Deep brain stimulation for Tourette syndrome: modulation of the limbic-motor interface network
CONCLUSIONS: The authors demonstrated the involvement of the limbic-motor interface network during effective DBS for tics in patients with TS. OCB redution was associated with the additional involvement of dmPFC/dACC connections passing dorsal to the head of the globus pallidus pars externa on its way to the thalamus and midbrain.PMID:38157543 | DOI:10.3171/2023.10.JNS231317 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - December 29, 2023 Category: Neurosurgery Authors: Josue M Avecillas-Chasin Tommaso Galbiati Mauro Porta Domenico Servello Source Type: research
Deep brain stimulation for Tourette syndrome: modulation of the limbic-motor interface network
CONCLUSIONS: The authors demonstrated the involvement of the limbic-motor interface network during effective DBS for tics in patients with TS. OCB redution was associated with the additional involvement of dmPFC/dACC connections passing dorsal to the head of the globus pallidus pars externa on its way to the thalamus and midbrain.PMID:38157543 | DOI:10.3171/2023.10.JNS231317 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - December 29, 2023 Category: Neurosurgery Authors: Josue M Avecillas-Chasin Tommaso Galbiati Mauro Porta Domenico Servello Source Type: research
Quantification of extravasation and binding of PSMA-targeted nanobubbles by modelling the second-wave phenomenon
ConclusionsThe estimation of parametric maps allows the estimation and visualization of specific binding of PSMA-NBs in PCa. The incorporation of the second-wave phenomenon enrich our understanding of NB kinetics in vivo and can possibly contribute to improved diagnostics of PCa in the future. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - December 27, 2023 Category: Molecular Biology Source Type: research
Neutrophil infiltration associated genes on the prognosis and tumor immune microenvironment of lung adenocarcinoma
In this study, we identified 30 hub genes that were significantly associated with neutrophil infiltration in LUAD through data mining, survival analysis, and multiple tumor-infiltrating immune cells (TICs) analysis, including TIMER, CIBERSORT, QUANTISEQ, XCELL, and MCPCOUNTER. Consensus clustering analysis showed that these 30 hub genes were correlated with clinical features in LUAD. We further developed a neutrophil scoring system based on these hub genes. The neutrophil score was significantly correlated with prognosis and tumor immune microenvironment (TIME) in LUAD. It was also positively associated with PD-L1 expressi...
Source: Frontiers in Immunology - December 22, 2023 Category: Allergy & Immunology Source Type: research
Effect of gamma irradiation and supercritical carbon dioxide sterilization with Novakill ™ or ethanol on the fracture toughness of cortical bone
AbstractSterilization of structural bone allografts is a critical process prior to their clinical use in large cortical bone defects. Gamma irradiation protocols are known to affect tissue integrity in a dose dependent manner. Alternative sterilization treatments, such as supercritical carbon dioxide (SCCO2), are gaining popularity due to advantages such as minimal exposure to denaturants, the lack of toxic residues, superior tissue penetration, and minor impacts on mechanical properties including strength and stiffness. The impact of SCCO2 on the fracture toughness of bone tissue, however, remains unknown. Here, we evalua...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - December 21, 2023 Category: Materials Science Authors: Mihee Shin,
Matthew H. Pelletier,
Vedran Lovric,
William R. Walsh,
Penny J. Martens,
Jamie J. Kruzic,
Bernd Gludovatz Tags: RESEARCH ARTICLE Source Type: research
Spatiotemporal analysis of contrast-enhanced ultrasound for differentiating between malignant and benign breast lesions
ConclusionsThe proposed spatiotemporal analysis for assessing the enhancement heterogeneity shows promising results to aid in the diagnosis of breast cancer by CEUS.Clinical relevance statementThe proposed spatiotemporal method can be developed as a standardized software to automatically quantify the enhancement heterogeneity of breast cancer on CEUS, possibly leading to the improved diagnostic accuracy of differentiation between benign and malignant lesions.Key Points•Advanced spatiotemporal analysis of ultrasound contrast-enhanced loops for aiding the differentiation of malignant or benign breast lesions.•Four parame...
Source: European Radiology - December 19, 2023 Category: Radiology Source Type: research
We know what attention is!
Trends Cogn Sci. 2023 Dec 15:S1364-6613(23)00286-3. doi: 10.1016/j.tics.2023.11.007. Online ahead of print.ABSTRACTAttention is one of the most thoroughly investigated psychological phenomena, yet skepticism about attention is widespread: we do not know what it is, it is too many things, there is no such thing. The deficiencies highlighted are not about experimental work but the adequacy of the scientific theory of attention. Combining common scientific claims about attention into a single theory leads to internal inconsistency. This paper demonstrates that a specific functional conception of attention is incorporated into...
Source: Trends Cogn Sci - December 16, 2023 Category: Neuroscience Authors: Wayne Wu Source Type: research
An active inference perspective for the amygdala complex
Trends Cogn Sci. 2023 Dec 15:S1364-6613(23)00283-8. doi: 10.1016/j.tics.2023.11.004. Online ahead of print.ABSTRACTThe amygdala is a heterogeneous network of subcortical nuclei with central importance in cognitive and clinical neuroscience. Various experimental designs in human psychology and animal model research have mapped multiple conceptual frameworks (e.g., valence/salience and decision making) to ever more refined amygdala circuitry. However, these predominantly bottom up-driven accounts often rely on interpretations tailored to a specific phenomenon, thus preventing comprehensive and integrative theories. We argue ...
Source: Trends Cogn Sci - December 16, 2023 Category: Neuroscience Authors: Ronald Sladky Dominic Kargl Wulf Haubensak Claus Lamm Source Type: research
We know what attention is!
Trends Cogn Sci. 2023 Dec 15:S1364-6613(23)00286-3. doi: 10.1016/j.tics.2023.11.007. Online ahead of print.ABSTRACTAttention is one of the most thoroughly investigated psychological phenomena, yet skepticism about attention is widespread: we do not know what it is, it is too many things, there is no such thing. The deficiencies highlighted are not about experimental work but the adequacy of the scientific theory of attention. Combining common scientific claims about attention into a single theory leads to internal inconsistency. This paper demonstrates that a specific functional conception of attention is incorporated into...
Source: Trends Cogn Sci - December 16, 2023 Category: Neuroscience Authors: Wayne Wu Source Type: research
An active inference perspective for the amygdala complex
Trends Cogn Sci. 2023 Dec 15:S1364-6613(23)00283-8. doi: 10.1016/j.tics.2023.11.004. Online ahead of print.ABSTRACTThe amygdala is a heterogeneous network of subcortical nuclei with central importance in cognitive and clinical neuroscience. Various experimental designs in human psychology and animal model research have mapped multiple conceptual frameworks (e.g., valence/salience and decision making) to ever more refined amygdala circuitry. However, these predominantly bottom up-driven accounts often rely on interpretations tailored to a specific phenomenon, thus preventing comprehensive and integrative theories. We argue ...
Source: Trends Cogn Sci - December 16, 2023 Category: Neuroscience Authors: Ronald Sladky Dominic Kargl Wulf Haubensak Claus Lamm Source Type: research
An active inference perspective for the amygdala complex
Trends Cogn Sci. 2023 Dec 15:S1364-6613(23)00283-8. doi: 10.1016/j.tics.2023.11.004. Online ahead of print.ABSTRACTThe amygdala is a heterogeneous network of subcortical nuclei with central importance in cognitive and clinical neuroscience. Various experimental designs in human psychology and animal model research have mapped multiple conceptual frameworks (e.g., valence/salience and decision making) to ever more refined amygdala circuitry. However, these predominantly bottom up-driven accounts often rely on interpretations tailored to a specific phenomenon, thus preventing comprehensive and integrative theories. We argue ...
Source: Trends Cogn Sci - December 16, 2023 Category: Neuroscience Authors: Ronald Sladky Dominic Kargl Wulf Haubensak Claus Lamm Source Type: research
We know what attention is!
Trends Cogn Sci. 2023 Dec 15:S1364-6613(23)00286-3. doi: 10.1016/j.tics.2023.11.007. Online ahead of print.ABSTRACTAttention is one of the most thoroughly investigated psychological phenomena, yet skepticism about attention is widespread: we do not know what it is, it is too many things, there is no such thing. The deficiencies highlighted are not about experimental work but the adequacy of the scientific theory of attention. Combining common scientific claims about attention into a single theory leads to internal inconsistency. This paper demonstrates that a specific functional conception of attention is incorporated into...
Source: Trends Cogn Sci - December 16, 2023 Category: Neuroscience Authors: Wayne Wu Source Type: research
An active inference perspective for the amygdala complex
Trends Cogn Sci. 2023 Dec 15:S1364-6613(23)00283-8. doi: 10.1016/j.tics.2023.11.004. Online ahead of print.ABSTRACTThe amygdala is a heterogeneous network of subcortical nuclei with central importance in cognitive and clinical neuroscience. Various experimental designs in human psychology and animal model research have mapped multiple conceptual frameworks (e.g., valence/salience and decision making) to ever more refined amygdala circuitry. However, these predominantly bottom up-driven accounts often rely on interpretations tailored to a specific phenomenon, thus preventing comprehensive and integrative theories. We argue ...
Source: Trends Cogn Sci - December 16, 2023 Category: Neuroscience Authors: Ronald Sladky Dominic Kargl Wulf Haubensak Claus Lamm Source Type: research
We know what attention is!
Trends Cogn Sci. 2023 Dec 15:S1364-6613(23)00286-3. doi: 10.1016/j.tics.2023.11.007. Online ahead of print.ABSTRACTAttention is one of the most thoroughly investigated psychological phenomena, yet skepticism about attention is widespread: we do not know what it is, it is too many things, there is no such thing. The deficiencies highlighted are not about experimental work but the adequacy of the scientific theory of attention. Combining common scientific claims about attention into a single theory leads to internal inconsistency. This paper demonstrates that a specific functional conception of attention is incorporated into...
Source: Trends Cogn Sci - December 16, 2023 Category: Neuroscience Authors: Wayne Wu Source Type: research
We know what attention is!
Trends Cogn Sci. 2023 Dec 15:S1364-6613(23)00286-3. doi: 10.1016/j.tics.2023.11.007. Online ahead of print.ABSTRACTAttention is one of the most thoroughly investigated psychological phenomena, yet skepticism about attention is widespread: we do not know what it is, it is too many things, there is no such thing. The deficiencies highlighted are not about experimental work but the adequacy of the scientific theory of attention. Combining common scientific claims about attention into a single theory leads to internal inconsistency. This paper demonstrates that a specific functional conception of attention is incorporated into...
Source: Trends Cogn Sci - December 16, 2023 Category: Neuroscience Authors: Wayne Wu Source Type: research
