Insights into metastatic roadmap of head and neck cancer squamous cell carcinoma based on clinical, histopathological and molecular profiles
Mol Biol Rep. 2024 Apr 29;51(1):597. doi: 10.1007/s11033-024-09476-8.ABSTRACTThe incidence of head and neck cancer (HNC), constituting approximately one in ten cancer cases worldwide, affects approximately 644,000 individuals annually. Managing this complex disease involves various treatment modalities such as systemic therapy, radiation, and surgery, particularly for patients with locally advanced disease. HNC treatment necessitates a multidisciplinary approach due to alterations in patients' genomes affecting their functionality. Predominantly, squamous cell carcinomas (SCCs), the majority of HNCs, arise from the upper a...
Source: Molecular Biology Reports - April 29, 2024 Category: Molecular Biology Authors: Nicholas S Mastronikolis Alexander Delides Efthymios Kyrodimos Zoi Piperigkou Despoina Spyropoulou Evangelos Giotakis Evangelos Tsiambas Nikos K Karamanos Source Type: research
Sarcopenia as a Predictor of Feeding Tube Placement in Individuals with Oropharyngeal Cancer
CONCLUSIONS: SMM measured at T4 may represent a novel and practical biomarker for sarcopenia detection that is associated with the need for FT placement. These findings suggest that the detection of baseline sarcopenia could guide decision-making related to the need for nutritional support in OPSCC patients undergoing RT/CRT.PMID:38681896 | PMC:PMC11043844 | DOI:10.1016/j.adro.2024.101484 (Source: Adv Data)
Source: Adv Data - April 29, 2024 Category: Epidemiology Authors: Nedeljko Jovanovic David A Palma Andrew Warner Sylvia Mitchell Philip C Doyle Julie A Theurer Source Type: research
Safety Profile of Upadacitinib up to 5 Years in Psoriatic Arthritis, Ankylosing Spondylitis, and Non-radiographic Axial Spondyloarthritis: An Integrated Analysis of Clinical Trials
CONCLUSION: Higher rates of serious infection, HZ, lymphopenia, and NMSC were observed with upadacitinib versus adalimumab in PsA; slightly elevated rates for most of these TEAEs were seen with upadacitinib in PsA versus axSpA. Upadacitinib 15 mg demonstrated a generally consistent safety profile across disease states with no new safety signals identified.TRIAL REGISTRATION: SELECT-AXIS 1: NCT03178487; SELECT-AXIS 2: NCT04169373; SELECT-PsA 1: NCT03104400; SELECT-PsA 2: NCT03104374.PMID:38683479 | DOI:10.1007/s40744-024-00671-4 (Source: Herpes)
Source: Herpes - April 29, 2024 Category: Infectious Diseases Authors: Gerd R Burmester Jayne Stigler Andrea Rubbert-Roth Yoshiya Tanaka Valderilio F Azevedo Derek Coombs Ivan Lagunes Ralph Lippe Peter Wung Lianne S Gensler Source Type: research
A Phase II study of ERK inhibition by ulixertinib (BVD-523) in Metastatic Uveal Melanoma
CONCLUSIONS: ERK inhibition with ulixertinib (BVD-523) did not demonstrate activity in patients with metastatic uveal melanoma. The toxicities observed were consistent with what would be expected with MAPK pathway inhibition.PMID:38683104 | DOI:10.1158/2767-9764.CRC-24-0036 (Source: Biomed Res)
Source: Biomed Res - April 29, 2024 Category: Research Authors: Elizabeth I Buchbinder Justine V Cohen Giuseppe Tarantino Christine G Lian David Liu Rizwan Haq F Stephen Hodi Donald P Lawrence Anita Giobbie-Hurder Deborah Knoerzer Ryan J Sullivan Source Type: research
Expression of CLLD7 and CHC1L Proteins in Oral Epithelial Dysplasia in a Group of Thai Patients
CONCLUSION: The subcellular mislocalization of CLLD7 and CHC1L in OED suggests that the expression of these potential tumor suppressor proteins might be dysregulated during the dysplastic process. The distinct membrane staining of CHC1L observed in OED but not in NOM is a useful characteristic that can be used to separate OED from NOM. Thus, CHC1L may be a good marker to assist in the diagnosis of OED.PMID:38679985 | DOI:10.31557/APJCP.2024.25.4.1257 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Patcharanun Wiphakphongpakorn Rachai Juengsomjit Sopee Poomsawat Ounruean Meesakul Bishwa Prakash Bhattarai Boworn Klongnoi Waranun Buajeeb Siribang-On Piboonniyom Khovidhunkit Source Type: research
Outcomes of Induction Chemotherapy Followed by Chemoradiotherapy Versus Chemoradiotherapy Alone in Esophageal Squamous Cell Carcinoma Induction chemotherapy in Esophageal Squamous Cell Carcinoma
CONCLUSION: Our data demonstrated that a combination of IC and CRT might be a promising treatment strategy to further improve OS in ESCC patients.PMID:38679976 | DOI:10.31557/APJCP.2024.25.4.1183 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Saeed Hosseini Toudeshki Maryam Garousi Amir Mohammad Arefpour Pedram Fadavi Ali Basi Ahmad Foroughi Seyed Alireza Javadinia Source Type: research
Insights into metastatic roadmap of head and neck cancer squamous cell carcinoma based on clinical, histopathological and molecular profiles
Mol Biol Rep. 2024 Apr 29;51(1):597. doi: 10.1007/s11033-024-09476-8.ABSTRACTThe incidence of head and neck cancer (HNC), constituting approximately one in ten cancer cases worldwide, affects approximately 644,000 individuals annually. Managing this complex disease involves various treatment modalities such as systemic therapy, radiation, and surgery, particularly for patients with locally advanced disease. HNC treatment necessitates a multidisciplinary approach due to alterations in patients' genomes affecting their functionality. Predominantly, squamous cell carcinomas (SCCs), the majority of HNCs, arise from the upper a...
Source: Cancer Control - April 29, 2024 Category: Cancer & Oncology Authors: Nicholas S Mastronikolis Alexander Delides Efthymios Kyrodimos Zoi Piperigkou Despoina Spyropoulou Evangelos Giotakis Evangelos Tsiambas Nikos K Karamanos Source Type: research
Development of Compendium for Esophageal Squamous Cell Carcinoma
J Vis Exp. 2024 Apr 12;(206). doi: 10.3791/65480.ABSTRACTEsophageal cancer (EC) ranks as the 8th most aggressive malignancy, and its treatment remains challenging due to the lack of biomarkers facilitating early detection. EC manifests in two major histological forms - adenocarcinoma (EAD) and squamous cell carcinoma (ESCC) - both exhibiting variations in incidence across geographically distinct populations. High-throughput technologies are transforming the understanding of diseases, including cancer. A significant challenge for the scientific community is dealing with scattered data in the literature. To address this, a s...
Source: Cancer Control - April 29, 2024 Category: Cancer & Oncology Authors: Lucky Krishnia Manoj Kumar Kashyap Source Type: research
RNA-binding protein HuR reprograms immune T cells and promotes oral squamous cell carcinoma
We examined HuR's effects on oral malignancies and immune cell function in vitro and in vivo using oral carcinoma cells and transgenic HuR knockout (KO) mice. CRISPR/Cas9-mediated HuR deletion in mice syngeneic oral cancer cells eliminated colony formation and tumor development. HuR-KO tumors had a lower tumor volume, fewer CD4+CD25+FoxP3+ regulatory T cells, and more CD8+ T cells, suggesting that HuR may suppress the immune response during oral cancer progression. In contrast, HuR KO oral epithelial tissues are resistant to 4NQO-induced oral malignancies compared to control tumor-bearing mice. HuR KO mice showed fewer Tre...
Source: Cancer Control - April 29, 2024 Category: Cancer & Oncology Authors: Mrinmoyee Majumder Harinarayanan Janakiraman Paramita Chakraborty Anitha Vijayakumar Sari Mayhue Hong Yu Toros Dincman Romeo Martin Elizabeth O'Quinn Shikhar Mehrotra Viswanathan Palanisamy Source Type: research
The Effect of Tumor Resection and Radiotherapy on the Expression of Stem Cell Markers (CD44 and CD133) in Patients with Squamous Cell Carcinoma
Conclusion: The results also indicated that the expression of CD44 significantly decreased after tumor resection and radiotherapy. The upregulation of mRNA level of Bcl-2 and ALDH, and the downregulation of Bax and Bak gene expression were noted in these cases when compared to the healthy control group.PMID:38680713 | PMC:PMC11055418 | DOI:10.18502/ijhoscr.v18i1.14748 (Source: Cancer Control)
Source: Cancer Control - April 29, 2024 Category: Cancer & Oncology Authors: Ladan Paya Ali Rafat Mehdi Talebi Amirala Aghbali Nikzad Shahidi Babak Nejati Parya Emamverdizadeh Hojjatollah Nozad Charoudeh Source Type: research
Composition of the sputum bacterial microbiome of patients with different pathomorphological forms of non-small-cell lung cancer
Vavilovskii Zhurnal Genet Selektsii. 2024 Apr;28(2):204-214. doi: 10.18699/vjgb-24-25.ABSTRACTRecent studies have shown that the bacterial microbiome of the respiratory tract influences the development of lung cancer. Changes in the composition of the microbiome are observed in patients with chronic inflammatory processes. Such microbiome changes may include the occurrence of bacteria that cause oxidative stress and that are capable of causing genome damage in the cells of the host organism directly and indirectly. To date, the composition of the respiratory microbiome in patients with various histological variants of lung...
Source: Cancer Control - April 29, 2024 Category: Cancer & Oncology Authors: V G Druzhinin E D Baranova P S Demenkov L V Matskova A V Larionov Source Type: research
Role of Insulin Use and Social Determinants of Health on Non-melanoma Skin Cancer: Results From the Behavioral Risk Factor Surveillance System
CONCLUSIONS: Our findings suggest that socioeconomic differences related to the healthcare system and behavioral patterns are linked to discrepancies in the use of insulin and the development of NMSC.PMID:38680117 | DOI:10.1177/10732748241249896 (Source: Cancer Control)
Source: Cancer Control - April 29, 2024 Category: Cancer & Oncology Authors: Nour Massouh Ayad A Jaffa Miran A Jaffa Source Type: research
Serum Cytokines Correlate with Pretreatment Body Mass Index-adjusted Body Weight Loss Grading and Cancer Progression in Patients with Stage III Esophageal Squamous Cell Carcinoma Undergoing Neoadjuvant Chemoradiotherapy Followed by Surgery
In conclusion, TNF-α, IL-1β, and IL-6 were independent markers of malnutrition status and IL-4 was a prognostic factor for cancer progression in this patient population.PMID:38680010 | DOI:10.1080/01635581.2024.2341461 (Source: Nutrition and Cancer)
Source: Nutrition and Cancer - April 29, 2024 Category: Cancer & Oncology Authors: Yi-Ping Pan Hsuan-Chih Kuo Jui-Ying Lin Wen-Chi Chou Pei-Hung Chang Hang Huong Ling Kun-Yun Yeh Source Type: research
The Effect of Tumor Resection and Radiotherapy on the Expression of Stem Cell Markers (CD44 and CD133) in Patients with Squamous Cell Carcinoma
Conclusion: The results also indicated that the expression of CD44 significantly decreased after tumor resection and radiotherapy. The upregulation of mRNA level of Bcl-2 and ALDH, and the downregulation of Bax and Bak gene expression were noted in these cases when compared to the healthy control group.PMID:38680713 | PMC:PMC11055418 | DOI:10.18502/ijhoscr.v18i1.14748 (Source: Cell Research)
Source: Cell Research - April 29, 2024 Category: Cytology Authors: Ladan Paya Ali Rafat Mehdi Talebi Amirala Aghbali Nikzad Shahidi Babak Nejati Parya Emamverdizadeh Hojjatollah Nozad Charoudeh Source Type: research
Safety Profile of Upadacitinib up to 5 Years in Psoriatic Arthritis, Ankylosing Spondylitis, and Non-radiographic Axial Spondyloarthritis: An Integrated Analysis of Clinical Trials
ConclusionHigher rates of serious infection, HZ, lymphopenia, and NMSC were observed with upadacitinib versus adalimumab in PsA; slightly elevated rates for most of these TEAEs were seen with upadacitinib in PsA versus axSpA. Upadacitinib 15 mg demonstrated a generally consistent safety profile across disease states with no new safety signals identified.Trial RegistrationSELECT-AXIS 1: NCT03178487; SELECT-AXIS 2: NCT04169373; SELECT-PsA 1: NCT03104400; SELECT-PsA 2: NCT03104374. (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - April 29, 2024 Category: Rheumatology Source Type: research
