Optimising recovery of consciousness after coma. From bench to bedside and vice versa
DISCUSSION: Personalised sensory stimulation, median nerve stimulation, transcranial direct current stimulation (tDCS), amantadine and zolpidem all have favourable risk-benefit ratios and are easy to implement in clinical practice. These treatments should be proposed to every patient with chronic DoC. Comprehensive patient management should also include regular lifting, pain assessment and treatment, attempts to restore sleep and circadian rhythms, implementation of rest periods, comfort and nursing care, and a rehabilitation program with a multi-disciplinary team with expertise in this field. More invasive treatments may ...
Source: Presse Medicale - March 22, 2023 Category: General Medicine Authors: Jacques Luaut é Maude Beaudoin-Gobert Source Type: research
Optimising recovery of consciousness after coma. From bench to bedside and vice versa
DISCUSSION: Personalised sensory stimulation, median nerve stimulation, transcranial direct current stimulation (tDCS), amantadine and zolpidem all have favourable risk-benefit ratios and are easy to implement in clinical practice. These treatments should be proposed to every patient with chronic DoC. Comprehensive patient management should also include regular lifting, pain assessment and treatment, attempts to restore sleep and circadian rhythms, implementation of rest periods, comfort and nursing care, and a rehabilitation program with a multi-disciplinary team with expertise in this field. More invasive treatments may ...
Source: Presse Medicale - March 22, 2023 Category: General Medicine Authors: Jacques Luaut é Maude Beaudoin-Gobert Source Type: research
Optimising recovery of consciousness after coma. From bench to bedside and vice versa
DISCUSSION: Personalised sensory stimulation, median nerve stimulation, transcranial direct current stimulation (tDCS), amantadine and zolpidem all have favourable risk-benefit ratios and are easy to implement in clinical practice. These treatments should be proposed to every patient with chronic DoC. Comprehensive patient management should also include regular lifting, pain assessment and treatment, attempts to restore sleep and circadian rhythms, implementation of rest periods, comfort and nursing care, and a rehabilitation program with a multi-disciplinary team with expertise in this field. More invasive treatments may ...
Source: Presse Medicale - March 22, 2023 Category: General Medicine Authors: Jacques Luaut é Maude Beaudoin-Gobert Source Type: research
Optimising recovery of consciousness after coma. From bench to bedside and vice versa
DISCUSSION: Personalised sensory stimulation, median nerve stimulation, transcranial direct current stimulation (tDCS), amantadine and zolpidem all have favourable risk-benefit ratios and are easy to implement in clinical practice. These treatments should be proposed to every patient with chronic DoC. Comprehensive patient management should also include regular lifting, pain assessment and treatment, attempts to restore sleep and circadian rhythms, implementation of rest periods, comfort and nursing care, and a rehabilitation program with a multi-disciplinary team with expertise in this field. More invasive treatments may ...
Source: Presse Medicale - March 22, 2023 Category: General Medicine Authors: Jacques Luaut é Maude Beaudoin-Gobert Source Type: research
Optimising recovery of consciousness after coma. From bench to bedside and vice versa
DISCUSSION: Personalised sensory stimulation, median nerve stimulation, transcranial direct current stimulation (tDCS), amantadine and zolpidem all have favourable risk-benefit ratios and are easy to implement in clinical practice. These treatments should be proposed to every patient with chronic DoC. Comprehensive patient management should also include regular lifting, pain assessment and treatment, attempts to restore sleep and circadian rhythms, implementation of rest periods, comfort and nursing care, and a rehabilitation program with a multi-disciplinary team with expertise in this field. More invasive treatments may ...
Source: Presse Medicale - March 22, 2023 Category: General Medicine Authors: Jacques Luaut é Maude Beaudoin-Gobert Source Type: research
Optimising recovery of consciousness after coma. From bench to bedside and vice versa
DISCUSSION: Personalised sensory stimulation, median nerve stimulation, transcranial direct current stimulation (tDCS), amantadine and zolpidem all have favourable risk-benefit ratios and are easy to implement in clinical practice. These treatments should be proposed to every patient with chronic DoC. Comprehensive patient management should also include regular lifting, pain assessment and treatment, attempts to restore sleep and circadian rhythms, implementation of rest periods, comfort and nursing care, and a rehabilitation program with a multi-disciplinary team with expertise in this field. More invasive treatments may ...
Source: Presse Medicale - March 22, 2023 Category: General Medicine Authors: Jacques Luaut é Maude Beaudoin-Gobert Source Type: research
Optimising recovery of consciousness after coma. From bench to bedside and vice versa
DISCUSSION: Personalised sensory stimulation, median nerve stimulation, transcranial direct current stimulation (tDCS), amantadine and zolpidem all have favourable risk-benefit ratios and are easy to implement in clinical practice. These treatments should be proposed to every patient with chronic DoC. Comprehensive patient management should also include regular lifting, pain assessment and treatment, attempts to restore sleep and circadian rhythms, implementation of rest periods, comfort and nursing care, and a rehabilitation program with a multi-disciplinary team with expertise in this field. More invasive treatments may ...
Source: Presse Medicale - March 22, 2023 Category: General Medicine Authors: Jacques Luaut é Maude Beaudoin-Gobert Source Type: research
Optimising recovery of consciousness after coma. From bench to bedside and vice versa
DISCUSSION: Personalised sensory stimulation, median nerve stimulation, transcranial direct current stimulation (tDCS), amantadine and zolpidem all have favourable risk-benefit ratios and are easy to implement in clinical practice. These treatments should be proposed to every patient with chronic DoC. Comprehensive patient management should also include regular lifting, pain assessment and treatment, attempts to restore sleep and circadian rhythms, implementation of rest periods, comfort and nursing care, and a rehabilitation program with a multi-disciplinary team with expertise in this field. More invasive treatments may ...
Source: Presse Medicale - March 22, 2023 Category: General Medicine Authors: Jacques Luaut é Maude Beaudoin-Gobert Source Type: research
Optimising recovery of consciousness after coma. From bench to bedside and vice versa
DISCUSSION: Personalised sensory stimulation, median nerve stimulation, transcranial direct current stimulation (tDCS), amantadine and zolpidem all have favourable risk-benefit ratios and are easy to implement in clinical practice. These treatments should be proposed to every patient with chronic DoC. Comprehensive patient management should also include regular lifting, pain assessment and treatment, attempts to restore sleep and circadian rhythms, implementation of rest periods, comfort and nursing care, and a rehabilitation program with a multi-disciplinary team with expertise in this field. More invasive treatments may ...
Source: Presse Medicale - March 22, 2023 Category: General Medicine Authors: Jacques Luaut é Maude Beaudoin-Gobert Source Type: research
Optimising recovery of consciousness after coma. From bench to bedside and vice versa
DISCUSSION: Personalised sensory stimulation, median nerve stimulation, transcranial direct current stimulation (tDCS), amantadine and zolpidem all have favourable risk-benefit ratios and are easy to implement in clinical practice. These treatments should be proposed to every patient with chronic DoC. Comprehensive patient management should also include regular lifting, pain assessment and treatment, attempts to restore sleep and circadian rhythms, implementation of rest periods, comfort and nursing care, and a rehabilitation program with a multi-disciplinary team with expertise in this field. More invasive treatments may ...
Source: Presse Medicale - March 22, 2023 Category: General Medicine Authors: Jacques Luaut é Maude Beaudoin-Gobert Source Type: research
Optimising recovery of consciousness after coma. From bench to bedside and vice versa
DISCUSSION: Personalised sensory stimulation, median nerve stimulation, transcranial direct current stimulation (tDCS), amantadine and zolpidem all have favourable risk-benefit ratios and are easy to implement in clinical practice. These treatments should be proposed to every patient with chronic DoC. Comprehensive patient management should also include regular lifting, pain assessment and treatment, attempts to restore sleep and circadian rhythms, implementation of rest periods, comfort and nursing care, and a rehabilitation program with a multi-disciplinary team with expertise in this field. More invasive treatments may ...
Source: Presse Medicale - March 22, 2023 Category: General Medicine Authors: Jacques Luaut é Maude Beaudoin-Gobert Source Type: research
Efficacy of oral amantadine among patients hospitalised with COVID-19: A randomised, double-blind, placebo-controlled, multicentre study
Respir Med. 2023 Mar 15:107198. doi: 10.1016/j.rmed.2023.107198. Online ahead of print.ABSTRACTBACKGROUND: Amantadine has been proposed as a treatment for COVID-19 because it shows anti-SARS-CoV-2 activity in vitro. However, to date, no controlled study has assessed the safety and efficacy of amantadine in COVID-19.RESEARCH QUESTION: Whether amantadine is effective and safe among patients with different COVID-19 severity classifications.STUDY DESIGN: and Methods: This was multi-centre, randomised, placebo-controlled study.Patients with oxygen saturation ≤94% and no need for high-flow oxygen or ventilatory support were ra...
Source: Respiratory Care - March 17, 2023 Category: Respiratory Medicine Authors: Adam Barczyk Ma łgorzata Czajkowska-Malinowska Ma łgorzata Farnik Marek Barczyk Łukasz Boda Szczepan Cofta Jan Du ława Maciej Dyrbu ś Rafa ł Harat Maciej Huk Sylwia Kotecka Artur Nahorecki Jacek Nasi łowski Wojciech Naumnik Grzegorz Przybylski Moni Source Type: research
Efficacy of oral amantadine among patients hospitalised with COVID-19: A randomised, double-blind, placebo-controlled, multicentre study
Adding amantadine to standard care in patients hospitalised with COVID-19 did not increase the likelihood of recovery. (Source: Respiratory Medicine)
Source: Respiratory Medicine - March 14, 2023 Category: Respiratory Medicine Authors: Adam Barczyk, Ma łgorzata Czajkowska-Malinowska, Małgorzata Farnik, Marek Barczyk, Łukasz Boda, Szczepan Cofta, Jan Duława, Maciej Dyrbuś, Rafał Harat, Maciej Huk, Sylwia Kotecka, Artur Nahorecki, Jacek Nasiłowski, Wojciech Naumnik, Grzegorz Przyby Tags: Original Research Source Type: research
Ethical challenges of clinical trials with a repurposed drug in outbreaks
AbstractDrug repurposing is a strategy of identifying new potential uses for already existing drugs. Many researchers adopted this method to identify treatment or prevention during the COVID-19 pandemic. However, despite the considerable number of repurposed drugs that were evaluated, only some of them were labeled for new indications. In this article, we present the case of amantadine, a drug commonly used in neurology that attracted new attention during the COVID-19 outbreak. This example illustrates some of the ethical challenges associated with the launch of clinical trials to evaluate already approved drugs. In our di...
Source: Medicine, Healthcare and Philosophy - March 7, 2023 Category: Medical Ethics Source Type: research
Celiac disease and catatonia: more than a coincidence?
CONCLUSIONS: Even without gastrointestinal manifestations, CD may present with neuropsychiatric symptoms. According to this case report, CD should be investigated in patients with unexplained catatonia, and that CD may only present with neuropsychiatric symptoms.PMID:36866995 | DOI:10.24953/turkjped.2022.411 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - March 3, 2023 Category: Pediatrics Authors: P ınar Özbudak Alev El çi Karaduman Deniz Karg ın Menderes Hakan Öztürk K ıvılcım Gücüyener Source Type: research
