Validating evidence for the knowledge, management and involvement of dentists in a dental approach to sickle-cell disease
In conclusion, the level of agreement among experts showed evidence of the content validity of the instrument.PMID:38597546 | DOI:10.1590/1807-3107bor-2024.vol38.0026 (Source: Cell Research)
Source: Cell Research - April 10, 2024 Category: Cytology Authors: Lucia Helena da Silva Ferreira Ancillotti Mauro Henrique Nogueira Guimar ães de Abreu Ang élica Maria Cupertino Lopes Marinho Marcia Pereira Alves Dos Santos Source Type: research
TSH Receptor Reduces Hemoglobin S Polymerization and Increases Deformability and Adhesion of Sickle Erythrocytes
Anemia. 2024 Apr 2;2024:7924015. doi: 10.1155/2024/7924015. eCollection 2024.ABSTRACTSCD is a hereditary disorder caused by genetic mutation in the beta-globin gene, resulting in abnormal hemoglobin, HbS that forms sickle-shaped erythrocytes under hypoxia. Patients with SCD have endocrine disorders and it was described that 7% of these patients have clinical hypothyroidism. Recent studies have shown that mature erythrocytes possess TSH receptors. Thus, we aimed to assess the effects of TSH on SCD erythrocytes. The experiments were conducted using different concentrations of TSH (1, 2, 3, and 5 mIU/L). In HbS polymerization...
Source: Anemia - April 10, 2024 Category: Hematology Authors: Evelyn Mendon ça-Reis Camila Cristina Guimar ães-Nobre Lyzes Rosa Teixeira-Alves Leandro Miranda-Alves Clemilson Berto-Junior Source Type: research
Factors associated with adverse outcome among children with sickle cell disease admitted to the pediatric intensive care unit: an observational cohort
Sickle cell disease (SCD) is one of the most frequent inherited diseases in the world. Over the last decades, in high-income countries, an important decrease in mortality have been observed due to the improvem... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - April 10, 2024 Category: Intensive Care Authors: Micha ël Levy, Jérôme Naudin, Guillaume Geslain, Arielle Maroni, Bérengère Koehl, Fleur Le Bourgeois, Géraldine Poncelet, Maryline Chomton, Anna Deho, Sébastien Julliand, Stéphane Dauger and Julie Sommet Tags: Research Source Type: research
Case-control study of heart rate variability and sleep apnea in childhood sickle cell disease
In conclusion, while the decrease in sympathetic modulation in control children may contribute to increasing pharyngeal compliance, its decrease seems protective in children with sickle cell disease, which underlines the specificity of OSAS pathophysiology in SCD that could be due to sickle cell disease related smooth muscle dystonia.PMID:38590226 | DOI:10.1111/jsr.14209 (Source: Journal of Sleep Research)
Source: Journal of Sleep Research - April 9, 2024 Category: Sleep Medicine Authors: Plamen Bokov B érengère Koehl Benjamin Dudoignon Malika Benkerrou Christophe Delclaux Source Type: research
Case-control study of heart rate variability and sleep apnea in childhood sickle cell disease
In conclusion, while the decrease in sympathetic modulation in control children may contribute to increasing pharyngeal compliance, its decrease seems protective in children with sickle cell disease, which underlines the specificity of OSAS pathophysiology in SCD that could be due to sickle cell disease related smooth muscle dystonia.PMID:38590226 | DOI:10.1111/jsr.14209 (Source: Journal of Sleep Research)
Source: Journal of Sleep Research - April 9, 2024 Category: Sleep Medicine Authors: Plamen Bokov B érengère Koehl Benjamin Dudoignon Malika Benkerrou Christophe Delclaux Source Type: research
Case-control study of heart rate variability and sleep apnea in childhood sickle cell disease
In conclusion, while the decrease in sympathetic modulation in control children may contribute to increasing pharyngeal compliance, its decrease seems protective in children with sickle cell disease, which underlines the specificity of OSAS pathophysiology in SCD that could be due to sickle cell disease related smooth muscle dystonia.PMID:38590226 | DOI:10.1111/jsr.14209 (Source: Journal of Sleep Research)
Source: Journal of Sleep Research - April 9, 2024 Category: Sleep Medicine Authors: Plamen Bokov B érengère Koehl Benjamin Dudoignon Malika Benkerrou Christophe Delclaux Source Type: research
Case-control study of heart rate variability and sleep apnea in childhood sickle cell disease
In conclusion, while the decrease in sympathetic modulation in control children may contribute to increasing pharyngeal compliance, its decrease seems protective in children with sickle cell disease, which underlines the specificity of OSAS pathophysiology in SCD that could be due to sickle cell disease related smooth muscle dystonia.PMID:38590226 | DOI:10.1111/jsr.14209 (Source: Cell Research)
Source: Cell Research - April 9, 2024 Category: Cytology Authors: Plamen Bokov B érengère Koehl Benjamin Dudoignon Malika Benkerrou Christophe Delclaux Source Type: research
Assessment of hypoxemia among young adults with sickle cell anaemia in steady state in southwestern Nigeria: a crosssectional study
BMC Res Notes. 2024 Apr 8;17(1):100. doi: 10.1186/s13104-024-06765-0.ABSTRACTOBJECTIVES: Hypoxia is a known feature of sickle cell anaemia (SCA) which results from chronic anaemia and recurrent vaso-occlusive crisis (VOC) which can cause tissue ischaemia that leads to an end organ damage. The hallmark of SCA is chronic anaemia and recurrent vaso-occlusive crisis. The aim of this study is to compare the oxygen saturation of sickle cell anaemic individuals with the normal haemoglobin type (Hb AA) control and also to determine the prevalence of hypoxemia among SCA.RESULTS: Two-hundred and twenty-two (136 Hb SS and 86 Hb AA) p...
Source: Cell Research - April 8, 2024 Category: Cytology Authors: Asafa M A Ahmed I O Afolabi M S Bolarinwa R A Ogunlade O Source Type: research
Comparative assessment of quality of life among adolescents with sickle cell disease and sickle cell trait: evidence from Odisha, India
This study found a significantly lower health-related QOL in adolescents wit h SCD. However, most psychosocial sub-domains, for instance, worry about the illness, frequency of angry days, feeling jealousness toward other normal adolescents, and negative feelings of sadness on some days, are similarly affected in adolescents with SCT and SCD. The overall QOL of SCD individual s is more affected (percentage of affected mean score = 60.93%), followed by SCT individuals (35.63%). Healthy adolescents' QOL is relatively unaffected (13% were affected). The yearly frequency of blood transfusion received (1.7 ± 0.4) and ho...
Source: Journal of Community Genetics - April 8, 2024 Category: Genetics & Stem Cells Source Type: research
Genes, Vol. 15, Pages 469: Genetic Modifiers of Sickle Cell Anemia Phenotype in a Cohort of Angolan Children
Miguel Brito
The aim of this study was to identify genetic markers in the HBB Cluster; HBS1L-MYB intergenic region; and BCL11A, KLF1, FOX3, and ZBTB7A genes associated with the heterogeneous phenotypes of Sickle Cell Anemia (SCA) using next-generation sequencing, as well as to assess their influence and prevalence in an Angolan population. Hematological, biochemical, and clinical data were considered to determine patients’ severity phenotypes. Samples from 192 patients were sequenced, and 5,019,378 variants of high quality were registered. A catalog of candidate modifier genes that clustered in pathophy...
Source: Genes - April 8, 2024 Category: Genetics & Stem Cells Authors: Catarina Ginete Mariana Delgadinho Br ígida Santos Armandina Miranda Carina Silva Paulo Guerreiro Emile R. Chimusa Miguel Brito Tags: Article Source Type: research
Assessment of hypoxemia among young adults with sickle cell anaemia in steady state in southwestern Nigeria: a crosssectional study
Hypoxia is a known feature of sickle cell anaemia (SCA) which results from chronic anaemia and recurrent vaso-occlusive crisis (VOC) which can cause tissue ischaemia that leads to an end organ damage. The hall... (Source: BMC Research Notes)
Source: BMC Research Notes - April 8, 2024 Category: Research Authors: Asafa M. A., Ahmed I. O, Afolabi M. S., Bolarinwa R. A. and Ogunlade O. Tags: Research Note Source Type: research
Short-term air pollution levels and sickle cell disease hospital encounters in South Carolina: A case-crossover analysis
CONCLUSIONS: Our findings suggest that short-term (within two-weeks) levels of EC and O3 and may be associated with SCD hospital encounters among children. Two-pollutant model results suggest that EC is more likely responsible for effects on SCD than O3. More research is needed to confirm our findings.PMID:38583660 | DOI:10.1016/j.envres.2024.118766 (Source: Environmental Research)
Source: Environmental Research - April 7, 2024 Category: Environmental Health Authors: Tong Wen Robin C Puett Duanping Liao Julie Kanter Murray A Mittleman Sophie M Lanzkron Jeff D Yanosky Source Type: research
Short-term air pollution levels and sickle cell disease hospital encounters in South Carolina: A case-crossover analysis
CONCLUSIONS: Our findings suggest that short-term (within two-weeks) levels of EC and O3 and may be associated with SCD hospital encounters among children. Two-pollutant model results suggest that EC is more likely responsible for effects on SCD than O3. More research is needed to confirm our findings.PMID:38583660 | DOI:10.1016/j.envres.2024.118766 (Source: Environmental Research)
Source: Environmental Research - April 7, 2024 Category: Environmental Health Authors: Tong Wen Robin C Puett Duanping Liao Julie Kanter Murray A Mittleman Sophie M Lanzkron Jeff D Yanosky Source Type: research
