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Infrared spectra and structures of protonated amantadine isomers: detection of ammonium and open-cage iminium ions
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Martin Andreas Robert George, Otto Dopfer The two isomers of the pharmaceutically active AmaH+ ion identified by IR spectroscopy are the canonical ammonium isomer (I) formed by protonation at the NH2 group and a protonated bicyclic iminium ion (II) formed by ionization of Ama followed by cage opening and H addition. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Phys. Chem. Chem. Phys. latest articles)
Source: RSC - Phys. Chem. Chem. Phys. latest articles - June 24, 2022 Category: Chemistry Authors: Martin Andreas Robert George Source Type: research

Amantadine extended release capsules (GOCOVRI ®) in Parkinson’s disease: a profile of its use in the USA
AbstractAmantadine extended release (ER) [GOCOVRI®], an NMDA receptor antagonist, is an important treatment option in the management of levodopa-induced dyskinesia (LID) and OFF episodes in patients with Parkinson ’s disease (PD). Taken at bedtime, amantadine ER provides low plasma levels overnight and high plasma concentrations during the waking day (i.e. delayed release). In randomized, double-blind, placebo-controlled phase III trials in adults with PD, once-daily amantadine ER was effective in improving LID, reducing OFF time and increasing ON time without troublesome dyskinesia, compared with placebo. Control of mo...
Source: Drugs and Therapy Perspectives - June 15, 2022 Category: Drugs & Pharmacology Source Type: research

Quantum dot nanobead immunochromatographic assay based on bispecific monoclonal antibody for the simultaneous detection of aflatoxin B1 and amantadine
Volume 33, Issue 1, December 2022, Page 403-418 . (Source: Food and Agricultural Immunology)
Source: Food and Agricultural Immunology - June 14, 2022 Category: Food Science Authors: Kezhuo Zhang Huadong Cai Min Lu Daixian Wei Jiaqi Yin Nengshui Ding Weihua Lai Juan Peng Source Type: research

Infrared Spectra and Structures of Protonated Amantadine Isomers: Detection of Ammonium and Open-Cage Iminium Ions
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Martin Andreas Robert George, Otto Dopfer The protonated form of amantadine (1-C10H15NH2, Ama), the amino derivative of adamantane (C10H16, Ada), is a wide-spread antiviral and anti-Parkinsonian drug and plays a key role in many pharmaceutical processes.... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Phys. Chem. Chem. Phys. latest articles)
Source: RSC - Phys. Chem. Chem. Phys. latest articles - June 13, 2022 Category: Chemistry Authors: Martin Andreas Robert George Source Type: research

Possible involvement of NO-cGMP signaling in the antidepressant like Effect of Amantadine in mice
In conclusion, amantadine exerted antidepressant like effect in mice and NO-cGMP signaling influences the antidepressant like effect of amantadine in mice. (Source: Metabolic Brain Disease)
Source: Metabolic Brain Disease - June 6, 2022 Category: Neurology Source Type: research

Amantadine treatment is associated with improved consciousness in patients with non-traumatic brain injury
Conclusions Amantadine treatment is associated with improved consciousness among patients with different types of non-traumatic brain injury in this observational cohort analysis. Epileptic seizures should be considered as potential side effects and randomised controlled trials are needed to confirm these findings. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 27, 2022 Category: Neurosurgery Authors: Rühl, L., Kuramatsu, J. B., Sembill, J. A., Kallmünzer, B., Madzar, D., Gerner, S. T., Giede-Jeppe, A., Balk, S., Mueller, T., Jäger, J., Schwab, S., Huttner, H. B., Sprügel, M. I. Tags: Open access Cerebrovascular disease Source Type: research

Opening of the Diamondoid Cage upon Ionization Probed by Infrared Spectra of the Amantadine Cation Solvated by Ar, N2, and H2O
Chemistry. 2022 May 25. doi: 10.1002/chem.202200577. Online ahead of print.ABSTRACTRadical cations of diamondoids, a fundamental class of very stable cyclic hydrocarbon molecules, play an important role in their functionalization reactions and the chemistry of the interstellar medium. Herein, we characterize the structure, energy, and intermolecular interaction of clusters of the amantadine radical cation (Ama + , 1-aminoadamantane) with solvent molecules of different interaction strength by infrared photodissociation (IRPD) spectroscopy of mass-selected Ama + L n clusters, with L=Ar ( n ≤3) and L=N 2 and H 2 O ( n =1), ...
Source: Chemistry - May 25, 2022 Category: Chemistry Authors: Martin Andreas Robert George Otto Dopfer Source Type: research

Identification of Human Case of Avian Influenza A(H5N1) Infection, India
Emerg Infect Dis. 2022 Jun;28(6):1269-1273. doi: 10.3201/eid2806.212246.ABSTRACTA 11-year-old boy with acute myeloid leukemia was brought for treatment of severe acute respiratory infection in the National Capital Region, New Delhi, India. Avian influenza A(H5N1) infection was laboratory confirmed. Complete genome analysis indicated hemagglutinin gene clade 2.3.2.1a. We found the strain to be susceptible to amantadine and neuraminidase inhibitors.PMID:35608874 | DOI:10.3201/eid2806.212246 (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - May 24, 2022 Category: Infectious Diseases Authors: Varsha Potdar Megha Brijwal Rakesh Lodha Pragya Yadav Santosh Jadhav Manohar Lal Choudhary Aashish Choudhary Veena Vipat Nivedita Gupta Ashok Kumar Deorari Lalit Dar Priya Abraham Source Type: research