How Long Do You Monitor Neonates for Neonatal Abstinence Syndrome (NAS)?
Discussion Neonatal abstinence syndrome (NAS) occurs in the first few days of life and is a complex withdrawal syndrome. The newborn is abruptly cut-off from their exposure to licit or illicit drugs that the mother is chronically consuming and which were being transmitted through the placenta to the fetus. “NAS is a highly variable and severe condition; it may be associated with central and autonomic nervous system dysfunction … and gastrointestinal disorders.” It can cause significant morbidity but is rarely fatal. Fetal exposure has been increasing in the United States. In 2011-12, almost 5.9% of pregn...
Source: PediatricEducation.org - January 11, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

FDA Drug Safety Communication: FDA urges caution about withholding opioid addiction medications from patients taking benzodiazepines or CNS depressants: careful medication management can reduce risks
Based on our additional review, the U.S. Food and Drug Administration (FDA) is advising that the opioid addiction medications buprenorphine and methadone should not be withheld from patients taking benzodiazepines or other drugs that depress the central nervous system (CNS). The combined use of these drugs increases the risk of serious side effects; however, the harm caused by untreated opioid addiction usually outweighs these risks. Careful medication management by health care professionals can reduce these risks. We are requiring this information to be added to the buprenorphine and methadone drug labels along with detai...
Source: FDA Center for Drug Evaluation and Research - What's New - January 7, 2021 Category: Drugs & Pharmacology Authors: FDA Source Type: news

A study of the effectiveness of naltrexone in preventing recurrence of methadone poisoning in opioid-naive children - Gholami N, Farnaghi F, Saberi M, Zamani N, McDonald R, Hassanian-Moghaddam H.
BACKGROUND: The prevalence of poisoning from methadone and prescription opioids is increasing in pediatric populations. Naloxone is the main antidote for treatment. Long-acting opioid toxicity may need close observation in the intensive care unit (ICU). In... (Source: SafetyLit)
Source: SafetyLit - December 10, 2020 Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news

Massachusetts Contact Tracing Program Hiring As Coronavirus Cases Rise
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Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - October 28, 2020 Category: Consumer Health News Authors: Health – CBS Boston Tags: Boston News Covid-19 Boston, MA Health Healthcare Status Syndicated CBSN Boston Syndicated Local Coronavirus Source Type: news

NH Soccer Teams Forfeit Tournament Games When Oppenents Decline To Wear Masks
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Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - October 28, 2020 Category: Consumer Health News Authors: Health – CBS Boston Tags: Covid-19 Boston, MA Health News schools Syndicated CBSN Boston Syndicated Local Beth Germano Newmarket NH Source Type: news

Baker: Families Should ‘ Think Long And Hard ’ About Holiday Plans And Skip Gatherings
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Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - October 27, 2020 Category: Consumer Health News Authors: Health – CBS Boston Tags: Boston News Covid-19 Boston, MA Health Healthcare Status Syndicated CBSN Boston Syndicated Local Coronavirus Gov. Charlie Baker Source Type: news

Baker Warns Of ‘ Significant Increase ’ In Coronavirus Cases Among Younger People
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Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - October 27, 2020 Category: Consumer Health News Authors: Health – CBS Boston Tags: Boston News Covid-19 Boston, MA Health Healthcare Status Syndicated CBSN Boston Syndicated Local Coronavirus Source Type: news

UPMC Chautauqua withdraws plans for methadone program
After four years of planning, the hospital says there are enough services by other providers and partnerships have improved. (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - October 22, 2020 Category: American Health Authors: Tracey Drury Source Type: news

Methadone (Methadone Oral Concentrate) - updated on RxList
Methadone Oral Concentrate may treat opioid addiction, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and more. (Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - October 22, 2020 Category: Drugs & Pharmacology Source Type: news

"That's no longer tolerated": policing patients' use of non-opioid substances in methadone maintenance treatment - Frank D.
The current overdose crisis in the United States emphasizes the importance of providing substance use treatment programs that are not only effective but tailored to meet the specific needs of the populations they serve. While Methadone Maintenance Treatmen... (Source: SafetyLit)
Source: SafetyLit - October 2, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

The relationship between mindfulness and borderline personality and suicidal thoughts in people under methadone maintenance therapy in Rafsanjan in 2018: a descriptive study - Sadeghi M, Mirzaeirad R.
In this study, the relationship between mindfulness and ... (Source: SafetyLit)
Source: SafetyLit - September 28, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Suicide attempts and death among heroin-involved women seeking methadone treatment in Taiwan - Chen WT, Wang SC, Wang IA, Tsay JH, Chen CY.
BACKGROUND: The present study aims to profile the hazard fluctuation of suicide attempts and deaths among heroin-involved women seeking methadone maintenance treatment (MMT) and to investigate sociodemographic and clinical factors predicting the time to ha... (Source: SafetyLit)
Source: SafetyLit - September 26, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Clinical characteristics and time trends of hospitalized methadone exposures in the United States based on the Toxicology Investigators Consortium (ToxIC) case registry: 2010-2017 - Mehrpour O, Hoyte C, Amirabadizadeh A, Brent J, Toxicology Investigators Consortium (ToxIC).
BACKGROUND: Methadone is well known for its long duration of action and propensity for mortality after an overdose. The present research was aimed at evaluating the clinical manifestations and time trends of methadone exposure in patients in US hospitals. ... (Source: SafetyLit)
Source: SafetyLit - July 27, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Travel Times to Opioid Addiction Programs Drive a Lack of Access Travel Times to Opioid Addiction Programs Drive a Lack of Access
Allowing pharmacies in the US to dispense methadone would significantly reduce the time involved in obtaining the medication and save money, new research shows.Medscape Medical News (Source: Medscape Internal Medicine Headlines)
Source: Medscape Internal Medicine Headlines - July 20, 2020 Category: Internal Medicine Tags: Psychiatry News Source Type: news

Patients with substance use disorder discriminated against by post-acute care facilities
(Boston Medical Center) A new study shows that 29 percent of private post-acute care facilities in Massachusetts explicitly discriminated against hospitalized individuals with opioid use disorder, rejecting their referral for admission. Led by researchers at Boston Medical Center's (BMC's) Grayken Center for Addiction, the study showed that 15 percent of the rejections among patients with substance use disorders were denied due to a substance use disorder diagnosis or because they were being treated for opioid use disorder with buprenorphine or methadone. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - July 16, 2020 Category: Infectious Diseases Source Type: news

Under 2% of Medicaid-covered youths get MAT after OD: study - Knopf A.
Fewer than one-third of youths receive addiction treatment after an opioid overdose, and only one in 54 receive pharmacotherapy (methadone, buprenorphine or naltrexone), a study published in JAMA Pediatrics reports. The researchers urge interventions to li... (Source: SafetyLit)
Source: SafetyLit - July 14, 2020 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

Kenya: Recovering Drug Addicts in Kenya Find Treatment Difficult With COVID-19
[RFI] Covid-19 regulations in Kenya pose additional challenges to recovering drug addicts along the coastal areas, who say they are finding it difficult to access their methadone recovery programs due to an inter-county lockdown and dusk to dawn curfew. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - July 6, 2020 Category: African Health Source Type: news

Methadone-related deaths among youth and young adults in Sweden 2006-2015 - Fugelstad A, Bremberg S, Hjelmstr öm P, Thiblin I.
AIMS: To identify methadone-related deaths and determine the prevalence among youth and young adults in Sweden 2006-2015. DESIGN, SETTING AND PARTICIPANTS: National retrospective registry study comparing data from all forensic autopsy examinations and ... (Source: SafetyLit)
Source: SafetyLit - June 17, 2020 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

Meds2Go Express Pharmacy, Inc. Sentenced for Role in Drug Diversion Scheme
FDA OCI, Alum Creek WV, Meds2Go Express Pharmacy, drug diversion, sentencing, money laundering, conspiracy, Hope Clinic, pain clinic, pill mill, opioids, oxycodone, methadone, addicts, illegal manufacturing, restitution, forfeiture, (Source: Office of Criminal Investigations (OCI) Press Releases)
Source: Office of Criminal Investigations (OCI) Press Releases - June 3, 2020 Category: Medical Law Authors: DOJ Source Type: news

Relationship between Buddhist belief and suicide risk in Chinese persons undergoing methadone maintenance therapy for heroin dependence - Huang JX, Xu YM, Zhong BL.
BACKGROUND: In western countries, there is a negative association between religious belief and suicide risk, while in China this association is positive. Nevertheless, few data are available on the association between one specific type of religion and suic... (Source: SafetyLit)
Source: SafetyLit - June 3, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

US relaxes rules for opioid substitutes during lockdowns
Trump administration makes it easier for addicts to obtain methadone and other treatment drugs (Source: FT.com - Drugs and Healthcare)
Source: FT.com - Drugs and Healthcare - May 28, 2020 Category: Pharmaceuticals Source Type: news

One-third of primary care physicians do not support the use of medications for treating opioid use disorders
(American College of Physicians) A survey of primary care physicians found that one-third did not perceive medications to treat OUD to be more effective than nonmedication treatment or safe for long-term use, despite conclusive evidence to the contrary. Physicians also reported low interest in treating OUD and low support for policy proposals allowing office-based physicians to prescribe buprenorphine and methadone. These findings are reported in a brief research report published in Annals of Internal Medicine. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - April 20, 2020 Category: International Medicine & Public Health Source Type: news

Coronavirus: Recovering heroin addicts offered monthly injections
Daily trips to the pharmacy for methadone are replaced with monthly buprenorphine injections. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - April 18, 2020 Category: Consumer Health News Source Type: news

Impact of pharmacological treatments for opioid use disorder on mortality - Kelty E, Hulse G, Joyce D, Preen DB.
The use of pharmacological treatments for opioid use disorders, including methadone, buprenorphine and naltrexone has been associated with a reduction in mortality compared with illicit opioid use. However, these treatments can also contribute significantl... (Source: SafetyLit)
Source: SafetyLit - March 31, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Flawed studies distort risk of opioid addiction treatment while pregnant
Studies that assess risks to pregnant women undergoing treatment for opioid addiction may have significant flaws that overstate the impact of drugs like buprenorphine and methadone on child development. (Source: Health News - UPI.com)
Source: Health News - UPI.com - March 19, 2020 Category: Consumer Health News Source Type: news

Drug and Opioid-Involved Overdose Deaths - United States, 2017-2018
From 2017 to 2018, U.S. overdose death rates involving synthetic opioids (excluding methadone) increased by 10%, death rates involving heroin decreased by 4%, and prescription opioid-involved overdose death rates decreased by 13.5%. (Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - March 19, 2020 Category: American Health Tags: MMWR Morbidity & Mortality Weekly Report Overdose Prescription Drug Abuse Synthetic Opioids Source Type: news

FAQs: Provision of Methadone and Buprenorphine for the Treatment of Opioid Use Disorder in the COVID-19 Emergency
Source: Substance Abuse and Mental Health Services Administration (SAMHSA). Published: 3/19/2020. This two-page document provides answers to frequently asked questions about providing methadone and buprenorphine for the treatment of opioid use disorder during the COVID-19 (coronavirus) epidemic. Topics include the use of telehealth for new and existing patients, and dispensing medication based on telehealth. (PDF) (Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health)
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - March 19, 2020 Category: International Medicine & Public Health Source Type: news

6 Italian inmates die during protest over virus measures
They died after breaking into the infirmary and overdosing on methadone. (Source: ABC News: Health)
Source: ABC News: Health - March 9, 2020 Category: Consumer Health News Tags: Health Source Type: news

Italy: 6 inmates protesting virus restrictions die after breaking into prison infirmary, overdosing on methadone
(Source: ABC News: Health)
Source: ABC News: Health - March 9, 2020 Category: Consumer Health News Tags: Health Source Type: news

Methadone poisonings: a seven-year retrospective study of the French poison center network focusing on suicide attempt vs. misuses - Franchitto N.
This editorial refers to the article ‘Methadone poisonings: a seven‐year retrospective study of the French poison center network focusing on suicide attempt vs. misuses’ by Romain Torrents et al. published in Fundamental and Clinical Pharmacology... (Source: SafetyLit)
Source: SafetyLit - March 7, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

New Data Strongly Support Opioid Agonists for Addiction New Data Strongly Support Opioid Agonists for Addiction
New research provides strong support that opioid agonists, methadone, or buprenorphine cut the risk of overdose death by 80%, yet many addiction programs don't offer them.Medscape Medical News (Source: Medscape Emergency Medicine Headlines)
Source: Medscape Emergency Medicine Headlines - February 28, 2020 Category: Emergency Medicine Tags: Psychiatry News Source Type: news

Study highlights effectiveness of methadone and buprenorphine
In a comparative effectiveness study of 6 approaches to treatment for opioid use disorders, only treatment with buprenorphine or methadone was associated with reduced risk of overdose and serious opioid-related acute care use. (Source: NIDA News)
Source: NIDA News - February 28, 2020 Category: Addiction Tags: Science Highlight, Opioids, Treatment Source Type: news

Anti-Addiction Meds Key to Saving Lives of People Hooked on Opioids
TUESDAY, Feb. 25, 2020 -- People treated for an opioid addiction stand a much better chance of breaking their dependency if they take opioid-blocking medications, a new study finds. In fact, addicts who took methadone or buprenorphine had an 80%... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - February 25, 2020 Category: General Medicine Source Type: news

Medication Treatment May Lower Risk for Opioid Overdose Death
TUESDAY, Feb. 25, 2020 -- Medication treatment with methadone and buprenorphine is associated with a significantly lower risk for overdose death for people with opioid use disorder (OUD) compared with nonmedication treatment, but this lower risk... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - February 25, 2020 Category: Pharmaceuticals Source Type: news

Medication treatments led to 80% lower risk of fatal overdose for patients with opioid use disorder
(NYU Langone Health / NYU School of Medicine) Patients with opioid use disorder (OUD) receiving treatment with opioid agonists (medications such as methadone or buprenorphine) had an 80 percent lower risk of dying from an opioid overdose compared to patients in treatment without the use of medications. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 25, 2020 Category: International Medicine & Public Health Source Type: news

Mortality decreased with further treatment for opioid use disorder after detox
(Boston Medical Center) A new study shows that people with opioid use disorder who enter inpatient medically managed withdrawal treatment (detox) do not usually receive further treatment, including medication for opioid use disorder or additional inpatient treatment. Those who did receive further treatment with medication (methadone, buprenorphine or naltrexone) or residential treatment were more likely to survive to 12 months. Published in Addiction, this study emphasizes the importance of keeping people with opioid use disorder engaged in treatment in order to increase their chances of survival. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 25, 2020 Category: International Medicine & Public Health Source Type: news

Patients most at risk of overdose at the beginning and after end of methadone treatment
(RCSI) A new study, led by RCSI researchers, has found that patients receiving methadone treatment are most at risk of overdosing in the month following the end of methadone treatment and during the first four weeks of treatment. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 20, 2020 Category: International Medicine & Public Health Source Type: news

Epidemiology of pediatric buprenorphine and methadone exposures reported to the poison centers - Rege SV, Ngo DA, Ait-Daoud N, Rizer J, Sharma S, Holstege CP.
BACKGROUND: Buprenorphine prescriptions have increased dramatically within the United States, whereas methadone continues to be used widely. We investigated the trends and characteristics of buprenorphine and methadone exposures in the pediatric population... (Source: SafetyLit)
Source: SafetyLit - January 31, 2020 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

Low-Dose Gabapentin in Combination with Methadone May Improve QOL in Patients with HNC
Administering a high dose of gabapentin also increased the percentage of patients who required no opioid during treatment, indicating that patients were possibly gleaning benefits from gabapentin in both treatment arms. (Source: CancerNetwork)
Source: CancerNetwork - January 23, 2020 Category: Cancer & Oncology Authors: Hannah Slater Source Type: news

Total Opioid Overdose Deaths Down With Medicaid Expansion
FRIDAY, Jan. 10, 2020 -- Medicaid expansion is associated with a reduction in total opioid overdose deaths and with increases in methadone-related mortality, according to a study published online Jan. 10 in JAMA Network Open. Nicole Kravitz-Wirtz,... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - January 10, 2020 Category: Pharmaceuticals Source Type: news

Meds2Go Express Pharmacy, Inc. Pleads Guilty to Money Laundering in Connection with Drug Diversion Scheme
Alum Creek WV, Meds2Go Express Pharmacy, plea, guilty, money laundering, drug diversion, pain clinic, pill mill, opioids, community restitution, drug abuse treatment, Rx opioids, red flags, oxycodone, drug addicts, methadone, compounding, Charleston WV, forfeiture, (Source: Office of Criminal Investigations (OCI) Press Releases)
Source: Office of Criminal Investigations (OCI) Press Releases - January 6, 2020 Category: Medical Law Authors: DOJ Source Type: news

Yale study urges lifesaving drug treatment to combat Ukraine's HIV epidemic
(Yale University) A new study led by Yale University researchers finds that scaling up use of methadone and buprenorphine could greatly reduce HIV transmission rates and prevent deaths in Ukraine. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 3, 2020 Category: International Medicine & Public Health Source Type: news

Study urges life-saving drug treatment to combat Ukraine ’s HIV epidemic
A new study finds that scaling up use of methadone and buprenorphine could greatly reduce HIV transmission rates and prevent deaths in Ukraine. (Source: Yale Science and Health News)
Source: Yale Science and Health News - January 2, 2020 Category: Universities & Medical Training Source Type: news

A comparison of blood toxicology in fatalities involving alcohol and other drugs in patients with an opioid use disorder treated with methadone, buprenorphine, and implant naltrexone - Kelty E, Hulse G, Joyce D.
Background: Methadone, buprenorphine, and implant naltrexone have comparable efficacy in preventing death from drug intoxication during treatment, but there may be differences between treatments in the specific drugs contributing to death and in the... (Source: SafetyLit)
Source: SafetyLit - December 23, 2019 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Chronic opioid treatment may raise risk of post-traumatic stress disorder, study finds
While opioids are often prescribed to treat people with trauma-related pain, a new UCLA-led study suggests doctors should use caution before prescribing the drug to those they believe may experience severe stress in the future, in order to reduce the risk the patient will develop PTSD.In the study, researchers administered doses of the opioid morphine to a group of 22 mice for one week, then gave the mice relatively strong foot shocks. After the morphine wore off, the mice were given mild electric foot shocks. These mice showed a substantially longer “freezing response” than a second, control group of 24 mice t...
Source: UCLA Newsroom: Health Sciences - December 3, 2019 Category: Universities & Medical Training Source Type: news

Seychelles: Drug Rehab Centre to Be Built in Bon Espoir to Tackle Drug Programme, Seychelles' Government Says
[Seychelles News Agency] Tackling the drug problem in Seychelles is a top priority of the government, which views the country's methadone programme as a cost-effective method to deal with the threat, top officials said on Monday. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - December 3, 2019 Category: African Health Source Type: news

Doctors should avoid co-prescribing benzodiazepines to opioid dependent patients due to increase in overdose death
Doctors should avoid co-prescribing benzodiazepines to opioid dependent patients who are being treated with methadone or buprenorphine, also known as opioid agonist treatment (OAT), due to a three-fold increase in risk of overdose death, according to a study led by researchers at the University of Bristol. (Source: University of Bristol news)
Source: University of Bristol news - November 26, 2019 Category: Universities & Medical Training Tags: Health, International, Research; Faculty of Health Sciences, Faculty of Health Sciences, Population Health Sciences, Faculty of Health Sciences, Bristol Medical School; Press Release Source Type: news

Cannabis found not to be a substitute for opioids
(McMaster University) The research team looked at all research on the effects of cannabis use on illicit opioid use during methadone maintenance therapy, which is a common treatment for opioid use disorder, and found six studies involving more than 3,600 participants. A meta-analysis of the studies found cannabis use didn't reduce illicit opioid use during treatment nor did it retain people in treatment. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - November 19, 2019 Category: International Medicine & Public Health Source Type: news

Drug abuse and behavioral transgressions during methadone maintenance treatment (MMT) are related to high psychopathy levels - Potik D, Abramsohn Y, Schreiber S, Adelson M, Peles E.
Introduction: Studies which used the Psychopathy Checklist-Revised (PCL-R) among methadone maintenance treatment (MMT) patients focused mostly on methodological issues, without addressing its relationship to patients' misconduct during treatment. Th... (Source: SafetyLit)
Source: SafetyLit - November 16, 2019 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news