Viruses, Vol. 16, Pages 593: Antiviral Chemotherapy in Avian Medicine & mdash;A Review
Viruses, Vol. 16, Pages 593: Antiviral Chemotherapy in Avian Medicine—A Review
Viruses doi: 10.3390/v16040593
Authors:
Ines Szotowska
Aleksandra Ledwoń
This review article describes the current knowledge about the use of antiviral chemotherapeutics in avian species, such as farm poultry and companion birds. Specific therapeutics are described in alphabetical order including classic antiviral drugs, such as acyclovir, abacavir, adefovir, amantadine, didanosine, entecavir, ganciclovir, interferon, lamivudine, penciclovir, famciclovir, oseltamivir, ribavirin, and zidovudine, repurposed drugs, such as iver...
Source: Viruses - April 12, 2024 Category: Virology Authors: Ines Szotowska Aleksandra Ledwo ń Tags: Review Source Type: research
Design, synthesis, anti-infective potency and mechanism study of novel Ru-based complexes containing substituted adamantane as antibacterial agents
Eur J Med Chem. 2024 Apr 2;270:116378. doi: 10.1016/j.ejmech.2024.116378. Online ahead of print.ABSTRACTInfections caused by Staphylococcus aureus (S. aureus) are increasing difficult to treat because this pathogen is easily resistant to antibiotics. However, the development of novel antibacterial agents with high antimicrobial activity and low frequency of resistance remains a huge challenge. Here, building on the coupling strategy, an adamantane moiety was linked to the membrane-active Ru-based structure and then developed three novel metalloantibiotics: [Ru(bpy)2(L)](PF6)2 (Ru1) (bpy = 2,2-bipyridine, L = amantadine mod...
Source: European Journal of Medicinal Chemistry - April 11, 2024 Category: Chemistry Authors: Liqiang Wang Lianghong Liu Chunyan Zhang Guangying Yu Wenjing Lin Xuemin Duan Yanshi Xiong Guijuan Jiang Jintao Wang Xiangwen Liao Source Type: research
Design, synthesis, anti-infective potency and mechanism study of novel Ru-based complexes containing substituted adamantane as antibacterial agents
Eur J Med Chem. 2024 Apr 2;270:116378. doi: 10.1016/j.ejmech.2024.116378. Online ahead of print.ABSTRACTInfections caused by Staphylococcus aureus (S. aureus) are increasing difficult to treat because this pathogen is easily resistant to antibiotics. However, the development of novel antibacterial agents with high antimicrobial activity and low frequency of resistance remains a huge challenge. Here, building on the coupling strategy, an adamantane moiety was linked to the membrane-active Ru-based structure and then developed three novel metalloantibiotics: [Ru(bpy)2(L)](PF6)2 (Ru1) (bpy = 2,2-bipyridine, L = amantadine mod...
Source: European Journal of Medicinal Chemistry - April 11, 2024 Category: Chemistry Authors: Liqiang Wang Lianghong Liu Chunyan Zhang Guangying Yu Wenjing Lin Xuemin Duan Yanshi Xiong Guijuan Jiang Jintao Wang Xiangwen Liao Source Type: research
Effects of total saikosaponins on CYP3A4 and CYP1A2 in HepaRG cells
Exp Ther Med. 2024 Mar 21;27(5):217. doi: 10.3892/etm.2024.12505. eCollection 2024 May.ABSTRACTTotal saikosaponins (TSS) form a group of chemically and biologically active components that can be extracted from Bupleurum, with reported antidepressive, anti-inflammatory, antiviral, antiendotoxin, antitumor, anti-pulmonary fibrosis and anti-gastric ulcer effects. Bupleurum or TSS is frequently utilized in clinical practice alongside other medications (such as entecavir, lamivudine, compound paracetamol and amantadine hydrochloride capsules), leading to an increased risk of drug-drug interactions. The cytochrome P450 (CYP) fam...
Source: Cancer Control - April 9, 2024 Category: Cancer & Oncology Authors: Yunyan Tang Hongfang Li Jianhua Tang Lei Hu Feifei Ma Yanmiao Liu Fushan Tang Source Type: research
Effects of total saikosaponins on CYP3A4 and CYP1A2 in HepaRG cells
Exp Ther Med. 2024 Mar 21;27(5):217. doi: 10.3892/etm.2024.12505. eCollection 2024 May.ABSTRACTTotal saikosaponins (TSS) form a group of chemically and biologically active components that can be extracted from Bupleurum, with reported antidepressive, anti-inflammatory, antiviral, antiendotoxin, antitumor, anti-pulmonary fibrosis and anti-gastric ulcer effects. Bupleurum or TSS is frequently utilized in clinical practice alongside other medications (such as entecavir, lamivudine, compound paracetamol and amantadine hydrochloride capsules), leading to an increased risk of drug-drug interactions. The cytochrome P450 (CYP) fam...
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Yunyan Tang Hongfang Li Jianhua Tang Lei Hu Feifei Ma Yanmiao Liu Fushan Tang Source Type: research
5-EPIFAT trial protocol: a multi-center, randomized, placebo-controlled trial of the efficacy of pharmacotherapy for fatigue using methylphenidate, bupropion, ginseng, and amantadine in advanced cancer patients on active treatment
Cancer-related fatigue (CRF) is still undertreated in most patients, as evidence for pharmacological treatments is limited and conflicting. Also, the efficacy of the pharmacological agents relative to each oth... (Source: Trials)
Source: Trials - April 3, 2024 Category: General Medicine Authors: Mojtaba Miladinia, Mina Jahangiri, Sharon Jackson White, Hossein Karimpourian, Alessandro Inno, Sally Wai-Chi Chan, Reza Ganji, Mahmood Maniati, Kourosh Zarea, Marziyeh Ghalamkari, Ali Farahat and Cecilia Fagerstr öm Tags: Study protocol Source Type: research
Catatonia in patients with dementia: A descriptive study of clinical profiles and treatment response
CONCLUSION: The findings indicate a frequent co-occurrence of catatonia and dementia, highlighting treatability yet suggesting a potential for resistance to lorazepam, which varies by dementia diagnosis. Investigating the mechanisms underlying this resistance and the variability in treatment response is crucial for developing more precise therapeutic strategies.PMID:38564875 | DOI:10.1016/j.ajp.2024.104033 (Source: Asian Journal of Psychiatry)
Source: Asian Journal of Psychiatry - April 2, 2024 Category: Psychiatry Authors: Vanina Ramognino Thomas Fovet Mathilde Horn Thibaud Lebouvier Ali Amad Source Type: research
Indices of Responsiveness for the Coma Recovery Scale - Revised in a Clinical Trial of Amantadine for Patients with Disorders of Consciousness
To establish indices of responsiveness on the Coma Recovery Scale - Revised (CRS-R) for patients with disorders of consciousness (DoC): (1) minimal detectable change with 95% confidence interval (MDC95), (2) conditional MDC95 (cMDC), and (3) distribution-based minimally clinically important difference (MCID). To compare participants ’ change in CRS-R scores between the control and placebo group of the Amantadine Trial. (Source: Archives of Physical Medicine and Rehabilitation)
Source: Archives of Physical Medicine and Rehabilitation - April 1, 2024 Category: Rehabilitation Authors: Patricia Grady-Dominguez, Alison Cogan, Allan Kozlowski, Katherine O'Brien, Joseph Giacino, Yelena Bodien, James Graham, Stephen Aichele, Paige Ford, Trisha Kot, Trudy Mallinson, Jennifer Weaver Tags: Research Poster 2522509 Source Type: research
Correction: < em > Amantadine toxicity causing visual hallucinations < /em >
Pract Neurol. 2024 Mar 19;24(2):e1. doi: 10.1136/pn-2023-003723corr1.NO ABSTRACTPMID:38503451 | DOI:10.1136/pn-2023-003723corr1 (Source: Practical Neurology)
Source: Practical Neurology - March 19, 2024 Category: Neurology Source Type: research
Correction: < em > Amantadine toxicity causing visual hallucinations < /em >
Pract Neurol. 2024 Mar 19;24(2):e1. doi: 10.1136/pn-2023-003723corr1.NO ABSTRACTPMID:38503451 | DOI:10.1136/pn-2023-003723corr1 (Source: Practical Neurology)
Source: Practical Neurology - March 19, 2024 Category: Neurology Source Type: research
Extended-release amantadine for OFF-related dystonia in Parkinson's disease
Dystonia is a painful OFF-related complication in Parkinson's disease (PD) with limited treatment options. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - March 4, 2024 Category: Neurology Authors: Alberto J. Espay, Jill L. Ostrem, Andrea E. Formella, Caroline M. Tanner Tags: Short communication Source Type: research
Suppression of presynaptic corticostriatal glutamate activity attenuates L-dopa-induced dyskinesia in 6-OHDA-lesioned Parkinson's disease mice
In this study, we explored whether suppression of presynaptic corticostriatal glutamate inputs might affect the behavioral and biochemical outcomes associated with LID. We first established an animal model in which 6-hydroxydopamine (6-OHDA)-lesioned mice were treated daily with L-dopa (10 mg/kg, i.p.) for 2 weeks; these mice developed stereotypical abnormal involuntary movements (AIMs). When the mice were pretreated with the NMDA antagonist, amantadine, we observed suppression of AIMs and reductions of phosphorylated ERK1/2 and NR2B in the striatum. We then took an optogenetic approach to manipulate glutamatergic activity...
Source: Neurobiology of Disease - February 24, 2024 Category: Neurology Authors: Yu-Ting Huang Ya-Wen Chen Tze-Yen Lin Jin-Chung Chen Source Type: research
Suppression of presynaptic corticostriatal glutamate activity attenuates L-dopa-induced dyskinesia in 6-OHDA-lesioned Parkinson's disease mice
In this study, we explored whether suppression of presynaptic corticostriatal glutamate inputs might affect the behavioral and biochemical outcomes associated with LID. We first established an animal model in which 6-hydroxydopamine (6-OHDA)-lesioned mice were treated daily with L-dopa (10 mg/kg, i.p.) for 2 weeks; these mice developed stereotypical abnormal involuntary movements (AIMs). When the mice were pretreated with the NMDA antagonist, amantadine, we observed suppression of AIMs and reductions of phosphorylated ERK1/2 and NR2B in the striatum. We then took an optogenetic approach to manipulate glutamatergic activity...
Source: Neurobiology of Disease - February 24, 2024 Category: Neurology Authors: Yu-Ting Huang Ya-Wen Chen Tze-Yen Lin Jin-Chung Chen Source Type: research
Exploration of newly synthesized amantadine-thiourea conjugates for their DNA binding, anti-elastase, and anti-glioma potentials
Int J Biol Macromol. 2024 Feb 16:130231. doi: 10.1016/j.ijbiomac.2024.130231. Online ahead of print.ABSTRACTThree newly synthesized amantadine thiourea conjugates namely MS-1 N-(((3 s,5 s,7 s)-adamantan-1-yl)carbamothioyl)benzamide, MS-2 N-(((3 s,5 s,7 s)-adamantan-1-yl)carbamothioyl)-4-methylbenzamide and MS-3 N-((3 s,5 s,7 s)-adamantan-1-ylcarbamothioyl)-4-chlorobenzamide were investigated for their structures, bindings (DNA/ elastase), and for their impact on healthy and cancerous cells. Theoretical (DFT/docking) and experimental {UV-visible (UV-), fluorescence (Flu-), and cyclic voltammetry (CV)} studies indicated bind...
Source: International Journal of Biological Macromolecules - February 18, 2024 Category: Biochemistry Authors: Nasima Arshad Muhammad Shakeel Aneela Javed Fouzia Perveen Aamer Saeed Atteeque Ahmed Hammad Ismail Pervaiz Ali Channar Fatima Naseer Source Type: research
