Perceived Negative Effects of Tic Management Strategies in Adults With Tic Disorders
This study explored perceived negative effects of tic management strategies in adults with TDs and predictors of these experiences. Participants (N = 72) completed semi-structured interviews 11 years after receiving behavior therapy or supportive therapy in a randomized clinical trial. We examined responses to interview questions about managing tics and predictors of reported negative effects. Most participants did not experience tic worsening (84%) or tic substitution (75%) from tic management strategies. The majority felt they could manage tics while participating in their environment (87%) and did not report life interf...
Source: Behavior Modification - April 1, 2024 Category: Psychiatry & Psychology Authors: Kathryn E Barber Brandon X Pitts Jordan T Stiede Flint M Espil Douglas W Woods Matthew W Specht Shannon M Bennett John T Walkup Emily J Ricketts Joseph F McGuire Alan L Peterson Scott N Compton Sabine Wilhelm Lawrence Scahill John C Piacentini Source Type: research
Perceived Negative Effects of Tic Management Strategies in Adults With Tic Disorders
This study explored perceived negative effects of tic management strategies in adults with TDs and predictors of these experiences. Participants (N = 72) completed semi-structured interviews 11 years after receiving behavior therapy or supportive therapy in a randomized clinical trial. We examined responses to interview questions about managing tics and predictors of reported negative effects. Most participants did not experience tic worsening (84%) or tic substitution (75%) from tic management strategies. The majority felt they could manage tics while participating in their environment (87%) and did not report life interf...
Source: Behavior Modification - April 1, 2024 Category: Psychiatry & Psychology Authors: Kathryn E Barber Brandon X Pitts Jordan T Stiede Flint M Espil Douglas W Woods Matthew W Specht Shannon M Bennett John T Walkup Emily J Ricketts Joseph F McGuire Alan L Peterson Scott N Compton Sabine Wilhelm Lawrence Scahill John C Piacentini Source Type: research
Perceived Negative Effects of Tic Management Strategies in Adults With Tic Disorders
This study explored perceived negative effects of tic management strategies in adults with TDs and predictors of these experiences. Participants (N = 72) completed semi-structured interviews 11 years after receiving behavior therapy or supportive therapy in a randomized clinical trial. We examined responses to interview questions about managing tics and predictors of reported negative effects. Most participants did not experience tic worsening (84%) or tic substitution (75%) from tic management strategies. The majority felt they could manage tics while participating in their environment (87%) and did not report life interf...
Source: Behavior Modification - April 1, 2024 Category: Psychiatry & Psychology Authors: Kathryn E Barber Brandon X Pitts Jordan T Stiede Flint M Espil Douglas W Woods Matthew W Specht Shannon M Bennett John T Walkup Emily J Ricketts Joseph F McGuire Alan L Peterson Scott N Compton Sabine Wilhelm Lawrence Scahill John C Piacentini Source Type: research
GSE243883 CRISPR pooled screen and QuantSeq 3' mRNA sequencing to identify microRNAs (miRNAs) important for Breast Cancer 3D growth [RNA-seq]
In this study, we conducted genome-wide CRISPR-Cas9 screens within 3D tumorspheres of two BC cell lines, MCF7 (ER+) and HCC1395 (TNBC). Our objective was to identify miRNAs that govern TIC viability, employing CRISPR/Cas9 pooled screens that targeted a total of 19,052 genes and 1,864 miRNAs. By suppressing relevant miRNAs following QuantSeq 3' mRNA sequencing we identify the genes regulated by those miRNAs (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - March 31, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE243882 CRISPR pooled screen and QuantSeq 3' mRNA sequencing to identify microRNAs (miRNAs) important for Breast Cancer 3D growth [CRISPR screen]
In this study, we conducted genome-wide CRISPR-Cas9 screens within 3D tumorspheres of two BC cell lines, MCF7 (ER+) and HCC1395 (TNBC). Our objective was to identify miRNAs that govern TIC viability, employing CRISPR/Cas9 pooled screens that targeted a total of 19,052 genes and 1,864 miRNAs. By suppressing relevant miRNAs following QuantSeq 3' mRNA sequencing we identify the genes regulated by those miRNAs (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - March 31, 2024 Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research
Computational role of structure in neural activity and connectivity
Trends Cogn Sci. 2024 Mar 28:S1364-6613(24)00056-1. doi: 10.1016/j.tics.2024.03.003. Online ahead of print.ABSTRACTOne major challenge of neuroscience is identifying structure in seemingly disorganized neural activity. Different types of structure have different computational implications that can help neuroscientists understand the functional role of a particular brain area. Here, we outline a unified approach to characterize structure by inspecting the representational geometry and the modularity properties of the recorded activity and show that a similar approach can also reveal structure in connectivity. We start by se...
Source: Trends Cogn Sci - March 29, 2024 Category: Neuroscience Authors: Srdjan Ostojic Stefano Fusi Source Type: research
Computational role of structure in neural activity and connectivity
Trends Cogn Sci. 2024 Mar 28:S1364-6613(24)00056-1. doi: 10.1016/j.tics.2024.03.003. Online ahead of print.ABSTRACTOne major challenge of neuroscience is identifying structure in seemingly disorganized neural activity. Different types of structure have different computational implications that can help neuroscientists understand the functional role of a particular brain area. Here, we outline a unified approach to characterize structure by inspecting the representational geometry and the modularity properties of the recorded activity and show that a similar approach can also reveal structure in connectivity. We start by se...
Source: Trends Cogn Sci - March 29, 2024 Category: Neuroscience Authors: Srdjan Ostojic Stefano Fusi Source Type: research
Computational role of structure in neural activity and connectivity
Trends Cogn Sci. 2024 Mar 28:S1364-6613(24)00056-1. doi: 10.1016/j.tics.2024.03.003. Online ahead of print.ABSTRACTOne major challenge of neuroscience is identifying structure in seemingly disorganized neural activity. Different types of structure have different computational implications that can help neuroscientists understand the functional role of a particular brain area. Here, we outline a unified approach to characterize structure by inspecting the representational geometry and the modularity properties of the recorded activity and show that a similar approach can also reveal structure in connectivity. We start by se...
Source: Trends Cogn Sci - March 29, 2024 Category: Neuroscience Authors: Srdjan Ostojic Stefano Fusi Source Type: research
Computational role of structure in neural activity and connectivity
Trends Cogn Sci. 2024 Mar 28:S1364-6613(24)00056-1. doi: 10.1016/j.tics.2024.03.003. Online ahead of print.ABSTRACTOne major challenge of neuroscience is identifying structure in seemingly disorganized neural activity. Different types of structure have different computational implications that can help neuroscientists understand the functional role of a particular brain area. Here, we outline a unified approach to characterize structure by inspecting the representational geometry and the modularity properties of the recorded activity and show that a similar approach can also reveal structure in connectivity. We start by se...
Source: Trends Cogn Sci - March 29, 2024 Category: Neuroscience Authors: Srdjan Ostojic Stefano Fusi Source Type: research
Aphantasia and hyperphantasia: exploring imagery vividness extremes
Trends Cogn Sci. 2024 Mar 9:S1364-6613(24)00034-2. doi: 10.1016/j.tics.2024.02.007. Online ahead of print.ABSTRACTThe vividness of imagery varies between individuals. However, the existence of people in whom conscious, wakeful imagery is markedly reduced, or absent entirely, was neglected by psychology until the recent coinage of 'aphantasia' to describe this phenomenon. 'Hyperphantasia' denotes the converse - imagery whose vividness rivals perceptual experience. Around 1% and 3% of the population experience extreme aphantasia and hyperphantasia, respectively. Aphantasia runs in families, often affects imagery across sever...
Source: Trends Cogn Sci - March 28, 2024 Category: Neuroscience Authors: Adam Zeman Source Type: research
Aphantasia and hyperphantasia: exploring imagery vividness extremes
Trends Cogn Sci. 2024 Mar 9:S1364-6613(24)00034-2. doi: 10.1016/j.tics.2024.02.007. Online ahead of print.ABSTRACTThe vividness of imagery varies between individuals. However, the existence of people in whom conscious, wakeful imagery is markedly reduced, or absent entirely, was neglected by psychology until the recent coinage of 'aphantasia' to describe this phenomenon. 'Hyperphantasia' denotes the converse - imagery whose vividness rivals perceptual experience. Around 1% and 3% of the population experience extreme aphantasia and hyperphantasia, respectively. Aphantasia runs in families, often affects imagery across sever...
Source: Trends Cogn Sci - March 28, 2024 Category: Neuroscience Authors: Adam Zeman Source Type: research
Type II Thyroplasty with Bilateral Partial Cricothyroid Myectomy for Vocal Tic in Child with Cerebral Dysgenesis
Vocal tics can occur in neuropsychiatric disorders and result in familial distress. Management is challenging, particularly in children with developmental delay. A 5-year-old with cerebral dysgenesis presented with a high amplitude, high-frequency vocal tic. Type II thyroplasty with bilateral cricothyroid muscle myectomy was performed after initial botulinum toxin trial. Amount, volume, and pitch of tics significantly decreased, without change in swallow. Benefits persisted at 1-year follow-up. This is the first description of combined type II thyroplasty with cricothyroid myectomy for high-frequency vocal tic. (Source: Journal of Voice)
Source: Journal of Voice - March 26, 2024 Category: ENT & OMF Authors: Matthew R. Hoffman, Abby Wickre, Emma Thayer, Marshall E. Smith Source Type: research
Link between neurodevelopmental disorders and suicidal risk in children
CONCLUSION: The observed frequency of traits indicative of neurodevelopmental disorders in our population was higher than that observed in the general population, without the presented symptoms being eligible for categorical diagnosis. Considering the dimensional aspects of neurodevelopmental symptoms would therefore enable better identification of children at suicidal risk and more tailored interventions to contribute to the prevention of suicide in children.PMID:38523026 | DOI:10.1016/j.encep.2023.12.002 (Source: L Encephale)
Source: L Encephale - March 24, 2024 Category: Psychiatry Authors: Julie L évy-Bencheton Pauline Chaste M élisande Sansen Source Type: research
