RICTOR amplification is associated with Rictor membrane staining and does not correlate with PD-L1 expression in lung squamous cell carcinoma
In conclusion, the correlation between RICTOR amplification and Rictor membrane staining suggests that the latter can potentially be used as a surrogate marker to identify lung SCC cases with RICTOR amplification. Since a significant proportion of PD-L1 negative SCC cases harbor RICTOR amplification, analyzing PD-L1 negative tumors by RICTOR FISH or Rictor IHC can help select patients who may benefit from mTORC2 inhibitor therapy.PMID:38706776 | PMC:PMC11066283 | DOI:10.3389/pore.2024.1611593 (Source: Cell Research)
Source: Cell Research - May 6, 2024 Category: Cytology Authors: Ildik ó Krencz D ániel Sztankovics Anna Sebesty én Judit P ápay Titanilla Dank ó Dorottya Moldvai Elmar Lutz Andras Khoor Source Type: research
USP39 Promotes the Viability and Migration of Head and Neck Squamous Cell Carcinoma Cell by Regulating STAT1
Conclusion: Our findings indicated that USP39 knockdown may inhibit HNSCC viability and migration by suppressing STAT1 expression. The results of this study suggest that USP39 may be a potential new target for HNSCC clinical therapy or a new biomarker for HNSCC.PMID:38706215 | DOI:10.1177/15330338241250298 (Source: Cell Research)
Source: Cell Research - May 6, 2024 Category: Cytology Authors: Yu Hu Yang Wang Wenrui Hu Chenrui Hu Bin Wang Congli Liu Anqi Deng Bing Shen Kaile Wu Yehai Liu Source Type: research
Capsaicin reverses cisplatin resistance in tongue squamous cell carcinoma by inhibiting the Warburg effect and facilitating mitochondrial-dependent apoptosis via the AMPK/AKT/mTOR axis
Cell Biol Int. 2024 May 5. doi: 10.1002/cbin.12169. Online ahead of print.ABSTRACTCisplatin is commonly used for the chemotherapy of tongue squamous cell carcinoma (TSCC); however, adverse side effects and drug resistance impact its therapeutic efficacy. Capsaicin is an active ingredient in chili peppers that exerts antitumor effects, whether it exerts antitumor effects on cisplatin-resistant cells remains unknown. Therefore, in this study, we investigated the effect of capsaicin on cisplatin resistance in TSCC cells and explored the underlying mechanisms. A cisplatin-resistant TSCC cell line was established by treated wit...
Source: Cell Biology International - May 6, 2024 Category: Cytology Authors: Xiayang Liu Zhuang Li Qiwei Zhao Xinyue Zhou Yu Wang Gang Zhao Xiaohong Guo Source Type: research
Chemopreventive Effects of Curcumin Against 7,12-Dimethylbenz[a]anthracene-Induced Hamster Buccal Pouch Carcinogenesis
CONCLUSION: Curcumin had chemopreventive effects against DMBA-induced buccal pouch OSCC through the modulating effect on the abnormal expression of VEGF. (Source: Dentistry 3000)
Source: Dentistry 3000 - May 6, 2024 Category: Dentistry Authors: Maher Al-assaf, Nabil Kochaji, Shaza Al laham, Issa Al-Assaf, Caroline Mousallam, Charif Barakat Source Type: research
NRN1 interacts with Notch to increase oncogenic STAT3 signaling in melanoma
Melanoma is a highly heterogeneous cancer, in which frequent changes in activation of signaling pathways lead to a high adaptability to ever changing tumor microenvironments. The elucidation of cancer specific... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - May 6, 2024 Category: Molecular Biology Authors: Lucia Devitt, Dana Westphal, Katharina Pieger, Nadja Schneider, Anja Katrin Bosserhoff and Silke Kuphal Tags: Research Source Type: research
LncRNA FOXD2-AS1 Promotes the Growth, Invasion and Migration of OSCC Cells by Regulating the MiR-185-5p/PLOD1/Akt/mTOR Pathway
One of the most prevalent types of cancer of the head and neck is oral squamous cell carcinoma (OSCC) [1]. Every year, about 14,290 new instances of OSCC are reported in the US [2], and the overall survival rate for those suffering with OSCC remains rather low [3]. At the same time, the developmental mechanism of OSCC is still unclear and lacks an effective drug target. Thus, a thorough investigation of OSCC's molecular mechanism is essential to understanding the disease's developmental mechanism and creating fresh, potent treatment strategies. (Source: Cancer Genetics and Cytogenetics)
Source: Cancer Genetics and Cytogenetics - May 6, 2024 Category: Genetics & Stem Cells Authors: Jian Liu, Yong Zhang, Jingjing Wu, Xin Liu, Lifang Li, Jinhong Zhang Tags: Original Article Source Type: research
WNT3 promotes chemoresistance to 5-Fluorouracil in oral squamous cell carcinoma via activating the canonical β-catenin pathway
5-Fluorouracil (5FU) is a primary chemotherapeutic agent used to treat oral squamous cell carcinoma (OSCC). However, the development of drug resistance has significantly limited its clinical application. There... (Source: BMC Cancer)
Source: BMC Cancer - May 6, 2024 Category: Cancer & Oncology Authors: Xuyang Zhang, Kairui Sun, Ruihuan Gan, Yuxiang Yan, Chaochao Zhang, Dali Zheng and Youguang Lu Tags: Research Source Type: research
Fatal myasthenia gravis (MG) associated with myositis and myocarditis in a patient with pre-existing MG treated by adjuvant nivolumab for a stage III melanoma.
Dear Editor (Source: European Journal of Cancer)
Source: European Journal of Cancer - May 6, 2024 Category: Cancer & Oncology Authors: J. Emile, C. Cauquil, D. Carpentier, E. Routier, Caroline Robert Tags: Letter to the Editor Source Type: research
Identification and characterization of a new potent inhibitor targeting CtBP1/BARS in melanoma cells
The C-terminal-binding protein 1/brefeldin A ADP-ribosylation substrate (CtBP1/BARS) acts both as an oncogenic transcriptional co-repressor and as a fission inducing protein required for membrane trafficking a... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - May 6, 2024 Category: Cancer & Oncology Authors: Angela Filograna, Stefano De Tito, Matteo Lo Monte, Rosario Oliva, Francesca Bruzzese, Maria Serena Roca, Antonella Zannetti, Adelaide Greco, Daniela Spano, Inmaculada Ayala, Assunta Liberti, Luigi Petraccone, Nina Dathan, Giuliana Catara, Laura Schembri, Tags: Research Source Type: research
A cross-linked macropore hydrogel based on M1 macrophage lysate and alginate regulates tumor-associated macrophages for the treatment of melanoma
This study supported that M1LMHA might be an effective and safe tool to activate tumor-associated immune cells, improving the efficiency of anti-tumor immunotherapy.PMID:38705331 | DOI:10.1016/j.ijbiomac.2024.132089 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - May 5, 2024 Category: Biochemistry Authors: Wanyu Li Qingbang Ye Zhonghao Jiang Dong Xia Zhuo Yan Dan Wang Yanan Chen Tianshou Cao Jilong Wang Chihao Lin Huiling Yang Junjie Deng Jiantao Lin Source Type: research
Injectable hydrogels based on biopolymers for the treatment of ocular diseases
This study provides a thorough analysis of applications of injectable hydrogels based on biopolymers across these ocular disorders. Injectable hydrogels based on biopolymers can be customized to have specific physical, chemical, and biological properties that make them suitable as drug delivery vehicles, tissue scaffolds, and sealants in the eye. For example, they can be engineered to have optimum viscosity to be injected intravitreally and sustain drug release to treat retinal diseases. Their porous structure and biocompatibility promote cellular infiltration to regenerate diseased corneal tissue. By accentuating their in...
Source: International Journal of Biological Macromolecules - May 5, 2024 Category: Biochemistry Authors: Caiyu Yu Jiahao Xu Golnaz Heidari Huijun Jiang Yifeng Shi Aimin Wu Pooyan Makvandi Rasoul Esmaeely Neisiany Ehsan Nazarzadeh Zare Minmin Shao Liang Hu Source Type: research
Latent-transforming growth factor β-binding protein 1/Transforming growth factor β1 complex drives antitumoral effects upon ERK5 targeting in melanoma
This study, therefore, identifies additional desirable effects of ERK5 targeting, providing evidence of an ERK5-dependent tumor suppressive role of TGF-β in melanoma.PMID:38705382 | DOI:10.1016/j.ajpath.2024.03.015 (Source: Am J Pathol)
Source: Am J Pathol - May 5, 2024 Category: Pathology Authors: Alessandro Tubita Alessio Menconi Zoe Lombardi Ignazia Tusa Azucena Espar ís-Ogando Atanasio Pandiella Tania Gamberi Barbara Stecca Elisabetta Rovida Source Type: research
Latent-transforming growth factor β-binding protein 1/Transforming growth factor β1 complex drives antitumoral effects upon ERK5 targeting in melanoma
This study, therefore, identifies additional desirable effects of ERK5 targeting, providing evidence of an ERK5-dependent tumor suppressive role of TGF-β in melanoma.PMID:38705382 | DOI:10.1016/j.ajpath.2024.03.015 (Source: The American Journal of Pathology)
Source: The American Journal of Pathology - May 5, 2024 Category: Pathology Authors: Alessandro Tubita Alessio Menconi Zoe Lombardi Ignazia Tusa Azucena Espar ís-Ogando Atanasio Pandiella Tania Gamberi Barbara Stecca Elisabetta Rovida Source Type: research
Phage-delivered melittin for oral squamous cell Carcinoma: A potential therapeutic agent
Int Immunopharmacol. 2024 May 4:112163. doi: 10.1016/j.intimp.2024.112163. Online ahead of print.NO ABSTRACTPMID:38705763 | DOI:10.1016/j.intimp.2024.112163 (Source: International Immunopharmacology)
Source: International Immunopharmacology - May 5, 2024 Category: Allergy & Immunology Authors: Maheswaran Easwaran Fatma Abdelrahman Sivagnanavelmurugan Madasamy Baskar Venkidasamy Source Type: research
Evaluating the efficacy and safety of nivolumab and ipilimumab combination therapy compared to nivolumab monotherapy in advanced cancers (excluding melanoma): a systemic review and meta-analysis
CONCLUSIONS: Combining nivolumab and ipilimumab did not significantly improve overall survival compared to nivolumab alone in advanced cancers (except melanoma). However, it did show slightly better PFS at the cost of increased toxicity, particularly grades 3-4 adverse events. Specific AEs occurred more frequently in the combination group. Further trials are needed to fully assess this combination in treating advanced cancers.PMID:38705953 | DOI:10.1186/s43046-024-00218-2 (Source: J Egypt Natl Canc In...)
Source: J Egypt Natl Canc In... - May 5, 2024 Category: Cancer & Oncology Authors: Hussain Sohail Rangwala Hareer Fatima Mirha Ali Sailesh Sunder Sonia Devi Burhanuddin Sohail Rangwala Syed Raza Abbas Source Type: research
