Exploration of newly synthesized amantadine-thiourea conjugates for their DNA binding, anti-elastase, and anti-glioma potentials
Int J Biol Macromol. 2024 Feb 16:130231. doi: 10.1016/j.ijbiomac.2024.130231. Online ahead of print.ABSTRACTThree newly synthesized amantadine thiourea conjugates namely MS-1 N-(((3 s,5 s,7 s)-adamantan-1-yl)carbamothioyl)benzamide, MS-2 N-(((3 s,5 s,7 s)-adamantan-1-yl)carbamothioyl)-4-methylbenzamide and MS-3 N-((3 s,5 s,7 s)-adamantan-1-ylcarbamothioyl)-4-chlorobenzamide were investigated for their structures, bindings (DNA/ elastase), and for their impact on healthy and cancerous cells. Theoretical (DFT/docking) and experimental {UV-visible (UV-), fluorescence (Flu-), and cyclic voltammetry (CV)} studies indicated bind...
Source: International Journal of Biological Macromolecules - February 18, 2024 Category: Biochemistry Authors: Nasima Arshad Muhammad Shakeel Aneela Javed Fouzia Perveen Aamer Saeed Atteeque Ahmed Hammad Ismail Pervaiz Ali Channar Fatima Naseer Source Type: research
Tackling Influenza A virus by M2 ion channel blockers: Latest progress and limitations
Eur J Med Chem. 2024 Feb 3;267:116172. doi: 10.1016/j.ejmech.2024.116172. Online ahead of print.ABSTRACTInfluenza outbreaks cause pandemics in millions of people. The treatment of influenza remains a challenge due to significant genetic polymorphism in the influenza virus. Also, developing vaccines to protect against seasonal and pandemic influenza infections is constantly impeded. Thus, antibiotics are the only first line of defense against antigenically distinct strains or new subtypes of influenza viruses. Among several anti-influenza targets, the M2 protein of the influenza virus performs several activities. M2 protein...
Source: European Journal of Medicinal Chemistry - February 8, 2024 Category: Chemistry Authors: Gautam Kumar Kakade Aditi Sakharam Source Type: research
Emerging drugs for the treatment of irritability associated with autism spectrum disorder
Expert Opin Emerg Drugs. 2024 Jan 31:1-12. doi: 10.1080/14728214.2024.2313650. Online ahead of print.ABSTRACTINTRODUCTION: Autism spectrum disorder (ASD) is an early-onset disorder with a prevalence of 1% among children and reported disability-adjusted life years of 4.31 million. Irritability is a challenging behavior associated with ASD, for which medication development has lagged. More specifically, pharmacotherapy effectiveness may be limited against high adverse effects (considering side effect profiles and patient medication sensitivity); thus, the possible benefits of pharmacological interventions must be balanced ag...
Source: Expert Opinion on Emerging Drugs - January 31, 2024 Category: Drugs & Pharmacology Authors: Ahmad Shamabadi Hanie Karimi Razman Arabzadeh Bahri Mohsen Motavaselian Shahin Akhondzadeh Source Type: research
Calcium Modulating Effect of Polycyclic Cages: A Suitable Therapeutic Approach Against Excitotoxic-induced Neurodegeneration
Mini Rev Med Chem. 2024 Jan 24. doi: 10.2174/0113895575273868231128104121. Online ahead of print.ABSTRACTNeurodegenerative disorders pose a significant challenge to global healthcare systems due to their progressive nature and the resulting loss of neuronal cells and functions. Excitotoxicity, characterized by calcium overload, plays a critical role in the pathophysiology of these disorders. In this review article, we explore the involvement of calcium dysregulation in neurodegeneration and neurodegenerative disorders. A promising therapeutic strategy to counter calcium dysregulation involves the use of calcium modulators,...
Source: Mini Reviews in Medicinal Chemistry - January 26, 2024 Category: Chemistry Authors: Ayodeji O Egunlusi Sarel F Malan Vitalii A Palchykov Jacques Joubert Source Type: research
The Association of Antidepressant Use and Impulse Control Disorder in Parkinson's Disease
CONCLUSIONS: Serotonergic antidepressant use appears to be temporally associated with ICD in patients with PD.PMID:38238235 | DOI:10.1016/j.jagp.2023.12.024 (Source: Am J Geriatr Psychia...)
Source: Am J Geriatr Psychia... - January 18, 2024 Category: Geriatrics Authors: Christopher B Morrow Jared T Hinkle Joseph Seemiller Kelly A Mills Gregory M Pontone Source Type: research
The Association of Antidepressant Use and Impulse Control Disorder in Parkinson's Disease
CONCLUSIONS: Serotonergic antidepressant use appears to be temporally associated with ICD in patients with PD.PMID:38238235 | DOI:10.1016/j.jagp.2023.12.024 (Source: The American Journal of Geriatric Psychiatry)
Source: The American Journal of Geriatric Psychiatry - January 18, 2024 Category: Psychiatry Authors: Christopher B Morrow Jared T Hinkle Joseph Seemiller Kelly A Mills Gregory M Pontone Source Type: research
Amantadine and/or transcranial magnetic stimulation for fatigue associated with multiple sclerosis (FETEM): study protocol for a phase 3 randomised, double-blind, cross-over, controlled clinical trial
Introduction
Fatigue is one of the most disabling symptoms of multiple sclerosis (MS), and effective treatments are lacking. Amantadine is one of the most used treatments, although its efficacy is under debate. Transcranial magnetic stimulation (TMS) is a promising intervention that has shown positive effects in some preliminary investigations. We aim to investigate the effect of 6 weeks of amantadine and/or TMS in fatigue due to MS.
Methods and analysis
The study is a national, multicentre, phase 3, randomised, double-blind, cross-over, placebo-controlled and sham-controlled clinical trial. Adult patients with relapsing-...
Source: BMJ Open - January 4, 2024 Category: General Medicine Authors: Matias-Guiu, J. A., Gonzalez-Rosa, J., Hernandez, M. A., Martinez-Gines, M. L., Portoles, A., Perez-Macias, N., Benito-Leon, J., Padron, I., Prieto, J., Matias-Guiu, J. Tags: Open access, Neurology Source Type: research
A bridge to recovery: Acute amantadine prior to environmental enrichment after brain trauma augments cognitive benefit
Exp Neurol. 2023 Dec 9:114648. doi: 10.1016/j.expneurol.2023.114648. Online ahead of print.ABSTRACTEnvironmental enrichment (EE) facilitates motor and cognitive recovery after traumatic brain injury (TBI). Historically, EE has been provided immediately and continuously after TBI, but this paradigm does not model the clinic where rehabilitation is typically not initiated until after critical care. Yet, treating TBI early may facilitate recovery. Hence, we sought to provide amantadine (AMT) as a bridge therapy before commencing EE. It was hypothesized that bridging EE with AMT would augment motor and cognitive benefits. Anes...
Source: Experimental Neurology - December 11, 2023 Category: Neurology Authors: Vincent J Vozzella Rachel A Bittner Tyler S Ranellone Kelsey M Grimm Kelsey N Palmer Anna N Carpio Quinn C Abel Eleni H Moschonas Corina O Bondi Anthony E Kline Source Type: research
A bridge to recovery: Acute amantadine prior to environmental enrichment after brain trauma augments cognitive benefit
Exp Neurol. 2023 Dec 9:114648. doi: 10.1016/j.expneurol.2023.114648. Online ahead of print.ABSTRACTEnvironmental enrichment (EE) facilitates motor and cognitive recovery after traumatic brain injury (TBI). Historically, EE has been provided immediately and continuously after TBI, but this paradigm does not model the clinic where rehabilitation is typically not initiated until after critical care. Yet, treating TBI early may facilitate recovery. Hence, we sought to provide amantadine (AMT) as a bridge therapy before commencing EE. It was hypothesized that bridging EE with AMT would augment motor and cognitive benefits. Anes...
Source: Experimental Neurology - December 11, 2023 Category: Neurology Authors: Vincent J Vozzella Rachel A Bittner Tyler S Ranellone Kelsey M Grimm Kelsey N Palmer Anna N Carpio Quinn C Abel Eleni H Moschonas Corina O Bondi Anthony E Kline Source Type: research
A bridge to recovery: Acute amantadine prior to environmental enrichment after brain trauma augments cognitive benefit
Exp Neurol. 2023 Dec 9:114648. doi: 10.1016/j.expneurol.2023.114648. Online ahead of print.ABSTRACTEnvironmental enrichment (EE) facilitates motor and cognitive recovery after traumatic brain injury (TBI). Historically, EE has been provided immediately and continuously after TBI, but this paradigm does not model the clinic where rehabilitation is typically not initiated until after critical care. Yet, treating TBI early may facilitate recovery. Hence, we sought to provide amantadine (AMT) as a bridge therapy before commencing EE. It was hypothesized that bridging EE with AMT would augment motor and cognitive benefits. Anes...
Source: Experimental Neurology - December 11, 2023 Category: Neurology Authors: Vincent J Vozzella Rachel A Bittner Tyler S Ranellone Kelsey M Grimm Kelsey N Palmer Anna N Carpio Quinn C Abel Eleni H Moschonas Corina O Bondi Anthony E Kline Source Type: research
Screening of Crucial Cytosolicproteins Interconnecting the Endoplasmic Reticulum and Mitochondria in Parkinson's Disease and the Impact of Anti-Parkinson Drugs in the Preservation of Organelle Connectivity
Brain Sci. 2023 Nov 5;13(11):1551. doi: 10.3390/brainsci13111551.ABSTRACTMitochondrial dysfunction is well-established in Parkinson's disease (PD); however, its dysfunctions associating with cell organelle connectivity remain unknown. We aimed to establish the crucial cytosolic protein involved in organelle connectivity between mitochondria and the endopalmic reticulum (ER) through a computational approach by constructing an organelle protein network to extract functional clusters presenting the crucial PD protein connecting organelles. Then, we assessed the influence of anti-parkinsonism drugs (n = 35) on the crucial prot...
Source: Cancer Control - November 25, 2023 Category: Cancer & Oncology Authors: Athira Anirudhan S Mahema Sheikh F Ahmad Talha Bin Emran Shiek S S J Ahmed Prabu Paramasivam Source Type: research
Cancers, Vol. 15, Pages 5541: Melanin & mdash;The & Eacute;minence Grise of Melanoma and Parkinson & rsquo;s Disease Development
This study also tested the hypothesis that certain drugs used in the treatment of PD (L-DOPA, MAO-B and COMT inhibitors, and amantadine), aimed at increasing dopamine concentration, could potentially contribute to the development of melanoma. The role and properties of melanins should continue to be researched. Whether excessive melanin synthesis or its accumulation in the extracellular space may be factors initiating the development of diseases remains an open question. (Source: Cancers)
Source: Cancers - November 23, 2023 Category: Cancer & Oncology Authors: Danuta Krasowska Agata Ma łek Joanna Kurzepa Lucyna Kapka-Skrzypczak Dorota Krasowska Jacek Kurzepa Tags: Review Source Type: research
Discussion
Dr Maggie Brandt (University of Oklahoma): In your amantadine group, you indicated it was physician-specific. Is there some sort of protocol in your institution, such as when you do or do not administer amantadine? Did you look at any of the other medications, like the atypical antipsychotic meds? If they were given amantadine and stopped amantadine, did you put them in the amantadine group, or were they included in the no-amantadine group? Was age a factor? If a patient was over a certain age or under a certain age, could you tell if that had any effect either on whether they received amantadine or what their outcome was?...
Source: Surgery - November 17, 2023 Category: Surgery Source Type: research
The effect of amantadine on acute cognitive disability after severe traumatic brain injury: An institutional pilot study
Amantadine is used in the post-acute care setting to improve cognitive function after a traumatic brain injury. Its utility in the acute postinjury period is unknown. In this pilot study, we sought to examine the effect of amantadine on short-term cognitive disability among patients with a severe traumatic brain injury and hypothesized that patients receiving amantadine would have a greater improvement in disability throughout their acute hospitalization. (Source: Surgery)
Source: Surgery - November 17, 2023 Category: Surgery Authors: Brett M. Tracy, Shruthi Srinivas, Kelly D. Nahum, Wendy L. Wahl, Rondi B. Gelbard Source Type: research
Improvement of Tardive Dyskinesias with Olanzapine
Case Rep Psychiatry. 2023 Oct 23;2023:6688623. doi: 10.1155/2023/6688623. eCollection 2023.ABSTRACTTardive dyskinesia (TD) is characterized by abnormal and involuntary movements that generally occur after prolonged exposure to neuroleptic medications. In this article, we present the case of a 29-year-old man with schizophrenia who developed TD following treatment with haloperidol. Despite various attempts with benzodiazepines, amantadine, and anticholinergics, the dyskinesias persisted. However, after 2 years of treatment with olanzapine alone, a progressive improvement occurred, leading to the complete disappearance of th...
Source: Case Reports in Psychiatry - November 1, 2023 Category: Psychiatry Authors: S Echater B Oneib Source Type: research
