Partial Splenic Embolization in Paediatric Sickle Cell Disease Patients with Hypersplenism
ConclusionPSE is a safe procedure in patients with SCD and hypersplenism, that do not have hypoechogenic nodules in the spleen. PSE improves the hematological parameters and reduces the frequency of blood transfusions.Graphical Abstract (Source: CardioVascular and Interventional Radiology)
Source: CardioVascular and Interventional Radiology - April 5, 2024 Category: Radiology Source Type: research
Effect of nutritional supplementation on bone mineral density in children with sickle cell disease: protocol for an open-label, randomised controlled clinical trial
This study aims to evaluate the effectiveness of an increase in food intake on bone mineral density and the clinical and biological complications of paediatric sickle cell disease.
Methods and analysis
The study is designed as an open-label randomised controlled clinical trial conducted in the Paediatrics Unit of the Orléans University Hospital Centre. Participants aged 3–16 years will be randomly divided into two groups: the intervention group will receive oral nutritional supplements (pharmacological nutritional hypercaloric products) while the control group will receive age-appropriate and gender-appropria...
Source: BMJ Open - April 5, 2024 Category: General Medicine Authors: Conde, M., Lespessailles, E., Wanneveich, M., Allemandou, D., Boulain, T., Dimitrov, G. Tags: Open access, Paediatrics Source Type: research
Endurance training improves oxygen uptake/demand mismatch, metabolic flexibility and recovery in patients with sickle cell disease
Haematologica. 2024 Apr 4. doi: 10.3324/haematol.2023.284474. Online ahead of print.ABSTRACTPatients with sickle cell disease (SCD) display lower slope coefficients of the oxygen uptake (V_O2) vs. work rate (W) relationship (delineating an O2 uptake/demand mismatch) and a poor metabolic flexibility. Because endurance training (ET) increases the microvascular network and oxidative enzymes activity including one involved in lipid oxidation, ET might improve the slope coefficient of the V_O2 vs. W curve and the metabolic flexibility of SCD patients. ET may also contribute to improve patient post-exercise cardiopulmonary and m...
Source: Haematologica - April 4, 2024 Category: Hematology Authors: Lo ïs Mougin Manon Riccetti Ang èle N Merlet Pablo Bartolucci Barnabas Gellen L éo Blervaque Thomas D'Humi ères Fr édéric Galactéros Chi-An W Emhoff L éonard Féasson Laurent A Messonnier Source Type: research
Endurance training improves oxygen uptake/demand mismatch, metabolic flexibility and recovery in patients with sickle cell disease
Haematologica. 2024 Apr 4. doi: 10.3324/haematol.2023.284474. Online ahead of print.ABSTRACTPatients with sickle cell disease (SCD) display lower slope coefficients of the oxygen uptake (V_O2) vs. work rate (W) relationship (delineating an O2 uptake/demand mismatch) and a poor metabolic flexibility. Because endurance training (ET) increases the microvascular network and oxidative enzymes activity including one involved in lipid oxidation, ET might improve the slope coefficient of the V_O2 vs. W curve and the metabolic flexibility of SCD patients. ET may also contribute to improve patient post-exercise cardiopulmonary and m...
Source: Haematologica - April 4, 2024 Category: Hematology Authors: Lo ïs Mougin Manon Riccetti Ang èle N Merlet Pablo Bartolucci Barnabas Gellen L éo Blervaque Thomas D'Humi ères Fr édéric Galactéros Chi-An W Emhoff L éonard Féasson Laurent A Messonnier Source Type: research
Endurance training and hydroxyurea have synergistic effects on muscle function and energetics in sickle cell disease mice
Blood Cells Mol Dis. 2024 Mar 29;107:102853. doi: 10.1016/j.bcmd.2024.102853. Online ahead of print.ABSTRACTSickle cell disease (SCD) is an hemoglobinopathy resulting in the production of an abnormal Hb (HbS) which can polymerize in deoxygenated conditions, leading to the sickling of red blood cells (RBC). These alterations can decrease the oxygen-carrying capacity leading to impaired function and energetics of skeletal muscle. Any strategy which could reverse the corresponding defects could be of interest. In SCD, endurance training is known to improve multiples muscle properties which restores patient's exercise capacity...
Source: Blood Cells, Molecules and Diseases - April 4, 2024 Category: Hematology Authors: Constance P Michel Laurent A Messonnier Benoit Giannesini Christophe Vilmen Joevin Sourdon Yann Le Fur David Bendahan Source Type: research
Endurance training improves oxygen uptake/demand mismatch, metabolic flexibility and recovery in patients with sickle cell disease
Haematologica. 2024 Apr 4. doi: 10.3324/haematol.2023.284474. Online ahead of print.ABSTRACTPatients with sickle cell disease (SCD) display lower slope coefficients of the oxygen uptake (V_O2) vs. work rate (W) relationship (delineating an O2 uptake/demand mismatch) and a poor metabolic flexibility. Because endurance training (ET) increases the microvascular network and oxidative enzymes activity including one involved in lipid oxidation, ET might improve the slope coefficient of the V_O2 vs. W curve and the metabolic flexibility of SCD patients. ET may also contribute to improve patient post-exercise cardiopulmonary and m...
Source: Haematologica - April 4, 2024 Category: Hematology Authors: Lo ïs Mougin Manon Riccetti Ang èle N Merlet Pablo Bartolucci Barnabas Gellen L éo Blervaque Thomas D'Humi ères Fr édéric Galactéros Chi-An W Emhoff L éonard Féasson Laurent A Messonnier Source Type: research
Endurance training improves oxygen uptake/demand mismatch, metabolic flexibility and recovery in patients with sickle cell disease
Haematologica. 2024 Apr 4. doi: 10.3324/haematol.2023.284474. Online ahead of print.ABSTRACTPatients with sickle cell disease (SCD) display lower slope coefficients of the oxygen uptake (V_O2) vs. work rate (W) relationship (delineating an O2 uptake/demand mismatch) and a poor metabolic flexibility. Because endurance training (ET) increases the microvascular network and oxidative enzymes activity including one involved in lipid oxidation, ET might improve the slope coefficient of the V_O2 vs. W curve and the metabolic flexibility of SCD patients. ET may also contribute to improve patient post-exercise cardiopulmonary and m...
Source: Haematologica - April 4, 2024 Category: Hematology Authors: Lo ïs Mougin Manon Riccetti Ang èle N Merlet Pablo Bartolucci Barnabas Gellen L éo Blervaque Thomas D'Humi ères Fr édéric Galactéros Chi-An W Emhoff L éonard Féasson Laurent A Messonnier Source Type: research
Endurance training improves oxygen uptake/demand mismatch, metabolic flexibility and recovery in patients with sickle cell disease
Haematologica. 2024 Apr 4. doi: 10.3324/haematol.2023.284474. Online ahead of print.ABSTRACTPatients with sickle cell disease (SCD) display lower slope coefficients of the oxygen uptake (V_O2) vs. work rate (W) relationship (delineating an O2 uptake/demand mismatch) and a poor metabolic flexibility. Because endurance training (ET) increases the microvascular network and oxidative enzymes activity including one involved in lipid oxidation, ET might improve the slope coefficient of the V_O2 vs. W curve and the metabolic flexibility of SCD patients. ET may also contribute to improve patient post-exercise cardiopulmonary and m...
Source: Haematologica - April 4, 2024 Category: Hematology Authors: Lo ïs Mougin Manon Riccetti Ang èle N Merlet Pablo Bartolucci Barnabas Gellen L éo Blervaque Thomas D'Humi ères Fr édéric Galactéros Chi-An W Emhoff L éonard Féasson Laurent A Messonnier Source Type: research
Endurance training improves oxygen uptake/demand mismatch, metabolic flexibility and recovery in patients with sickle cell disease
Haematologica. 2024 Apr 4. doi: 10.3324/haematol.2023.284474. Online ahead of print.ABSTRACTPatients with sickle cell disease (SCD) display lower slope coefficients of the oxygen uptake (V_O2) vs. work rate (W) relationship (delineating an O2 uptake/demand mismatch) and a poor metabolic flexibility. Because endurance training (ET) increases the microvascular network and oxidative enzymes activity including one involved in lipid oxidation, ET might improve the slope coefficient of the V_O2 vs. W curve and the metabolic flexibility of SCD patients. ET may also contribute to improve patient post-exercise cardiopulmonary and m...
Source: Haematologica - April 4, 2024 Category: Hematology Authors: Lo ïs Mougin Manon Riccetti Ang èle N Merlet Pablo Bartolucci Barnabas Gellen L éo Blervaque Thomas D'Humi ères Fr édéric Galactéros Chi-An W Emhoff L éonard Féasson Laurent A Messonnier Source Type: research
Endurance training and hydroxyurea have synergistic effects on muscle function and energetics in sickle cell disease mice
Blood Cells Mol Dis. 2024 Mar 29;107:102853. doi: 10.1016/j.bcmd.2024.102853. Online ahead of print.ABSTRACTSickle cell disease (SCD) is an hemoglobinopathy resulting in the production of an abnormal Hb (HbS) which can polymerize in deoxygenated conditions, leading to the sickling of red blood cells (RBC). These alterations can decrease the oxygen-carrying capacity leading to impaired function and energetics of skeletal muscle. Any strategy which could reverse the corresponding defects could be of interest. In SCD, endurance training is known to improve multiples muscle properties which restores patient's exercise capacity...
Source: Blood Cells, Molecules and Diseases - April 4, 2024 Category: Hematology Authors: Constance P Michel Laurent A Messonnier Benoit Giannesini Christophe Vilmen Joevin Sourdon Yann Le Fur David Bendahan Source Type: research
Endurance training improves oxygen uptake/demand mismatch, metabolic flexibility and recovery in patients with sickle cell disease
Haematologica. 2024 Apr 4. doi: 10.3324/haematol.2023.284474. Online ahead of print.ABSTRACTPatients with sickle cell disease (SCD) display lower slope coefficients of the oxygen uptake (V_O2) vs. work rate (W) relationship (delineating an O2 uptake/demand mismatch) and a poor metabolic flexibility. Because endurance training (ET) increases the microvascular network and oxidative enzymes activity including one involved in lipid oxidation, ET might improve the slope coefficient of the V_O2 vs. W curve and the metabolic flexibility of SCD patients. ET may also contribute to improve patient post-exercise cardiopulmonary and m...
Source: Haematologica - April 4, 2024 Category: Hematology Authors: Lo ïs Mougin Manon Riccetti Ang èle N Merlet Pablo Bartolucci Barnabas Gellen L éo Blervaque Thomas D'Humi ères Fr édéric Galactéros Chi-An W Emhoff L éonard Féasson Laurent A Messonnier Source Type: research
Endurance training and hydroxyurea have synergistic effects on muscle function and energetics in sickle cell disease mice
Blood Cells Mol Dis. 2024 Mar 29;107:102853. doi: 10.1016/j.bcmd.2024.102853. Online ahead of print.ABSTRACTSickle cell disease (SCD) is an hemoglobinopathy resulting in the production of an abnormal Hb (HbS) which can polymerize in deoxygenated conditions, leading to the sickling of red blood cells (RBC). These alterations can decrease the oxygen-carrying capacity leading to impaired function and energetics of skeletal muscle. Any strategy which could reverse the corresponding defects could be of interest. In SCD, endurance training is known to improve multiples muscle properties which restores patient's exercise capacity...
Source: Blood Cells, Molecules and Diseases - April 4, 2024 Category: Hematology Authors: Constance P Michel Laurent A Messonnier Benoit Giannesini Christophe Vilmen Joevin Sourdon Yann Le Fur David Bendahan Source Type: research
Endurance training improves oxygen uptake/demand mismatch, metabolic flexibility and recovery in patients with sickle cell disease
Haematologica. 2024 Apr 4. doi: 10.3324/haematol.2023.284474. Online ahead of print.ABSTRACTPatients with sickle cell disease (SCD) display lower slope coefficients of the oxygen uptake (V_O2) vs. work rate (W) relationship (delineating an O2 uptake/demand mismatch) and a poor metabolic flexibility. Because endurance training (ET) increases the microvascular network and oxidative enzymes activity including one involved in lipid oxidation, ET might improve the slope coefficient of the V_O2 vs. W curve and the metabolic flexibility of SCD patients. ET may also contribute to improve patient post-exercise cardiopulmonary and m...
Source: Haematologica - April 4, 2024 Category: Hematology Authors: Lo ïs Mougin Manon Riccetti Ang èle N Merlet Pablo Bartolucci Barnabas Gellen L éo Blervaque Thomas D'Humi ères Fr édéric Galactéros Chi-An W Emhoff L éonard Féasson Laurent A Messonnier Source Type: research
A Novel Mechanistic Model for Future Research in the Elements of the ERAS Program in Patients With Sickle Cell Disease
AANA J. 2024 Apr;92(2):87-92.ABSTRACTEnhanced recovery after surgery (ERAS) is a patient-centered, evidence-based, multidisciplinary team-developed approach to a surgical stress response that is implemented to optimize physiological function and facilitate recovery for the best possible outcomes from surgery. Although there are currently well-known published guidelines for the perioperative management of patients with sickle cell disease, there are currently no specific and evidencebased ERAS protocols that address the needs of these patients. A novel mechanistic model has recently been found that could change ERAS protoco...
Source: AANA Journal - April 2, 2024 Category: Anesthesiology Authors: Marcy Purnell Michong Rayborn Source Type: research
A Novel Mechanistic Model for Future Research in the Elements of the ERAS Program in Patients With Sickle Cell Disease
AANA J. 2024 Apr;92(2):87-92.ABSTRACTEnhanced recovery after surgery (ERAS) is a patient-centered, evidence-based, multidisciplinary team-developed approach to a surgical stress response that is implemented to optimize physiological function and facilitate recovery for the best possible outcomes from surgery. Although there are currently well-known published guidelines for the perioperative management of patients with sickle cell disease, there are currently no specific and evidencebased ERAS protocols that address the needs of these patients. A novel mechanistic model has recently been found that could change ERAS protoco...
Source: AANA Journal - April 2, 2024 Category: Anesthesiology Authors: Marcy Purnell Michong Rayborn Source Type: research
