Pharmacological interventions for preventing opioid-induced hyperalgesia in adults after opioid-based anesthesia: a systematic review and network meta-analysis

Conclusion: Amantadine was identified as the best in controlling postoperative pain intensity and non-inferior to placebo in the incidence of PONV. Dexmedetomidine was the only intervention that outperformed placebo in all indicators.Clinical Trial Registration:https://www.crd.york.ac. uk/prospero/display_record.php?, CRD42021225361.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research