Aerobic physical capacity and health-related quality of life in children with sickle cell disease
CONCLUSION: Aerobic capacity is poor in children with sickle cell disease. VO2max decrease is associated with the level of anemia, the existence of a homozygote HbS/S mutation, lung function, and health-related quality of life. These results represent a signal in favor of early initiation of cardiac rehabilitation in patients with sickle cell disease.CLINICAL TRIALS: NCT05995743.IMPACT: Aerobic fitness is a predictor of cardiovascular health which correlates with health-related quality of life in the general population. Aerobic capacity (VO2max) is poor in children with sickle cell disease, despite the absence of any patte...
Source: Pediatric Research - March 16, 2024 Category: Pediatrics Authors: Corentin Laurent-Lacroix Marie Vincenti Stefan Matecki Perrine Mah é Lionel Moulis Gregoire De La Villeon Sophie Guillaumont Anne Requirand Johan Moreau Muriel Lalande Marie-Christine Picot Pascal Amedro Arthur Gavotto Source Type: research
Aerobic physical capacity and health-related quality of life in children with sickle cell disease
CONCLUSION: Aerobic capacity is poor in children with sickle cell disease. VO2max decrease is associated with the level of anemia, the existence of a homozygote HbS/S mutation, lung function, and health-related quality of life. These results represent a signal in favor of early initiation of cardiac rehabilitation in patients with sickle cell disease.CLINICAL TRIALS: NCT05995743.IMPACT: Aerobic fitness is a predictor of cardiovascular health which correlates with health-related quality of life in the general population. Aerobic capacity (VO2max) is poor in children with sickle cell disease, despite the absence of any patte...
Source: Cell Research - March 16, 2024 Category: Cytology Authors: Corentin Laurent-Lacroix Marie Vincenti Stefan Matecki Perrine Mah é Lionel Moulis Gregoire De La Villeon Sophie Guillaumont Anne Requirand Johan Moreau Muriel Lalande Marie-Christine Picot Pascal Amedro Arthur Gavotto Source Type: research
Exploring Factors Associated with Quality of Life in Caregivers of Children and Adolescents with Sickle Cell Disease and HIV: A Comparative Analysis
CONCLUSION: Quality of life is lower in caregivers of children and adolescents with SCD than with HIV. Preventing depression and anxiety as well as advocating for the subsidization of medications through a national SCD program may improve quality of life in SCD caregivers.PMID:38487039 | PMC:PMC10937083 | DOI:10.1155/2024/4429541 (Source: Anemia)
Source: Anemia - March 15, 2024 Category: Hematology Authors: Charlotte Eposse Ekoube Dora Mbonjo Bitsie Erero F Njiengwe Edgar Mandeng Ma Linwa Christian Eyoum Ritha Mbono Betoko Jeannette Disso Massako Emmanuel Heles Nsang Abba Soumaiyatou Callixte Tegueu Kuate Source Type: research
The relationship between cumulative risk and health-related quality of life in youth with sickle cell disease: Moderating effects of secondary control engagement coping
CONCLUSIONS: SCE coping may selectively benefit children with SCD experiencing lower cumulative risk, warranting encouragement of this strategy in clinical settings. Findings do not support SCE coping benefits for youth with higher risk, suggesting that the strategy may not be useful when risk-related stressors are especially pervasive; alternative protective factors should be identified for this risk group.PMID:38488719 | DOI:10.1002/pbc.30950 (Source: Cancer Control)
Source: Cancer Control - March 15, 2024 Category: Cancer & Oncology Authors: Elise M Belkin Natalie Koskela-Staples Elise Turner L Vandy Black David A Fedele Source Type: research
Exploring Factors Associated with Quality of Life in Caregivers of Children and Adolescents with Sickle Cell Disease and HIV: A Comparative Analysis
CONCLUSION: Quality of life is lower in caregivers of children and adolescents with SCD than with HIV. Preventing depression and anxiety as well as advocating for the subsidization of medications through a national SCD program may improve quality of life in SCD caregivers.PMID:38487039 | PMC:PMC10937083 | DOI:10.1155/2024/4429541 (Source: Anemia)
Source: Anemia - March 15, 2024 Category: Hematology Authors: Charlotte Eposse Ekoube Dora Mbonjo Bitsie Erero F Njiengwe Edgar Mandeng Ma Linwa Christian Eyoum Ritha Mbono Betoko Jeannette Disso Massako Emmanuel Heles Nsang Abba Soumaiyatou Callixte Tegueu Kuate Source Type: research
Durable engraftment after pharmacological pre-transplant immune suppression followed by reduced-toxicity myeloablative haploidentical stem cell transplantation in highly HLA-immunized adults with sickle cell disease
We report the results of five patients with SCD, whereas three with DSA, who underwent an unmanipulated haploidentical stem cell transplantation (Haplo-SCT) after a busulfan-based RT-MAC regimen with PT-Cy. To reduce the risk of engraftment failure, a sequential two courses pharmacological pre-transplant immune suppression (PTIS) phase was added prior to the conditioning regimen. All patients engrafted successfully. The procedure was well tolerated. None of the patients developed acute GVHD, whereas one developed moderate chronic GVHD. After a median follow-up of 5 years (range, 2.2-9), all patients are free of pain with e...
Source: Cancer Control - March 15, 2024 Category: Cancer & Oncology Authors: Sabine F ürst Emmanuelle Bernit Faezeh Legrand Angela Granata Samia Harbi Raynier Devillier Valerio Maisano Benjamin Bouchacourt Thomas Pagliardini Djamel Mokart Claude Lemari é Boris Calmels Christophe Picard Agn ès Basire Borje S Andersson Didier Bla Source Type: research
Exploring Factors Associated with Quality of Life in Caregivers of Children and Adolescents with Sickle Cell Disease and HIV: A Comparative Analysis
CONCLUSION: Quality of life is lower in caregivers of children and adolescents with SCD than with HIV. Preventing depression and anxiety as well as advocating for the subsidization of medications through a national SCD program may improve quality of life in SCD caregivers.PMID:38487039 | PMC:PMC10937083 | DOI:10.1155/2024/4429541 (Source: Anemia)
Source: Anemia - March 15, 2024 Category: Hematology Authors: Charlotte Eposse Ekoube Dora Mbonjo Bitsie Erero F Njiengwe Edgar Mandeng Ma Linwa Christian Eyoum Ritha Mbono Betoko Jeannette Disso Massako Emmanuel Heles Nsang Abba Soumaiyatou Callixte Tegueu Kuate Source Type: research
Comparative transcriptomic analysis of circulating endothelial cells in sickle cell stroke
AbstractIschemic stroke (IS) is one of the most impairing complications of sickle cell anemia (SCA), responsible for 20% of mortality in patients. Rheological alterations, adhesive properties of sickle reticulocytes, leukocyte adhesion, inflammation and endothelial dysfunction are related to the vasculopathy observed prior to ischemic events. The role of the vascular endothelium in this complex cascade of mechanisms is emphasized, as well as in the process of ischemia-induced repair and neovascularization. The aim of the present study was to perform a comparative transcriptomic analysis of endothelial colony-forming cells ...
Source: Annals of Hematology - March 15, 2024 Category: Hematology Source Type: research
