Chorea and Cognitive Impairment in JAK2V617F-Positive Myeloproliferative Disorders: A Case Report and Literature Review
We present a case of a male patient with evolving PMF over several years who was admitted for progressive cognitive impairment and generalized involuntary movement disorder. We also present a review of all cases of myeloproliferative disorders presenting with chorea published in the last 40 years.PMID:38276052 | PMC:PMC10817622 | DOI:10.3390/medicina60010018 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - January 26, 2024 Category: Universities & Medical Training Authors: Ioana Butnariu Dana Antonescu-Ghelmez Adriana Moraru Daniela Nicoleta Anghel Florentina Melania Cojocaru Sorin Tu ță Adela Magdalena Ciobanu Florian Antonescu Source Type: research
Chorea and Cognitive Impairment in JAK2V617F-Positive Myeloproliferative Disorders: A Case Report and Literature Review
We present a case of a male patient with evolving PMF over several years who was admitted for progressive cognitive impairment and generalized involuntary movement disorder. We also present a review of all cases of myeloproliferative disorders presenting with chorea published in the last 40 years.PMID:38276052 | PMC:PMC10817622 | DOI:10.3390/medicina60010018 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - January 26, 2024 Category: Universities & Medical Training Authors: Ioana Butnariu Dana Antonescu-Ghelmez Adriana Moraru Daniela Nicoleta Anghel Florentina Melania Cojocaru Sorin Tu ță Adela Magdalena Ciobanu Florian Antonescu Source Type: research
Evaluation of FRESH scores in predicting outcome and quality of life after aneurysmal subarachnoid haemorrhage in a European patient cohort
ConclusionsThis study found no correlation between FRESH scores and validated QoL tools in a European population of aSAH patients. The study highlights the complexity of reliable long-term QoL prognostication in aSAH patients and emphasises the need for further prospective research to also focus on QoL as an important outcome parameter. (Source: Acta Neurochirurgica)
Source: Acta Neurochirurgica - January 23, 2024 Category: Neurosurgery Source Type: research
Antidepressant-induced Paradoxical Anxiety, Akathisia, and Complex Vocal Tics in a Patient with Panic Disorder and Crohn's Disease: A Case Report
CONCLUSION: Antidepressant-induced akathisia and tics are often distressing both to the patient and their loved ones, and they can be very puzzling to the clinician. It is important for clinicians to recognise that, although rare, antidepressants can have the adverse effects of akathisia and tics in patients. When these symptoms arise, it should prompt immediate discontinuation of the offending antidepressant.PMID:38251693 | DOI:10.2174/0115748863270093231114075934 (Source: Current Drug Safety)
Source: Current Drug Safety - January 22, 2024 Category: Drugs & Pharmacology Authors: Azriel Hk Koh Soon Shan Loh Leslie Lim Source Type: research
A synergetic turn in cognitive neuroscience of brain diseases
Trends Cogn Sci. 2024 Jan 20:S1364-6613(23)00306-6. doi: 10.1016/j.tics.2023.12.006. Online ahead of print.ABSTRACTDespite significant improvements in our understanding of brain diseases, many barriers remain. Cognitive neuroscience faces four major challenges: complex structure-function associations; disease phenotype heterogeneity; the lack of transdiagnostic models; and oversimplified cognitive approaches restricted to the laboratory. Here, we propose a synergetics framework that can help to perform the necessary dimensionality reduction of complex interactions between the brain, body, and environment. The key solutions...
Source: Trends Cogn Sci - January 21, 2024 Category: Neuroscience Authors: Agustin Ibanez Morten L Kringelbach Gustavo Deco Source Type: research
Studying large language models as compression algorithms for human culture
Trends Cogn Sci. 2024 Jan 19:S1364-6613(24)00001-9. doi: 10.1016/j.tics.2024.01.001. Online ahead of print.ABSTRACTLarge language models (LLMs) extract and reproduce the statistical regularities in their training data. Researchers can use these models to study the conceptual relationships encoded in this training data (i.e., the open internet), providing a remarkable opportunity to understand the cultural distinctions embedded within much of recorded human communication.PMID:38245431 | DOI:10.1016/j.tics.2024.01.001 (Source: Trends Cogn Sci)
Source: Trends Cogn Sci - January 20, 2024 Category: Neuroscience Authors: Nicholas Buttrick Source Type: research
Genes, Vol. 15, Pages 130: First Case of a Dominant De Novo SEC23A Mutation with Neurological and Psychiatric Features: New Insights into Cranio-Lenticulo-Sutural Dysplasia with Literature Review
Carmelo Piscopo
Cranio-lenticulo-sutural dysplasia (CLSD, OMIM #607812) is a rare genetic condition characterized by late-closing fontanels, skeletal defects, dysmorphisms, and congenital cataracts that are caused by bi-allelic or monoallelic variants in the SEC23A gene. Autosomal recessive inheritance (AR-CLSD) has been extensively documented in several cases with homozygous or compound heterozygous variants in SEC23A, whereas autosomal dominant inheritance (AD-CLSD) involving heterozygous inherited variants has been reported just in three patients. The SEC23A gene encodes for one of the main components of a protein c...
Source: Genes - January 20, 2024 Category: Genetics & Stem Cells Authors: Elia Marco Paolo Minale Alessandro De De Falco Emanuele Agolini Antonio Novelli Roberta Russo Immacolata Andolfo Achille Iolascon Carmelo Piscopo Tags: Article Source Type: research
Co-morbid tics and stereotypies: a systematic literature review
DiscussionTics and stereotypies can often develop in co-morbidity. The association of tics and stereotypies in the same patient has practical implications, in consideration of the different treatment approaches. Future research should focus on the assessment and management of both conditions, particularly in special populations (e.g. patients with pervasive developmental disorders). (Source: Neurological Sciences)
Source: Neurological Sciences - January 18, 2024 Category: Neurology Source Type: research
Relationship between transcranial magnetic stimulation markers of motor control and clinical recovery in obsessive compulsive disorder/Gilles de la Tourette syndrome: a proof of concept case study
ConclusionThis study highlights the importance of better understanding motor inhibitory mechanisms in neurodevelopmental disorders and suggests a biofeedback approach as a potential novel treatment. (Source: Frontiers in Psychiatry)
Source: Frontiers in Psychiatry - January 17, 2024 Category: Psychiatry Source Type: research
What distinguishes patients with mass social media-induced illness presenting with Tourette-like behavior from those with Tourette syndrome? Results of a prospective cohort study
AbstractSince 2019, a global increase in patients presenting with functional Tourette-like behaviors (FTB) has been observed. This has been related to the exposure of tic-related content in social media, although other factors seem to further fuel this phenomenon. Recently, we, therefore, proposed the term mass social media-induced illness (MSMI) as, in our opinion, this phenomenon constitutes a new type of mass sociogenic illness (MSI) that is in contrast to all recent outbreaks spread solely via social media. In accordance with this hypothesis, we were able to identify the host of the German YouTube channel"Gewitter...
Source: European Archives of Psychiatry and Clinical Neuroscience - January 13, 2024 Category: Neuroscience Source Type: research
Online group therapies for anxiety, obsessive-compulsive, and trauma-related disorders: a systematic review
ConclusionThere is evidence supporting the effectiveness of online group treatments for SAD and PTSD. Further studies from different research groups may be needed to replicate the use of these and other forms of online treatments in individuals with SAD, PTSD, and other clinical populations, such as OCD, panic disorder, agoraphobia and specific phobias.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42023408491. (Source: Frontiers in Human Neuroscience)
Source: Frontiers in Human Neuroscience - January 11, 2024 Category: Neuroscience Source Type: research
Information decomposition and the informational architecture of the brain
Trends Cogn Sci. 2024 Jan 9:S1364-6613(23)00284-X. doi: 10.1016/j.tics.2023.11.005. Online ahead of print.ABSTRACTTo explain how the brain orchestrates information-processing for cognition, we must understand information itself. Importantly, information is not a monolithic entity. Information decomposition techniques provide a way to split information into its constituent elements: unique, redundant, and synergistic information. We review how disentangling synergistic and redundant interactions is redefining our understanding of integrative brain function and its neural organisation. To explain how the brain navigates the ...
Source: Trends Cogn Sci - January 10, 2024 Category: Neuroscience Authors: Andrea I Luppi Fernando E Rosas Pedro A M Mediano David K Menon Emmanuel A Stamatakis Source Type: research
Towards an AI policy framework in scholarly publishing
Trends Cogn Sci. 2024 Jan 8:S1364-6613(23)00288-7. doi: 10.1016/j.tics.2023.12.002. Online ahead of print.ABSTRACTThe rapid adoption of artificial intelligence (AI) tools in academic research raises pressing ethical concerns. I examine major publishing policies in science and medicine, uncovering inconsistencies and limitations in guiding AI usage. To encourage responsible AI integration while upholding transparency, I propose an enabling framework with author and reviewer policy templates.PMID:38195365 | DOI:10.1016/j.tics.2023.12.002 (Source: Trends Cogn Sci)
Source: Trends Cogn Sci - January 9, 2024 Category: Neuroscience Authors: Zhicheng Lin Source Type: research
Political reinforcement learners
Trends Cogn Sci. 2024 Jan 8:S1364-6613(23)00287-5. doi: 10.1016/j.tics.2023.12.001. Online ahead of print.ABSTRACTPolitics can seem home to the most calculating and yet least rational elements of humanity. How might we systematically characterize this spectrum of political cognition? Here, we propose reinforcement learning (RL) as a unified framework to dissect the political mind. RL describes how agents algorithmically navigate complex and uncertain domains like politics. Through this computational lens, we outline three routes to political differences, stemming from variability in agents' conceptions of a problem, the co...
Source: Trends Cogn Sci - January 9, 2024 Category: Neuroscience Authors: Lion Schulz Rahul Bhui Source Type: research
