Fixed Drug Eruption in a Patient Taking Valacyclovir without Cross-Reactivity to Acyclovir
We report a 33-year-old male who presented with a recurrent, localized, brownish-to-erythematous macule and papules on the peri-philtrum area two hours after taking valacyclovir. Three episodes of valacyclovir ingestion for treatment of Herpes simplex virus infection provoked a similar skin rash at the same site. Histopathology results showed vacuolar degeneration in the basal layer of the epidermis, pigmentary incontinence, and perivascular inflammatory cell infiltration in the papillary dermis. Although patch test and skin prick test showed negative responses to acyclovir and valacyclovir, an intradermal test showed a po...
Source: Annals of Dermatology - October 19, 2023 Category: Dermatology Authors: Yeon-Gu Choi Hyeon Jeong Park Sunmin Yim Heun Joo Lee Young Jun Choi Won-Serk Kim Ga-Young Lee Source Type: research
