Current diagnostic and treatment strategies for urachal cancer
Orv Hetil. 2023 Apr 23;164(16):602-609. doi: 10.1556/650.2023.32754. Print 2023 Apr 23.ABSTRACTUrachal carcinoma is a rare malignancy that is uniquely associated with the field of urology. Urachal carcinoma is mostly diagnosed in urological care centers due to its most frequently presenting symptom that is hematuria. Currently available diagnostic and therapeutic knowledge is solely based on case reports and single center series, while no prospective clinical studies are carried out due to the modest number of patients. These circumstances have made creating professional guidelines challenging, hence the treatment of urach...
Source: Orvosi Hetilap - April 23, 2023 Category: General Medicine Authors: Orsolya M ódos Melinda V áradi B álint Dér Attila Keszthelyi Mikl ós Szűcs Henning Reis P éter Nyirády Tibor Szarvas Source Type: research
Current diagnostic and treatment strategies for urachal cancer
Orv Hetil. 2023 Apr 23;164(16):602-609. doi: 10.1556/650.2023.32754. Print 2023 Apr 23.ABSTRACTUrachal carcinoma is a rare malignancy that is uniquely associated with the field of urology. Urachal carcinoma is mostly diagnosed in urological care centers due to its most frequently presenting symptom that is hematuria. Currently available diagnostic and therapeutic knowledge is solely based on case reports and single center series, while no prospective clinical studies are carried out due to the modest number of patients. These circumstances have made creating professional guidelines challenging, hence the treatment of urach...
Source: Orvosi Hetilap - April 23, 2023 Category: General Medicine Authors: Orsolya M ódos Melinda V áradi B álint Dér Attila Keszthelyi Mikl ós Szűcs Henning Reis P éter Nyirády Tibor Szarvas Source Type: research
Current diagnostic and treatment strategies for urachal cancer
Orv Hetil. 2023 Apr 23;164(16):602-609. doi: 10.1556/650.2023.32754. Print 2023 Apr 23.ABSTRACTUrachal carcinoma is a rare malignancy that is uniquely associated with the field of urology. Urachal carcinoma is mostly diagnosed in urological care centers due to its most frequently presenting symptom that is hematuria. Currently available diagnostic and therapeutic knowledge is solely based on case reports and single center series, while no prospective clinical studies are carried out due to the modest number of patients. These circumstances have made creating professional guidelines challenging, hence the treatment of urach...
Source: Orvosi Hetilap - April 23, 2023 Category: General Medicine Authors: Orsolya M ódos Melinda V áradi B álint Dér Attila Keszthelyi Mikl ós Szűcs Henning Reis P éter Nyirády Tibor Szarvas Source Type: research
Transperitoneal laparoscopic umbilical resection of urachal remnants: a feasible surgical method
To date, there is no standard established laparoscopic surgical method for managing urachal remnants because of their rarity, and several questions remain unanswered. Are there any problems for considering the... (Source: BMC Urology)
Source: BMC Urology - April 4, 2023 Category: Urology & Nephrology Authors: Hideo Yuki, Naoya Ohkubo, Ryo Kurashina, Kazumasa Sakamoto, Issei Suzuki, Kohei Takei, Hironori Betsunoh, Akinori Nukui, Masahiro Yashi and Takao Kamai Tags: Research Source Type: research
Complicated urachal cyst in two pediatric patients: a case report
A urachal cyst has a rare incidence that has been reported as 1/5,000 live birth. (Source: BMC Pediatrics)
Source: BMC Pediatrics - March 31, 2023 Category: Pediatrics Authors: Karol Kamel, Hadeer Nasr, Sherifa Tawfik, Ahmed Azzam, Mohamed Elsaid, Mohamed Qinawy, Ahmed Kamal and Heba Taher Tags: Case report Source Type: research
Urachal Adenocarcinoma: a Case Report and Review of the Literature
AbstractUrachal adenocarcinoma is one of the rare and aggressive neoplasms that often presents at an advanced stage and has a poor prognosis. Urachal adenocarcinoma makes up 0.17 to 0.34% of all bladder carcinomas. Patients commonly present with hematuria. Wide local excision of urachal mass with umbilicus and surrounding soft tissue en bloc combined with partial or radical cystectomy and bilateral pelvic lymphadenectomy is considered to be the primary surgical management. However, many publications in literature report that en bloc removal of tumor with umbilicus, entire urachal ligament, and bladder dome alone has long-t...
Source: Indian Journal of Surgical Oncology - March 27, 2023 Category: Cancer & Oncology Source Type: research
Surgical treatment of urachal remnants in an adult population —a single-centre experience
ConclusionThere is a paucity of data available on the management of urachal remnants in the adult population; however, an endoscopic or laparoscopic approach is a safe and effective method of excising symptomatic urachal remnants. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - March 20, 2023 Category: General Medicine Source Type: research
Urachal carcinoma: The journey so far and the road ahead
Pathol Res Pract. 2023 Feb 17;243:154379. doi: 10.1016/j.prp.2023.154379. Online ahead of print.ABSTRACTUrachal carcinoma, a rare cancer arising from urachus, accounts for about 1% of bladder cancer. The diagnosis at stage I shows about 63% 5-year survival whereas only 8% of the patients at stage IV shows a 5-year survival. Above 90% of urachal carcinomas are adenocarcinomas and most of the urachal carcinoma cases are invasive, showing a high resemblance to adenocarcinoma of various origins, making it hard for a conclusive diagnosis. Even though inconclusive, immunohistochemistry can play a significant role in identifying ...
Source: Pathology, Research and Practice - February 23, 2023 Category: Pathology Authors: Rajesh Kumar Seetha Harilal Mohamed A Abdelgawad Mohammed M Ghoneim Arun Kumar Bijo Mathew Source Type: research
Urachal carcinoma: The journey so far and the road ahead
Pathol Res Pract. 2023 Feb 17;243:154379. doi: 10.1016/j.prp.2023.154379. Online ahead of print.ABSTRACTUrachal carcinoma, a rare cancer arising from urachus, accounts for about 1% of bladder cancer. The diagnosis at stage I shows about 63% 5-year survival whereas only 8% of the patients at stage IV shows a 5-year survival. Above 90% of urachal carcinomas are adenocarcinomas and most of the urachal carcinoma cases are invasive, showing a high resemblance to adenocarcinoma of various origins, making it hard for a conclusive diagnosis. Even though inconclusive, immunohistochemistry can play a significant role in identifying ...
Source: Pathology, Research and Practice - February 23, 2023 Category: Pathology Authors: Rajesh Kumar Seetha Harilal Mohamed A Abdelgawad Mohammed M Ghoneim Arun Kumar Bijo Mathew Source Type: research
Clinical value of preoperative serum tumor markers CEA, CA19-9, CA125, and CA15-3 in surgically treated urachal cancer
CONCLUSION: A subset of patients with surgically treated UrAC has elevated STMs preoperatively. CEA was most frequently (40%) elevated and correlated with unfavorable tumor characteristics. However, STM levels did not correlate with prognostic outcomes.PMID:36813613 | DOI:10.1016/j.urolonc.2023.01.018 (Source: Urologic Oncology)
Source: Urologic Oncology - February 22, 2023 Category: Urology & Nephrology Authors: Laura E Stokkel Huub H van Rossum Maaike W van de Kamp Thierry N Boellaard Elise M Bekers Niels F M Kok Bas W G van Rhijn Laura S Mertens Source Type: research
Clinical value of preoperative serum tumor markers CEA, CA19-9, CA125, and CA15-3 in surgically treated urachal cancer
CONCLUSION: A subset of patients with surgically treated UrAC has elevated STMs preoperatively. CEA was most frequently (40%) elevated and correlated with unfavorable tumor characteristics. However, STM levels did not correlate with prognostic outcomes.PMID:36813613 | DOI:10.1016/j.urolonc.2023.01.018 (Source: Urologic Oncology)
Source: Urologic Oncology - February 22, 2023 Category: Urology & Nephrology Authors: Laura E Stokkel Huub H van Rossum Maaike W van de Kamp Thierry N Boellaard Elise M Bekers Niels F M Kok Bas W G van Rhijn Laura S Mertens Source Type: research
Infected Urachal Cyst Mimicking Urachal Carcinoma: A Rare Cause of Lower Abdominal Tenderness
Teaching Point: Infected urachal cysts are a rare cause of abdominal complaints and can be accurately diagnosed by abdominal ultrasound and computed tomography (CT). Published on 2023-02-09 11:22:27 (Source: Journal of the Belgian Society of Radiology)
Source: Journal of the Belgian Society of Radiology - February 9, 2023 Category: Radiology Source Type: research
Preoperative accuracy of diagnostic evaluation of urachal carcinoma
CONCLUSIONS: Imaging and cystoscopy are the powerful diagnostic methods for UrC. Serum tumor markers may assist in diagnosis, prognosis, and monitoring. Positive urine FISH can easily misdiagnose UrC as UCa.PMID:36734315 | DOI:10.1002/cam4.5648 (Source: Cancer Control)
Source: Cancer Control - February 3, 2023 Category: Cancer & Oncology Authors: Chunjin Ke Zhiquan Hu Chunguang Yang Source Type: research
Preoperative accuracy of diagnostic evaluation of urachal carcinoma
ConclusionsImaging and cystoscopy are the powerful diagnostic methods for UrC. Serum tumor markers may assist in diagnosis, prognosis, and monitoring. Positive urine FISH can easily misdiagnose UrC as UCa (Source: Cancer Medicine)
Source: Cancer Medicine - February 3, 2023 Category: Cancer & Oncology Authors: Chunjin Ke,
Zhiquan Hu,
Chunguang Yang Tags: RESEARCH ARTICLE Source Type: research
Clinical sequencing identifies potential actionable alterations in a high rate of urachal and primary bladder adenocarcinomas
ConclusionsIn this study, we developed a data-processing pipeline for the detection and therapeutic interpretation of genetic alterations in two rare cancers. Our analyses revealed actionable mutations in a high rate of cases, suggesting that this approach is a potentially feasible strategy for both UrC and PBAC treatments. (Source: Cancer Medicine)
Source: Cancer Medicine - January 21, 2023 Category: Cancer & Oncology Authors: Melinda Varadi,
Nikolett Nagy,
Henning Reis,
Boris Hadaschik,
Christian Niedworok,
Orsolya Modos,
Attila Szendroi,
Jason Ablat,
Peter C. Black,
David Keresztes,
Anita Csizmarik,
Csilla Olah,
Nadine T. Gaisa,
Andras Kiss,
Jozsef Timar,
Erika Tags: RESEARCH ARTICLE Source Type: research
