Safety review of current pharmacotherapies for levodopa-treated patients with Parkinson's disease
Expert Opin Drug Saf. 2023 Jul 4:1-17. doi: 10.1080/14740338.2023.2227096. Online ahead of print.ABSTRACTINTRODUCTION: Levodopa remains the gold standard for treatment of Parkinson's disease (PD). Patients develop complications with disease progression, necessitating adjunctive therapy to control fluctuations in motor and non-motor symptoms and dyskinesia. Knowledge of medication safety and tolerability is critical to ascertain the benefit-risk ratio and select an adjunctive therapy that provides the highest chance for medication adherence. Posing a challenge are the sheer abundance of options, stemming from the developmen...
Source: Expert Opinion on Drug Safety - July 4, 2023 Category: Drugs & Pharmacology Authors: Angela M Richmond Kelly E Lyons Rajesh Pahwa Source Type: research
Adamantyl Amines Activity Study Against Mutant Influenza A M2 Channels Identified a Polycyclic Cage Amine Triple blocker Explored with MD simulations and Solid state NMR
ChemMedChem. 2023 Jun 28:e202300182. doi: 10.1002/cmdc.202300182. Online ahead of print.ABSTRACTWe compared the anti-influenza potencies of 57 adamantyl amines and analogs against influenza A virus with serine-31 M2 proton channel, usually termed as WT M2 channel, which is amantadine sensitive. We also tested a sub-set of these compounds against viruses with the amantadine resistant L26F, V27A, A30T, G34E M2 mutant channels. (a) Four compounds inhibited WT M2 virus in vitro with mid-nanomolar and 27 compounds with sub-micromolar to low micromolar potency. (b) Several compounds inhibited L26F M2 virus in vitro with sub-micr...
Source: ChemMedChem - June 28, 2023 Category: Chemistry Authors: Anja Hoffman Marianna Stampolaki Christina Tzitzoglaki Patrick Schmerer Chunlong Ma Kristin D öring Andreea Turcu Jun Wang Santiago Vazquez Michaela Schmidtke Antonios Kolokouris Ioannis Stylianakis Kumar Tekwani Movellan Loren Andreas Stefan Becker Source Type: research
Adamantyl Amines Activity Study Against Mutant Influenza A M2 Channels Identified a Polycyclic Cage Amine Triple blocker Explored with MD simulations and Solid state NMR
ChemMedChem. 2023 Jun 28:e202300182. doi: 10.1002/cmdc.202300182. Online ahead of print.ABSTRACTWe compared the anti-influenza potencies of 57 adamantyl amines and analogs against influenza A virus with serine-31 M2 proton channel, usually termed as WT M2 channel, which is amantadine sensitive. We also tested a sub-set of these compounds against viruses with the amantadine resistant L26F, V27A, A30T, G34E M2 mutant channels. (a) Four compounds inhibited WT M2 virus in vitro with mid-nanomolar and 27 compounds with sub-micromolar to low micromolar potency. (b) Several compounds inhibited L26F M2 virus in vitro with sub-micr...
Source: ChemMedChem - June 28, 2023 Category: Chemistry Authors: Anja Hoffman Marianna Stampolaki Christina Tzitzoglaki Patrick Schmerer Chunlong Ma Kristin D öring Andreea Turcu Jun Wang Santiago Vazquez Michaela Schmidtke Antonios Kolokouris Ioannis Stylianakis Kumar Tekwani Movellan Loren Andreas Stefan Becker Source Type: research
Adamantyl Amines Activity Study Against Mutant Influenza A M2 Channels Identified a Polycyclic Cage Amine Triple blocker Explored with MD simulations and Solid state NMR
ChemMedChem. 2023 Jun 28:e202300182. doi: 10.1002/cmdc.202300182. Online ahead of print.ABSTRACTWe compared the anti-influenza potencies of 57 adamantyl amines and analogs against influenza A virus with serine-31 M2 proton channel, usually termed as WT M2 channel, which is amantadine sensitive. We also tested a sub-set of these compounds against viruses with the amantadine resistant L26F, V27A, A30T, G34E M2 mutant channels. (a) Four compounds inhibited WT M2 virus in vitro with mid-nanomolar and 27 compounds with sub-micromolar to low micromolar potency. (b) Several compounds inhibited L26F M2 virus in vitro with sub-micr...
Source: ChemMedChem - June 28, 2023 Category: Chemistry Authors: Anja Hoffman Marianna Stampolaki Christina Tzitzoglaki Patrick Schmerer Chunlong Ma Kristin D öring Andreea Turcu Jun Wang Santiago Vazquez Michaela Schmidtke Antonios Kolokouris Ioannis Stylianakis Kumar Tekwani Movellan Loren Andreas Stefan Becker Source Type: research
Correction: Supramolecular self-assembly of amantadine hydrochloride with ferulic acid via dual optimization strategy establishes a precedent of synergistic antiviral drug-phenolic acid nutraceutical cocrystal
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Ling-Yang Wang, Yuan-Yuan Niu, Ming-Yu Zhao, Yue-Ming Yu, Yan-Tuan Li, Zhi-Yong Wu, Cui-Wei Yan To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - June 26, 2023 Category: Chemistry Authors: Ling-Yang Wang Source Type: research
Prescribing patterns and determinants for elderly patients with Parkinson's disease in Japan: a retrospective observational study using insurance claims databases
ConclusionPrescribing patterns for patients ≥75 years were levodopa centered and less complex than for those <75 years. Factors significantly associated with levodopa monotherapy and continued use of levodopa were older age and cognitive disorder.Clinical trial registrationUMIN Clinical Trials Registry, https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000053425 (UMIN000046823). (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - June 23, 2023 Category: Neurology Source Type: research
Pharmacological interventions for preventing opioid-induced hyperalgesia in adults after opioid-based anesthesia: a systematic review and network meta-analysis
Conclusion: Amantadine was identified as the best in controlling postoperative pain intensity and non-inferior to placebo in the incidence of PONV. Dexmedetomidine was the only intervention that outperformed placebo in all indicators.Clinical Trial Registration:https://www.crd.york.ac. uk/prospero/display_record.php?, CRD42021225361. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - June 22, 2023 Category: Drugs & Pharmacology Source Type: research
Toxic Encephalopathy Induced by Compound Paracetamol and Amantadine Hydrochloride in Dialysis Patients
Lihua Shi, Linfang Deng, Xiaolan YeNeurology India 2023 71(3):565-566 (Source: Neurology India)
Source: Neurology India - June 15, 2023 Category: Neurology Authors: Lihua Shi Linfang Deng Xiaolan Ye Source Type: research
Correction: A crystalline solid adduct of sulfathiazole –amantadine: the first dual-drug molecular salt containing both antiviral and antibacterial ingredients
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Ling-Yang Wang, Yue-Ming Yu, Ming-Chao Yu, Yan-Tuan Li, Zhi-Yong Wu, Cui-Wei Yan To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - CrystEngComm latest articles)
Source: RSC - CrystEngComm latest articles - June 13, 2023 Category: Chemistry Authors: Ling-Yang Wang Source Type: research
Correction: Molecular adduct of amantadine ferulate presents a pathway for slowing in vitro/vivo releases and raising synergistic antiviral effects via dual optimization salification strategy
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Yuan-Yuan Niu, Ling-Yang Wang, Yue-Ming Yu, Yan-Tuan Li, Zhi-Yong Wu, Cui-Wei Yan To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - CrystEngComm latest articles)
Source: RSC - CrystEngComm latest articles - June 8, 2023 Category: Chemistry Authors: Yuan-Yuan Niu Source Type: research
Structurally dynamic self-healable hydrogel cooperatively inhibits intestinal inflammation and promotes mucosal repair for enhanced ulcerative colitis treatment
Biomaterials. 2023 May 31;299:122184. doi: 10.1016/j.biomaterials.2023.122184. Online ahead of print.ABSTRACTHydrogels are a class of biocompatible materials with versatile functions that have been increasing explored for the localized treatment of ulcerative colitis (UC), but various mechanical stimuli may cause premature hydrogel breakage and detachment, impeding their further clinical translation. Here we report a multifunctional mechanically-resilient self-healing hydrogel for effective UC treatment, which is synthesized through the host-guest interaction between dopamine/β-cyclodextrin-modified hyaluronic acid (HA-CD...
Source: Biomaterials - June 5, 2023 Category: Materials Science Authors: Xinyue Ge Hong Wen Yang Fei Rui Xue Zhuo Cheng Yanan Li Kaiyong Cai Liqi Li Menghuan Li Zhong Luo Source Type: research
Structurally dynamic self-healable hydrogel cooperatively inhibits intestinal inflammation and promotes mucosal repair for enhanced ulcerative colitis treatment
Biomaterials. 2023 May 31;299:122184. doi: 10.1016/j.biomaterials.2023.122184. Online ahead of print.ABSTRACTHydrogels are a class of biocompatible materials with versatile functions that have been increasing explored for the localized treatment of ulcerative colitis (UC), but various mechanical stimuli may cause premature hydrogel breakage and detachment, impeding their further clinical translation. Here we report a multifunctional mechanically-resilient self-healing hydrogel for effective UC treatment, which is synthesized through the host-guest interaction between dopamine/β-cyclodextrin-modified hyaluronic acid (HA-CD...
Source: Biomaterials - June 5, 2023 Category: Materials Science Authors: Xinyue Ge Hong Wen Yang Fei Rui Xue Zhuo Cheng Yanan Li Kaiyong Cai Liqi Li Menghuan Li Zhong Luo Source Type: research
Structurally dynamic self-healable hydrogel cooperatively inhibits intestinal inflammation and promotes mucosal repair for enhanced ulcerative colitis treatment
Biomaterials. 2023 May 31;299:122184. doi: 10.1016/j.biomaterials.2023.122184. Online ahead of print.ABSTRACTHydrogels are a class of biocompatible materials with versatile functions that have been increasing explored for the localized treatment of ulcerative colitis (UC), but various mechanical stimuli may cause premature hydrogel breakage and detachment, impeding their further clinical translation. Here we report a multifunctional mechanically-resilient self-healing hydrogel for effective UC treatment, which is synthesized through the host-guest interaction between dopamine/β-cyclodextrin-modified hyaluronic acid (HA-CD...
Source: Biomaterials - June 5, 2023 Category: Materials Science Authors: Xinyue Ge Hong Wen Yang Fei Rui Xue Zhuo Cheng Yanan Li Kaiyong Cai Liqi Li Menghuan Li Zhong Luo Source Type: research
