Other Wounds Encountered in Clinical Practice
This chapter delves into uncommon wounds including pyoderma gangrenosum, sickle cell disease ulcers, vasculitic wounds, Martorell hypertensive ischemic leg ulcers, and malignant ulcers. Emphasizing a multidisciplinary approach, it covers diagnostics, treatments, and challenges, with case studies illustrating complexities in managing these conditions. The discussion extends to radiation-related wounds, underscoring the need for patient-centered care, interdisciplinary collaboration, and realistic goal setting. Overall, the chapter navigates the intricacies of uncommon wounds, emphasizing the importance of tailored approache...
Source: Clinics in Geriatric Medicine - April 27, 2024 Category: Geriatrics Authors: Scott Matthew Bolhack Source Type: research
Prevalence of arboviruses in sickle cell disease patients from two major cities in northeast region of Brazil
Braz J Infect Dis. 2024 Apr 23:103741. doi: 10.1016/j.bjid.2024.103741. Online ahead of print.ABSTRACTSickle Cell Disease (SCD) is a hereditary disease characterized by extravascular and intravascular hemolysis and clinical variability, from mild pain to potentially life-threatening. Arboviruses include mainly Zika (ZIKV), Chikungunya (CHKV), and Dengue (DENV) virus, and are considered a public and social health problem. The present cross-sectional observational study aimed to investigate the prevalence of arbovirus infection in SCD patients from two Brazilian cities, Salvador and Manaus located in Bahia and Amazonas state...
Source: Braz J Infect Dis - April 26, 2024 Category: Infectious Diseases Authors: Jos é Pereira Moura Neto Cinthia Cristina Matheus Xerez Albuquerque Setondji Cocou Modeste Alexandre Yahouedehou Marcos Vinicius Lima Francisco Nelson Abrahim Fraiji Isadora Cristina de Siqueira Marilda Souza Gon çalves Source Type: research
Prevalence of arboviruses in sickle cell disease patients from two major cities in northeast region of Brazil
Braz J Infect Dis. 2024 Apr 23:103741. doi: 10.1016/j.bjid.2024.103741. Online ahead of print.ABSTRACTSickle Cell Disease (SCD) is a hereditary disease characterized by extravascular and intravascular hemolysis and clinical variability, from mild pain to potentially life-threatening. Arboviruses include mainly Zika (ZIKV), Chikungunya (CHKV), and Dengue (DENV) virus, and are considered a public and social health problem. The present cross-sectional observational study aimed to investigate the prevalence of arbovirus infection in SCD patients from two Brazilian cities, Salvador and Manaus located in Bahia and Amazonas state...
Source: Braz J Infect Dis - April 26, 2024 Category: Infectious Diseases Authors: Jos é Pereira Moura Neto Cinthia Cristina Matheus Xerez Albuquerque Setondji Cocou Modeste Alexandre Yahouedehou Marcos Vinicius Lima Francisco Nelson Abrahim Fraiji Isadora Cristina de Siqueira Marilda Souza Gon çalves Source Type: research
Health education to promote knowledge about sickle cell disease and newborn screening in pregnant women: a community-based pilot study using the healthy beginning initiative
Pregnancy presents a critical period for any maternal and child health intervention that may impact the health of the newborn. With low antenatal care attendance by pregnant women in health facilities in Niger... (Source: BMC Pregnancy and Childbirth)
Source: BMC Pregnancy and Childbirth - April 26, 2024 Category: OBGYN Authors: Osita U. Ezenwosu, John O. Olawepo, Lorraine J. Lacroix-Willliamson, Ijeoma U. Itanyi, Amaka Ogidi, Tonia C. Onyeka, Madeline Gully, Maisha Gregory, Janis L. Breeze, Stephanie Ibemere, Ngozi Idemili-Aronu, Beth E. Molnar and Echezona E. Ezeanolue Tags: Research Source Type: research
Sickle Cell Disease in Brazil: Current Management
. (Source: Hemoglobin)
Source: Hemoglobin - April 26, 2024 Category: Hematology Authors: Aderson da Silva Ara újoAna Cristina Silva PintoClarisse Lopes de Castro LoboMaria Stella FigueiredoSandra Fátima Menosi GualandroSara Teresinha Olalla SaadRodolfo Delfini Cançadoa Department of Hematology, Fundação de Hematologia e Hemoterapia de Pe Source Type: research
IJERPH, Vol. 21, Pages 530: A Mixed-Methods Evaluation of a Project ECHO Program for the Evidence-Based Management of Sickle Cell Disease
e Shook
Sickle cell disease (SCD) is a group of chronic, genetic disorders of the red blood cells with significant gaps in access to evidence-based clinical care. Sickle Treatment and Outcomes Research in the Midwest (STORM), a provider network, utilized Project ECHO (Extension for Community Health Outcomes), a telementoring model, to deliver evidence-based education about SCD management. The purpose of this mixed-methods study is to evaluate the utility of Project ECHO as an educational strategy for healthcare providers treating children and adults with SCD. Annual evaluations were administered to STORM TeleECHO parti...
Source: International Journal of Environmental Research and Public Health - April 25, 2024 Category: Environmental Health Authors: Cami Mosley Christina Bennett Farrell Charles T. Quinn Lisa Marie Shook Tags: Article Source Type: research
Case Report: Obstetric and COVID-19-Related Morbidity and Mortality in Three Patients with Sickle Hemoglobinopathy
We describe the maternal and neonatal outcomes of three patients with COVID-19 and SCD (including two with hemoglobin SC disease and one with hemoglobin SS disease), with complications including the demise of a mother and a newborn. Vaso-occlusive crisis was the more common presentation. Two patients required ventilatory support. Although previous reports have shown similar clinical sequelae in pregnant and nonpregnant patients with SCD and COVID-19, maternal and neonatal deaths remain possible.PMID:38653217 | DOI:10.4269/ajtmh.23-0761 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - April 23, 2024 Category: Tropical Medicine Authors: Shanea Gibson Tiffany Hunter Nadine Johnson Source Type: research
Case Report: Obstetric and COVID-19-Related Morbidity and Mortality in Three Patients with Sickle Hemoglobinopathy
We describe the maternal and neonatal outcomes of three patients with COVID-19 and SCD (including two with hemoglobin SC disease and one with hemoglobin SS disease), with complications including the demise of a mother and a newborn. Vaso-occlusive crisis was the more common presentation. Two patients required ventilatory support. Although previous reports have shown similar clinical sequelae in pregnant and nonpregnant patients with SCD and COVID-19, maternal and neonatal deaths remain possible.PMID:38653217 | DOI:10.4269/ajtmh.23-0761 (Source: Am J Trop Med Hyg)
Source: Am J Trop Med Hyg - April 23, 2024 Category: Infectious Diseases Authors: Shanea Gibson Tiffany Hunter Nadine Johnson Source Type: research
Case Report: Obstetric and COVID-19-Related Morbidity and Mortality in Three Patients with Sickle Hemoglobinopathy
We describe the maternal and neonatal outcomes of three patients with COVID-19 and SCD (including two with hemoglobin SC disease and one with hemoglobin SS disease), with complications including the demise of a mother and a newborn. Vaso-occlusive crisis was the more common presentation. Two patients required ventilatory support. Although previous reports have shown similar clinical sequelae in pregnant and nonpregnant patients with SCD and COVID-19, maternal and neonatal deaths remain possible.PMID:38653217 | DOI:10.4269/ajtmh.23-0761 (Source: Am J Trop Med Hyg)
Source: Am J Trop Med Hyg - April 23, 2024 Category: Infectious Diseases Authors: Shanea Gibson Tiffany Hunter Nadine Johnson Source Type: research
Unraveling DEHP influence on hemoglobin S polymerization in sickle cell disease: Ex vivo, in vitro and in silico analysis
This study aimed to unravel DEHP effect on SCD patient's hemoglobin function. We found that HbS polymerization using whole erythrocytes is decreased by DEHP in ex vivo experiments and this effect might be mediated by the DEHP-VAL6 interaction, evaluated in silico. Isolated HbS exhibited less polymerization at low DEHP concentrations and increased polymerization rate at higher concentration. When analyzing the propensity to aggregate, HbS is more inclined to aggregate when compared to HbA due to the residue 6 mutation. Circular dichroism showed characteristic hemoglobin peaks for oxygenated HbS that are lost when oxygen is ...
Source: Toxicology in Vitro - April 23, 2024 Category: Toxicology Authors: Rodrigo Abreu Camacho Aghata Vitoria Machado Fernanda de Oliveira Mendon ça Lyzes Rosa Teixeira-Alves Camila Cristina Guimar ães-Nobre Evelyn Mendon ça-Reis Priscila Ferreira da Silva Thyago R Cardim-Pires Leandro Miranda-Alves Clemilson Berto-Junior Source Type: research
Case Report: Obstetric and COVID-19-Related Morbidity and Mortality in Three Patients with Sickle Hemoglobinopathy
We describe the maternal and neonatal outcomes of three patients with COVID-19 and SCD (including two with hemoglobin SC disease and one with hemoglobin SS disease), with complications including the demise of a mother and a newborn. Vaso-occlusive crisis was the more common presentation. Two patients required ventilatory support. Although previous reports have shown similar clinical sequelae in pregnant and nonpregnant patients with SCD and COVID-19, maternal and neonatal deaths remain possible.PMID:38653217 | DOI:10.4269/ajtmh.23-0761 (Source: Am J Trop Med Hyg)
Source: Am J Trop Med Hyg - April 23, 2024 Category: Infectious Diseases Authors: Shanea Gibson Tiffany Hunter Nadine Johnson Source Type: research
Case Report: Obstetric and COVID-19-Related Morbidity and Mortality in Three Patients with Sickle Hemoglobinopathy
We describe the maternal and neonatal outcomes of three patients with COVID-19 and SCD (including two with hemoglobin SC disease and one with hemoglobin SS disease), with complications including the demise of a mother and a newborn. Vaso-occlusive crisis was the more common presentation. Two patients required ventilatory support. Although previous reports have shown similar clinical sequelae in pregnant and nonpregnant patients with SCD and COVID-19, maternal and neonatal deaths remain possible.PMID:38653217 | DOI:10.4269/ajtmh.23-0761 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - April 23, 2024 Category: Tropical Medicine Authors: Shanea Gibson Tiffany Hunter Nadine Johnson Source Type: research
Unraveling DEHP influence on hemoglobin S polymerization in sickle cell disease: Ex vivo, in vitro and in silico analysis
This study aimed to unravel DEHP effect on SCD patient's hemoglobin function. We found that HbS polymerization using whole erythrocytes is decreased by DEHP in ex vivo experiments and this effect might be mediated by the DEHP-VAL6 interaction, evaluated in silico. Isolated HbS exhibited less polymerization at low DEHP concentrations and increased polymerization rate at higher concentration. When analyzing the propensity to aggregate, HbS is more inclined to aggregate when compared to HbA due to the residue 6 mutation. Circular dichroism showed characteristic hemoglobin peaks for oxygenated HbS that are lost when oxygen is ...
Source: Toxicology in Vitro - April 23, 2024 Category: Toxicology Authors: Rodrigo Abreu Camacho Aghata Vitoria Machado Fernanda de Oliveira Mendon ça Lyzes Rosa Teixeira-Alves Camila Cristina Guimar ães-Nobre Evelyn Mendon ça-Reis Priscila Ferreira da Silva Thyago R Cardim-Pires Leandro Miranda-Alves Clemilson Berto-Junior Source Type: research
Case Report: Obstetric and COVID-19-Related Morbidity and Mortality in Three Patients with Sickle Hemoglobinopathy
We describe the maternal and neonatal outcomes of three patients with COVID-19 and SCD (including two with hemoglobin SC disease and one with hemoglobin SS disease), with complications including the demise of a mother and a newborn. Vaso-occlusive crisis was the more common presentation. Two patients required ventilatory support. Although previous reports have shown similar clinical sequelae in pregnant and nonpregnant patients with SCD and COVID-19, maternal and neonatal deaths remain possible.PMID:38653217 | DOI:10.4269/ajtmh.23-0761 (Source: Am J Trop Med Hyg)
Source: Am J Trop Med Hyg - April 23, 2024 Category: Infectious Diseases Authors: Shanea Gibson Tiffany Hunter Nadine Johnson Source Type: research
Case Report: Obstetric and COVID-19-Related Morbidity and Mortality in Three Patients with Sickle Hemoglobinopathy
We describe the maternal and neonatal outcomes of three patients with COVID-19 and SCD (including two with hemoglobin SC disease and one with hemoglobin SS disease), with complications including the demise of a mother and a newborn. Vaso-occlusive crisis was the more common presentation. Two patients required ventilatory support. Although previous reports have shown similar clinical sequelae in pregnant and nonpregnant patients with SCD and COVID-19, maternal and neonatal deaths remain possible.PMID:38653217 | DOI:10.4269/ajtmh.23-0761 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - April 23, 2024 Category: Tropical Medicine Authors: Shanea Gibson Tiffany Hunter Nadine Johnson Source Type: research
