Identification of Human Case of Avian Influenza A(H5N1) Infection, India
Emerg Infect Dis. 2022 Jun;28(6):1269-1273. doi: 10.3201/eid2806.212246.ABSTRACTA 11-year-old boy with acute myeloid leukemia was brought for treatment of severe acute respiratory infection in the National Capital Region, New Delhi, India. Avian influenza A(H5N1) infection was laboratory confirmed. Complete genome analysis indicated hemagglutinin gene clade 2.3.2.1a. We found the strain to be susceptible to amantadine and neuraminidase inhibitors.PMID:35608874 | DOI:10.3201/eid2806.212246 (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - May 24, 2022 Category: Infectious Diseases Authors: Varsha Potdar Megha Brijwal Rakesh Lodha Pragya Yadav Santosh Jadhav Manohar Lal Choudhary Aashish Choudhary Veena Vipat Nivedita Gupta Ashok Kumar Deorari Lalit Dar Priya Abraham Source Type: research
The Hypothiocyanite and Amantadine Combination Treatment Prevents Lethal Influenza A Virus Infection in Mice
The influenza virus has a large clinical burden and is associated with significant mortality and morbidity. The development of effective drugs for the treatment or prevention of influenza is important in order to reduce its impact. Adamantanes and neuraminidase inhibitors are two classes of anti-influenza drugs in which resistance has developed; thus, there is an urgent need to explore new therapeutic options. Boosting antiviral innate immune mechanisms in the airways represents an attractive approach. Hypothiocyanite (OSCN−) is produced by the airway epithelium and is effective in reducing the replication of several inf...
Source: Frontiers in Immunology - May 18, 2022 Category: Allergy & Immunology Source Type: research
Single particle plasmonic and electrochemical dual mode detection of amantadine
Anal Chim Acta. 2022 May 29;1209:339838. doi: 10.1016/j.aca.2022.339838. Epub 2022 Apr 19.ABSTRACTHerein, a facile and sensitive dual mode sensing strategy for amantadine (AMD) level evaluation by coupling the plasmonic Au nanorod (NR) and supramolecular SH-cyclodextrin (CD) through strong Au-S bond is proposed. Methylene blue (MB) molecules can be inserted into the cavity of CD molecules through the hydrophobic interaction, which would cause the plasmon resonance energy transfer (PRET) process as well as electrochemical signal response due to the spectrum overlap between Au NR and MB molecules and the electrochemical conv...
Source: Analytica Chimica Acta - May 15, 2022 Category: Chemistry Authors: Hui Wang Shu-Min Wang Wei Zhao Hong-Yuan Chen Jing-Juan Xu Source Type: research
Single particle plasmonic and electrochemical dual mode detection of amantadine
Anal Chim Acta. 2022 May 29;1209:339838. doi: 10.1016/j.aca.2022.339838. Epub 2022 Apr 19.ABSTRACTHerein, a facile and sensitive dual mode sensing strategy for amantadine (AMD) level evaluation by coupling the plasmonic Au nanorod (NR) and supramolecular SH-cyclodextrin (CD) through strong Au-S bond is proposed. Methylene blue (MB) molecules can be inserted into the cavity of CD molecules through the hydrophobic interaction, which would cause the plasmon resonance energy transfer (PRET) process as well as electrochemical signal response due to the spectrum overlap between Au NR and MB molecules and the electrochemical conv...
Source: Analytica Chimica Acta - May 15, 2022 Category: Chemistry Authors: Hui Wang Shu-Min Wang Wei Zhao Hong-Yuan Chen Jing-Juan Xu Source Type: research
Single particle plasmonic and electrochemical dual mode detection of amantadine
Anal Chim Acta. 2022 May 29;1209:339838. doi: 10.1016/j.aca.2022.339838. Epub 2022 Apr 19.ABSTRACTHerein, a facile and sensitive dual mode sensing strategy for amantadine (AMD) level evaluation by coupling the plasmonic Au nanorod (NR) and supramolecular SH-cyclodextrin (CD) through strong Au-S bond is proposed. Methylene blue (MB) molecules can be inserted into the cavity of CD molecules through the hydrophobic interaction, which would cause the plasmon resonance energy transfer (PRET) process as well as electrochemical signal response due to the spectrum overlap between Au NR and MB molecules and the electrochemical conv...
Source: Analytica Chimica Acta - May 15, 2022 Category: Chemistry Authors: Hui Wang Shu-Min Wang Wei Zhao Hong-Yuan Chen Jing-Juan Xu Source Type: research
