: S Antunes-Duarte A Marcos-Pinto L Soares-de-Almeida J Borges-Costa Source Type: research
Imiquimod in Association With Valacyclovir for Refractory Verrucous Perianal Herpes in an AIDS Patient
Actas Dermosifiliogr. 2023 Dec 2:S0001-7310(23)00947-X. doi: 10.1016/j.ad.2023.11.006. Online ahead of print.NO ABSTRACTPMID:38048950 | DOI:10.1016/j.ad.2023.11.006 (Source: Actas Dermo-Sifiliograficas)
Source: Actas Dermo-Sifiliograficas - December 4, 2023 Category: Dermatology Authors: S Antunes-Duarte A Marcos-Pinto L Soares-de-Almeida J Borges-Costa Source Type: research
HSD121 Study of Effective Treatment of Genital Herpes in Women in Ukraine
Genital herpes is a common sexually transmitted disease caused by the herpes simplex virus (HSV), characterized by lifelong infection,periodic reactivation. Worldwide, more than 400 million people have genital herpes caused by HSV-2. For patients with genital HSV-1 infection or those with asymptomatic HSV-2 infection, suppressive therapy may be considered for those with significant psychosocial distress due to genital herpes and suspected sexual partner infection.There are several strategies for the use of antiherpetic drugs (acyclovir, famciclovir, valacyclovir), which have been studied and tested in cases of first infect...
Source: Value in Health - December 1, 2023 Category: International Medicine & Public Health Authors: O. Zaliska, O. Matvienko, Y. Matvienko, N. Maksymovych, M. Malachynska, L. Minko Source Type: research
Bilateral Acute Retinal Necrosis Treated With Antivirals and Corticosteroids
We report on the case of a Hispanic male with bilateral acute retinal necrosis (BARN), whose disease was managed with intravenous acyclovir, topical prednisolone, topical atropine, intravitreal ganciclovir, oral valacyclovir, and oral prednisone. The oral corticosteroid was added to his treatment regimen eight days after his initial presentation. The 55-year-old patient presented with a two-week history of bilateral blurred vision. His medical history was pertinent for remote varicella and herpes zoster (the latter limited to the forehead). His best-corrected visual acuity (BCVA) was counting fingers in both eyes (OU). His...
Source: Herpes - November 29, 2023 Category: Infectious Diseases Authors: Estefania Ramirez Marquez Alejandra Santiago Israel Mendez Jan C Santiago Jos é J López-Fontanet Noraliz Garcia Armando L Oliver Source Type: research
Unique Attributes of Guinea Pigs as New Models to Study Ocular Herpes Pathophysiology and Recurrence
CONCLUSIONS: This study demonstrates the potential suitability of guinea pigs as new models for ocular HSV-1 investigations, filling a critical preclinical void of models capable of showcasing spontaneous HSV reactivation in the eye. The observed similarities and differences in the reactions of guinea pigs and rabbits to HSV-1 infection and treatments provide crucial insights, laying the foundation for future studies on ocular HSV pathogenesis, latency, and improved treatment options.PMID:38015175 | DOI:10.1167/iovs.64.14.41 (Source: Herpes)
Source: Herpes - November 28, 2023 Category: Infectious Diseases Authors: Tejabhiram Yadavalli Chandrashekhar Patil Pankaj Sharma Ipsita Volety Hemant Borase Divya Kapoor Deepak Shukla Source Type: research
Unique Attributes of Guinea Pigs as New Models to Study Ocular Herpes Pathophysiology and Recurrence
CONCLUSIONS: This study demonstrates the potential suitability of guinea pigs as new models for ocular HSV-1 investigations, filling a critical preclinical void of models capable of showcasing spontaneous HSV reactivation in the eye. The observed similarities and differences in the reactions of guinea pigs and rabbits to HSV-1 infection and treatments provide crucial insights, laying the foundation for future studies on ocular HSV pathogenesis, latency, and improved treatment options.PMID:38015175 | DOI:10.1167/iovs.64.14.41 (Source: Herpes)
Source: Herpes - November 28, 2023 Category: Infectious Diseases Authors: Tejabhiram Yadavalli Chandrashekhar Patil Pankaj Sharma Ipsita Volety Hemant Borase Divya Kapoor Deepak Shukla Source Type: research
Korean Chestnut Honey Suppresses HSV-1 Infection by Regulating the ROS-NLRP3 Inflammasome Pathway
Antioxidants (Basel). 2023 Oct 30;12(11):1935. doi: 10.3390/antiox12111935.ABSTRACTHerpes simplex virus 1 (HSV-1) is double-stranded DNA virus that belongs to the Orthoherpesviridae family. It causes serious neurological diseases of the central nervous system, such as encephalitis. The current U.S. Food and Drug Administration (FDA)-approved drugs for preventing HSV-1 infection include acyclovir (ACV) and valacyclovir; however, their long-term use causes severe side effects and often results in the emergence of drug-resistant strains. Therefore, it is important to discover new antiviral agents that are safe and effective a...
Source: Herpes - November 25, 2023 Category: Infectious Diseases Authors: Eun-Bin Kwon Young Soo Kim Buyun Kim Se-Gun Kim Sung-Joon Na Younghoon Go Hong Min Choi Hye Jin Lee Sang Mi Han Jang-Gi Choi Source Type: research
Korean Chestnut Honey Suppresses HSV-1 Infection by Regulating the ROS-NLRP3 Inflammasome Pathway
Antioxidants (Basel). 2023 Oct 30;12(11):1935. doi: 10.3390/antiox12111935.ABSTRACTHerpes simplex virus 1 (HSV-1) is double-stranded DNA virus that belongs to the Orthoherpesviridae family. It causes serious neurological diseases of the central nervous system, such as encephalitis. The current U.S. Food and Drug Administration (FDA)-approved drugs for preventing HSV-1 infection include acyclovir (ACV) and valacyclovir; however, their long-term use causes severe side effects and often results in the emergence of drug-resistant strains. Therefore, it is important to discover new antiviral agents that are safe and effective a...
Source: Herpes - November 25, 2023 Category: Infectious Diseases Authors: Eun-Bin Kwon Young Soo Kim Buyun Kim Se-Gun Kim Sung-Joon Na Younghoon Go Hong Min Choi Hye Jin Lee Sang Mi Han Jang-Gi Choi Source Type: research
