Design, synthesis, ADME, biological evaluation and molecular dynamic studies of natural and synthetic remedy of Herpes simplex virus type-1
Pak J Pharm Sci. 2022 Jul;35(4(Special)):1181-1190.ABSTRACTGarlic (known as; Allium sativum) is one of the most widely used medicinal plants in the world. Allicin is the major agent of garlic that gives its known pharmacological activities as anti-inflammatory, antibacterial, antifungal, antiviral and antioxidant agent. It could be extracted from bulbs of Allium sativum by water extraction to give allicin in low yield therefore other better methods were followed for extraction such as ultrasonic-assisted method that gives good yield. Attempts to optimize allicin extraction were found with sliced garlic at 25 °C for 90 min...
Source: Herpes - October 11, 2022 Category: Infectious Diseases Authors: Suhad Sami Humadi Samir Mohamed Awad Ahmed Abd Elkader El-Rashedy Mohamed Fathy El-Shehry Source Type: research

Design, synthesis, ADME, biological evaluation and molecular dynamic studies of natural and synthetic remedy of Herpes simplex virus type-1
Pak J Pharm Sci. 2022 Jul;35(4(Special)):1181-1190.ABSTRACTGarlic (known as; Allium sativum) is one of the most widely used medicinal plants in the world. Allicin is the major agent of garlic that gives its known pharmacological activities as anti-inflammatory, antibacterial, antifungal, antiviral and antioxidant agent. It could be extracted from bulbs of Allium sativum by water extraction to give allicin in low yield therefore other better methods were followed for extraction such as ultrasonic-assisted method that gives good yield. Attempts to optimize allicin extraction were found with sliced garlic at 25 °C for 90 min...
Source: Herpes - October 11, 2022 Category: Infectious Diseases Authors: Suhad Sami Humadi Samir Mohamed Awad Ahmed Abd Elkader El-Rashedy Mohamed Fathy El-Shehry Source Type: research

Case report: Blepharospasm in peak-dose dyskinesia may benefit from amantadine in Parkinson's disease
ConclusionThe current report expands the phenomenology of peak-dose dykinesia in PD to include dystonic blepharospasm. This complication of levodopa therapy may respond to amantadine despite the dystonic appearance of movements. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - September 30, 2022 Category: Neurology Source Type: research

Improved survival in ICU in severe COVID-19 associated with amantadine use – retrospective study.
Possible immunomodulatory effect of amantadine in patients treated in intensive care units (ICU), mostly among patients with brain injuries or vascular diseases was observed in several studies. Potential antiviral effect of amantadine against SARS CoV-2 was discarded in clinical trials, however immunomodulatory potential was not studied. Objectives: The aim of the study was to investigate the effect of immunomodulatory amantadine therapy on mortality in patients with respiratory insufficiency due to COVID-19 requiring mechanical ventilation in ICU. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - September 21, 2022 Category: Infectious Diseases Authors: Daniel Chober, Zenon Czajkowski, Bogusz Aksak-W ąs, Katarzyna Dalewska-Kucharczyk, Katarzyna Hołubczak, Sylwia Karasińska-Milchert, Mateusz Jaremko, Miłosz Skowron, Malwina Karasińska-Cieślak, Miłosz Parczewski Source Type: research

Improved survival in intensive care unit in severe COVID-19 associated with amantadine use - retrospective study
The first reports on the possible uses of amantadine were published as early as 1960s (Monto and Arden,  1992). Following initial reports on antiviral properties described in 1963, amantadine obtained approval for prophylaxis and treatment of influenza type A viruses infections in 1976 (Hubsher et al., 2012); however, in the following decades it was withdrawn from influenza's treatment recommendatio ns due to universal viral protein M2 resistance (Influenza Antiviral Drug Resistance, 2021). (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - September 21, 2022 Category: Infectious Diseases Authors: Daniel Chober, Zenon Czajkowski, Bogusz Aksak-W ąs, Katarzyna Dalewska-Kucharczyk, Katarzyna Hołubczak, Sylwia Karasińska-Milchert, Mateusz Jaremko, Miłosz Skowron, Malwina Karasińska-Cieślak, Miłosz Parczewski Source Type: research

Study of the Effects of Nicotine and Caffeine for the Treatment of Parkinson's Disease
Appl Biochem Biotechnol. 2022 Sep 19. doi: 10.1007/s12010-022-04155-5. Online ahead of print.ABSTRACTParkinson's disease (PD) is considered to be a highly severe neurological disorder. PD occurs due to a decrease in dopamine production by the degeneration of dopamine-secreting neurons. Genetic mutations, environmental toxins and lifestyle are some of the risk factors of the progressive neurodegenerative disorder PD. Parkin protein, which is encoded by the PARK gene, is one of the important proteins, which is one of the causative agents. The Parkin protein has several mutations which lead to the development of the disease. ...
Source: Applied Biochemistry and Biotechnology - September 19, 2022 Category: Biochemistry Authors: Sima Biswas Angshuman Bagchi Source Type: research

Study of the Effects of Nicotine and Caffeine for the Treatment of Parkinson's Disease
Appl Biochem Biotechnol. 2022 Sep 19. doi: 10.1007/s12010-022-04155-5. Online ahead of print.ABSTRACTParkinson's disease (PD) is considered to be a highly severe neurological disorder. PD occurs due to a decrease in dopamine production by the degeneration of dopamine-secreting neurons. Genetic mutations, environmental toxins and lifestyle are some of the risk factors of the progressive neurodegenerative disorder PD. Parkin protein, which is encoded by the PARK gene, is one of the important proteins, which is one of the causative agents. The Parkin protein has several mutations which lead to the development of the disease. ...
Source: Applied Biochemistry and Biotechnology - September 19, 2022 Category: Biochemistry Authors: Sima Biswas Angshuman Bagchi Source Type: research

Pharmacologic Therapies to Promote Recovery of Consciousness
This article provides a concise summary of scientific evidence supporting the use of pharmacologic therapies to stimulate recovery of consciousness in patients with DoC. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Seminars in Neurology)
Source: Seminars in Neurology - September 13, 2022 Category: Neurology Authors: Barra, Megan E. Edlow, Brian L. Brophy, Gretchen M. Tags: Review Article Source Type: research

[ASAP] Novel Multipotent Amantadine –M30D Hybrids with Highly Selective Butyrylcholinesterase Inhibition and Neuroprotective Effects as Effective Anti-Alzheimer’s Agents
ACS Chemical NeuroscienceDOI: 10.1021/acschemneuro.2c00300 (Source: ACS Chemical Neuroscience)
Source: ACS Chemical Neuroscience - September 8, 2022 Category: Neuroscience Authors: Marlyn S. Rada, Wilson Cardona-Galeano, Jorge Quintero-Saumeth, Karina Sierra, Edison Osorio, Luis Alfonso Gonzalez-Molina, Rafael Posada-Duque, and Andre ́s F. Yepes Source Type: research

Pharmacological Interventions of Atypical Antipsychotics Induced Weight Gain in the Pediatric Population: A Systemic Review of Current Evidence
Child Psychiatry Hum Dev. 2022 Sep 6. doi: 10.1007/s10578-022-01424-6. Online ahead of print.ABSTRACTTo systematically review studies evaluating pharmacological treatment intervention of the atypical antipsychotic induced weight gain in the pediatric population and summarize the current evidence of the pharmacological treatment. According to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines, we searched the various databases Medline, PubMed, PubMed central (PMC), CINAHL, and clinicaltrial.gov. until Jan 30th, 2022 for relevant clinical studies. Medical subject heading (MeSH) terms o...
Source: Child Psychiatry and Human Development - September 6, 2022 Category: Child Development Authors: Wisam Al Jumaili Ashraf Muzwagi Kaushal Shah Chintan Trivedi Priya Durga Zeeshan Mansuri Shailesh Jain Yousif Al Jumaili Source Type: research

Insights into binding molecular mechanism of hemagglutinin H3N2 of influenza virus complexed with arbidol and its derivative: A molecular dynamics simulation perspective
Comput Biol Chem. 2022 Aug 28;101:107764. doi: 10.1016/j.compbiolchem.2022.107764. Online ahead of print.ABSTRACTRecently, the H3N2 influenza outbreak has caused serious global public health concern for future control of the next influenza pandemic. Since using current anti-influenza drugs targeting neuraminidase (oseltamivir and zanamivir) and the proton M2 channel (amantadine and rimantadine) leads to drug resistance, it is essential to seek new anti-viral agents that act on additional viral targets. Hemagglutinin (HA), a glycoprotein embedded in the viral surface and playing a critical role in influenza the viral replic...
Source: Computational Biology and Chemistry - September 1, 2022 Category: Bioinformatics Authors: Thitiya Boonma Nattharuja Soikudrua Bodee Nutho Thanyada Rungrotmongkol Nadtanet Nunthaboot Source Type: research

Insights into binding molecular mechanism of hemagglutinin H3N2 of influenza virus complexed with arbidol and its derivative: A molecular dynamics simulation perspective
Comput Biol Chem. 2022 Aug 28;101:107764. doi: 10.1016/j.compbiolchem.2022.107764. Online ahead of print.ABSTRACTRecently, the H3N2 influenza outbreak has caused serious global public health concern for future control of the next influenza pandemic. Since using current anti-influenza drugs targeting neuraminidase (oseltamivir and zanamivir) and the proton M2 channel (amantadine and rimantadine) leads to drug resistance, it is essential to seek new anti-viral agents that act on additional viral targets. Hemagglutinin (HA), a glycoprotein embedded in the viral surface and playing a critical role in influenza the viral replic...
Source: Computational Biology and Chemistry - September 1, 2022 Category: Bioinformatics Authors: Thitiya Boonma Nattharuja Soikudrua Bodee Nutho Thanyada Rungrotmongkol Nadtanet Nunthaboot Source Type: research

Insights into binding molecular mechanism of hemagglutinin H3N2 of influenza virus complexed with arbidol and its derivative: A molecular dynamics simulation perspective
Comput Biol Chem. 2022 Aug 28;101:107764. doi: 10.1016/j.compbiolchem.2022.107764. Online ahead of print.ABSTRACTRecently, the H3N2 influenza outbreak has caused serious global public health concern for future control of the next influenza pandemic. Since using current anti-influenza drugs targeting neuraminidase (oseltamivir and zanamivir) and the proton M2 channel (amantadine and rimantadine) leads to drug resistance, it is essential to seek new anti-viral agents that act on additional viral targets. Hemagglutinin (HA), a glycoprotein embedded in the viral surface and playing a critical role in influenza the viral replic...
Source: Computational Biology and Chemistry - September 1, 2022 Category: Bioinformatics Authors: Thitiya Boonma Nattharuja Soikudrua Bodee Nutho Thanyada Rungrotmongkol Nadtanet Nunthaboot Source Type: research

Insights into binding molecular mechanism of hemagglutinin H3N2 of influenza virus complexed with arbidol and its derivative: A molecular dynamics simulation perspective
Comput Biol Chem. 2022 Aug 28;101:107764. doi: 10.1016/j.compbiolchem.2022.107764. Online ahead of print.ABSTRACTRecently, the H3N2 influenza outbreak has caused serious global public health concern for future control of the next influenza pandemic. Since using current anti-influenza drugs targeting neuraminidase (oseltamivir and zanamivir) and the proton M2 channel (amantadine and rimantadine) leads to drug resistance, it is essential to seek new anti-viral agents that act on additional viral targets. Hemagglutinin (HA), a glycoprotein embedded in the viral surface and playing a critical role in influenza the viral replic...
Source: Computational Biology and Chemistry - September 1, 2022 Category: Bioinformatics Authors: Thitiya Boonma Nattharuja Soikudrua Bodee Nutho Thanyada Rungrotmongkol Nadtanet Nunthaboot Source Type: research

Insights into binding molecular mechanism of hemagglutinin H3N2 of influenza virus complexed with arbidol and its derivative: A molecular dynamics simulation perspective
Comput Biol Chem. 2022 Aug 28;101:107764. doi: 10.1016/j.compbiolchem.2022.107764. Online ahead of print.ABSTRACTRecently, the H3N2 influenza outbreak has caused serious global public health concern for future control of the next influenza pandemic. Since using current anti-influenza drugs targeting neuraminidase (oseltamivir and zanamivir) and the proton M2 channel (amantadine and rimantadine) leads to drug resistance, it is essential to seek new anti-viral agents that act on additional viral targets. Hemagglutinin (HA), a glycoprotein embedded in the viral surface and playing a critical role in influenza the viral replic...
Source: Computational Biology and Chemistry - September 1, 2022 Category: Bioinformatics Authors: Thitiya Boonma Nattharuja Soikudrua Bodee Nutho Thanyada Rungrotmongkol Nadtanet Nunthaboot Source Type: research