Abnormal H3K4 enzyme catalytic activity and neuronal morphology caused by ASH1L mutations in individuals with Tourette syndrome
In this study, we validated five pathogenicASH1L rare variants and observed symptoms in patients with simple tics and behavioral comorbidities. Mutations near the catalytic domain of TS patients cause mental state abnormalities and disruptASH1L function by destabilizing its spatial conformation, leading to decreased activity of catalytic H3K4, thereby affecting the neurite growth. We need to conduct larger-scale studies on TS patients and perform additional neurological evaluations on mature neurons. We first reported the effects ofASH1L mutations in TS patients, including phenotypic heterogeneity, protein function, and ne...
Source: European Child and Adolescent Psychiatry - April 18, 2024 Category: Psychiatry Source Type: research
What is abstract about seeing social interactions?
Trends Cogn Sci. 2024 Feb 17:S1364-6613(24)00031-7. doi: 10.1016/j.tics.2024.02.004. Online ahead of print.NO ABSTRACTPMID:38632008 | DOI:10.1016/j.tics.2024.02.004 (Source: Trends Cogn Sci)
Source: Trends Cogn Sci - April 17, 2024 Category: Neuroscience Authors: Liuba Papeo Source Type: research
Abstract social interaction representations along the lateral pathway
Trends Cogn Sci. 2024 Mar 26:S1364-6613(24)00073-1. doi: 10.1016/j.tics.2024.03.007. Online ahead of print.NO ABSTRACTPMID:38632007 | DOI:10.1016/j.tics.2024.03.007 (Source: Trends Cogn Sci)
Source: Trends Cogn Sci - April 17, 2024 Category: Neuroscience Authors: Emalie McMahon Leyla Isik Source Type: research
Information density as a predictor of communication dynamics
Trends Cogn Sci. 2024 Apr 16:S1364-6613(24)00079-2. doi: 10.1016/j.tics.2024.03.012. Online ahead of print.ABSTRACTIn a recent paper, Aceves and Evans computed information and semantic density measures for hundreds of languages, and showed that these measures predict the pace and breadth of ideas in communication. Here, we summarize their key findings and situate them in a broader debate about the adaptive nature of language.PMID:38632006 | DOI:10.1016/j.tics.2024.03.012 (Source: Trends Cogn Sci)
Source: Trends Cogn Sci - April 17, 2024 Category: Neuroscience Authors: Gary Lupyan Pablo Contreras Kallens Rick Dale Source Type: research
Predictors of Impairment and Self-Concept in Children and Adolescents with Persistent Tic Disorder
This study examined predictors of, and associations between, self-concept, demographic variables, and clinical measures in fifty-eight children and adolescents with Persistent Tic Disorder (PTD; 44 males, Mage = 11.9 years, SD = 2.74). Participants completed measures that assessed self-concept, tic severity, tic-related impairment, and comorbid psychological symptoms. Results showed that generalized anxiety disorder, major depressive disorder, persistent depressive disorder, total tic severity, number and complexity of tics, and total and social tic-related impairment were associated with self-concept. Tic-related social i...
Source: Child Psychiatry and Human Development - April 15, 2024 Category: Child Development Authors: Kirsten R Bootes Michael B Himle Jordan T Stiede Brianna C M Wellen Suzanne Mouton-Odum Douglas W Woods Source Type: research
In praise of folly: flexible goals and human cognition
Trends Cogn Sci. 2024 Apr 13:S1364-6613(24)00059-7. doi: 10.1016/j.tics.2024.03.006. Online ahead of print.ABSTRACTHumans often pursue idiosyncratic goals that appear remote from functional ends, including information gain. We suggest that this is valuable because goals (even prima facie foolish or unachievable ones) contain structured information that scaffolds thinking and planning. By evaluating hypotheses and plans with respect to their goals, humans can discover new ideas that go beyond prior knowledge and observable evidence. These hypotheses and plans can be transmitted independently of their original motivations, a...
Source: Trends Cogn Sci - April 15, 2024 Category: Neuroscience Authors: Junyi Chu Joshua B Tenenbaum Laura E Schulz Source Type: research
In praise of folly: flexible goals and human cognition
Trends Cogn Sci. 2024 Apr 13:S1364-6613(24)00059-7. doi: 10.1016/j.tics.2024.03.006. Online ahead of print.ABSTRACTHumans often pursue idiosyncratic goals that appear remote from functional ends, including information gain. We suggest that this is valuable because goals (even prima facie foolish or unachievable ones) contain structured information that scaffolds thinking and planning. By evaluating hypotheses and plans with respect to their goals, humans can discover new ideas that go beyond prior knowledge and observable evidence. These hypotheses and plans can be transmitted independently of their original motivations, a...
Source: Trends Cogn Sci - April 15, 2024 Category: Neuroscience Authors: Junyi Chu Joshua B Tenenbaum Laura E Schulz Source Type: research
Predictors of Impairment and Self-Concept in Children and Adolescents with Persistent Tic Disorder
This study examined predictors of, and associations between, self-concept, demographic variables, and clinical measures in fifty-eight children and adolescents with Persistent Tic Disorder (PTD; 44 males, Mage = 11.9 years, SD = 2.74). Participants completed measures that assessed self-concept, tic severity, tic-related impairment, and comorbid psychological symptoms. Results showed that generalized anxiety disorder, major depressive disorder, persistent depressive disorder, total tic severity, number and complexity of tics, and total and social tic-related impairment were associated with self-concept. Tic-related social i...
Source: Child Psychiatry and Human Development - April 15, 2024 Category: Child Development Authors: Kirsten R Bootes Michael B Himle Jordan T Stiede Brianna C M Wellen Suzanne Mouton-Odum Douglas W Woods Source Type: research
In praise of folly: flexible goals and human cognition
Trends Cogn Sci. 2024 Apr 13:S1364-6613(24)00059-7. doi: 10.1016/j.tics.2024.03.006. Online ahead of print.ABSTRACTHumans often pursue idiosyncratic goals that appear remote from functional ends, including information gain. We suggest that this is valuable because goals (even prima facie foolish or unachievable ones) contain structured information that scaffolds thinking and planning. By evaluating hypotheses and plans with respect to their goals, humans can discover new ideas that go beyond prior knowledge and observable evidence. These hypotheses and plans can be transmitted independently of their original motivations, a...
Source: Trends Cogn Sci - April 15, 2024 Category: Neuroscience Authors: Junyi Chu Joshua B Tenenbaum Laura E Schulz Source Type: research
The dynamic and reciprocal relationship between perceived everyday discrimination and cognitive function in later life
CONCLUSION: Results suggested that a decline in cognitive function may precede and contribute to the worsening of perceived discrimination, which may result in further decline in cognitive function. Lifetime experience of discrimination was discussed as a possible source of the racial/ethnic variations in the relationship. Further study is needed to examine whether this relationship holds among people with cognitive impairment and dementia.PMID:38590239 | DOI:10.1080/13607863.2024.2338196 (Source: Aging and Mental Health)
Source: Aging and Mental Health - April 9, 2024 Category: Geriatrics Authors: Takashi Amano Yuane Jia Audrey Redding Source Type: research
Response to Fittipaldi etal. (2024)
Trends Cogn Sci. 2024 Apr 5:S1364-6613(24)00074-3. doi: 10.1016/j.tics.2024.03.008. Online ahead of print.NO ABSTRACTPMID:38582655 | DOI:10.1016/j.tics.2024.03.008 (Source: Trends Cogn Sci)
Source: Trends Cogn Sci - April 6, 2024 Category: Neuroscience Authors: Nicholas J Fendinger Pia Dietze Eric D Knowles Source Type: research
Brain states as wave-like motifs
Trends Cogn Sci. 2024 Apr 5:S1364-6613(24)00057-3. doi: 10.1016/j.tics.2024.03.004. Online ahead of print.ABSTRACTThere is ample evidence of wave-like activity in the brain at multiple scales and levels. This emerging literature supports the broader adoption of a wave perspective of brain activity. Specifically, a brain state can be described as a set of recurring, sequential patterns of propagating brain activity, namely a wave. We examine a collective body of experimental work investigating wave-like properties. Based on these works, we consider brain states as waves using a scale-agnostic framework across time and space...
Source: Trends Cogn Sci - April 6, 2024 Category: Neuroscience Authors: Maya Foster Dustin Scheinost Source Type: research
Response to Fittipaldi etal. (2024)
Trends Cogn Sci. 2024 Apr 5:S1364-6613(24)00074-3. doi: 10.1016/j.tics.2024.03.008. Online ahead of print.NO ABSTRACTPMID:38582655 | DOI:10.1016/j.tics.2024.03.008 (Source: Trends Cogn Sci)
Source: Trends Cogn Sci - April 6, 2024 Category: Neuroscience Authors: Nicholas J Fendinger Pia Dietze Eric D Knowles Source Type: research
Brain states as wave-like motifs
Trends Cogn Sci. 2024 Apr 5:S1364-6613(24)00057-3. doi: 10.1016/j.tics.2024.03.004. Online ahead of print.ABSTRACTThere is ample evidence of wave-like activity in the brain at multiple scales and levels. This emerging literature supports the broader adoption of a wave perspective of brain activity. Specifically, a brain state can be described as a set of recurring, sequential patterns of propagating brain activity, namely a wave. We examine a collective body of experimental work investigating wave-like properties. Based on these works, we consider brain states as waves using a scale-agnostic framework across time and space...
Source: Trends Cogn Sci - April 6, 2024 Category: Neuroscience Authors: Maya Foster Dustin Scheinost Source Type: research
Response to Fittipaldi etal. (2024)
Trends Cogn Sci. 2024 Apr 5:S1364-6613(24)00074-3. doi: 10.1016/j.tics.2024.03.008. Online ahead of print.NO ABSTRACTPMID:38582655 | DOI:10.1016/j.tics.2024.03.008 (Source: Trends Cogn Sci)
Source: Trends Cogn Sci - April 6, 2024 Category: Neuroscience Authors: Nicholas J Fendinger Pia Dietze Eric D Knowles Source Type: research
