Carcinogenic effect of human tumor-derived cell-free filtrates in nude mice
This study confirms and extends our hypothesis that tumor homogenates contain and may act as vectors for "malignancy drivers," which ultimately implement a carcinogenesis process in otherwise healthy mice.PMID:38698774 | PMC:PMC11063718 | DOI:10.3389/fmolb.2024.1361377 (Source: Cancer Control)
Source: Cancer Control - May 3, 2024 Category: Cancer & Oncology Authors: Jorge Berlanga-Acosta Ernesto Arteaga-Hernandez Ariana Garcia-Ojalvo Dayanis Duvergel-Calderin Marisol Rodriguez-Touseiro Laura Lopez-Marin Jose Suarez-Alba Dasha Fuentes-Morales Osmany Mendoza-Fuentes Sheyla Fern ández-Puentes Yanier Nu ñez-Figueredo G Source Type: research
Voriconazole Metabolism is Associated with the Number of Skin Cancers Per Patient
Res Sq [Preprint]. 2024 Apr 19:rs.3.rs-4152279. doi: 10.21203/rs.3.rs-4152279/v1.ABSTRACTVoriconazole exposure is associated with skin cancer, but it is unknown how the full spectrum of its metabolizer phenotypes impacts this association. We conducted a retrospective cohort study to determine how variation in metabolism of voriconazole as measured by metabolizer status of CYP2C19 is associated with the total number of skin cancers a patient develops and the rate of development of the first skin cancer after treatment. There were 1,739 organ transplant recipients with data on CYP2C19 phenotype. Of these, 134 were exposed to...
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Jacqueline I Ike Isabelle T Smith Dominique Mosley Christopher Madden Sarah Grossarth Briana R Halle Adam Lewis Frank Mentch Hakon Hakonarson Lisa Bastarache Lee Wheless Source Type: research
The laterality of skin cancer: a retrospective study
Arch Dermatol Res. 2024 May 3;316(5):148. doi: 10.1007/s00403-024-02877-6.NO ABSTRACTPMID:38700710 | DOI:10.1007/s00403-024-02877-6 (Source: Cell Research)
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Andrew Cho Patrick Ting Ingrid Freeny Source Type: research
GSE165335 SmallRNAome profile of melanoma cell lines A375 and A375-BIR (BIR-BRAF INHIBITOR RESISTANT) during dabrafenib treatment
Contributors : R De Cegli ; P CarotenutoSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism :To analyse smallRNA expression differences between A375 and A375-BIR during the treatment with dabrafenib (DAB) (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - May 3, 2024 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Source Type: research
GSE165337 Transcriptomic profile of melanoma clinical samples treated with BRAF and MEK- inhibitors
Contributors : R De Cegli ; P CarotenutoSeries Type : Expression profiling by high throughput sequencingOrganism :To analyse the RNA expression differences between melanoma tumour samples treated with BRAF and MEK-inhibitors at different time points (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - May 3, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Source Type: research
GSE165338 RNAseq and Small-RNAseq dataset to comprehensively study the miRNA expression profiling of drug-resistant melanoma patients and cell lines
Series Type : Expression profiling by high throughput sequencing ; Non-coding RNA profiling by high throughput sequencingOrganism :This SuperSeries is composed of the SubSeries listed below. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - May 3, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Non-coding RNA profiling by high throughput sequencing Source Type: research
Clinical image: Cervicofacial rotation skin flap in PLWD patients
This article outlines a surgical protocol designed for people living with dementia (PLWD). It proposes that simultaneous resection and reconstruction of skin cancer can minimizes the need for initial care. The method outlined involves primary closure via a cervicofacial rotation flap technique and the use of monofilament resorbable sutures. (Source: Clinical Case Reports)
Source: Clinical Case Reports - May 3, 2024 Category: General Medicine Authors: C. Politis,
V. Lenaerts,
L. Evrard,
F. Shall,
D. Gorl é Tags: CASE IMAGE Source Type: research
MUC1 promotes cervical squamous cell carcinoma through ERK phosphorylation-mediated regulation of ITGA2/ITGA3
In contrast to the decreasing trends in developed countries, the incidence and mortality rates of cervical squamous cell carcinoma in China have increased significantly. The screening and identification of rel... (Source: BMC Cancer)
Source: BMC Cancer - May 3, 2024 Category: Cancer & Oncology Authors: Aiqin Zhao, Yunzhi Pan, Yingyin Gao, Zheng Zhi, Haiying Lu, Bei Dong, Xuan Zhang, Meiying Wu, Fenxia Zhu, Sufang Zhou and Sai Ma Tags: Research Source Type: research
Radiation-induced upregulation of FGL1 promotes esophageal squamous cell carcinoma metastasis via IMPDH1
This study inves... (Source: BMC Cancer)
Source: BMC Cancer - May 3, 2024 Category: Cancer & Oncology Authors: Shan Huang, Jiayi Zhang, Pu He, Xinyue Cui, Yuzhu Hou, Wanghui Su and Fang Li Tags: Research Source Type: research
Latent-transforming growth factor β-binding protein 1/Transforming growth factor β1 complex drives antitumoral effects upon ERK5 targeting in melanoma
Melanoma is the deadliest skin cancer, with a poor prognosis in advanced stages. Available treatments have improved the survival, although long-term benefits are still unsatisfactory. The mitogen-activated protein kinase ERK5 promotes melanoma growth, and ERK5 inhibition determines cellular senescence and the senescence-associated secretory phenotype. Here, latent-transforming growth factor β-binding protein 1 (LTBP1) mRNA was found to be upregulated in A375 and SK-Mel-5 BRAFV600E melanoma cells after ERK5 inhibition. (Source: American Journal of Pathology)
Source: American Journal of Pathology - May 3, 2024 Category: Pathology Authors: Alessandro Tubita, Alessio Menconi, Zoe Lombardi, Ignazia Tusa, Azucena Espar ís-Ogando, Atanasio Pandiella, Tania Gamberi, Barbara Stecca, Elisabetta Rovida Tags: Regular Article Source Type: research
Correction notice: Skin cancer-related conditions managed in general practice in Australia, 2000-2016: a nationally representative, cross-sectional survey
Reyes-Marcelino G, McLoughlin K, Harrison C, et al. Skin cancer-related conditions managed in general practice in Australia, 2000–2016: a nationally representative, cross-sectional survey. BMJ Open 2023;13:e067744. doi: 10.1136/bmjopen-2022-067744
Above mentioned article is revised since it was published as figures 2A and 3A did not include data on benign neoplasms, despite these being mentioned in the figure legend. Therefore, figures 2A and 3A is revised to correctly include the data on benign neoplasms. (Source: BMJ Open)
Source: BMJ Open - May 3, 2024 Category: General Medicine Tags: Open access Correction Source Type: research
The efficacy of indocyanine green fluoroscopy for sentinel node biopsy in head and neck melanoma: a systematic review and meta-analysis
The objective of this review was to conduct a systematic review and meta-analysis on the efficacy of ICG (indocyanine green) for sentinel lymph node (SLN) detection in head and neck melanoma.Study design: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement standards (PRISMA) were followed when conducting this review with a comprehensive search of the following online databases; Google Scholar, PubMed, MEDLINE, CINAHL, and CENTRAL, World Health Organization International Clinical Trials Registry (http://apps.who.int/trialsearch/), ClinicalTrials.gov (http://clinical-trials.gov/), and the ISRCTN ...
Source: The British Journal of Oral and Maxillofacial Surgery - May 3, 2024 Category: ENT & OMF Authors: Angus Hotchkies, Saniya Saiyed, Subbramanian Palaniappan, Paul Koroma, Tania Sarsam, Derek Falls, Sannia Hanif, Shafiq Rahman, Amr ElBatawy Tags: Systematic review Source Type: research
Cancers, Vol. 16, Pages 1771: Sex Differences in Odds of Brain Metastasis and Outcomes by Brain Metastasis Status after Advanced Melanoma Diagnosis
This study showed that males had greater odds of brain metastasis and, among those with brain metastasis, poorer rwOS compared to females, while there were no sex differences in clinical outcomes for those with advanced melanoma without brain metastasis. (Source: Cancers)
Source: Cancers - May 3, 2024 Category: Cancer & Oncology Authors: Gino Cioffi Mustafa S. Ascha Kristin A. Waite Mantas Dmukauskas Xiaoliang Wang Trevor J. Royce Gregory S. Calip Timothy Waxweiler Chad G. Rusthoven Brian D. Kavanagh Jill S. Barnholtz-Sloan Tags: Article Source Type: research
Targeting leucine-rich PPR motif-containing protein/LRPPRC by 5,7,4'-trimethoxyflavone suppresses esophageal squamous cell carcinoma progression
In this study, genes associated with JAK2, STAT3, and MYC were analyzed, and potential target genes were selected. Leucine-rich PPR motif-containing protein (LRPPRC) whose function and regulation are not fully understood, emerged as one of top 3 genes in terms of RNA epigenetic modification. Here, we demonstrate LRPPRC may be an independent prognostic indicator besides JAK2, STAT3, and MYC. Mechanistically, LRPPRC impairs N6-methyladenosine (m6A) modification of JAK2, STAT3, and MYC to facilitate nuclear mRNA export and expression. Meanwhile, excess LRPPRC act as a scaffold protein binding to JAK2 and STAT3 to enhance stab...
Source: International Journal of Biological Macromolecules - May 2, 2024 Category: Biochemistry Authors: Hui Liu Yubing Zhou Mangaladoss Fredimoses Peijia Niu Yunxiao Ge Rui Wu Tingting Liu Pan Li Yang Shi Yaqian Shi Kangdong Liu Zigang Dong Source Type: research
Clinicopathological profile of head and neck cancers in Army Hospital of Nepal: a retrospective study
CONCLUSIONS: Head and neck cancers are not uncommon and majority of patients present late with advanced stage cancer. Hence, public awareness, early diagnosis with cost-effective treatment and regular follow-up are needed to improve outcomes of these patients in our society.PMID:38694395 | PMC:PMC11060235 | DOI:10.1097/MS9.0000000000001918 (Source: Annals of Medicine)
Source: Annals of Medicine - May 2, 2024 Category: Internal Medicine Authors: Reeba Karki Anupama Marasini Rajeev Kumar Mahaseth Ranishma Bista Suman Raj Dongol Yuvraj Adhikari Source Type: research
