Mechanisms for survival: vagal control of goal-directed behavior
Trends Cogn Sci. 2023 Nov 29:S1364-6613(23)00278-4. doi: 10.1016/j.tics.2023.11.001. Online ahead of print.ABSTRACTSurvival is a fundamental physiological drive, and neural circuits have evolved to prioritize actions that meet the energy demands of the body. This fine-tuning of goal-directed actions based on metabolic states ('allostasis') is deeply rooted in our brain, and hindbrain nuclei orchestrate the vital communication between the brain and body through the vagus nerve. Despite mounting evidence for vagal control of allostatic behavior in animals, its broader function in humans is still contested. Based on stimulati...
Source: Trends Cogn Sci - November 30, 2023 Category: Neuroscience Authors: Vanessa Teckentrup Nils B Kroemer Source Type: research
Mechanisms for survival: vagal control of goal-directed behavior
Trends Cogn Sci. 2023 Nov 29:S1364-6613(23)00278-4. doi: 10.1016/j.tics.2023.11.001. Online ahead of print.ABSTRACTSurvival is a fundamental physiological drive, and neural circuits have evolved to prioritize actions that meet the energy demands of the body. This fine-tuning of goal-directed actions based on metabolic states ('allostasis') is deeply rooted in our brain, and hindbrain nuclei orchestrate the vital communication between the brain and body through the vagus nerve. Despite mounting evidence for vagal control of allostatic behavior in animals, its broader function in humans is still contested. Based on stimulati...
Source: Trends Cogn Sci - November 30, 2023 Category: Neuroscience Authors: Vanessa Teckentrup Nils B Kroemer Source Type: research
Mechanisms for survival: vagal control of goal-directed behavior
Trends Cogn Sci. 2023 Nov 29:S1364-6613(23)00278-4. doi: 10.1016/j.tics.2023.11.001. Online ahead of print.ABSTRACTSurvival is a fundamental physiological drive, and neural circuits have evolved to prioritize actions that meet the energy demands of the body. This fine-tuning of goal-directed actions based on metabolic states ('allostasis') is deeply rooted in our brain, and hindbrain nuclei orchestrate the vital communication between the brain and body through the vagus nerve. Despite mounting evidence for vagal control of allostatic behavior in animals, its broader function in humans is still contested. Based on stimulati...
Source: Trends Cogn Sci - November 30, 2023 Category: Neuroscience Authors: Vanessa Teckentrup Nils B Kroemer Source Type: research
Intermediate science knowledge predicts overconfidence
Trends Cogn Sci. 2023 Nov 28:S1364-6613(23)00282-6. doi: 10.1016/j.tics.2023.11.003. Online ahead of print.ABSTRACTLackner et al. found science overconfidence peaks at intermediate levels of knowledge. Those with intermediate knowledge also hold the most negative attitudes toward scientists. In doing so, they provide a novel measure of overconfidence that measures the tendency to give incorrect answers as opposed to answering, 'I don't know'.PMID:38030533 | DOI:10.1016/j.tics.2023.11.003 (Source: Trends Cogn Sci)
Source: Trends Cogn Sci - November 29, 2023 Category: Neuroscience Authors: Carmen Sanchez David Dunning Source Type: research
Intermediate science knowledge predicts overconfidence
Trends Cogn Sci. 2023 Nov 28:S1364-6613(23)00282-6. doi: 10.1016/j.tics.2023.11.003. Online ahead of print.ABSTRACTLackner et al. found science overconfidence peaks at intermediate levels of knowledge. Those with intermediate knowledge also hold the most negative attitudes toward scientists. In doing so, they provide a novel measure of overconfidence that measures the tendency to give incorrect answers as opposed to answering, 'I don't know'.PMID:38030533 | DOI:10.1016/j.tics.2023.11.003 (Source: Trends Cogn Sci)
Source: Trends Cogn Sci - November 29, 2023 Category: Neuroscience Authors: Carmen Sanchez David Dunning Source Type: research
Extracranial malignant rhabdoid tumors in children: high mortality even with the help of an aggressive clinical approach
Conclusion: EMRTs are highly malignant tumors associated with high mortality rates. The loss of SMARCB1/INI1 gene and the protein expression is observed in the vast majority of eMRTs patients. Patients that suffered MRTK are younger than patients with extrarenal EERT and are more prone to lung metastasis, but there is no significant difference in overall survival, possibly due to the higher rate of R0 resection of primary tumors in MRTK. Trial registration: The study was registered on PROSPERO with registration number CRD42023400985.What is Known:• Malignant rhabdoid tumor (MRT) is a rare and highly malignant tumo...
Source: European Journal of Pediatrics - November 29, 2023 Category: Pediatrics Source Type: research
TAC-tics for Leveraging Proximity Biology in Drug Discovery
Chembiochem. 2023 Nov 28:e202300712. doi: 10.1002/cbic.202300712. Online ahead of print.ABSTRACTChemically induced proximity (CIP) refers to co-opting naturally occurring biological pathways using synthetic molecules to recruit neosubstrates that are not normally encountered or to enhance the affinity of naturally occurring interactions. Leveraging proximity biology through CIPs has become a rapidly evolving field and has garnered considerable interest in basic research and drug discovery. PROteolysis Targeting Chimera (PROTAC) is a well-established CIP modality that induces the proximity between a target protein and an E3...
Source: Chembiochem - November 28, 2023 Category: Biochemistry Authors: Dhanusha A Nalawansha Kyle Mangano Willem den Besten Patrick Ryan Potts Source Type: research
TAC-tics for Leveraging Proximity Biology in Drug Discovery
Chembiochem. 2023 Nov 28:e202300712. doi: 10.1002/cbic.202300712. Online ahead of print.ABSTRACTChemically induced proximity (CIP) refers to co-opting naturally occurring biological pathways using synthetic molecules to recruit neosubstrates that are not normally encountered or to enhance the affinity of naturally occurring interactions. Leveraging proximity biology through CIPs has become a rapidly evolving field and has garnered considerable interest in basic research and drug discovery. PROteolysis Targeting Chimera (PROTAC) is a well-established CIP modality that induces the proximity between a target protein and an E3...
Source: Chembiochem - November 28, 2023 Category: Biochemistry Authors: Dhanusha A Nalawansha Kyle Mangano Willem den Besten Patrick Ryan Potts Source Type: research
Generating meaning: active inference and the scope and limits of passive AI
Trends Cogn Sci. 2023 Nov 14:S1364-6613(23)00260-7. doi: 10.1016/j.tics.2023.10.002. Online ahead of print.ABSTRACTProminent accounts of sentient behavior depict brains as generative models of organismic interaction with the world, evincing intriguing similarities with current advances in generative artificial intelligence (AI). However, because they contend with the control of purposive, life-sustaining sensorimotor interactions, the generative models of living organisms are inextricably anchored to the body and world. Unlike the passive models learned by generative AI systems, they must capture and control the sensory co...
Source: Trends Cogn Sci - November 16, 2023 Category: Neuroscience Authors: Giovanni Pezzulo Thomas Parr Paul Cisek Andy Clark Karl Friston Source Type: research
Diagnostic Significance of DCE-MRI-Related Quantitative Parameters for Nasal Cavity and Sinus Tumors
CONCLUSION: DCE-MRI-related quantitative parameters are ideal for the diagnosis of benign and malignant nasal sinus tumors. This modality provides more data for the identification of the nature of the tumor, and thus merits clinical promotion and application.PMID:37971454 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - November 16, 2023 Category: Complementary Medicine Authors: Huan Zhang Lu-Yan Li Li-Yuan Yu Nai-Bin Liu Dong Yang Shao-Jie Zhang Jian-Hua Xu Source Type: research
Generating meaning: active inference and the scope and limits of passive AI
Trends Cogn Sci. 2023 Nov 14:S1364-6613(23)00260-7. doi: 10.1016/j.tics.2023.10.002. Online ahead of print.ABSTRACTProminent accounts of sentient behavior depict brains as generative models of organismic interaction with the world, evincing intriguing similarities with current advances in generative artificial intelligence (AI). However, because they contend with the control of purposive, life-sustaining sensorimotor interactions, the generative models of living organisms are inextricably anchored to the body and world. Unlike the passive models learned by generative AI systems, they must capture and control the sensory co...
Source: Trends Cogn Sci - November 16, 2023 Category: Neuroscience Authors: Giovanni Pezzulo Thomas Parr Paul Cisek Andy Clark Karl Friston Source Type: research
Diagnostic Significance of DCE-MRI-Related Quantitative Parameters for Nasal Cavity and Sinus Tumors
CONCLUSION: DCE-MRI-related quantitative parameters are ideal for the diagnosis of benign and malignant nasal sinus tumors. This modality provides more data for the identification of the nature of the tumor, and thus merits clinical promotion and application.PMID:37971454 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - November 16, 2023 Category: Complementary Medicine Authors: Huan Zhang Lu-Yan Li Li-Yuan Yu Nai-Bin Liu Dong Yang Shao-Jie Zhang Jian-Hua Xu Source Type: research
Generating meaning: active inference and the scope and limits of passive AI
Trends Cogn Sci. 2023 Nov 14:S1364-6613(23)00260-7. doi: 10.1016/j.tics.2023.10.002. Online ahead of print.ABSTRACTProminent accounts of sentient behavior depict brains as generative models of organismic interaction with the world, evincing intriguing similarities with current advances in generative artificial intelligence (AI). However, because they contend with the control of purposive, life-sustaining sensorimotor interactions, the generative models of living organisms are inextricably anchored to the body and world. Unlike the passive models learned by generative AI systems, they must capture and control the sensory co...
Source: Trends Cogn Sci - November 16, 2023 Category: Neuroscience Authors: Giovanni Pezzulo Thomas Parr Paul Cisek Andy Clark Karl Friston Source Type: research
Diagnostic Significance of DCE-MRI-Related Quantitative Parameters for Nasal Cavity and Sinus Tumors
CONCLUSION: DCE-MRI-related quantitative parameters are ideal for the diagnosis of benign and malignant nasal sinus tumors. This modality provides more data for the identification of the nature of the tumor, and thus merits clinical promotion and application.PMID:37971454 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - November 16, 2023 Category: Complementary Medicine Authors: Huan Zhang Lu-Yan Li Li-Yuan Yu Nai-Bin Liu Dong Yang Shao-Jie Zhang Jian-Hua Xu Source Type: research
Generating meaning: active inference and the scope and limits of passive AI
Trends Cogn Sci. 2023 Nov 14:S1364-6613(23)00260-7. doi: 10.1016/j.tics.2023.10.002. Online ahead of print.ABSTRACTProminent accounts of sentient behavior depict brains as generative models of organismic interaction with the world, evincing intriguing similarities with current advances in generative artificial intelligence (AI). However, because they contend with the control of purposive, life-sustaining sensorimotor interactions, the generative models of living organisms are inextricably anchored to the body and world. Unlike the passive models learned by generative AI systems, they must capture and control the sensory co...
Source: Trends Cogn Sci - November 16, 2023 Category: Neuroscience Authors: Giovanni Pezzulo Thomas Parr Paul Cisek Andy Clark Karl Friston Source Type: research
