CRISPR for SCD
Seems like a new world but not without its challenges. Would love some insights/opinions from those directly involved.
F.D.A. Approves Sickle Cell Treatments, Including One That Uses CRISPR
People with the genetic disease have new opportunities to eliminate their symptoms, but the treatments come with obstacles that limit their reach.
www.nytimes.com
FDA Approves World’s First Crispr Gene-Editing Drug for Sickle-Cell Disease
FDA Approves World’s First Crispr Gene-Editing Drug...
Source: Student Doctor Network - December 8, 2023 Category: Universities & Medical Training Authors: nimbus Tags: Hematology / Oncology Source Type: forums
Recently accepted to medical school.. how competitive is this specialty for DO?
Hi, looking for some advice. I am currently in the med school application cycle and have been accepted by a DO program. A large part of my interest in medicine is having several family members affected by cancer and my best friend's battle with sickle cell anemia. Through shadowing and research experience at a med school this is a specialty I could see myself in. I have a few more interviews, but if granted no more acceptances, will it be an uphill battle for a heme/onc fellowship? Thanks in...
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Source: Student Doctor Network - October 13, 2023 Category: Universities & Medical Training Authors: TennCare Tags: Hematology / Oncology Source Type: forums
WAMC/School List c3.92/s3.96, 519, nontrad, CA ORM
Thanks so much in advance!
cGPA: 3.92. sGPA: 3.96
MCAT: 519 (130/129/128/132)
CA resident
White female
Undergrad: top tier public
Clinical experience: 10,000+ hrs clinical research coordinator (5+ years full time lead roles at T10s)
Research: 12 pubs (1 co-first author), 4 posters presented. Now working in research admin (2500 hrs clinical trials activation, IRB, budgets etc.) +200 undergrad lab
Shadowing: listing 50 hrs in Sickle Cell and Gen Peds (underserved...
Read more (Source: Student Doctor Network)
Source: Student Doctor Network - May 17, 2023 Category: Universities & Medical Training Authors: additionalrabbit Tags: What Are My Chances? WAMC Medical Source Type: forums
What is anesthesiology research? What research matters?
I am considering a research position doing bench work at my school for the summer. The project concerns the mechanism of opioids in resolving sickle cell pain crises using mice as a model organism. Is this research anesthesiology related? More generally, does research have to apply to the field one is aiming for to be impressive to PDs? Also, as I'm doing "bench work", does that mean I won't be involved in the final publication?
If it isn't anesthesiology related, what are some good places...
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Source: Student Doctor Network - April 28, 2023 Category: Universities & Medical Training Authors: kwb18200 Tags: Medical Students (DO) Source Type: forums
WAMC 3.0 cgpa 2.77 sgpa 2.97grad gpa 524 MCAT URM Non-Trad
What are my chances?
I'm a non-trad, URM, first generation
Undergrad GPA: 3.0
Science GPA: 2.77
Grad GPA: 2.97
MCAT: 524
Tons of paid clinical hours
Tons of volunteering
Own a non-profit/charity geared toward helping Sickle Cell patients who are underserved
Some research no pubs
Have stories of why my GPAs suffered, worked full time through undergrad, gave birth during my Master's (upward trend in my masters if that matters)
I think my personal statement is amazing (I have a really good...
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Source: Student Doctor Network - March 25, 2023 Category: Universities & Medical Training Authors: docdoc912 Tags: What Are My Chances? WAMC Medical Source Type: forums
Making space to learn directly from people with sickle cell disease
(Source: BMJ Comments)
Source: BMJ Comments - November 24, 2021 Category: General Medicine Source Type: forums
Concerns about Equity and Bias in New Revised CDC Guidelines
See attached.
Observations on CDC Guideline for Prescribing Opioids – United States, 2022
This document outlines the observations of the Opioid Workgroup on the updated CDC Guideline for Prescribing
Opioids. CDC recommendations for prescribing opioids for outpatients with pain outside of sickle cell disease-related
pain management, cancer pain treatment, palliative care, and end-of-life care. The observations presented here follow
the ordering of the draft Guideline.
Overall Observations...
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Source: Student Doctor Network - July 18, 2021 Category: Universities & Medical Training Authors: drusso Tags: Pain Medicine Source Type: forums
Malaria-resistant red blood cells for malaria patients?
Infectious disease docs,
Do you recommend transfusion / exchange transfusion of malaria-resistant RBCs for Plasmodium falciparum malaria patients (especially now that parasites are becoming drug-resistant)?
Some background for those unfamiliar with malaria: Type O RBCs (universal donor RBCs) are malaria-resistant along with sickle trait RBCs and many others. Evolution selected for type O RBCs and sickle cell trait RBCs due to a survival advantage with Pf malaria. These RBCs are found...
Malaria-resistant red blood cells for malaria patients? (Source: Student Doctor Network)
Source: Student Doctor Network - March 1, 2020 Category: Universities & Medical Training Authors: Seeking MD Perspective Tags: Other Subspecialties Source Type: forums
Why would hospitalist think this is a good idea.. sickle cell pt
20 something year old HbSS, being hospitalized with acute sickle cell vaso-occlusive crisis,
Hgb sitting around 7. No exchange transfusion or blood transfusion. On hydroxyurea.
Poor pain control for several days. Still 10/10 pain, hypertensive, tachycardic, on NC.
Recent URI, has bacteremia being treated on IV antibiotics. Their plan was for several weeks of IV abx.
But hospitalist also want to do a TEE to rule out endocarditis.
- antibiotic plan would not change regardless of outcome of...
Why would hospitalist think this is a good idea.. sickle cell pt (Source: Student Doctor Network)
Source: Student Doctor Network - July 3, 2019 Category: Universities & Medical Training Authors: eikenhein Tags: Anesthesiology Source Type: forums
How often have you caught patients in a lie perpetuated for years?
Recently saw a 50 something year old gentleman with supposed sickle cell disease who still had both native hips, no heart failure, no strokes, no CKD, or any other medical co-morbidities. I found all of that to be beyond abnormal given the low life expectancy and the typical disease burden of someone living that long with SCD. He is apparently a regular at our hospital presenting to the ER at least 5-6x/month and being admitted 1-2x/month and has been doing this for the last 3 years. He was...
How often have you caught patients in a lie perpetuated for years? (Source: Student Doctor Network)
Source: Student Doctor Network - May 15, 2019 Category: Universities & Medical Training Authors: Zebra Hunter Tags: Emergency Medicine Source Type: forums
Re: Management of sickle cell disease in the community: Role of Exercise
(Source: BMJ Comments)
Source: BMJ Comments - March 26, 2019 Category: General Medicine Source Type: forums
Re: Management of sickle cell disease in the community. The advice of NICE
(Source: BMJ Comments)
Source: BMJ Comments - March 26, 2019 Category: General Medicine Source Type: forums
Jaundice and splenomegaly?
Thread Starter
Jaundice and splenomegaly?
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Rather than thi...
Source: The Student Room - May 21, 2018 Category: Universities & Medical Training Authors: junior.doctor Tags: Medicine Source Type: forums
Re: Management of an acute painful sickle cell episode in hospital: summary of NICE guidance
(Source: BMJ Comments)
Source: BMJ Comments - July 1, 2016 Category: Journals (General) Source Type: forums
Southern Blotting Confusion
Researchers conducted an experiment by comparing DNA samples from 3 individuals: homozygote for the normal ß globin gene, homozygote for mutant sickle cell allele and heterozygote for a carrier.
Each DNA sample is mixed with the same restriction enzyme, DdeI. Digestion leads to thousands of fragments. Gel electrophoresis is conducted forming a characteristic of bands and treated later with a stain. The gel is transferred and via capillary action the alkaline solution is pulled through the...
Southern Blotting Confusion (Source: Student Doctor Network)
Source: Student Doctor Network - April 8, 2016 Category: Universities & Medical Training Authors: betterfuture Source Type: forums
