Cancers, Vol. 16, Pages 1773: MIF and CD74 as Emerging Biomarkers for Immune Checkpoint Blockade Therapy
Kulkarni
Immune checkpoint blockade (ICB) therapy is used to treat a wide range of cancers; however, some patients are at risk of developing treatment resistance and/or immune-related adverse events (irAEs). Thus, there is a great need for the identification of reliable predictive biomarkers for response and toxicity. The cytokine MIF (macrophage migration inhibitory factor) and its cognate receptor CD74 are intimately connected with cancer progression and have previously been proposed as prognostic biomarkers for patient outcome in various cancers, including solid tumors such as malignant melanoma. Here, we assess th...
Source: Cancers - May 4, 2024 Category: Cancer & Oncology Authors: Rosalyn M. Fey Rebecca A. Nichols Thuy T. Tran Arthur A. Vandenbark Rajan P. Kulkarni Tags: Review Source Type: research
A Frequent Diagnostic Pitfall: Dermatological Clinical Features and Pathological Results in Diagnosing Pagetoid Squamous Cell Carcinoma in situ (Case Series)
In this study, three patients underwent pathological routine and auxiliary immunohistochemical (IHC) examination and were ultimately diagnosed with pagetoid SCC in situ - a different diagnosis from the initial clinical assessment. All three patients received a complete resection of the skin mass. After follow-up, as of June 2023, the patients had no tumour recurrence or metastasis. Pagetoid SCC in situ is a particular type of SCC in situ that has no specific features in clinical manifestations, gross diagnosis or histopathological sections. The final diagnosis depends on IHC staining. Pagetoid SCC in situ expresses EMA, CK...
Source: Clinical, Cosmetic and Investigational Dermatology - May 3, 2024 Category: Dermatology Authors: Sheng-Kai Wang Jia-Wei Cai Yu Zhang Ya-Jing Lin Yi-Hui Yang Source Type: research
Extracellular vesicles from Aggregatibacter actinomycetemcomitans exhibit potential antitumorigenic effects in oral cancer: a comparative in vitro study
Arch Microbiol. 2024 May 3;206(6):244. doi: 10.1007/s00203-024-03976-8.ABSTRACTAggregatibacter actinomycetemcomitans is an opportunistic Gram-negative periodontopathogen strongly associated with periodontitis and infective endocarditis. Recent evidence suggests that periodontopathogens can influence the initiation and progression of oral squamous cell carcinoma (OSCC). Herein we aimed to investigate the effect of A. actinomycetemcomitans-derived extracellular vesicles (EVs) on OSCC cell behavior compared with EVs from periodontopathogens known to associate with carcinogenesis. EVs were isolated from: A. actinomycetemcomita...
Source: Archives of Microbiology - May 3, 2024 Category: Microbiology Authors: Marjut Mets äniitty Shrabon Hasnat Carina Öhman Tuula Salo Kari K Eklund Jan Oscarsson Abdelhakim Salem Source Type: research
PLAU, transcriptionally negatively regulated by GATA6, promotes lung squamous carcinoma cell proliferation and migration
CONCLUSION: In this work, it was revealed that PLAU is a novel oncogene for LUSC and a new molecular regulatory mechanism of GATA6 in LUSC was unveiled. Targeting the GATA6/PLAU pathway might help in the development of novel therapeutic treatment strategies for LUSC.PMID:38702016 | DOI:10.1016/j.bbamcr.2024.119744 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - May 3, 2024 Category: Biochemistry Authors: Jiankun Guo Hailong Wang Changhua Huang Caihong Lai Wenli Shang Shiwen Luo Limin Chen Source Type: research
Cancer stem-like cells in uveal melanoma: Novel insights and therapeutic implications
Biochim Biophys Acta Rev Cancer. 2024 May 1:189104. doi: 10.1016/j.bbcan.2024.189104. Online ahead of print.ABSTRACTUveal melanoma (UM) is the most common primary ocular tumor in the adult population. Even though these primary tumors are successfully treated in 90% of cases, almost 50% of patients ultimately develop metastasis, mainly in the liver, via hematological dissemination, with a median survival spanning from 6 to 12 months after diagnosis. In this context, chemotherapy regimens and molecular targeted therapies have demonstrated poor response rates and failed to improve survival. Among the multiple reasons for ther...
Source: Biochimica et Biophysica Acta - May 3, 2024 Category: Biochemistry Authors: Alessandra Loda Francesco Semeraro Silvia Parolini Roberto Ronca Sara Rezzola Source Type: research
A Frequent Diagnostic Pitfall: Dermatological Clinical Features and Pathological Results in Diagnosing Pagetoid Squamous Cell Carcinoma in situ (Case Series)
In this study, three patients underwent pathological routine and auxiliary immunohistochemical (IHC) examination and were ultimately diagnosed with pagetoid SCC in situ - a different diagnosis from the initial clinical assessment. All three patients received a complete resection of the skin mass. After follow-up, as of June 2023, the patients had no tumour recurrence or metastasis. Pagetoid SCC in situ is a particular type of SCC in situ that has no specific features in clinical manifestations, gross diagnosis or histopathological sections. The final diagnosis depends on IHC staining. Pagetoid SCC in situ expresses EMA, CK...
Source: Clinical, Cosmetic and Investigational Dermatology - May 3, 2024 Category: Dermatology Authors: Sheng-Kai Wang Jia-Wei Cai Yu Zhang Ya-Jing Lin Yi-Hui Yang Source Type: research
ALDH1A1 confers resistance to RAF/MEK inhibitors in melanoma cells by maintaining stemness phenotype and activating PI3K/AKT signaling
This study demonstrates that melanoma cells overexpressing ALDH1A1 displayed resistance to vemurafenib and trametinib through the activation of PI3K/AKT signaling instead of MAPK axis. Inhibition of PI3K/AKT signaling partially rescued sensitivity to the drugs. Consistently, pharmacological inhibition of ALDH1A1 activity downregulated the activation of AKT and partially recovered responsiveness to vemurafenib and trametinib. We propose ALDH1A1 as a new potential target for treating melanoma resistant to MAPK/ERK inhibitors.PMID:38701866 | DOI:10.1016/j.bcp.2024.116252 (Source: Biochemical Pharmacology)
Source: Biochemical Pharmacology - May 3, 2024 Category: Drugs & Pharmacology Authors: Valerio Ciccone Vittoria Simonis Cinzia Del Gaudio Claudio Cucini Marina Ziche Lucia Morbidelli Sandra Donnini Source Type: research
ASO Author Reflections: Tumor Response After the First Course of Neoadjuvant Chemotherapy Reflects Prognosis After Surgery in Patients with Esophageal Squamous Cell Carcinoma
Ann Surg Oncol. 2024 May 3. doi: 10.1245/s10434-024-15371-0. Online ahead of print.NO ABSTRACTPMID:38702391 | DOI:10.1245/s10434-024-15371-0 (Source: Ann Oncol)
Source: Ann Oncol - May 3, 2024 Category: Cancer & Oncology Authors: Takaomi Hagi Osamu Shiraishi Takushi Yasuda Source Type: research
Association of glucagon-like peptide-1 receptor agonists with risk of cancers-evidence from a drug target Mendelian randomization and clinical trials
CONCLUSIONS: Our study suggests that GLP1RA may decrease the risk of breast cancer and basal cell carcinoma, but increase the risk of colorectal cancer. However, according to the systematic review of RCTs, the incidence of cancer in patients treated with GLP1RA is low. Larger sample sizes of RCTs with long-term follow-up are necessary to establish the incidence of cancers and evaluate the risk-benefit ratios.PMID:38701500 | DOI:10.1097/JS9.0000000000001514 (Source: Cancer Control)
Source: Cancer Control - May 3, 2024 Category: Cancer & Oncology Authors: Yuming Sun Yongjia Liu Yating Dian Furong Zeng Guangtong Deng Shaorong Lei Source Type: research
PLAU, transcriptionally negatively regulated by GATA6, promotes lung squamous carcinoma cell proliferation and migration
CONCLUSION: In this work, it was revealed that PLAU is a novel oncogene for LUSC and a new molecular regulatory mechanism of GATA6 in LUSC was unveiled. Targeting the GATA6/PLAU pathway might help in the development of novel therapeutic treatment strategies for LUSC.PMID:38702016 | DOI:10.1016/j.bbamcr.2024.119744 (Source: Cell Research)
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Jiankun Guo Hailong Wang Changhua Huang Caihong Lai Wenli Shang Shiwen Luo Limin Chen Source Type: research
The laterality of skin cancer: a retrospective study
Arch Dermatol Res. 2024 May 3;316(5):148. doi: 10.1007/s00403-024-02877-6.NO ABSTRACTPMID:38700710 | DOI:10.1007/s00403-024-02877-6 (Source: Cell Research)
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Andrew Cho Patrick Ting Ingrid Freeny Source Type: research
Voriconazole Metabolism is Associated with the Number of Skin Cancers Per Patient
Res Sq [Preprint]. 2024 Apr 19:rs.3.rs-4152279. doi: 10.21203/rs.3.rs-4152279/v1.ABSTRACTVoriconazole exposure is associated with skin cancer, but it is unknown how the full spectrum of its metabolizer phenotypes impacts this association. We conducted a retrospective cohort study to determine how variation in metabolism of voriconazole as measured by metabolizer status of CYP2C19 is associated with the total number of skin cancers a patient develops and the rate of development of the first skin cancer after treatment. There were 1,739 organ transplant recipients with data on CYP2C19 phenotype. Of these, 134 were exposed to...
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Jacqueline I Ike Isabelle T Smith Dominique Mosley Christopher Madden Sarah Grossarth Briana R Halle Adam Lewis Frank Mentch Hakon Hakonarson Lisa Bastarache Lee Wheless Source Type: research
Extracellular vesicles from Aggregatibacter actinomycetemcomitans exhibit potential antitumorigenic effects in oral cancer: a comparative in vitro study
Arch Microbiol. 2024 May 3;206(6):244. doi: 10.1007/s00203-024-03976-8.ABSTRACTAggregatibacter actinomycetemcomitans is an opportunistic Gram-negative periodontopathogen strongly associated with periodontitis and infective endocarditis. Recent evidence suggests that periodontopathogens can influence the initiation and progression of oral squamous cell carcinoma (OSCC). Herein we aimed to investigate the effect of A. actinomycetemcomitans-derived extracellular vesicles (EVs) on OSCC cell behavior compared with EVs from periodontopathogens known to associate with carcinogenesis. EVs were isolated from: A. actinomycetemcomita...
Source: Archives of Microbiology - May 3, 2024 Category: Microbiology Authors: Marjut Mets äniitty Shrabon Hasnat Carina Öhman Tuula Salo Kari K Eklund Jan Oscarsson Abdelhakim Salem Source Type: research
Incidence Rates and Outcomes of Nodular and Superficial Spreading Melanoma along the Rural-Urban Continuum in Kentucky and Their Relationship to Provider Care Access
CONCLUSIONS: Our results suggest that a disparity in patients' ability or tendency to access primary care and/or specialist providers postdiagnosis may be critical factors in determining the ultimate outcome of a melanoma diagnosis. Further studies should explore the availability of dermatologists and/or treatment options for melanoma in rural areas. Our data also provide additional support for inclusion of melanoma subtype in the American Joint Committee on Cancer guidelines.PMID:38701843 | DOI:10.14423/SMJ.0000000000001681 (Source: Southern Medical Journal)
Source: Southern Medical Journal - May 3, 2024 Category: General Medicine Authors: Doug McElroy Mason Towery Seiry Molina-Lopez Ruth Eastham Sarah Grace Alexander Natalie J Mountjoy Source Type: research
Cancer stem-like cells in uveal melanoma: Novel insights and therapeutic implications
Biochim Biophys Acta Rev Cancer. 2024 May 1:189104. doi: 10.1016/j.bbcan.2024.189104. Online ahead of print.ABSTRACTUveal melanoma (UM) is the most common primary ocular tumor in the adult population. Even though these primary tumors are successfully treated in 90% of cases, almost 50% of patients ultimately develop metastasis, mainly in the liver, via hematological dissemination, with a median survival spanning from 6 to 12 months after diagnosis. In this context, chemotherapy regimens and molecular targeted therapies have demonstrated poor response rates and failed to improve survival. Among the multiple reasons for ther...
Source: Biochimica et Biophysica Acta - May 3, 2024 Category: Biochemistry Authors: Alessandra Loda Francesco Semeraro Silvia Parolini Roberto Ronca Sara Rezzola Source Type: research
